P31261 (HXA2_NOTVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Homeobox protein Hox-A2 Alternative name(s): Homeobox protein Hbox-2.8 Short name=NvHbox-2.8
Organism	Notophthalmus viridescens (Eastern newt) (Triturus viridescens)
Taxonomic identifier	8316 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Caudata › Salamandroidea › Salamandridae › Notophthalmus

Protein attributes

Sequence length	90 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›90	›90	Homeobox protein Hox-A2		PRO_0000200042
Regions
	DNA binding	2 – 61	60	Homeobox
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	90	1

Sequences

	Sequence		Length	Mass (Da)
	P31261 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: C9F486132E2B1FA7	FASTA	90	10,764
	10 20 30 40 50 60 GSRRLRTAYT NTQLLELEKE FHFNKYLCRP RRVEIAALLD LTERQVKVWF QNRRMKHKRQ 70 80 90 TQCKENQNGE GKGKGLEEGD RSEDEEEKAL

References

[1]	"Homeobox-containing genes in the newt are organized in clusters similar to other vertebrates." Belleville S., Beauchemin M., Tremblay M., Noiseux N., Savard P. Gene 114:179-186(1992) [PubMed: 1351019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M84002 Genomic DNA. Translation: AAA49396.1.
PIR	JC1163.
3D structure databases
ProteinModelPortal	P31261.
SMR	P31261. Positions 4-60.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. Partial match. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA2_NOTVI

Accession

Primary (citable) accession number: P31261

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program