Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-A7

Gene

HOXA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi130 – 18960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • anterior/posterior pattern specification Source: Ensembl
  • embryonic skeletal system morphogenesis Source: Ensembl
  • negative regulation of cell-matrix adhesion Source: UniProtKB
  • negative regulation of keratinocyte differentiation Source: MGI
  • negative regulation of leukocyte migration Source: UniProtKB
  • negative regulation of monocyte differentiation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • stem cell differentiation Source: Ensembl
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A7
Alternative name(s):
Homeobox protein Hox 1.1
Homeobox protein Hox-1A
Gene namesi
Name:HOXA7
Synonyms:HOX1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:5108. HOXA7.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29385.

Polymorphism and mutation databases

BioMutaiHOXA7.
DMDMi311033439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Homeobox protein Hox-A7PRO_0000200071Add
BLAST

Proteomic databases

PaxDbiP31268.
PRIDEiP31268.

PTM databases

PhosphoSiteiP31268.

Expressioni

Gene expression databases

BgeeiP31268.
CleanExiHS_HOXA7.
ExpressionAtlasiP31268. baseline and differential.
GenevisibleiP31268. HS.

Interactioni

Protein-protein interaction databases

BioGridi109444. 3 interactions.
IntActiP31268. 3 interactions.
STRINGi9606.ENSP00000242159.

Structurei

3D structure databases

ProteinModelPortaliP31268.
SMRiP31268. Positions 134-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi119 – 1246Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 1604Poly-Arg
Compositional biasi196 – 1994Poly-Ala
Compositional biasi214 – 23017Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi223 – 2308Poly-Glu

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP31268.
KOiK09307.
OMAiWKKEHKD.
OrthoDBiEOG780RP4.
PhylomeDBiP31268.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST
60 70 80 90 100
VPGLYNVNSP LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA
110 120 130 140 150
CDKTDEGALH GAAEANFRIY PWMRSSGPDR KRGRQTYTRY QTLELEKEFH
160 170 180 190 200
FNRYLTRRRR IEIAHALCLT ERQIKIWFQN RRMKWKKEHK DEGPTAAAAP
210 220 230
EGAVPSAAAT AAADKADEED DDEEEEDEEE
Length:230
Mass (Da):25,355
Last modified:November 2, 2010 - v3
Checksum:i8F77A6B0AFB516D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 762DA → RR in AAD00727 (Ref. 8) Curated
Sequence conflicti78 – 781Missing in CAA59270 (Ref. 4) Curated
Sequence conflicti174 – 1741I → V in AAD01939 (PubMed:10911612).Curated
Sequence conflicti194 – 1952PT → RL in CAA59270 (Ref. 4) Curated
Sequence conflicti195 – 1951T → I no nucleotide entry (PubMed:2576652).Curated
Sequence conflicti222 – 2221D → Y in CAA59270 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181A → T.5 Publications
Corresponds to variant rs2301721 [ dbSNP | Ensembl ].
VAR_028001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026397 mRNA. Translation: AAB94604.1.
AJ005814 mRNA. Translation: CAA06713.1.
AF032095 Genomic DNA. Translation: AAD01939.2.
X84803, X84804 Genomic DNA. Translation: CAA59270.1.
CH236948 Genomic DNA. Translation: EAL24221.1.
AC004080 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93877.1.
U92543 Genomic DNA. Translation: AAD00727.1.
CCDSiCCDS5408.1.
PIRiS15536.
RefSeqiNP_008827.2. NM_006896.3.
UniGeneiHs.610216.
Hs.660918.

Genome annotation databases

EnsembliENST00000242159; ENSP00000242159; ENSG00000122592.
GeneIDi3204.
KEGGihsa:3204.
UCSCiuc003sys.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026397 mRNA. Translation: AAB94604.1.
AJ005814 mRNA. Translation: CAA06713.1.
AF032095 Genomic DNA. Translation: AAD01939.2.
X84803, X84804 Genomic DNA. Translation: CAA59270.1.
CH236948 Genomic DNA. Translation: EAL24221.1.
AC004080 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93877.1.
U92543 Genomic DNA. Translation: AAD00727.1.
CCDSiCCDS5408.1.
PIRiS15536.
RefSeqiNP_008827.2. NM_006896.3.
UniGeneiHs.610216.
Hs.660918.

3D structure databases

ProteinModelPortaliP31268.
SMRiP31268. Positions 134-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109444. 3 interactions.
IntActiP31268. 3 interactions.
STRINGi9606.ENSP00000242159.

PTM databases

PhosphoSiteiP31268.

Polymorphism and mutation databases

BioMutaiHOXA7.
DMDMi311033439.

Proteomic databases

PaxDbiP31268.
PRIDEiP31268.

Protocols and materials databases

DNASUi3204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242159; ENSP00000242159; ENSG00000122592.
GeneIDi3204.
KEGGihsa:3204.
UCSCiuc003sys.3. human.

Organism-specific databases

CTDi3204.
GeneCardsiGC07M027193.
HGNCiHGNC:5108. HOXA7.
MIMi142950. gene.
neXtProtiNX_P31268.
PharmGKBiPA29385.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP31268.
KOiK09307.
OMAiWKKEHKD.
OrthoDBiEOG780RP4.
PhylomeDBiP31268.
TreeFamiTF316310.

Miscellaneous databases

GeneWikiiHOXA7.
GenomeRNAii3204.
NextBioi12748.
PROiP31268.
SOURCEiSearch...

Gene expression databases

BgeeiP31268.
CleanExiHS_HOXA7.
ExpressionAtlasiP31268. baseline and differential.
GenevisibleiP31268. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation."
    La Celle P.T., Polakowska R.R.
    J. Biol. Chem. 276:32844-32853(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-18.
  2. "Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1."
    McIlhatton M.A., Bremner P.S., McMullin M.F., Maxwell A.P., Winter P.C., Lappin T.R.
    Biochim. Biophys. Acta 1442:329-333(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-18.
  3. "Sequence analysis and tissue specific expression of human HOXA7."
    Kim M.H., Jin H., Seol E.Y., Yoo M., Park H.W.
    Mol. Biotechnol. 14:19-24(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-18.
  4. Albrechtsen R., Wewer U.
    Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-18.
    Tissue: Placenta.
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cho M., Kim M.H., Hwang C.Y., Min W.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91, VARIANT THR-18.
  9. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-195.

Entry informationi

Entry nameiHXA7_HUMAN
AccessioniPrimary (citable) accession number: P31268
Secondary accession number(s): A4D191
, O43368, O43486, O95655, Q9NSC8, Q9UDM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 2, 2010
Last modified: July 22, 2015
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.