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P31260 (HXA10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A10
Alternative name(s):
Homeobox protein Hox-1.8
Homeobox protein Hox-1H
PL
Gene names
Name:HOXA10
Synonyms:HOX1H
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAB96917.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH13971.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAB86198.1 differs from that shown. Reason: Frameshift at several positions.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SPI1P179472EBI-2293516,EBI-2293548

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P31260-1)

Also known as: PL1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P31260-2)

Also known as: PL2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-319: DSL → MCQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Homeobox protein Hox-A10
PRO_0000200090

Regions

DNA binding336 – 39560Homeobox
Compositional bias43 – 5614Poly-Gly
Compositional bias95 – 10612Poly-Gly
Compositional bias133 – 1375Poly-Pro
Compositional bias141 – 15010Poly-Pro
Compositional bias225 – 2328Poly-Gly
Compositional bias273 – 2764Poly-Pro

Natural variations

Alternative sequence1 – 316316Missing in isoform 2.
VSP_002384
Alternative sequence317 – 3193DSL → MCQ in isoform 2.
VSP_002385

Experimental info

Sequence conflict201C → S in CAB86198. Ref.1
Sequence conflict751L → W in CAB86198. Ref.1
Sequence conflict861G → R in CAB86198. Ref.1
Sequence conflict153 – 1542QA → HR in CAB86198. Ref.1
Sequence conflict1921P → R in CAB86198. Ref.1
Sequence conflict2161L → P in CAB86198. Ref.1
Sequence conflict2211G → A in CAB86198. Ref.1
Sequence conflict2311G → C in CAB86198. Ref.1
Sequence conflict234 – 2352QQ → HE in CAB86198. Ref.1
Sequence conflict2411F → V in CAB86198. Ref.1
Sequence conflict2481R → G in CAB86198. Ref.1
Sequence conflict260 – 2612SA → GS in CAB86198. Ref.1
Sequence conflict2921A → G in CAB86198. Ref.1
Sequence conflict2951S → R in CAB86198. Ref.1
Sequence conflict3491L → S in AAD14031. Ref.9
Sequence conflict3511L → F in AAD14031. Ref.9
Sequence conflict3561L → H in AAD14030. Ref.9
Sequence conflict3591M → R in AAD14030. Ref.9
Sequence conflict3641E → R in AAD14030. Ref.9
Sequence conflict3671L → I in AAD14030. Ref.9
Sequence conflict370 – 3745SRSVH → ANALC in AAD14030. Ref.9
Sequence conflict3771D → E in AAD14030. Ref.9
Sequence conflict3801V → S in AAD14030. Ref.9
Sequence conflict3871R → P in AAD14030. Ref.9
Sequence conflict3871R → P in AAD14031. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (PL1) [UniParc].

Last modified April 20, 2010. Version 3.
Checksum: E9544C35145FE7A4

FASTA41042,414
        10         20         30         40         50         60 
MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGGGGGGAG GGGGGGYYAH 

        70         80         90        100        110        120 
GGVYLPPAAD LPYGLQSCGL FPTLGGKRNE AASPGSGGGG GGLGPGAHGY GPSPIDLWLD 

       130        140        150        160        170        180 
APRSCRMEPP DGPPPPPQQQ PPPPPQPPQP APQATSCSFA QNIKEESSYC LYDSADKCPK 

       190        200        210        220        230        240 
VSATAAELAP FPRGPPPDGC ALGTSSGVPV PGYFRLSQAY GTAKGYGSGG GGAQQLGAGP 

       250        260        270        280        290        300 
FPAQPPGRGF DLPPALASGS ADAARKERAL DSPPPPTLAC GSGGGSQGDE EAHASSSAAE 

       310        320        330        340        350        360 
ELSPAPSESS KASPEKDSLG NSKGENAANW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY 

       370        380        390        400        410 
LTRERRLEIS RSVHLTDRQV KIWFQNRRMK LKKMNRENRI RELTANFNFS 

« Hide

Isoform 2 (PL2) [UniParc].

Checksum: 1F5C2E451B309ED2
Show »

FASTA9411,452

References

« Hide 'large scale' references
[1]"A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells."
Lowney P., Corral J.C., Detmer K., Lebeau M.M., Deaven L., Lawrence H.J., Largman C.
Nucleic Acids Res. 19:3443-3449(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[2]Mi X., Winters J.L., Stevens D.B., Fleischman R.A.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Caudate nucleus.
[4]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-410 (ISOFORM 1).
Tissue: Muscle and Salivary gland.
[7]"Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines."
Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J.
Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-400.
[8]"The human HOX gene family."
Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.
Nucleic Acids Res. 17:10385-10402(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 336-396.
[9]"Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype."
Castronovo V., Kusaka M., Chariot A., Gielen J., Sobel M.
Biochem. Pharmacol. 47:137-143(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 349-387.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58430 Genomic DNA. Translation: CAB86198.1. Frameshift.
AF040714 Genomic DNA. Translation: AAB96917.1. Different initiation.
AK312450 mRNA. Translation: BAG35357.1.
AC004080 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93885.1.
BC013971 mRNA. Translation: AAH13971.1. Different initiation.
BC071843 mRNA. Translation: AAH71843.1.
BC094807 mRNA. Translation: AAH94807.1.
M30599 mRNA. Translation: AAA36006.1.
S69027 mRNA. Translation: AAD14030.1.
S69029 mRNA. Translation: AAD14031.1.
PIRI65264.
I65265.
S26402.
S28814.
RefSeqNP_061824.3. NM_018951.3.
UniGeneHs.110637.
Hs.659350.

3D structure databases

ProteinModelPortalP31260.
SMRP31260. Positions 337-395.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109446. 8 interactions.
IntActP31260. 3 interactions.
MINTMINT-243009.
STRING9606.ENSP00000283921.

PTM databases

PhosphoSiteP31260.

Polymorphism databases

DMDM294862509.

Proteomic databases

PaxDbP31260.
PRIDEP31260.

Protocols and materials databases

DNASU3206.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283921; ENSP00000283921; ENSG00000253293. [P31260-1]
ENST00000396344; ENSP00000379633; ENSG00000253293. [P31260-2]
GeneID3206.
KEGGhsa:3206.
UCSCuc011jzm.2. human. [P31260-1]

Organism-specific databases

CTD3206.
GeneCardsGC07M027210.
HGNCHGNC:5100. HOXA10.
HPACAB019384.
MIM142957. gene.
neXtProtNX_P31260.
PharmGKBPA29377.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG248153.
HOGENOMHOG000231182.
HOVERGENHBG052934.
InParanoidP31260.
KOK17443.
OMACRMEPPE.
OrthoDBEOG72JWGM.
PhylomeDBP31260.
TreeFamTF317819.

Gene expression databases

BgeeP31260.
CleanExHS_HOXA10.
GenevestigatorP31260.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHOXA10. human.
GeneWikiHomeobox_A10.
GenomeRNAi3206.
NextBio12756.
PROP31260.
SOURCESearch...

Entry information

Entry nameHXA10_HUMAN
AccessionPrimary (citable) accession number: P31260
Secondary accession number(s): O43370 expand/collapse secondary AC list , O43605, Q15949, Q504T1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries