P31263 (HXD11_NOTVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D11

Alternative name(s):
NvHox-2

Gene names

Name:	HOXD11
Synonyms:	NVHOX2

Organism

Notophthalmus viridescens (Eastern newt) (Triturus viridescens)

Taxonomic identifier

8316 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Caudata › Salamandroidea › Salamandridae › Notophthalmus

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Homeobox protein Hox-D11		PRO_0000200236
Regions
	DNA binding	205 – 264	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	P31263 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: EC805399F6BA2B9F	FASTA	277	31,783
	10 20 30 40 50 60 MTEFDGCTNG ATNMYLPGCA YYVSPSEFST KTSFLSQGSS CPVTFPYSSN LPHVQPVREM 70 80 90 100 110 120 AFREYGWRRS KWQYRGSYPS YYPSEEVVAR DFIQPSNRRS DVLFKADPLC AHHGTPSAAS 130 140 150 160 170 180 NLYSTVGRNG VLPQEFDQFY EASQPTSVPP EHVGSLDKTG SKTQEVPPKI THSPDKKMGA 190 200 210 220 230 240 EGRADSPSGE VAADKSNSSA TPQRSRKKRC PYTKYQIREL EREFFFNVYI NKEKRLQLSR 250 260 270 MLNLTDRQVK IWFQNRRMKE KKLNRDRLQY FTGNPLF

References

[1]	"Identification and expression of a regeneration-specific homeobox gene in the newt limb blastema." Brown R., Brockes J.P. Development 111:489-496(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X57674 mRNA. No translation available.
PIR	A43783.
3D structure databases
ProteinModelPortal	P31263.
SMR	P31263. Positions 203-267.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG052048.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR021918. DUF3528. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF12045. DUF3528. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXD11_NOTVI

Accession

Primary (citable) accession number: P31263

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program