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Protein

Homeobox protein Hox-A6

Gene

HOXA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 214HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A6
Alternative name(s):
Homeobox protein Hox-1B
Gene namesi
Name:HOXA6
Synonyms:HOX1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106006.6.
HGNCiHGNC:5107. HOXA6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3203.
OpenTargetsiENSG00000106006.
PharmGKBiPA29384.

Polymorphism and mutation databases

BioMutaiHOXA6.
DMDMi17378385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000671 – 233Homeobox protein Hox-A6Add BLAST233

Proteomic databases

MaxQBiP31267.
PaxDbiP31267.
PeptideAtlasiP31267.
PRIDEiP31267.

PTM databases

iPTMnetiP31267.
PhosphoSitePlusiP31267.

Expressioni

Gene expression databases

BgeeiENSG00000106006.
CleanExiHS_HOXA6.
GenevisibleiP31267. HS.

Organism-specific databases

HPAiHPA004203.

Interactioni

Protein-protein interaction databases

BioGridi109443. 1 interactor.
STRINGi9606.ENSP00000222728.

Structurei

3D structure databases

ProteinModelPortaliP31267.
SMRiP31267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 141Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP31267.
KOiK09306.
OMAiIACNRAS.
OrthoDBiEOG091G09XD.
PhylomeDBiP31267.
TreeFamiTF316310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P31267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNPTF PGSLPSGQDS FLGQLPLYQA GYDALRPFPA SYGASSLPDK
60 70 80 90 100
TYTSPCFYQQ SNSVLACNRA SYEYGASCFY SDKDLSGASP SGSGKQRGPG
110 120 130 140 150
DYLHFSPEQQ YKPDSSSGQG KALHDEGADR KYTSPVYPWM QRMNSCAGAV
160 170 180 190 200
YGSHGRRGRQ TYTRYQTLEL EKEFHFNRYL TRRRRIEIAN ALCLTERQIK
210 220 230
IWFQNRRMKW KKENKLINST QPSGEDSEAK AGE
Length:233
Mass (Da):26,339
Last modified:May 30, 2000 - v2
Checksum:i9D9DFD03FAF25967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004080 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24222.1.
CH471073 Genomic DNA. Translation: EAW93875.1.
BC069497 mRNA. Translation: AAH69497.1.
BC104915 mRNA. Translation: AAI04916.1.
BC104917 mRNA. Translation: AAI04918.1.
CCDSiCCDS5407.1.
PIRiS15538.
RefSeqiNP_076919.1. NM_024014.3.
UniGeneiHs.679517.

Genome annotation databases

EnsembliENST00000222728; ENSP00000222728; ENSG00000106006.
GeneIDi3203.
KEGGihsa:3203.
UCSCiuc003syo.3. human.

Similar proteinsi

Entry informationi

Entry nameiHXA6_HUMAN
AccessioniPrimary (citable) accession number: P31267
Secondary accession number(s): A4D192, Q2M3G3, Q9UPM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 30, 2000
Last modified: September 27, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families