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Protein

Homeobox protein Hox-A10

Gene

HOXA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi336 – 395HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP31260

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A10
Alternative name(s):
Homeobox protein Hox-1.8
Homeobox protein Hox-1H
PL
Gene namesi
Name:HOXA10
Synonyms:HOX1H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000253293.4
HGNCiHGNC:5100 HOXA10
MIMi142957 gene
neXtProtiNX_P31260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3206
OpenTargetsiENSG00000253293
PharmGKBiPA29377

Polymorphism and mutation databases

BioMutaiHOXA10
DMDMi294862509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000901 – 410Homeobox protein Hox-A10Add BLAST410

Proteomic databases

MaxQBiP31260
PaxDbiP31260
PeptideAtlasiP31260
PRIDEiP31260

PTM databases

iPTMnetiP31260
PhosphoSitePlusiP31260

Expressioni

Gene expression databases

BgeeiENSG00000253293
CleanExiHS_HOXA10
ExpressionAtlasiP31260 baseline and differential
GenevisibleiP31260 HS

Organism-specific databases

HPAiCAB019384

Interactioni

Subunit structurei

Interacts with SIRT2; the interaction is direct.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPI1P179472EBI-2293516,EBI-2293548

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109446, 17 interactors
IntActiP31260, 8 interactors
MINTiP31260
STRINGi9606.ENSP00000283921

Structurei

3D structure databases

ProteinModelPortaliP31260
SMRiP31260
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 56Poly-GlyAdd BLAST14
Compositional biasi95 – 106Poly-GlyAdd BLAST12
Compositional biasi133 – 137Poly-Pro5
Compositional biasi141 – 150Poly-Pro10
Compositional biasi225 – 232Poly-Gly8
Compositional biasi273 – 276Poly-Pro4

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231182
HOVERGENiHBG052934
InParanoidiP31260
KOiK17443
OMAiCRMEPPE
OrthoDBiEOG091G0DAN
PhylomeDBiP31260
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31260-1) [UniParc]FASTAAdd to basket
Also known as: PL1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGGGGGGAG
60 70 80 90 100
GGGGGGYYAH GGVYLPPAAD LPYGLQSCGL FPTLGGKRNE AASPGSGGGG
110 120 130 140 150
GGLGPGAHGY GPSPIDLWLD APRSCRMEPP DGPPPPPQQQ PPPPPQPPQP
160 170 180 190 200
APQATSCSFA QNIKEESSYC LYDSADKCPK VSATAAELAP FPRGPPPDGC
210 220 230 240 250
ALGTSSGVPV PGYFRLSQAY GTAKGYGSGG GGAQQLGAGP FPAQPPGRGF
260 270 280 290 300
DLPPALASGS ADAARKERAL DSPPPPTLAC GSGGGSQGDE EAHASSSAAE
310 320 330 340 350
ELSPAPSESS KASPEKDSLG NSKGENAANW LTAKSGRKKR CPYTKHQTLE
360 370 380 390 400
LEKEFLFNMY LTRERRLEIS RSVHLTDRQV KIWFQNRRMK LKKMNRENRI
410
RELTANFNFS
Length:410
Mass (Da):42,414
Last modified:April 20, 2010 - v3
Checksum:iE9544C35145FE7A4
GO
Isoform 2 (identifier: P31260-2) [UniParc]FASTAAdd to basket
Also known as: PL2

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-319: DSL → MCQ

Show »
Length:94
Mass (Da):11,452
Checksum:i1F5C2E451B309ED2
GO

Sequence cautioni

The sequence AAB96917 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH13971 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB86198 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20C → S in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti75L → W in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti86G → R in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti153 – 154QA → HR in CAB86198 (PubMed:1676505).Curated2
Sequence conflicti192P → R in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti216L → P in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti221G → A in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti231G → C in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti234 – 235QQ → HE in CAB86198 (PubMed:1676505).Curated2
Sequence conflicti241F → V in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti248R → G in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti260 – 261SA → GS in CAB86198 (PubMed:1676505).Curated2
Sequence conflicti292A → G in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti295S → R in CAB86198 (PubMed:1676505).Curated1
Sequence conflicti349L → S in AAD14031 (PubMed:7906121).Curated1
Sequence conflicti351L → F in AAD14031 (PubMed:7906121).Curated1
Sequence conflicti356L → H in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti359M → R in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti364E → R in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti367L → I in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti370 – 374SRSVH → ANALC in AAD14030 (PubMed:7906121).Curated5
Sequence conflicti377D → E in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti380V → S in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti387R → P in AAD14030 (PubMed:7906121).Curated1
Sequence conflicti387R → P in AAD14031 (PubMed:7906121).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023841 – 316Missing in isoform 2. 2 PublicationsAdd BLAST316
Alternative sequenceiVSP_002385317 – 319DSL → MCQ in isoform 2. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58430 Genomic DNA Translation: CAB86198.1 Frameshift.
AF040714 Genomic DNA Translation: AAB96917.1 Different initiation.
AK312450 mRNA Translation: BAG35357.1
AC004080 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93885.1
BC013971 mRNA Translation: AAH13971.1 Different initiation.
BC071843 mRNA Translation: AAH71843.1
BC094807 mRNA Translation: AAH94807.1
M30599 mRNA Translation: AAA36006.1
S69027 mRNA Translation: AAD14030.1
S69029 mRNA Translation: AAD14031.1
CCDSiCCDS5410.2 [P31260-1]
PIRiI65264
I65265
S26402
S28814
RefSeqiNP_061824.3, NM_018951.3 [P31260-1]
UniGeneiHs.110637
Hs.659350

Genome annotation databases

EnsembliENST00000283921; ENSP00000283921; ENSG00000253293 [P31260-1]
ENST00000396344; ENSP00000379633; ENSG00000253293 [P31260-2]
GeneIDi3206
KEGGihsa:3206
UCSCiuc011jzm.3 human [P31260-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHXA10_HUMAN
AccessioniPrimary (citable) accession number: P31260
Secondary accession number(s): O43370
, O43605, Q15949, Q504T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health