P31260 (HXA10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A10

Alternative name(s):
Homeobox protein Hox-1.8
Homeobox protein Hox-1H
PL

Gene names

Name:	HOXA10
Synonyms:	HOX1H

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence AAB96917.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH13971.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB86198.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Traceable author statement. Source: ProtInc spermatogenesis Traceable author statement. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SPI1	P17947	2	EBI-2293516,EBI-2293548

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P31260-1)

Also known as: PL1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P31260-2)

Also known as: PL2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-319: DSL → MCQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Homeobox protein Hox-A10		PRO_0000200090
Regions
	DNA binding	336 – 395	60	Homeobox
	Compositional bias	43 – 56	14	Poly-Gly
	Compositional bias	95 – 106	12	Poly-Gly
	Compositional bias	133 – 137	5	Poly-Pro
	Compositional bias	141 – 150	10	Poly-Pro
	Compositional bias	225 – 232	8	Poly-Gly
	Compositional bias	273 – 276	4	Poly-Pro
Natural variations
	Alternative sequence	1 – 316	316	Missing in isoform 2.		VSP_002384
	Alternative sequence	317 – 319	3	DSL → MCQ in isoform 2.		VSP_002385
Experimental info
	Sequence conflict	20	1	C → S in CAB86198. Ref.1
	Sequence conflict	75	1	L → W in CAB86198. Ref.1
	Sequence conflict	86	1	G → R in CAB86198. Ref.1
	Sequence conflict	153 – 154	2	QA → HR in CAB86198. Ref.1
	Sequence conflict	192	1	P → R in CAB86198. Ref.1
	Sequence conflict	216	1	L → P in CAB86198. Ref.1
	Sequence conflict	221	1	G → A in CAB86198. Ref.1
	Sequence conflict	231	1	G → C in CAB86198. Ref.1
	Sequence conflict	234 – 235	2	QQ → HE in CAB86198. Ref.1
	Sequence conflict	241	1	F → V in CAB86198. Ref.1
	Sequence conflict	248	1	R → G in CAB86198. Ref.1
	Sequence conflict	260 – 261	2	SA → GS in CAB86198. Ref.1
	Sequence conflict	292	1	A → G in CAB86198. Ref.1
	Sequence conflict	295	1	S → R in CAB86198. Ref.1
	Sequence conflict	349	1	L → S in AAD14031. Ref.7
	Sequence conflict	351	1	L → F in AAD14031. Ref.7
	Sequence conflict	356	1	L → H in AAD14030. Ref.7
	Sequence conflict	359	1	M → R in AAD14030. Ref.7
	Sequence conflict	364	1	E → R in AAD14030. Ref.7
	Sequence conflict	367	1	L → I in AAD14030. Ref.7
	Sequence conflict	370 – 374	5	SRSVH → ANALC in AAD14030. Ref.7
	Sequence conflict	377	1	D → E in AAD14030. Ref.7
	Sequence conflict	380	1	V → S in AAD14030. Ref.7
	Sequence conflict	387	1	R → P in AAD14030. Ref.7
	Sequence conflict	387	1	R → P in AAD14031. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PL1) [UniParc]. Last modified April 20, 2010. Version 3. Checksum: E9544C35145FE7A4	FASTA	410	42,414
	10 20 30 40 50 60 MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGGGGGGAG GGGGGGYYAH 70 80 90 100 110 120 GGVYLPPAAD LPYGLQSCGL FPTLGGKRNE AASPGSGGGG GGLGPGAHGY GPSPIDLWLD 130 140 150 160 170 180 APRSCRMEPP DGPPPPPQQQ PPPPPQPPQP APQATSCSFA QNIKEESSYC LYDSADKCPK 190 200 210 220 230 240 VSATAAELAP FPRGPPPDGC ALGTSSGVPV PGYFRLSQAY GTAKGYGSGG GGAQQLGAGP 250 260 270 280 290 300 FPAQPPGRGF DLPPALASGS ADAARKERAL DSPPPPTLAC GSGGGSQGDE EAHASSSAAE 310 320 330 340 350 360 ELSPAPSESS KASPEKDSLG NSKGENAANW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY 370 380 390 400 410 LTRERRLEIS RSVHLTDRQV KIWFQNRRMK LKKMNRENRI RELTANFNFS
	Isoform 2 (PL2) [UniParc]. Checksum: 1F5C2E451B309ED2	FASTA	94	11,452
	10 20 30 40 50 60 MCQGNSKGEN AANWLTAKSG RKKRCPYTKH QTLELEKEFL FNMYLTRERR LEISRSVHLT 70 80 90 DRQVKIWFQN RRMKLKKMNR ENRIRELTAN FNFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells." Lowney P., Corral J.C., Detmer K., Lebeau M.M., Deaven L., Lawrence H.J., Largman C. Nucleic Acids Res. 19:3443-3449(1991) [PubMed: 1676505] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[2]	Mi X., Winters J.L., Stevens D.B., Fleischman R.A. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-410 (ISOFORM 1). Tissue: Muscle and Salivary gland.
[5]	"Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines." Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J. Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed: 2573064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-400.
[6]	"The human HOX gene family." Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E. Nucleic Acids Res. 17:10385-10402(1989) [PubMed: 2574852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 336-396.
[7]	"Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype." Castronovo V., Kusaka M., Chariot A., Gielen J., Sobel M. Biochem. Pharmacol. 47:137-143(1994) [PubMed: 7906121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 349-387.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X58430 Genomic DNA. Translation: CAB86198.1. Frameshift. AF040714 Genomic DNA. Translation: AAB96917.1. Different initiation. AC004080 Genomic DNA. No translation available. BC013971 mRNA. Translation: AAH13971.1. Different initiation. BC071843 mRNA. Translation: AAH71843.1. M30599 mRNA. Translation: AAA36006.1. S69027 mRNA. Translation: AAD14030.1. S69029 mRNA. Translation: AAD14031.1.
IPI	IPI00170686. IPI00941400.
PIR	I65264. I65265. S26402. S28814.
RefSeq	NP_061824.3. NM_018951.3.
UniGene	Hs.110637. Hs.659350.
3D structure databases
ProteinModelPortal	P31260.
SMR	P31260. Positions 327-397.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31260. 2 interactions.
STRING	P31260.
PTM databases
PhosphoSite	P31260.
Polymorphism databases
DMDM	294862509.
Proteomic databases
PRIDE	P31260.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000283921; ENSP00000283921; ENSG00000078399. ENST00000421352; ENSP00000409641; ENSG00000078399.
GeneID	3206.
KEGG	hsa:3206.
UCSC	uc003syv.1. human.
Organism-specific databases
CTD	3206.
GeneCards	GC07M027210.
HGNC	HGNC:5100. HOXA10.
HPA	CAB019384.
MIM	142957. gene.
neXtProt	NX_P31260.
PharmGKB	PA29377.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05343.
GeneTree	ENSGT00560000076560.
HOGENOM	HBG445572.
HOVERGEN	HBG052934.
InParanoid	P31260.
OMA	PQATSCS.
PhylomeDB	P31260.
Enzyme and pathway databases
Pathway_Interaction_DB	hdac_classiii_pathway. Signaling events mediated by HDAC Class III.
Gene expression databases
ArrayExpress	P31260.
Bgee	P31260.
CleanEx	HS_HOXA10.
Genevestigator	P31260.
GermOnline	ENSG00000153807. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09295.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	12756.
SOURCE	Search...

Entry information

Entry name

HXA10_HUMAN

Accession

Primary (citable) accession number: P31260
Secondary accession number(s): O43370, O43605, Q15949

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	April 20, 2010
Last modified:	January 25, 2012
This is version 129 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.