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P31267

- HXA6_HUMAN

UniProt

P31267 - HXA6_HUMAN

Protein

Homeobox protein Hox-A6

Gene

HOXA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi155 – 21460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. embryonic skeletal system morphogenesis Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A6
    Alternative name(s):
    Homeobox protein Hox-1B
    Gene namesi
    Name:HOXA6
    Synonyms:HOX1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:5107. HOXA6.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29384.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Homeobox protein Hox-A6PRO_0000200067Add
    BLAST

    Proteomic databases

    PaxDbiP31267.
    PRIDEiP31267.

    PTM databases

    PhosphoSiteiP31267.

    Expressioni

    Gene expression databases

    BgeeiP31267.
    CleanExiHS_HOXA6.
    GenevestigatoriP31267.

    Organism-specific databases

    HPAiHPA004203.

    Interactioni

    Protein-protein interaction databases

    BioGridi109443. 1 interaction.
    STRINGi9606.ENSP00000222728.

    Structurei

    3D structure databases

    ProteinModelPortaliP31267.
    SMRiP31267. Positions 159-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi136 – 1416Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG305812.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP31267.
    KOiK09306.
    OMAiPEQQYKS.
    OrthoDBiEOG780RP4.
    PhylomeDBiP31267.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31267-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNPTF PGSLPSGQDS FLGQLPLYQA GYDALRPFPA SYGASSLPDK    50
    TYTSPCFYQQ SNSVLACNRA SYEYGASCFY SDKDLSGASP SGSGKQRGPG 100
    DYLHFSPEQQ YKPDSSSGQG KALHDEGADR KYTSPVYPWM QRMNSCAGAV 150
    YGSHGRRGRQ TYTRYQTLEL EKEFHFNRYL TRRRRIEIAN ALCLTERQIK 200
    IWFQNRRMKW KKENKLINST QPSGEDSEAK AGE 233
    Length:233
    Mass (Da):26,339
    Last modified:May 30, 2000 - v2
    Checksum:i9D9DFD03FAF25967
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004080 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24222.1.
    CH471073 Genomic DNA. Translation: EAW93875.1.
    BC069497 mRNA. Translation: AAH69497.1.
    BC104915 mRNA. Translation: AAI04916.1.
    BC104917 mRNA. Translation: AAI04918.1.
    CCDSiCCDS5407.1.
    PIRiS15538.
    RefSeqiNP_076919.1. NM_024014.3.
    UniGeneiHs.679517.

    Genome annotation databases

    EnsembliENST00000222728; ENSP00000222728; ENSG00000106006.
    GeneIDi3203.
    KEGGihsa:3203.
    UCSCiuc003syo.2. human.

    Polymorphism databases

    DMDMi17378385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004080 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24222.1 .
    CH471073 Genomic DNA. Translation: EAW93875.1 .
    BC069497 mRNA. Translation: AAH69497.1 .
    BC104915 mRNA. Translation: AAI04916.1 .
    BC104917 mRNA. Translation: AAI04918.1 .
    CCDSi CCDS5407.1.
    PIRi S15538.
    RefSeqi NP_076919.1. NM_024014.3.
    UniGenei Hs.679517.

    3D structure databases

    ProteinModelPortali P31267.
    SMRi P31267. Positions 159-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109443. 1 interaction.
    STRINGi 9606.ENSP00000222728.

    PTM databases

    PhosphoSitei P31267.

    Polymorphism databases

    DMDMi 17378385.

    Proteomic databases

    PaxDbi P31267.
    PRIDEi P31267.

    Protocols and materials databases

    DNASUi 3203.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222728 ; ENSP00000222728 ; ENSG00000106006 .
    GeneIDi 3203.
    KEGGi hsa:3203.
    UCSCi uc003syo.2. human.

    Organism-specific databases

    CTDi 3203.
    GeneCardsi GC07M027185.
    HGNCi HGNC:5107. HOXA6.
    HPAi HPA004203.
    MIMi 142951. gene.
    neXtProti NX_P31267.
    PharmGKBi PA29384.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305812.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P31267.
    KOi K09306.
    OMAi PEQQYKS.
    OrthoDBi EOG780RP4.
    PhylomeDBi P31267.
    TreeFami TF316310.

    Miscellaneous databases

    GeneWikii HOXA6.
    GenomeRNAii 3203.
    NextBioi 12744.
    PROi P31267.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31267.
    CleanExi HS_HOXA6.
    Genevestigatori P31267.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-220.

    Entry informationi

    Entry nameiHXA6_HUMAN
    AccessioniPrimary (citable) accession number: P31267
    Secondary accession number(s): A4D192, Q2M3G3, Q9UPM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3