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P31261 (HXA2_NOTVI) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A2
Alternative name(s):
Homeobox protein Hbox-2.8
Short name=NvHbox-2.8
OrganismNotophthalmus viridescens (Eastern newt) (Triturus viridescens)
Taxonomic identifier8316 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaeNotophthalmus

Protein attributes

Sequence length90 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›90›90Homeobox protein Hox-A2
PRO_0000200042

Regions

DNA binding2 – 6160Homeobox

Experimental info

Non-terminal residue11
Non-terminal residue901

Sequences

Sequence LengthMass (Da)Tools
P31261 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: C9F486132E2B1FA7

FASTA9010,764
        10         20         30         40         50         60 
GSRRLRTAYT NTQLLELEKE FHFNKYLCRP RRVEIAALLD LTERQVKVWF QNRRMKHKRQ 

        70         80         90 
TQCKENQNGE GKGKGLEEGD RSEDEEEKAL 

« Hide

References

[1]"Homeobox-containing genes in the newt are organized in clusters similar to other vertebrates."
Belleville S., Beauchemin M., Tremblay M., Noiseux N., Savard P.
Gene 114:179-186(1992) [PubMed: 1351019] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84002 Genomic DNA. Translation: AAA49396.1.
PIRJC1163.

3D structure databases

ProteinModelPortalP31261.
SMRP31261. Positions 4-60.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001356. Homeobox.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_eu.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. Partial match.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXA2_NOTVI
AccessionPrimary (citable) accession number: P31261
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

SIMILARITY comments

Index of protein domains and families