P31268 (HXA7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A7

Alternative name(s):
Homeobox protein Hox 1.1
Homeobox protein Hox-1A

Gene names

Name:	HOXA7
Synonyms:	HOX1A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	angiogenesis Inferred from expression pattern. Source: UniProtKB negative regulation of cell-matrix adhesion Inferred from direct assay. Source: UniProtKB negative regulation of keratinocyte differentiation Inferred from direct assay Ref.1. Source: MGI negative regulation of leukocyte migration Inferred from direct assay. Source: UniProtKB negative regulation of monocyte differentiation Inferred from direct assay. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.1. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred by curator Ref.1. Source: UniProtKB
Molecular function	sequence-specific DNA binding Inferred from direct assay Ref.1. Source: UniProtKB transcription factor binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Homeobox protein Hox-A7		PRO_0000200071
Regions
	DNA binding	130 – 189	60	Homeobox
	Motif	119 – 124	6	Antp-type hexapeptide
	Compositional bias	157 – 160	4	Poly-Arg
	Compositional bias	196 – 199	4	Poly-Ala
	Compositional bias	214 – 230	17	Asp/Glu-rich (highly acidic)
	Compositional bias	223 – 230	8	Poly-Glu
Natural variations
	Natural variant	18	1	A → T. Ref.1 Ref.2 Ref.3 Ref.4 Ref.8 Corresponds to variant rs2301721 [ dbSNP | Ensembl ].		VAR_028001
Experimental info
	Sequence conflict	75 – 76	2	DA → RR in AAD00727. Ref.8
	Sequence conflict	78	1	Missing in CAA59270. Ref.4
	Sequence conflict	174	1	I → V in AAD01939. Ref.3
	Sequence conflict	194 – 195	2	PT → RL in CAA59270. Ref.4
	Sequence conflict	195	1	T → I no nucleotide entry Ref.9
	Sequence conflict	222	1	D → Y in CAA59270. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P31268 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: 8F77A6B0AFB516D5	FASTA	230	25,355
	10 20 30 40 50 60 MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP 70 80 90 100 110 120 LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY 130 140 150 160 170 180 PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN 190 200 210 220 230 RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation." La Celle P.T., Polakowska R.R. J. Biol. Chem. 276:32844-32853(2001) [PubMed: 11435435] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-18.
[2]	"Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1." McIlhatton M.A., Bremner P.S., McMullin M.F., Maxwell A.P., Winter P.C., Lappin T.R. Biochim. Biophys. Acta 1442:329-333(1998) [PubMed: 9804983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-18.
[3]	"Sequence analysis and tissue specific expression of human HOXA7." Kim M.H., Jin H., Seol E.Y., Yoo M., Park H.W. Mol. Biotechnol. 14:19-24(2000) [PubMed: 10911612] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-18.
[4]	Albrechtsen R., Wewer U. Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-18. Tissue: Placenta.
[5]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Cho M., Kim M.H., Hwang C.Y., Min W. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91, VARIANT THR-18.
[9]	"Organization of human class I homeobox genes." Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A. Genome 31:745-756(1989) [PubMed: 2576652] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-195.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF026397 mRNA. Translation: AAB94604.1. AJ005814 mRNA. Translation: CAA06713.1. AF032095 Genomic DNA. Translation: AAD01939.2. X84803, X84804 Genomic DNA. Translation: CAA59270.1. CH236948 Genomic DNA. Translation: EAL24221.1. AC004080 Genomic DNA. No translation available. CH471073 Genomic DNA. Translation: EAW93877.1. U92543 Genomic DNA. Translation: AAD00727.1.
IPI	IPI00010743.
PIR	S15536.
RefSeq	NP_008827.2. NM_006896.3.
UniGene	Hs.610216. Hs.660918.
3D structure databases
ProteinModelPortal	P31268.
SMR	P31268. Positions 134-189.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31268. 3 interactions.
STRING	P31268.
Polymorphism databases
DMDM	311033439.
Proteomic databases
PRIDE	P31268.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000242159; ENSP00000242159; ENSG00000122592.
GeneID	3204.
KEGG	hsa:3204.
Organism-specific databases
CTD	3204.
GeneCards	GC07M027159.
H-InvDB	HIX0201182.
HGNC	HGNC:5108. HOXA7.
MIM	142950. gene.
neXtProt	NX_P31268.
PharmGKB	PA29385.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084133.
HOGENOM	HBG715745.
HOVERGEN	HBG016849.
InParanoid	P31268.
OMA	HKDEGPT.
OrthoDB	EOG4C87V5.
PhylomeDB	P31268.
Gene expression databases
ArrayExpress	P31268.
Bgee	P31268.
CleanEx	HS_HOXA7.
Genevestigator	P31268.
GermOnline	ENSG00000122592. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09307.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	12748.
SOURCE	Search...

Entry information

Entry name

HXA7_HUMAN

Accession

Primary (citable) accession number: P31268
Secondary accession number(s): A4D191 , O43368, O43486, O95655, Q9NSC8, Q9UDM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	November 2, 2010
Last modified:	December 14, 2011
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.