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Protein

Homeobox protein Hox-A7

Gene

HOXA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi130 – 189HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • anterior/posterior pattern specification Source: Ensembl
  • embryonic skeletal system morphogenesis Source: Ensembl
  • negative regulation of cell-matrix adhesion Source: UniProtKB
  • negative regulation of keratinocyte differentiation Source: MGI
  • negative regulation of leukocyte migration Source: UniProtKB
  • negative regulation of monocyte differentiation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • stem cell differentiation Source: Ensembl

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP31268

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A7
Alternative name(s):
Homeobox protein Hox 1.1
Homeobox protein Hox-1A
Gene namesi
Name:HOXA7
Synonyms:HOX1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122592.7
HGNCiHGNC:5108 HOXA7
MIMi142950 gene
neXtProtiNX_P31268

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3204
OpenTargetsiENSG00000122592
PharmGKBiPA29385

Polymorphism and mutation databases

BioMutaiHOXA7
DMDMi311033439

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000711 – 230Homeobox protein Hox-A7Add BLAST230

Proteomic databases

MaxQBiP31268
PaxDbiP31268
PeptideAtlasiP31268
PRIDEiP31268

PTM databases

iPTMnetiP31268
PhosphoSitePlusiP31268

Expressioni

Gene expression databases

BgeeiENSG00000122592
CleanExiHS_HOXA7
ExpressionAtlasiP31268 baseline and differential
GenevisibleiP31268 HS

Organism-specific databases

HPAiHPA074048

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005604EBI-3910421,EBI-727004

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109444, 3 interactors
IntActiP31268, 4 interactors
STRINGi9606.ENSP00000242159

Structurei

3D structure databases

ProteinModelPortaliP31268
SMRiP31268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi119 – 124Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 160Poly-Arg4
Compositional biasi196 – 199Poly-Ala4
Compositional biasi214 – 230Asp/Glu-rich (highly acidic)Add BLAST17
Compositional biasi223 – 230Poly-Glu8

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP31268
KOiK09307
OMAiWKKEHKD
OrthoDBiEOG091G09XD
PhylomeDBiP31268
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST
60 70 80 90 100
VPGLYNVNSP LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA
110 120 130 140 150
CDKTDEGALH GAAEANFRIY PWMRSSGPDR KRGRQTYTRY QTLELEKEFH
160 170 180 190 200
FNRYLTRRRR IEIAHALCLT ERQIKIWFQN RRMKWKKEHK DEGPTAAAAP
210 220 230
EGAVPSAAAT AAADKADEED DDEEEEDEEE
Length:230
Mass (Da):25,355
Last modified:November 2, 2010 - v3
Checksum:i8F77A6B0AFB516D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75 – 76DA → RR in AAD00727 (Ref. 8) Curated2
Sequence conflicti78Missing in CAA59270 (Ref. 4) Curated1
Sequence conflicti174I → V in AAD01939 (PubMed:10911612).Curated1
Sequence conflicti194 – 195PT → RL in CAA59270 (Ref. 4) Curated2
Sequence conflicti195T → I no nucleotide entry (PubMed:2576652).Curated1
Sequence conflicti222D → Y in CAA59270 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02800118A → T5 PublicationsCorresponds to variant dbSNP:rs2301721Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026397 mRNA Translation: AAB94604.1
AJ005814 mRNA Translation: CAA06713.1
AF032095 Genomic DNA Translation: AAD01939.2
X84803, X84804 Genomic DNA Translation: CAA59270.1
CH236948 Genomic DNA Translation: EAL24221.1
AC004080 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93877.1
U92543 Genomic DNA Translation: AAD00727.1
CCDSiCCDS5408.1
PIRiS15536
RefSeqiNP_008827.2, NM_006896.3
UniGeneiHs.610216
Hs.660918

Genome annotation databases

EnsembliENST00000242159; ENSP00000242159; ENSG00000122592
GeneIDi3204
KEGGihsa:3204
UCSCiuc003sys.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHXA7_HUMAN
AccessioniPrimary (citable) accession number: P31268
Secondary accession number(s): A4D191
, O43368, O43486, O95655, Q9NSC8, Q9UDM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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