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P31268 (HXA7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A7
Alternative name(s):
Homeobox protein Hox 1.1
Homeobox protein Hox-1A
Gene names
Name:HOXA7
Synonyms:HOX1A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from expression pattern PubMed 17972163. Source: UniProtKB

anterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell-matrix adhesion

Inferred from direct assay PubMed 14704364. Source: UniProtKB

negative regulation of keratinocyte differentiation

Inferred from direct assay Ref.1. Source: MGI

negative regulation of leukocyte migration

Inferred from direct assay PubMed 14704364. Source: UniProtKB

negative regulation of monocyte differentiation

Inferred from direct assay PubMed 14704364. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.1PubMed 14704364. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

stem cell differentiation

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred by curator Ref.1. Source: UniProtKB

   Molecular_functionsequence-specific DNA binding

Inferred from direct assay Ref.1. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

transcription factor binding

Inferred from physical interaction PubMed 18973687. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Homeobox protein Hox-A7
PRO_0000200071

Regions

DNA binding130 – 18960Homeobox
Motif119 – 1246Antp-type hexapeptide
Compositional bias157 – 1604Poly-Arg
Compositional bias196 – 1994Poly-Ala
Compositional bias214 – 23017Asp/Glu-rich (highly acidic)
Compositional bias223 – 2308Poly-Glu

Natural variations

Natural variant181A → T. Ref.1 Ref.2 Ref.3 Ref.4 Ref.8
Corresponds to variant rs2301721 [ dbSNP | Ensembl ].
VAR_028001

Experimental info

Sequence conflict75 – 762DA → RR in AAD00727. Ref.8
Sequence conflict781Missing in CAA59270. Ref.4
Sequence conflict1741I → V in AAD01939. Ref.3
Sequence conflict194 – 1952PT → RL in CAA59270. Ref.4
Sequence conflict1951T → I no nucleotide entry Ref.9
Sequence conflict2221D → Y in CAA59270. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P31268 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: 8F77A6B0AFB516D5

FASTA23025,355
        10         20         30         40         50         60 
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP 

        70         80         90        100        110        120 
LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY 

       130        140        150        160        170        180 
PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN 

       190        200        210        220        230 
RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE 

« Hide

References

« Hide 'large scale' references
[1]"Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation."
La Celle P.T., Polakowska R.R.
J. Biol. Chem. 276:32844-32853(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-18.
[2]"Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1."
McIlhatton M.A., Bremner P.S., McMullin M.F., Maxwell A.P., Winter P.C., Lappin T.R.
Biochim. Biophys. Acta 1442:329-333(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-18.
[3]"Sequence analysis and tissue specific expression of human HOXA7."
Kim M.H., Jin H., Seol E.Y., Yoo M., Park H.W.
Mol. Biotechnol. 14:19-24(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-18.
[4]Albrechtsen R., Wewer U.
Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-18.
Tissue: Placenta.
[5]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Cho M., Kim M.H., Hwang C.Y., Min W.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91, VARIANT THR-18.
[9]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-195.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF026397 mRNA. Translation: AAB94604.1.
AJ005814 mRNA. Translation: CAA06713.1.
AF032095 Genomic DNA. Translation: AAD01939.2.
X84803, X84804 Genomic DNA. Translation: CAA59270.1.
CH236948 Genomic DNA. Translation: EAL24221.1.
AC004080 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93877.1.
U92543 Genomic DNA. Translation: AAD00727.1.
CCDSCCDS5408.1.
PIRS15536.
RefSeqNP_008827.2. NM_006896.3.
UniGeneHs.610216.
Hs.660918.

3D structure databases

ProteinModelPortalP31268.
SMRP31268. Positions 134-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109444. 4 interactions.
IntActP31268. 3 interactions.
STRING9606.ENSP00000242159.

PTM databases

PhosphoSiteP31268.

Polymorphism databases

DMDM311033439.

Proteomic databases

PaxDbP31268.
PRIDEP31268.

Protocols and materials databases

DNASU3204.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000242159; ENSP00000242159; ENSG00000122592.
GeneID3204.
KEGGhsa:3204.
UCSCuc003sys.3. human.

Organism-specific databases

CTD3204.
GeneCardsGC07M027193.
HGNCHGNC:5108. HOXA7.
MIM142950. gene.
neXtProtNX_P31268.
PharmGKBPA29385.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238660.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP31268.
KOK09307.
OMAHKDEGPA.
OrthoDBEOG780RP4.
PhylomeDBP31268.
TreeFamTF316310.

Gene expression databases

ArrayExpressP31268.
BgeeP31268.
CleanExHS_HOXA7.
GenevestigatorP31268.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXA7.
GenomeRNAi3204.
NextBio12748.
PROP31268.
SOURCESearch...

Entry information

Entry nameHXA7_HUMAN
AccessionPrimary (citable) accession number: P31268
Secondary accession number(s): A4D191 expand/collapse secondary AC list , O43368, O43486, O95655, Q9NSC8, Q9UDM1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries