ID HXA10_HUMAN Reviewed; 410 AA. AC P31260; O43370; O43605; Q15949; Q504T1; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 20-APR-2010, sequence version 3. DT 24-JAN-2024, entry version 217. DE RecName: Full=Homeobox protein Hox-A10; DE AltName: Full=Homeobox protein Hox-1.8; DE AltName: Full=Homeobox protein Hox-1H; DE AltName: Full=PL; GN Name=HOXA10; Synonyms=HOX1H; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING. RX PubMed=1676505; DOI=10.1093/nar/19.12.3443; RA Lowney P., Corral J.C., Detmer K., Lebeau M.M., Deaven L., Lawrence H.J., RA Largman C.; RT "A human Hox 1 homeobox gene exhibits myeloid-specific expression of RT alternative transcripts in human hematopoietic cells."; RL Nucleic Acids Res. 19:3443-3449(1991). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Mi X., Winters J.L., Stevens D.B., Fleischman R.A.; RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Caudate nucleus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 2-410 (ISOFORM 1). RC TISSUE=Muscle, and Salivary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] OF 318-400. RX PubMed=2573064; DOI=10.1073/pnas.86.21.8536; RA Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., RA Simonitch T.A., Hack F.M., Lawrence H.J.; RT "Lineage-restricted expression of homeobox-containing genes in human RT hematopoietic cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 336-396. RX PubMed=2574852; DOI=10.1093/nar/17.24.10385; RA Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., RA Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.; RT "The human HOX gene family."; RL Nucleic Acids Res. 17:10385-10402(1989). RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] OF 349-387. RX PubMed=7906121; DOI=10.1016/0006-2952(94)90447-2; RA Castronovo V., Kusaka M., Chariot A., Gielen J., Sobel M.; RT "Homeobox genes: potential candidates for the transcriptional control of RT the transformed and invasive phenotype."; RL Biochem. Pharmacol. 47:137-143(1994). RN [10] RP INTERACTION WITH SIRT2. RX PubMed=15213244; DOI=10.1093/jb/mvh084; RA Bae N.S., Swanson M.J., Vassilev A., Howard B.H.; RT "Human histone deacetylase SIRT2 interacts with the homeobox transcription RT factor HOXA10."; RL J. Biochem. 135:695-700(2004). CC -!- FUNCTION: Sequence-specific transcription factor which is part of a CC developmental regulatory system that provides cells with specific CC positional identities on the anterior-posterior axis. Binds to the DNA CC sequence 5'-AA[AT]TTTTATTAC-3'. CC -!- SUBUNIT: Interacts with SIRT2; the interaction is direct. CC {ECO:0000269|PubMed:15213244}. CC -!- INTERACTION: CC P31260; P17947: SPI1; NbExp=2; IntAct=EBI-2293516, EBI-2293548; CC P31260-2; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-12896693, EBI-11427343; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=PL1; CC IsoId=P31260-1; Sequence=Displayed; CC Name=2; Synonyms=PL2; CC IsoId=P31260-2; Sequence=VSP_002384, VSP_002385; CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAB96917.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAH13971.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=CAB86198.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X58430; CAB86198.1; ALT_FRAME; Genomic_DNA. DR EMBL; AF040714; AAB96917.1; ALT_INIT; Genomic_DNA. DR EMBL; AK312450; BAG35357.1; -; mRNA. DR EMBL; AC004080; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471073; EAW93885.1; -; Genomic_DNA. DR EMBL; BC013971; AAH13971.1; ALT_INIT; mRNA. DR EMBL; BC071843; AAH71843.1; -; mRNA. DR EMBL; BC094807; AAH94807.1; -; mRNA. DR EMBL; M30599; AAA36006.1; -; mRNA. DR EMBL; S69027; AAD14030.1; -; mRNA. DR EMBL; S69029; AAD14031.1; -; mRNA. DR CCDS; CCDS5410.2; -. [P31260-1] DR PIR; I65264; I65264. DR PIR; I65265; I65265. DR PIR; S26402; S26402. DR PIR; S28814; S28814. DR RefSeq; NP_061824.3; NM_018951.3. [P31260-1] DR AlphaFoldDB; P31260; -. DR SMR; P31260; -. DR BioGRID; 109446; 39. DR IntAct; P31260; 17. DR MINT; P31260; -. DR STRING; 9606.ENSP00000283921; -. DR DrugBank; DB00136; Calcitriol. DR GlyGen; P31260; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; P31260; -. DR PhosphoSitePlus; P31260; -. DR BioMuta; HOXA10; -. DR DMDM; 294862509; -. DR jPOST; P31260; -. DR MassIVE; P31260; -. DR MaxQB; P31260; -. DR PaxDb; 9606-ENSP00000283921; -. DR PeptideAtlas; P31260; -. DR ProteomicsDB; 54766; -. [P31260-1] DR ProteomicsDB; 54767; -. [P31260-2] DR Pumba; P31260; -. DR Antibodypedia; 48441; 289 antibodies from 26 providers. DR DNASU; 3206; -. DR Ensembl; ENST00000283921.5; ENSP00000283921.4; ENSG00000253293.6. [P31260-1] DR Ensembl; ENST00000396344.4; ENSP00000379633.4; ENSG00000253293.6. [P31260-2] DR GeneID; 3206; -. DR KEGG; hsa:3206; -. DR MANE-Select; ENST00000283921.5; ENSP00000283921.4; NM_018951.4; NP_061824.3. DR UCSC; uc011jzm.3; human. [P31260-1] DR AGR; HGNC:5100; -. DR CTD; 3206; -. DR DisGeNET; 3206; -. DR GeneCards; HOXA10; -. DR HGNC; HGNC:5100; HOXA10. DR HPA; ENSG00000253293; Tissue enhanced (endometrium, skeletal muscle, smooth muscle). DR MIM; 142957; gene. DR neXtProt; NX_P31260; -. DR OpenTargets; ENSG00000253293; -. DR PharmGKB; PA29377; -. DR VEuPathDB; HostDB:ENSG00000253293; -. DR eggNOG; KOG0487; Eukaryota. DR GeneTree; ENSGT00940000162440; -. DR HOGENOM; CLU_057871_0_0_1; -. DR InParanoid; P31260; -. DR OMA; YYPHYLP; -. DR OrthoDB; 728401at2759; -. DR PhylomeDB; P31260; -. DR TreeFam; TF317819; -. DR PathwayCommons; P31260; -. DR SignaLink; P31260; -. DR SIGNOR; P31260; -. DR BioGRID-ORCS; 3206; 20 hits in 1172 CRISPR screens. DR GeneWiki; Homeobox_A10; -. DR GenomeRNAi; 3206; -. DR Pharos; P31260; Tbio. DR PRO; PR:P31260; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; P31260; Protein. DR Bgee; ENSG00000253293; Expressed in biceps brachii and 146 other cell types or tissues. DR ExpressionAtlas; P31260; baseline and differential. DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. DR GO; GO:0042826; F:histone deacetylase binding; IPI:UniProtKB. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl. DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl. DR GO; GO:0008584; P:male gonad development; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB. DR GO; GO:0030850; P:prostate gland development; IEA:Ensembl. DR GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl. DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl. DR GO; GO:0007338; P:single fertilization; IEA:Ensembl. DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl. DR GO; GO:0007283; P:spermatogenesis; TAS:ProtInc. DR GO; GO:0060065; P:uterus development; IEA:Ensembl. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR020479; Homeobox_metazoa. DR InterPro; IPR046333; HXA10/ABDB-like. DR PANTHER; PTHR45874; HOMEOBOX PROTEIN ABDOMINAL-B; 1. DR PANTHER; PTHR45874:SF1; HOMEOBOX PROTEIN HOX-A10; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR Genevisible; P31260; HS. PE 1: Evidence at protein level; KW Alternative splicing; Developmental protein; DNA-binding; Homeobox; KW Nucleus; Reference proteome; Transcription; Transcription regulation. FT CHAIN 1..410 FT /note="Homeobox protein Hox-A10" FT /id="PRO_0000200090" FT DNA_BIND 336..395 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 89..158 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 221..339 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 127..152 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 300..329 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..316 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_002384" FT VAR_SEQ 317..319 FT /note="DSL -> MCQ (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_002385" FT CONFLICT 20 FT /note="C -> S (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 75 FT /note="L -> W (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 86 FT /note="G -> R (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 153..154 FT /note="QA -> HR (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 192 FT /note="P -> R (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 216 FT /note="L -> P (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 221 FT /note="G -> A (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 231 FT /note="G -> C (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 234..235 FT /note="QQ -> HE (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 241 FT /note="F -> V (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 248 FT /note="R -> G (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 260..261 FT /note="SA -> GS (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 292 FT /note="A -> G (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 295 FT /note="S -> R (in Ref. 1; CAB86198)" FT /evidence="ECO:0000305" FT CONFLICT 349 FT /note="L -> S (in Ref. 9; AAD14031)" FT /evidence="ECO:0000305" FT CONFLICT 351 FT /note="L -> F (in Ref. 9; AAD14031)" FT /evidence="ECO:0000305" FT CONFLICT 356 FT /note="L -> H (in Ref. 9; AAD14030)" FT /evidence="ECO:0000305" FT CONFLICT 359 FT /note="M -> R (in Ref. 9; AAD14030)" FT /evidence="ECO:0000305" FT CONFLICT 364 FT /note="E -> R (in Ref. 9; AAD14030)" FT /evidence="ECO:0000305" FT CONFLICT 367 FT /note="L -> I (in Ref. 9; AAD14030)" FT /evidence="ECO:0000305" FT CONFLICT 370..374 FT /note="SRSVH -> ANALC (in Ref. 9; AAD14030)" FT /evidence="ECO:0000305" FT CONFLICT 377 FT /note="D -> E (in Ref. 9; AAD14030)" FT /evidence="ECO:0000305" FT CONFLICT 380 FT /note="V -> S (in Ref. 9; AAD14030)" FT /evidence="ECO:0000305" FT CONFLICT 387 FT /note="R -> P (in Ref. 9; AAD14030/AAD14031)" FT /evidence="ECO:0000305" SQ SEQUENCE 410 AA; 42414 MW; E9544C35145FE7A4 CRC64; MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGGGGGGAG GGGGGGYYAH GGVYLPPAAD LPYGLQSCGL FPTLGGKRNE AASPGSGGGG GGLGPGAHGY GPSPIDLWLD APRSCRMEPP DGPPPPPQQQ PPPPPQPPQP APQATSCSFA QNIKEESSYC LYDSADKCPK VSATAAELAP FPRGPPPDGC ALGTSSGVPV PGYFRLSQAY GTAKGYGSGG GGAQQLGAGP FPAQPPGRGF DLPPALASGS ADAARKERAL DSPPPPTLAC GSGGGSQGDE EAHASSSAAE ELSPAPSESS KASPEKDSLG NSKGENAANW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS RSVHLTDRQV KIWFQNRRMK LKKMNRENRI RELTANFNFS //