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P31266

- SUH_MOUSE

UniProt

P31266 - SUH_MOUSE

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Protein

Recombining binding protein suppressor of hairless

Gene

Rbpj

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi84 – 918By similarity
DNA bindingi218 – 22710
DNA bindingi291 – 32333Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. protein N-terminus binding Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  6. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  7. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  8. sequence-specific DNA binding Source: MGI
  9. transcription factor binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. arterial endothelial cell fate commitment Source: BHF-UCL
  3. atrioventricular canal development Source: BHF-UCL
  4. auditory receptor cell fate commitment Source: MGI
  5. B cell differentiation Source: MGI
  6. blood vessel endothelial cell fate specification Source: BHF-UCL
  7. blood vessel lumenization Source: BHF-UCL
  8. blood vessel remodeling Source: BHF-UCL
  9. cardiac left ventricle morphogenesis Source: BHF-UCL
  10. cell fate commitment Source: MGI
  11. Clara cell differentiation Source: MGI
  12. defense response to bacterium Source: MGI
  13. determination of heart left/right asymmetry Source: BHF-UCL
  14. dorsal aorta morphogenesis Source: BHF-UCL
  15. endocardium development Source: BHF-UCL
  16. endocardium morphogenesis Source: BHF-UCL
  17. epidermal cell fate specification Source: MGI
  18. epithelial to mesenchymal transition Source: MGI
  19. epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  20. hair follicle maturation Source: MGI
  21. heart development Source: MGI
  22. heart looping Source: BHF-UCL
  23. hemopoiesis Source: MGI
  24. humoral immune response Source: MGI
  25. inflammatory response to antigenic stimulus Source: MGI
  26. interleukin-4 secretion Source: MGI
  27. keratinocyte differentiation Source: MGI
  28. labyrinthine layer blood vessel development Source: BHF-UCL
  29. myeloid dendritic cell differentiation Source: MGI
  30. negative regulation of cell differentiation Source: MGI
  31. negative regulation of cell proliferation Source: MGI
  32. negative regulation of ossification Source: BHF-UCL
  33. negative regulation of transcription, DNA-templated Source: MGI
  34. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  35. neuron differentiation Source: MGI
  36. Notch signaling pathway Source: MGI
  37. Notch signaling pathway involved in arterial endothelial cell fate commitment Source: BHF-UCL
  38. outflow tract morphogenesis Source: BHF-UCL
  39. pituitary gland development Source: MGI
  40. positive regulation of BMP signaling pathway Source: BHF-UCL
  41. positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: MGI
  42. positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  43. positive regulation of cell proliferation Source: MGI
  44. positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
  45. positive regulation of ephrin receptor signaling pathway Source: BHF-UCL
  46. positive regulation of ERBB signaling pathway Source: BHF-UCL
  47. positive regulation of gene expression Source: BHF-UCL
  48. positive regulation of Notch signaling pathway involved in heart induction Source: BHF-UCL
  49. positive regulation of transcription, DNA-templated Source: MGI
  50. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  51. positive regulation of transcription of Notch receptor target Source: UniProtKB
  52. regulation of cell adhesion involved in heart morphogenesis Source: BHF-UCL
  53. regulation of gene expression Source: MGI
  54. regulation of timing of cell differentiation Source: MGI
  55. regulation of transcription from RNA polymerase II promoter Source: MGI
  56. regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
  57. sebaceous gland development Source: MGI
  58. secondary heart field specification Source: MGI
  59. somatic stem cell maintenance Source: MGI
  60. somitogenesis Source: BHF-UCL
  61. ventricular trabecula myocardium morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196520. Pre-NOTCH Transcription and Translation.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196593. NOTCH2 intracellular domain regulates transcription.
REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
REACT_223683. Notch-HLH transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Recombining binding protein suppressor of hairless
Alternative name(s):
J kappa-recombination signal-binding protein
RBP-J kappa
Gene namesi
Name:Rbpj
Synonyms:Igkjrb1, Igkrsbp, Rbpsuh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:96522. Rbpj.

Subcellular locationi

Nucleus. Cytoplasm By similarity
Note: Mainly nuclear, upon interaction with RITA1, translocates to the cytoplasm, down-regulating the Notch signaling pathway.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. MAML1-RBP-Jkappa- ICN1 complex Source: Ensembl
  3. nucleolus Source: Ensembl
  4. nucleoplasm Source: Reactome
  5. nucleus Source: UniProtKB
  6. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Recombining binding protein suppressor of hairlessPRO_0000208568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP31266.
PaxDbiP31266.
PRIDEiP31266.

PTM databases

PhosphoSiteiP31266.

Expressioni

Gene expression databases

BgeeiP31266.
ExpressionAtlasiP31266. baseline and differential.
GenevestigatoriP31266.

Interactioni

Subunit structurei

Interacts with RITA1, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway (By similarity). Interacts with activated NOTCH1, NOTCH2 and NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with SNW1.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Notch1Q017056EBI-1392666,EBI-1392707

Protein-protein interaction databases

BioGridi202832. 9 interactions.
DIPiDIP-171N.
IntActiP31266. 3 interactions.

Structurei

Secondary structure

1
526
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi59 – 6810
Beta strandi72 – 8312
Beta strandi98 – 1036
Helixi105 – 11511
Helixi120 – 1234
Beta strandi124 – 13310
Beta strandi139 – 1413
Beta strandi146 – 1505
Beta strandi163 – 1653
Beta strandi167 – 1737
Beta strandi178 – 1836
Beta strandi187 – 1926
Helixi200 – 2056
Beta strandi211 – 2177
Beta strandi219 – 2213
Helixi223 – 2253
Beta strandi227 – 2326
Beta strandi235 – 2417
Beta strandi246 – 2505
Beta strandi257 – 2593
Beta strandi273 – 2786
Turni279 – 2813
Beta strandi288 – 2947
Beta strandi297 – 3015
Beta strandi311 – 3166
Beta strandi319 – 3279
Beta strandi330 – 3356
Beta strandi345 – 3473
Helixi350 – 3523
Beta strandi354 – 36815
Beta strandi382 – 3887
Beta strandi392 – 3943
Beta strandi396 – 4038
Beta strandi408 – 4125
Beta strandi419 – 4235
Beta strandi426 – 4305
Helixi434 – 4363
Beta strandi448 – 4569
Beta strandi459 – 47012

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BRGX-ray2.20C53-474[»]
3IAGX-ray2.00C53-474[»]
4J2XX-ray2.85A/C53-474[»]
ProteinModelPortaliP31266.
SMRiP31266. Positions 53-474.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31266.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini381 – 47191IPT/TIGAdd
BLAST

Sequence similaritiesi

Belongs to the Su(H) family.Curated
Contains 1 IPT/TIG domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
HOVERGENiHBG006618.
InParanoidiP31266.
KOiK06053.
OMAiMGPVHAP.
PhylomeDBiP31266.
TreeFamiTF314117.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P31266-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSGFPQSPR TSPRARPKTR ITGALPMDYS EGLSAEERPA HAPSAGKFGE
60 70 80 90 100
RPPPKRLTRE AMRNYLKERG DQTVLILHAK VAQKSYGNEK RFFCPPPCVY
110 120 130 140 150
LMGSGWKKKK EQMERDGCSE QESQPCAFIG IGNSDQEMQQ LNLEGKNYCT
160 170 180 190 200
AKTLYISDSD KRKHFMLSVK MFYGNSDDIG VFLSKRIKVI SKPSKKKQSL
210 220 230 240 250
KNADLCIASG TKVALFNRLR SQTVSTRYLH VEGGNFHASS QQWGAFYIHL
260 270 280 290 300
LDDDESEGEE FTVRDGYIHY GQTVKLVCSV TGMALPRLII RKVDKQTALL
310 320 330 340 350
DADDPVSQLH KCAFYLKDTE RMYLCLSQER IIQFQATPCP KEQNKEMIND
360 370 380 390 400
GASWTIISTD KAEYTFYEGM GPVLAPVTPV PVVESLQLNG GGDVAMLELT
410 420 430 440 450
GQNFTPNLRV WFGDVEAETM YRCGESMLCV VPDISAFREG WRWVRQPVQV
460 470 480 490 500
PVTLVRNDGV IYSTSLTFTY TPEPGPRPHC SAAGAILRAN SSQVPSNESN
510 520
TNSEGNYTNA STNSTSVTSS TATVVS
Length:526
Mass (Da):58,537
Last modified:July 1, 1993 - v1
Checksum:i8BF517CC24099E03
GO
Isoform 2 (identifier: P31266-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-45: AHAPSA → MAPVVT

Note: No experimental confirmation available.

Show »
Length:487
Mass (Da):54,347
Checksum:i88C0D1DCECACC9E2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_008392Add
BLAST
Alternative sequencei40 – 456AHAPSA → MAPVVT in isoform 2. 1 PublicationVSP_008393

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S63463 mRNA. Translation: AAB20195.1.
X17459 mRNA. Translation: CAA35501.1.
X58337 Genomic DNA. No translation available.
M81867, M81865, M81866 Genomic DNA. Translation: AAA39018.1.
M81868 Genomic DNA. Translation: AAA39019.1.
M81870, M81869 Genomic DNA. Translation: AAA39020.1. Sequence problems.
M81873, M81872 Genomic DNA. Translation: AAA39021.1.
M81875, M81874 Genomic DNA. Translation: AAA39022.1.
M81876 Genomic DNA. Translation: AAA39023.1.
M81877 Genomic DNA. No translation available.
BC051387 mRNA. Translation: AAH51387.1.
AK080359 mRNA. Translation: BAC37889.1.
CCDSiCCDS19292.1. [P31266-1]
CCDS51504.1. [P31266-2]
PIRiA42267.
A43567.
RefSeqiNP_001074396.1. NM_001080927.2. [P31266-2]
NP_033061.3. NM_009035.5. [P31266-1]
UniGeneiMm.209292.
Mm.488709.

Genome annotation databases

EnsembliENSMUST00000037618; ENSMUSP00000040694; ENSMUSG00000039191. [P31266-1]
ENSMUST00000113865; ENSMUSP00000109496; ENSMUSG00000039191. [P31266-2]
GeneIDi19664.
KEGGimmu:19664.
UCSCiuc008xli.1. mouse. [P31266-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S63463 mRNA. Translation: AAB20195.1 .
X17459 mRNA. Translation: CAA35501.1 .
X58337 Genomic DNA. No translation available.
M81867 , M81865 , M81866 Genomic DNA. Translation: AAA39018.1 .
M81868 Genomic DNA. Translation: AAA39019.1 .
M81870 , M81869 Genomic DNA. Translation: AAA39020.1 . Sequence problems.
M81873 , M81872 Genomic DNA. Translation: AAA39021.1 .
M81875 , M81874 Genomic DNA. Translation: AAA39022.1 .
M81876 Genomic DNA. Translation: AAA39023.1 .
M81877 Genomic DNA. No translation available.
BC051387 mRNA. Translation: AAH51387.1 .
AK080359 mRNA. Translation: BAC37889.1 .
CCDSi CCDS19292.1. [P31266-1 ]
CCDS51504.1. [P31266-2 ]
PIRi A42267.
A43567.
RefSeqi NP_001074396.1. NM_001080927.2. [P31266-2 ]
NP_033061.3. NM_009035.5. [P31266-1 ]
UniGenei Mm.209292.
Mm.488709.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BRG X-ray 2.20 C 53-474 [» ]
3IAG X-ray 2.00 C 53-474 [» ]
4J2X X-ray 2.85 A/C 53-474 [» ]
ProteinModelPortali P31266.
SMRi P31266. Positions 53-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202832. 9 interactions.
DIPi DIP-171N.
IntActi P31266. 3 interactions.

PTM databases

PhosphoSitei P31266.

Proteomic databases

MaxQBi P31266.
PaxDbi P31266.
PRIDEi P31266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037618 ; ENSMUSP00000040694 ; ENSMUSG00000039191 . [P31266-1 ]
ENSMUST00000113865 ; ENSMUSP00000109496 ; ENSMUSG00000039191 . [P31266-2 ]
GeneIDi 19664.
KEGGi mmu:19664.
UCSCi uc008xli.1. mouse. [P31266-1 ]

Organism-specific databases

CTDi 3516.
MGIi MGI:96522. Rbpj.

Phylogenomic databases

eggNOGi NOG295376.
GeneTreei ENSGT00390000005197.
HOGENOMi HOG000253907.
HOVERGENi HBG006618.
InParanoidi P31266.
KOi K06053.
OMAi MGPVHAP.
PhylomeDBi P31266.
TreeFami TF314117.

Enzyme and pathway databases

Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196520. Pre-NOTCH Transcription and Translation.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196593. NOTCH2 intracellular domain regulates transcription.
REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
REACT_223683. Notch-HLH transcription pathway.

Miscellaneous databases

EvolutionaryTracei P31266.
NextBioi 296966.
PROi P31266.
SOURCEi Search...

Gene expression databases

Bgeei P31266.
ExpressionAtlasi P31266. baseline and differential.
Genevestigatori P31266.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProi IPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view ]
Pfami PF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view ]
SUPFAMi SSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif."
    Matsunami N., Hamaguchi Y., Yamamoto Y., Kuze K., Kangawa K., Matsuo H., Kawaichi M., Honjo T.
    Nature 342:934-937(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
  2. "Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene."
    Kawaichi M., Oka C., Shibayama S., Koromilas A.E., Matsunami N., Hamaguchi Y., Honjo T.
    J. Biol. Chem. 267:4016-4022(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Liver.
  3. "Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes."
    Hamaguchi Y., Matsunami N., Yamamoto Y., Kuze K., Kangawa K., Matsuo H., Kawaichi M., Honjo T.
    Adv. Exp. Med. Biol. 292:177-186(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-341 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Thymus.
  6. "Signalling downstream of activated mammalian Notch."
    Jarriault S., Brou C., Logeat F., Schroeter E.H., Kopan R., Israel A.
    Nature 377:355-358(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NOTCH1.
  7. "LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein."
    Taniguchi Y., Furukawa T., Tun T., Han H., Honjo T.
    Mol. Cell. Biol. 18:644-654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FHL1.
  8. Cited for: INTERACTION WITH EP300.
  9. "p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos."
    Obata J., Yano M., Mimura H., Goto T., Nakayama R., Mibu Y., Oka C., Kawaichi M.
    Genes Cells 6:345-360(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTF1A.
    Strain: ICR.
    Tissue: Embryo.
  10. "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression."
    Kao H.-Y., Downes M., Ordentlich P., Evans R.M.
    Genes Dev. 14:55-66(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH NCOR2 AND HDAC1.
  11. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-201, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSUH_MOUSE
AccessioniPrimary (citable) accession number: P31266
Secondary accession number(s): Q80UN8, Q8C4Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3