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P31263 (HXD11_NOTVI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D11
Alternative name(s):
NvHox-2
Gene names
Name:HOXD11
Synonyms:NVHOX2
OrganismNotophthalmus viridescens (Eastern newt) (Triturus viridescens)
Taxonomic identifier8316 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaeNotophthalmus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Homeobox protein Hox-D11
PRO_0000200236

Regions

DNA binding205 – 26460Homeobox

Sequences

Sequence LengthMass (Da)Tools
P31263 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: EC805399F6BA2B9F

FASTA27731,783
        10         20         30         40         50         60 
MTEFDGCTNG ATNMYLPGCA YYVSPSEFST KTSFLSQGSS CPVTFPYSSN LPHVQPVREM 

        70         80         90        100        110        120 
AFREYGWRRS KWQYRGSYPS YYPSEEVVAR DFIQPSNRRS DVLFKADPLC AHHGTPSAAS 

       130        140        150        160        170        180 
NLYSTVGRNG VLPQEFDQFY EASQPTSVPP EHVGSLDKTG SKTQEVPPKI THSPDKKMGA 

       190        200        210        220        230        240 
EGRADSPSGE VAADKSNSSA TPQRSRKKRC PYTKYQIREL EREFFFNVYI NKEKRLQLSR 

       250        260        270 
MLNLTDRQVK IWFQNRRMKE KKLNRDRLQY FTGNPLF 

« Hide

References

[1]"Identification and expression of a regeneration-specific homeobox gene in the newt limb blastema."
Brown R., Brockes J.P.
Development 111:489-496(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57674 mRNA. No translation available.
PIRA43783.

3D structure databases

ProteinModelPortalP31263.
SMRP31263. Positions 203-267.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG052048.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXD11_NOTVI
AccessionPrimary (citable) accession number: P31263
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries