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Protein

Homeobox protein Hox-A10

Gene

HOXA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi336 – 395HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153807-MONOMER.
SIGNORiP31260.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A10
Alternative name(s):
Homeobox protein Hox-1.8
Homeobox protein Hox-1H
PL
Gene namesi
Name:HOXA10
Synonyms:HOX1H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:5100. HOXA10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3206.
OpenTargetsiENSG00000253293.
PharmGKBiPA29377.

Polymorphism and mutation databases

BioMutaiHOXA10.
DMDMi294862509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000901 – 410Homeobox protein Hox-A10Add BLAST410

Proteomic databases

MaxQBiP31260.
PaxDbiP31260.
PeptideAtlasiP31260.
PRIDEiP31260.

PTM databases

iPTMnetiP31260.
PhosphoSitePlusiP31260.

Expressioni

Gene expression databases

BgeeiENSG00000253293.
CleanExiHS_HOXA10.
ExpressionAtlasiP31260. baseline and differential.
GenevisibleiP31260. HS.

Organism-specific databases

HPAiCAB019384.

Interactioni

Subunit structurei

Interacts with SIRT2; the interaction is direct.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPI1P179472EBI-2293516,EBI-2293548

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109446. 16 interactors.
IntActiP31260. 7 interactors.
MINTiMINT-243009.
STRINGi9606.ENSP00000283921.

Structurei

3D structure databases

ProteinModelPortaliP31260.
SMRiP31260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 56Poly-GlyAdd BLAST14
Compositional biasi95 – 106Poly-GlyAdd BLAST12
Compositional biasi133 – 137Poly-Pro5
Compositional biasi141 – 150Poly-Pro10
Compositional biasi225 – 232Poly-Gly8
Compositional biasi273 – 276Poly-Pro4

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiP31260.
KOiK17443.
OMAiCRMEPPE.
OrthoDBiEOG091G0DAN.
PhylomeDBiP31260.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31260-1) [UniParc]FASTAAdd to basket
Also known as: PL1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGGGGGGAG
60 70 80 90 100
GGGGGGYYAH GGVYLPPAAD LPYGLQSCGL FPTLGGKRNE AASPGSGGGG
110 120 130 140 150
GGLGPGAHGY GPSPIDLWLD APRSCRMEPP DGPPPPPQQQ PPPPPQPPQP
160 170 180 190 200
APQATSCSFA QNIKEESSYC LYDSADKCPK VSATAAELAP FPRGPPPDGC
210 220 230 240 250
ALGTSSGVPV PGYFRLSQAY GTAKGYGSGG GGAQQLGAGP FPAQPPGRGF
260 270 280 290 300
DLPPALASGS ADAARKERAL DSPPPPTLAC GSGGGSQGDE EAHASSSAAE
310 320 330 340 350
ELSPAPSESS KASPEKDSLG NSKGENAANW LTAKSGRKKR CPYTKHQTLE
360 370 380 390 400
LEKEFLFNMY LTRERRLEIS RSVHLTDRQV KIWFQNRRMK LKKMNRENRI
410
RELTANFNFS
Length:410
Mass (Da):42,414
Last modified:April 20, 2010 - v3
Checksum:iE9544C35145FE7A4
GO
Isoform 2 (identifier: P31260-2) [UniParc]FASTAAdd to basket
Also known as: PL2

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-319: DSL → MCQ

Show »
Length:94
Mass (Da):11,452
Checksum:i1F5C2E451B309ED2
GO

Sequence cautioni

The sequence AAB96917 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH13971 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB86198 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20C → S in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti75L → W in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti86G → R in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti153 – 154QA → HR in CAB86198 (PubMed:1676505).Curated2
Sequence conflicti192P → R in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti216L → P in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti221G → A in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti231G → C in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti234 – 235QQ → HE in CAB86198 (PubMed:1676505).Curated2
Sequence conflicti241F → V in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti248R → G in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti260 – 261SA → GS in CAB86198 (PubMed:1676505).Curated2
Sequence conflicti292A → G in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti295S → R in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti349L → S in AAD14031 (PubMed:7906121).Curated1
Sequence conflicti351L → F in AAD14031 (PubMed:7906121).Curated1
Sequence conflicti356L → H in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti359M → R in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti364E → R in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti367L → I in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti370 – 374SRSVH → ANALC in AAD14030 (PubMed:7906121).Curated5
Sequence conflicti377D → E in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti380V → S in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti387R → P in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti387R → P in AAD14031 (PubMed:7906121).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023841 – 316Missing in isoform 2. 2 PublicationsAdd BLAST316
Alternative sequenceiVSP_002385317 – 319DSL → MCQ in isoform 2. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58430 Genomic DNA. Translation: CAB86198.1. Frameshift.
AF040714 Genomic DNA. Translation: AAB96917.1. Different initiation.
AK312450 mRNA. Translation: BAG35357.1.
AC004080 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93885.1.
BC013971 mRNA. Translation: AAH13971.1. Different initiation.
BC071843 mRNA. Translation: AAH71843.1.
BC094807 mRNA. Translation: AAH94807.1.
M30599 mRNA. Translation: AAA36006.1.
S69027 mRNA. Translation: AAD14030.1.
S69029 mRNA. Translation: AAD14031.1.
CCDSiCCDS5410.2. [P31260-1]
PIRiI65264.
I65265.
S26402.
S28814.
RefSeqiNP_061824.3. NM_018951.3. [P31260-1]
UniGeneiHs.110637.
Hs.659350.

Genome annotation databases

EnsembliENST00000283921; ENSP00000283921; ENSG00000253293. [P31260-1]
ENST00000396344; ENSP00000379633; ENSG00000253293. [P31260-2]
GeneIDi3206.
KEGGihsa:3206.
UCSCiuc011jzm.3. human. [P31260-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58430 Genomic DNA. Translation: CAB86198.1. Frameshift.
AF040714 Genomic DNA. Translation: AAB96917.1. Different initiation.
AK312450 mRNA. Translation: BAG35357.1.
AC004080 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93885.1.
BC013971 mRNA. Translation: AAH13971.1. Different initiation.
BC071843 mRNA. Translation: AAH71843.1.
BC094807 mRNA. Translation: AAH94807.1.
M30599 mRNA. Translation: AAA36006.1.
S69027 mRNA. Translation: AAD14030.1.
S69029 mRNA. Translation: AAD14031.1.
CCDSiCCDS5410.2. [P31260-1]
PIRiI65264.
I65265.
S26402.
S28814.
RefSeqiNP_061824.3. NM_018951.3. [P31260-1]
UniGeneiHs.110637.
Hs.659350.

3D structure databases

ProteinModelPortaliP31260.
SMRiP31260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109446. 16 interactors.
IntActiP31260. 7 interactors.
MINTiMINT-243009.
STRINGi9606.ENSP00000283921.

PTM databases

iPTMnetiP31260.
PhosphoSitePlusiP31260.

Polymorphism and mutation databases

BioMutaiHOXA10.
DMDMi294862509.

Proteomic databases

MaxQBiP31260.
PaxDbiP31260.
PeptideAtlasiP31260.
PRIDEiP31260.

Protocols and materials databases

DNASUi3206.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283921; ENSP00000283921; ENSG00000253293. [P31260-1]
ENST00000396344; ENSP00000379633; ENSG00000253293. [P31260-2]
GeneIDi3206.
KEGGihsa:3206.
UCSCiuc011jzm.3. human. [P31260-1]

Organism-specific databases

CTDi3206.
DisGeNETi3206.
GeneCardsiHOXA10.
HGNCiHGNC:5100. HOXA10.
HPAiCAB019384.
MIMi142957. gene.
neXtProtiNX_P31260.
OpenTargetsiENSG00000253293.
PharmGKBiPA29377.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiP31260.
KOiK17443.
OMAiCRMEPPE.
OrthoDBiEOG091G0DAN.
PhylomeDBiP31260.
TreeFamiTF317819.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153807-MONOMER.
SIGNORiP31260.

Miscellaneous databases

GeneWikiiHomeobox_A10.
GenomeRNAii3206.
PROiP31260.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000253293.
CleanExiHS_HOXA10.
ExpressionAtlasiP31260. baseline and differential.
GenevisibleiP31260. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXA10_HUMAN
AccessioniPrimary (citable) accession number: P31260
Secondary accession number(s): O43370
, O43605, Q15949, Q504T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 173 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.