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Protein

Recombining binding protein suppressor of hairless

Gene

Rbpj

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi84 – 918By similarity
DNA bindingi218 – 22710
DNA bindingi291 – 32333Add
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • arterial endothelial cell fate commitment Source: BHF-UCL
  • artery morphogenesis Source: MGI
  • atrioventricular canal development Source: BHF-UCL
  • auditory receptor cell fate commitment Source: MGI
  • B cell differentiation Source: MGI
  • blood vessel endothelial cell fate specification Source: BHF-UCL
  • blood vessel lumenization Source: BHF-UCL
  • blood vessel remodeling Source: BHF-UCL
  • cardiac left ventricle morphogenesis Source: BHF-UCL
  • cell fate commitment Source: MGI
  • Clara cell differentiation Source: MGI
  • defense response to bacterium Source: MGI
  • determination of heart left/right asymmetry Source: BHF-UCL
  • dorsal aorta morphogenesis Source: BHF-UCL
  • endocardium development Source: BHF-UCL
  • endocardium morphogenesis Source: BHF-UCL
  • epidermal cell fate specification Source: MGI
  • epithelial to mesenchymal transition Source: MGI
  • epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  • hair follicle maturation Source: MGI
  • heart development Source: MGI
  • heart looping Source: BHF-UCL
  • hemopoiesis Source: MGI
  • humoral immune response Source: MGI
  • inflammatory response to antigenic stimulus Source: MGI
  • interleukin-4 secretion Source: MGI
  • keratinocyte differentiation Source: MGI
  • labyrinthine layer blood vessel development Source: BHF-UCL
  • myeloid dendritic cell differentiation Source: MGI
  • negative regulation of cell differentiation Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of ossification Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • neuron differentiation Source: MGI
  • Notch signaling pathway Source: MGI
  • Notch signaling pathway involved in arterial endothelial cell fate commitment Source: BHF-UCL
  • outflow tract morphogenesis Source: BHF-UCL
  • pituitary gland development Source: MGI
  • positive regulation of BMP signaling pathway Source: BHF-UCL
  • positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: MGI
  • positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
  • positive regulation of ephrin receptor signaling pathway Source: BHF-UCL
  • positive regulation of ERBB signaling pathway Source: BHF-UCL
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of Notch signaling pathway involved in heart induction Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
  • positive regulation of transcription of Notch receptor target Source: UniProtKB
  • regulation of cell adhesion involved in heart morphogenesis Source: BHF-UCL
  • regulation of gene expression Source: MGI
  • regulation of timing of cell differentiation Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
  • sebaceous gland development Source: MGI
  • secondary heart field specification Source: MGI
  • somatic stem cell maintenance Source: MGI
  • somitogenesis Source: BHF-UCL
  • transcription from RNA polymerase II promoter Source: GOC
  • ventricular trabecula myocardium morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_278898. NOTCH2 intracellular domain regulates transcription.
REACT_302694. Notch-HLH transcription pathway.
REACT_334977. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_346510. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
REACT_347220. Pre-NOTCH Transcription and Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
Recombining binding protein suppressor of hairless
Alternative name(s):
J kappa-recombination signal-binding protein
RBP-J kappa
Gene namesi
Name:Rbpj
Synonyms:Igkjrb1, Igkrsbp, Rbpsuh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:96522. Rbpj.

Subcellular locationi

  • Nucleus
  • Cytoplasm By similarity

  • Note: Mainly nuclear, upon interaction with RITA1, translocates to the cytoplasm, down-regulating the Notch signaling pathway.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Recombining binding protein suppressor of hairlessPRO_0000208568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP31266.
PaxDbiP31266.
PRIDEiP31266.

PTM databases

PhosphoSiteiP31266.

Expressioni

Gene expression databases

BgeeiP31266.
ExpressionAtlasiP31266. baseline and differential.
GenevisibleiP31266. MM.

Interactioni

Subunit structurei

Interacts with RITA1, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway (By similarity). Interacts with activated NOTCH1, NOTCH2 and NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with SNW1. Interacts with CHCHD2 and CXXC5 (By similarity).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Notch1Q017056EBI-1392666,EBI-1392707

Protein-protein interaction databases

BioGridi202832. 9 interactions.
DIPiDIP-171N.
IntActiP31266. 4 interactions.
STRINGi10090.ENSMUSP00000040694.

Structurei

Secondary structure

1
526
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi59 – 6810Combined sources
Beta strandi72 – 8312Combined sources
Beta strandi98 – 1036Combined sources
Helixi105 – 11511Combined sources
Helixi120 – 1234Combined sources
Beta strandi124 – 13310Combined sources
Beta strandi139 – 1413Combined sources
Beta strandi146 – 1505Combined sources
Beta strandi163 – 1653Combined sources
Beta strandi167 – 1737Combined sources
Beta strandi178 – 1836Combined sources
Beta strandi187 – 1926Combined sources
Helixi200 – 2056Combined sources
Beta strandi211 – 2177Combined sources
Beta strandi219 – 2213Combined sources
Helixi223 – 2253Combined sources
Beta strandi227 – 2326Combined sources
Beta strandi235 – 2417Combined sources
Beta strandi246 – 2505Combined sources
Beta strandi257 – 2593Combined sources
Beta strandi273 – 2786Combined sources
Turni279 – 2813Combined sources
Beta strandi288 – 2947Combined sources
Beta strandi297 – 3015Combined sources
Beta strandi311 – 3166Combined sources
Beta strandi319 – 3279Combined sources
Beta strandi330 – 3356Combined sources
Beta strandi345 – 3473Combined sources
Helixi350 – 3523Combined sources
Beta strandi354 – 36815Combined sources
Beta strandi382 – 3887Combined sources
Beta strandi392 – 3943Combined sources
Beta strandi396 – 4038Combined sources
Beta strandi408 – 4125Combined sources
Beta strandi419 – 4235Combined sources
Beta strandi426 – 4305Combined sources
Helixi434 – 4363Combined sources
Beta strandi448 – 4569Combined sources
Beta strandi459 – 47012Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BRGX-ray2.20C53-474[»]
3IAGX-ray2.00C53-474[»]
4J2XX-ray2.85A/C53-474[»]
ProteinModelPortaliP31266.
SMRiP31266. Positions 53-474.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31266.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini381 – 47191IPT/TIGAdd
BLAST

Sequence similaritiesi

Belongs to the Su(H) family.Curated
Contains 1 IPT/TIG domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
HOVERGENiHBG006618.
InParanoidiP31266.
KOiK06053.
OMAiVIVILHA.
PhylomeDBiP31266.
TreeFamiTF314117.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31266-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSGFPQSPR TSPRARPKTR ITGALPMDYS EGLSAEERPA HAPSAGKFGE
60 70 80 90 100
RPPPKRLTRE AMRNYLKERG DQTVLILHAK VAQKSYGNEK RFFCPPPCVY
110 120 130 140 150
LMGSGWKKKK EQMERDGCSE QESQPCAFIG IGNSDQEMQQ LNLEGKNYCT
160 170 180 190 200
AKTLYISDSD KRKHFMLSVK MFYGNSDDIG VFLSKRIKVI SKPSKKKQSL
210 220 230 240 250
KNADLCIASG TKVALFNRLR SQTVSTRYLH VEGGNFHASS QQWGAFYIHL
260 270 280 290 300
LDDDESEGEE FTVRDGYIHY GQTVKLVCSV TGMALPRLII RKVDKQTALL
310 320 330 340 350
DADDPVSQLH KCAFYLKDTE RMYLCLSQER IIQFQATPCP KEQNKEMIND
360 370 380 390 400
GASWTIISTD KAEYTFYEGM GPVLAPVTPV PVVESLQLNG GGDVAMLELT
410 420 430 440 450
GQNFTPNLRV WFGDVEAETM YRCGESMLCV VPDISAFREG WRWVRQPVQV
460 470 480 490 500
PVTLVRNDGV IYSTSLTFTY TPEPGPRPHC SAAGAILRAN SSQVPSNESN
510 520
TNSEGNYTNA STNSTSVTSS TATVVS
Length:526
Mass (Da):58,537
Last modified:July 1, 1993 - v1
Checksum:i8BF517CC24099E03
GO
Isoform 2 (identifier: P31266-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-45: AHAPSA → MAPVVT

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):54,347
Checksum:i88C0D1DCECACC9E2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_008392Add
BLAST
Alternative sequencei40 – 456AHAPSA → MAPVVT in isoform 2. 1 PublicationVSP_008393

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63463 mRNA. Translation: AAB20195.1.
X17459 mRNA. Translation: CAA35501.1.
X58337 Genomic DNA. No translation available.
M81867, M81865, M81866 Genomic DNA. Translation: AAA39018.1.
M81868 Genomic DNA. Translation: AAA39019.1.
M81870, M81869 Genomic DNA. Translation: AAA39020.1. Sequence problems.
M81873, M81872 Genomic DNA. Translation: AAA39021.1.
M81875, M81874 Genomic DNA. Translation: AAA39022.1.
M81876 Genomic DNA. Translation: AAA39023.1.
M81877 Genomic DNA. No translation available.
BC051387 mRNA. Translation: AAH51387.1.
AK080359 mRNA. Translation: BAC37889.1.
CCDSiCCDS19292.1. [P31266-1]
CCDS51504.1. [P31266-2]
PIRiA42267.
A43567.
RefSeqiNP_001074396.1. NM_001080927.2. [P31266-2]
NP_033061.3. NM_009035.5. [P31266-1]
UniGeneiMm.209292.
Mm.488709.

Genome annotation databases

EnsembliENSMUST00000037618; ENSMUSP00000040694; ENSMUSG00000039191. [P31266-1]
GeneIDi19664.
KEGGimmu:19664.
UCSCiuc008xli.2. mouse. [P31266-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63463 mRNA. Translation: AAB20195.1.
X17459 mRNA. Translation: CAA35501.1.
X58337 Genomic DNA. No translation available.
M81867, M81865, M81866 Genomic DNA. Translation: AAA39018.1.
M81868 Genomic DNA. Translation: AAA39019.1.
M81870, M81869 Genomic DNA. Translation: AAA39020.1. Sequence problems.
M81873, M81872 Genomic DNA. Translation: AAA39021.1.
M81875, M81874 Genomic DNA. Translation: AAA39022.1.
M81876 Genomic DNA. Translation: AAA39023.1.
M81877 Genomic DNA. No translation available.
BC051387 mRNA. Translation: AAH51387.1.
AK080359 mRNA. Translation: BAC37889.1.
CCDSiCCDS19292.1. [P31266-1]
CCDS51504.1. [P31266-2]
PIRiA42267.
A43567.
RefSeqiNP_001074396.1. NM_001080927.2. [P31266-2]
NP_033061.3. NM_009035.5. [P31266-1]
UniGeneiMm.209292.
Mm.488709.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BRGX-ray2.20C53-474[»]
3IAGX-ray2.00C53-474[»]
4J2XX-ray2.85A/C53-474[»]
ProteinModelPortaliP31266.
SMRiP31266. Positions 53-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202832. 9 interactions.
DIPiDIP-171N.
IntActiP31266. 4 interactions.
STRINGi10090.ENSMUSP00000040694.

PTM databases

PhosphoSiteiP31266.

Proteomic databases

MaxQBiP31266.
PaxDbiP31266.
PRIDEiP31266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037618; ENSMUSP00000040694; ENSMUSG00000039191. [P31266-1]
GeneIDi19664.
KEGGimmu:19664.
UCSCiuc008xli.2. mouse. [P31266-1]

Organism-specific databases

CTDi3516.
MGIiMGI:96522. Rbpj.

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
HOVERGENiHBG006618.
InParanoidiP31266.
KOiK06053.
OMAiVIVILHA.
PhylomeDBiP31266.
TreeFamiTF314117.

Enzyme and pathway databases

ReactomeiREACT_278898. NOTCH2 intracellular domain regulates transcription.
REACT_302694. Notch-HLH transcription pathway.
REACT_334977. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_346510. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
REACT_347220. Pre-NOTCH Transcription and Translation.

Miscellaneous databases

ChiTaRSiRbpj. mouse.
EvolutionaryTraceiP31266.
NextBioi296966.
PROiP31266.
SOURCEiSearch...

Gene expression databases

BgeeiP31266.
ExpressionAtlasiP31266. baseline and differential.
GenevisibleiP31266. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif."
    Matsunami N., Hamaguchi Y., Yamamoto Y., Kuze K., Kangawa K., Matsuo H., Kawaichi M., Honjo T.
    Nature 342:934-937(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
  2. "Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene."
    Kawaichi M., Oka C., Shibayama S., Koromilas A.E., Matsunami N., Hamaguchi Y., Honjo T.
    J. Biol. Chem. 267:4016-4022(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Liver.
  3. "Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes."
    Hamaguchi Y., Matsunami N., Yamamoto Y., Kuze K., Kangawa K., Matsuo H., Kawaichi M., Honjo T.
    Adv. Exp. Med. Biol. 292:177-186(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-341 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Thymus.
  6. "Signalling downstream of activated mammalian Notch."
    Jarriault S., Brou C., Logeat F., Schroeter E.H., Kopan R., Israel A.
    Nature 377:355-358(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NOTCH1.
  7. "LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein."
    Taniguchi Y., Furukawa T., Tun T., Han H., Honjo T.
    Mol. Cell. Biol. 18:644-654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FHL1.
  8. Cited for: INTERACTION WITH EP300.
  9. "p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos."
    Obata J., Yano M., Mimura H., Goto T., Nakayama R., Mibu Y., Oka C., Kawaichi M.
    Genes Cells 6:345-360(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTF1A.
    Strain: ICR.
    Tissue: Embryo.
  10. "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression."
    Kao H.-Y., Downes M., Ordentlich P., Evans R.M.
    Genes Dev. 14:55-66(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH NCOR2 AND HDAC1.
  11. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-201, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSUH_MOUSE
AccessioniPrimary (citable) accession number: P31266
Secondary accession number(s): Q80UN8, Q8C4Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 22, 2015
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Despite some similarity with the "phage" integrase family, it has no recombinase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.