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P31268

- HXA7_HUMAN

UniProt

P31268 - HXA7_HUMAN

Protein

Homeobox protein Hox-A7

Gene

HOXA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi130 – 18960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. anterior/posterior pattern specification Source: Ensembl
    3. embryonic skeletal system morphogenesis Source: Ensembl
    4. negative regulation of cell-matrix adhesion Source: UniProtKB
    5. negative regulation of keratinocyte differentiation Source: MGI
    6. negative regulation of leukocyte migration Source: UniProtKB
    7. negative regulation of monocyte differentiation Source: UniProtKB
    8. negative regulation of transcription, DNA-templated Source: UniProtKB
    9. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. stem cell differentiation Source: Ensembl
    12. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A7
    Alternative name(s):
    Homeobox protein Hox 1.1
    Homeobox protein Hox-1A
    Gene namesi
    Name:HOXA7
    Synonyms:HOX1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:5108. HOXA7.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29385.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Homeobox protein Hox-A7PRO_0000200071Add
    BLAST

    Proteomic databases

    PaxDbiP31268.
    PRIDEiP31268.

    PTM databases

    PhosphoSiteiP31268.

    Expressioni

    Gene expression databases

    ArrayExpressiP31268.
    BgeeiP31268.
    CleanExiHS_HOXA7.
    GenevestigatoriP31268.

    Interactioni

    Protein-protein interaction databases

    BioGridi109444. 4 interactions.
    IntActiP31268. 3 interactions.
    STRINGi9606.ENSP00000242159.

    Structurei

    3D structure databases

    ProteinModelPortaliP31268.
    SMRiP31268. Positions 134-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi119 – 1246Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi157 – 1604Poly-Arg
    Compositional biasi196 – 1994Poly-Ala
    Compositional biasi214 – 23017Asp/Glu-rich (highly acidic)Add
    BLAST
    Compositional biasi223 – 2308Poly-Glu

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG238660.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP31268.
    KOiK09307.
    OMAiHKDEGPA.
    OrthoDBiEOG780RP4.
    PhylomeDBiP31268.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31268-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST    50
    VPGLYNVNSP LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA 100
    CDKTDEGALH GAAEANFRIY PWMRSSGPDR KRGRQTYTRY QTLELEKEFH 150
    FNRYLTRRRR IEIAHALCLT ERQIKIWFQN RRMKWKKEHK DEGPTAAAAP 200
    EGAVPSAAAT AAADKADEED DDEEEEDEEE 230
    Length:230
    Mass (Da):25,355
    Last modified:November 2, 2010 - v3
    Checksum:i8F77A6B0AFB516D5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 762DA → RR in AAD00727. 1 PublicationCurated
    Sequence conflicti78 – 781Missing in CAA59270. 1 PublicationCurated
    Sequence conflicti174 – 1741I → V in AAD01939. (PubMed:10911612)Curated
    Sequence conflicti194 – 1952PT → RL in CAA59270. 1 PublicationCurated
    Sequence conflicti195 – 1951T → I no nucleotide entry (PubMed:2576652)Curated
    Sequence conflicti222 – 2221D → Y in CAA59270. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181A → T.5 Publications
    Corresponds to variant rs2301721 [ dbSNP | Ensembl ].
    VAR_028001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026397 mRNA. Translation: AAB94604.1.
    AJ005814 mRNA. Translation: CAA06713.1.
    AF032095 Genomic DNA. Translation: AAD01939.2.
    X84803, X84804 Genomic DNA. Translation: CAA59270.1.
    CH236948 Genomic DNA. Translation: EAL24221.1.
    AC004080 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93877.1.
    U92543 Genomic DNA. Translation: AAD00727.1.
    CCDSiCCDS5408.1.
    PIRiS15536.
    RefSeqiNP_008827.2. NM_006896.3.
    UniGeneiHs.610216.
    Hs.660918.

    Genome annotation databases

    EnsembliENST00000242159; ENSP00000242159; ENSG00000122592.
    GeneIDi3204.
    KEGGihsa:3204.
    UCSCiuc003sys.3. human.

    Polymorphism databases

    DMDMi311033439.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026397 mRNA. Translation: AAB94604.1 .
    AJ005814 mRNA. Translation: CAA06713.1 .
    AF032095 Genomic DNA. Translation: AAD01939.2 .
    X84803 , X84804 Genomic DNA. Translation: CAA59270.1 .
    CH236948 Genomic DNA. Translation: EAL24221.1 .
    AC004080 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93877.1 .
    U92543 Genomic DNA. Translation: AAD00727.1 .
    CCDSi CCDS5408.1.
    PIRi S15536.
    RefSeqi NP_008827.2. NM_006896.3.
    UniGenei Hs.610216.
    Hs.660918.

    3D structure databases

    ProteinModelPortali P31268.
    SMRi P31268. Positions 134-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109444. 4 interactions.
    IntActi P31268. 3 interactions.
    STRINGi 9606.ENSP00000242159.

    PTM databases

    PhosphoSitei P31268.

    Polymorphism databases

    DMDMi 311033439.

    Proteomic databases

    PaxDbi P31268.
    PRIDEi P31268.

    Protocols and materials databases

    DNASUi 3204.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000242159 ; ENSP00000242159 ; ENSG00000122592 .
    GeneIDi 3204.
    KEGGi hsa:3204.
    UCSCi uc003sys.3. human.

    Organism-specific databases

    CTDi 3204.
    GeneCardsi GC07M027193.
    HGNCi HGNC:5108. HOXA7.
    MIMi 142950. gene.
    neXtProti NX_P31268.
    PharmGKBi PA29385.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238660.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P31268.
    KOi K09307.
    OMAi HKDEGPA.
    OrthoDBi EOG780RP4.
    PhylomeDBi P31268.
    TreeFami TF316310.

    Miscellaneous databases

    GeneWikii HOXA7.
    GenomeRNAii 3204.
    NextBioi 12748.
    PROi P31268.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P31268.
    Bgeei P31268.
    CleanExi HS_HOXA7.
    Genevestigatori P31268.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation."
      La Celle P.T., Polakowska R.R.
      J. Biol. Chem. 276:32844-32853(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-18.
    2. "Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1."
      McIlhatton M.A., Bremner P.S., McMullin M.F., Maxwell A.P., Winter P.C., Lappin T.R.
      Biochim. Biophys. Acta 1442:329-333(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-18.
    3. "Sequence analysis and tissue specific expression of human HOXA7."
      Kim M.H., Jin H., Seol E.Y., Yoo M., Park H.W.
      Mol. Biotechnol. 14:19-24(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-18.
    4. Albrechtsen R., Wewer U.
      Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-18.
      Tissue: Placenta.
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cho M., Kim M.H., Hwang C.Y., Min W.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91, VARIANT THR-18.
    9. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-195.

    Entry informationi

    Entry nameiHXA7_HUMAN
    AccessioniPrimary (citable) accession number: P31268
    Secondary accession number(s): A4D191
    , O43368, O43486, O95655, Q9NSC8, Q9UDM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 137 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3