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Protein

Homeobox protein Hox-D11

Gene

HOXD11

Organism
Notophthalmus viridescens (Eastern newt) (Triturus viridescens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi205 – 26460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D11
Alternative name(s):
NvHox-2
Gene namesi
Name:HOXD11
Synonyms:NVHOX2
OrganismiNotophthalmus viridescens (Eastern newt) (Triturus viridescens)
Taxonomic identifieri8316 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaeNotophthalmus

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Homeobox protein Hox-D11PRO_0000200236Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP31263.
SMRiP31263. Positions 203-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG052048.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFDGCTNG ATNMYLPGCA YYVSPSEFST KTSFLSQGSS CPVTFPYSSN
60 70 80 90 100
LPHVQPVREM AFREYGWRRS KWQYRGSYPS YYPSEEVVAR DFIQPSNRRS
110 120 130 140 150
DVLFKADPLC AHHGTPSAAS NLYSTVGRNG VLPQEFDQFY EASQPTSVPP
160 170 180 190 200
EHVGSLDKTG SKTQEVPPKI THSPDKKMGA EGRADSPSGE VAADKSNSSA
210 220 230 240 250
TPQRSRKKRC PYTKYQIREL EREFFFNVYI NKEKRLQLSR MLNLTDRQVK
260 270
IWFQNRRMKE KKLNRDRLQY FTGNPLF
Length:277
Mass (Da):31,783
Last modified:June 30, 1993 - v1
Checksum:iEC805399F6BA2B9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57674 mRNA. No translation available.
PIRiA43783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57674 mRNA. No translation available.
PIRiA43783.

3D structure databases

ProteinModelPortaliP31263.
SMRiP31263. Positions 203-267.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052048.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and expression of a regeneration-specific homeobox gene in the newt limb blastema."
    Brown R., Brockes J.P.
    Development 111:489-496(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHXD11_NOTVI
AccessioniPrimary (citable) accession number: P31263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1993
Last sequence update: June 30, 1993
Last modified: January 6, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.