ID   HXA7_HUMAN              Reviewed;         230 AA.
AC   P31268; A4D191; O43368; O43486; O95655; Q9NSC8; Q9UDM1;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 3.
DT   24-JAN-2024, entry version 198.
DE   RecName: Full=Homeobox protein Hox-A7;
DE   AltName: Full=Homeobox protein Hox 1.1;
DE   AltName: Full=Homeobox protein Hox-1A;
GN   Name=HOXA7; Synonyms=HOX1A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-18.
RX   PubMed=11435435; DOI=10.1074/jbc.m104598200;
RA   La Celle P.T., Polakowska R.R.;
RT   "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and
RT   inhibits differentiation.";
RL   J. Biol. Chem. 276:32844-32853(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-18.
RX   PubMed=9804983; DOI=10.1016/s0167-4781(98)00170-5;
RA   McIlhatton M.A., Bremner P.S., McMullin M.F., Maxwell A.P., Winter P.C.,
RA   Lappin T.R.;
RT   "Sequence characterisation and expression of homeobox HOX A7 in the multi-
RT   potential erythroleukaemic cell line TF-1.";
RL   Biochim. Biophys. Acta 1442:329-333(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-18.
RX   PubMed=10911612; DOI=10.1385/mb:14:1:19;
RA   Kim M.H., Jin H., Seol E.Y., Yoo M., Park H.W.;
RT   "Sequence analysis and tissue specific expression of human HOXA7.";
RL   Mol. Biotechnol. 14:19-24(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-18.
RC   TISSUE=Placenta;
RA   Albrechtsen R., Wewer U.;
RL   Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91, AND VARIANT THR-18.
RA   Cho M., Kim M.H., Hwang C.Y., Min W.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-195.
RX   PubMed=2576652; DOI=10.1139/g89-133;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- INTERACTION:
CC       P31268; O00560: SDCBP; NbExp=3; IntAct=EBI-3910421, EBI-727004;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF026397; AAB94604.1; -; mRNA.
DR   EMBL; AJ005814; CAA06713.1; -; mRNA.
DR   EMBL; AF032095; AAD01939.2; -; Genomic_DNA.
DR   EMBL; X84803; CAA59270.1; -; Genomic_DNA.
DR   EMBL; X84804; CAA59270.1; JOINED; Genomic_DNA.
DR   EMBL; CH236948; EAL24221.1; -; Genomic_DNA.
DR   EMBL; AC004080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471073; EAW93877.1; -; Genomic_DNA.
DR   EMBL; U92543; AAD00727.1; -; Genomic_DNA.
DR   CCDS; CCDS5408.1; -.
DR   PIR; S15536; S15536.
DR   RefSeq; NP_008827.2; NM_006896.3.
DR   AlphaFoldDB; P31268; -.
DR   SMR; P31268; -.
DR   BioGRID; 109444; 90.
DR   IntAct; P31268; 4.
DR   STRING; 9606.ENSP00000242159; -.
DR   iPTMnet; P31268; -.
DR   PhosphoSitePlus; P31268; -.
DR   BioMuta; HOXA7; -.
DR   DMDM; 311033439; -.
DR   jPOST; P31268; -.
DR   MassIVE; P31268; -.
DR   MaxQB; P31268; -.
DR   PaxDb; 9606-ENSP00000242159; -.
DR   PeptideAtlas; P31268; -.
DR   ProteomicsDB; 54769; -.
DR   Antibodypedia; 12389; 198 antibodies from 26 providers.
DR   DNASU; 3204; -.
DR   Ensembl; ENST00000242159.5; ENSP00000242159.3; ENSG00000122592.8.
DR   GeneID; 3204; -.
DR   KEGG; hsa:3204; -.
DR   MANE-Select; ENST00000242159.5; ENSP00000242159.3; NM_006896.4; NP_008827.2.
DR   UCSC; uc003sys.4; human.
DR   AGR; HGNC:5108; -.
DR   CTD; 3204; -.
DR   DisGeNET; 3204; -.
DR   GeneCards; HOXA7; -.
DR   HGNC; HGNC:5108; HOXA7.
DR   HPA; ENSG00000122592; Low tissue specificity.
DR   MIM; 142950; gene.
DR   neXtProt; NX_P31268; -.
DR   OpenTargets; ENSG00000122592; -.
DR   PharmGKB; PA29385; -.
DR   VEuPathDB; HostDB:ENSG00000122592; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161013; -.
DR   HOGENOM; CLU_061398_1_1_1; -.
DR   InParanoid; P31268; -.
DR   OMA; YRMYPWM; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P31268; -.
DR   TreeFam; TF316310; -.
DR   PathwayCommons; P31268; -.
DR   SignaLink; P31268; -.
DR   SIGNOR; P31268; -.
DR   BioGRID-ORCS; 3204; 18 hits in 1170 CRISPR screens.
DR   GeneWiki; HOXA7; -.
DR   GenomeRNAi; 3204; -.
DR   Pharos; P31268; Tbio.
DR   PRO; PR:P31268; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; P31268; Protein.
DR   Bgee; ENSG00000122592; Expressed in oocyte and 136 other cell types or tissues.
DR   ExpressionAtlas; P31268; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0031965; C:nuclear membrane; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0001525; P:angiogenesis; IEP:UniProtKB.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR   GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IDA:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:UniProtKB.
DR   GO; GO:0045617; P:negative regulation of keratinocyte differentiation; IDA:MGI.
DR   GO; GO:0002686; P:negative regulation of leukocyte migration; IDA:UniProtKB.
DR   GO; GO:0045656; P:negative regulation of monocyte differentiation; IDA:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF12; HOMEOBOX PROTEIN HOX-A7; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P31268; HS.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..230
FT                   /note="Homeobox protein Hox-A7"
FT                   /id="PRO_0000200071"
FT   DNA_BIND        130..189
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          187..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           119..124
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        215..230
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         18
FT                   /note="A -> T (in dbSNP:rs2301721)"
FT                   /evidence="ECO:0000269|PubMed:10911612,
FT                   ECO:0000269|PubMed:11435435, ECO:0000269|PubMed:9804983,
FT                   ECO:0000269|Ref.4, ECO:0000269|Ref.8"
FT                   /id="VAR_028001"
FT   CONFLICT        75..76
FT                   /note="DA -> RR (in Ref. 8; AAD00727)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        78
FT                   /note="Missing (in Ref. 4; CAA59270)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        174
FT                   /note="I -> V (in Ref. 3; AAD01939)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        194..195
FT                   /note="PT -> RL (in Ref. 4; CAA59270)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        195
FT                   /note="T -> I (in Ref. 9; no nucleotide entry)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        222
FT                   /note="D -> Y (in Ref. 4; CAA59270)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   230 AA;  25355 MW;  8F77A6B0AFB516D5 CRC64;
     MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP
     LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY
     PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN
     RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE
//