Reviewed, UniProtKB/Swiss-Prot P31260 (HXA10_HUMAN)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A10
Alternative name(s):
    Hox-1H
    Hox-1.8
    PL

Gene names

Name:	HOXA10
Synonyms:	HOX1H

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence CAB86198.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Traceable author statement. Source: ProtInc regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Traceable author statement. Source: ProtInc transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P31260-1)

Also known as: PL1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P31260-2)

Also known as: PL2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.
     300-302: DSL → MCQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Homeobox protein Hox-A10		PRO_0000200090
Regions
	DNA binding	319 – 378	60	Homeobox
	Compositional bias	26 – 39	14	Poly-Gly
	Compositional bias	78 – 89	12	Poly-Gly
	Compositional bias	116 – 120	5	Poly-Pro
	Compositional bias	124 – 133	10	Poly-Pro
	Compositional bias	208 – 215	8	Poly-Gly
	Compositional bias	256 – 259	4	Poly-Pro
Natural variations
	Alternative sequence	1 – 299	299	Missing in isoform 2.		VSP_002384
	Alternative sequence	300 – 302	3	DSL → MCQ in isoform 2.		VSP_002385
Experimental info
	Sequence conflict	1 – 6	6	MSCSES → MFCTRNVSQKGLSAPFAKLS HNNVMLGE in CAB86198. Ref.1
	Sequence conflict	69	1	G → R in CAB86198. Ref.1
	Sequence conflict	136 – 137	2	QA → HR in CAB86198. Ref.1
	Sequence conflict	332	1	L → S Ref.5
	Sequence conflict	334	1	L → F Ref.5
	Sequence conflict	370	1	R → P Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PL1) [UniParc]. Last modified February 21, 2001. Version 2. Checksum: 20F89542582D6F25	FASTA	393	40,536
	10 20 30 40 50 60 MSCSESPAAN SFLVDSLISS GRGEAGGGGG GAGGGGGGGY YAHGGVYLPP AADLPYGLQS 70 80 90 100 110 120 CGLFPTLGGK RNEAASPGSG GGGGGLGPGA HGYGPSPIDL WLDAPRSCRM EPPDGPPPPP 130 140 150 160 170 180 QQQPPPPPQP PQPAPQATSC SFAQNIKEES SYCLYDSADK CPKVSATAAE LAPFPRGPPP 190 200 210 220 230 240 DGCALGTSSG VPVPGYFRLS QAYGTAKGYG SGGGGAQQLG AGPFPAQPPG RGFDLPPALA 250 260 270 280 290 300 SGSADAARKE RALDSPPPPT LACGSGGGSQ GDEEAHASSS AAEELSPAPS ESSKASPEKD 310 320 330 340 350 360 SLGNSKGENA ANWLTAKSGR KKRCPYTKHQ TLELEKEFLF NMYLTRERRL EISRSVHLTD 370 380 390 RQVKIWFQNR RMKLKKMNRE NRIRELTANF NFS
	Isoform 2 (PL2). Checksum: 1F5C2E451B309ED2	FASTA	94	11,452
	10 20 30 40 50 60 MCQGNSKGEN AANWLTAKSG RKKRCPYTKH QTLELEKEFL FNMYLTRERR LEISRSVHLT 70 80 90 DRQVKIWFQN RRMKLKKMNR ENRIRELTAN FNFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells." Lowney P., Corral J.C., Detmer K., Lebeau M.M., Deaven L., Lawrence H.J., Largman C. Nucleic Acids Res. 19:3443-3449(1991) [PubMed: 1676505] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[2]	Mi X., Winters J.L., Stevens D.B., Fleischman R.A. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Muscle and Salivary gland.
[5]	"Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines." Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J. Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed: 2573064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 301-383.
[6]	"The human HOX gene family." Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E. Nucleic Acids Res. 17:10385-10402(1989) [PubMed: 2574852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 319-384.
[7]	"Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype." Castronovo V., Kusaka M., Chariot A., Gielen J., Sobel M. Biochem. Pharmacol. 47:137-143(1994) [PubMed: 7906121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-370.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X58430 Genomic DNA. Translation: CAB86198.1. Frameshift. AF040714 Genomic DNA. Translation: AAB96917.1. AC004080 Genomic DNA. No translation available. BC013971 mRNA. Translation: AAH13971.1. BC071843 mRNA. Translation: AAH71843.1. M30599 mRNA. Translation: AAA36006.1. S69027 mRNA. Translation: AAD14030.1. S69029 mRNA. Translation: AAD14031.1.
IPI	IPI00010731. IPI00170686.
PIR	I65264. I65265. S26402. S28814.
RefSeq	NP_061824.3. NP_714926.1.
UniGene	Hs.592166
3D structure databases
HSSP	HSSP built from PDB template 9ANT based on UniProtKB P02833.
SMR	P31260. Positions 310-380.
ModBase	Search...
PTM databases
PhosphoSite	P31260.
Proteomic databases
PRIDE	P31260.
Genome annotation databases
Ensembl	ENSG00000153807. Homo sapiens. [Contig view]
GeneID	3206.
KEGG	hsa:3206.
Organism-specific databases
GeneCards	GC07M027176.
H-InvDB	HIX0006548.
HGNC	HGNC:5100. HOXA10.
HPA	CAB019384.
MIM	142957. gene.
Orphanet	99861. Leukemia, precursor T-cell lymphoblastic, acute.
PharmGKB	PA29377.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P31260.
HOVERGEN	P31260.
OMA	P31260. PQATSCS.
Enzyme and pathway databases
Pathway_Interaction_DB	hdac_classiii_pathway. Signaling events mediated by HDAC Class III.
Gene expression databases
ArrayExpress	P31260.
Bgee	P31260.
CleanEx	HS_HOXA10.
GermOnline	ENSG00000153807. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	12756.
SOURCE	Search...

Entry information

Entry name

HXA10_HUMAN

Accession

Primary (citable) accession number: P31260
Secondary accession number(s): O43370, O43605, Q15949

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	February 21, 2001
Last modified:	June 16, 2009
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)