P31260 (HXA10_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 129.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Homeobox protein Hox-A10 Alternative name(s): Homeobox protein Hox-1.8 Homeobox protein Hox-1H PL | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 410 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. |
| Subcellular location | |
| Sequence similarities | Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain. |
| Sequence caution | The sequence AAB96917.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH13971.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB86198.1 differs from that shown. Reason: Frameshift at several positions. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Domain | Homeobox |
| Ligand | DNA-binding |
| Molecular function | Developmental protein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | multicellular organismal development Traceable author statement. Source: ProtInc spermatogenesisTraceable author statement. Source: ProtInc transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| SPI1 | P17947 | 2 | EBI-2293516,EBI-2293548 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P31260-1) Also known as: PL1; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P31260-2) Also known as: PL2; The sequence of this isoform differs from the canonical sequence as follows: 1-316: Missing. 317-319: DSL → MCQ |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 410 | 410 | Homeobox protein Hox-A10 | PRO_0000200090 | |||||
Regions | |||||||||
| DNA binding | 336 – 395 | 60 | Homeobox | ||||||
| Compositional bias | 43 – 56 | 14 | Poly-Gly | ||||||
| Compositional bias | 95 – 106 | 12 | Poly-Gly | ||||||
| Compositional bias | 133 – 137 | 5 | Poly-Pro | ||||||
| Compositional bias | 141 – 150 | 10 | Poly-Pro | ||||||
| Compositional bias | 225 – 232 | 8 | Poly-Gly | ||||||
| Compositional bias | 273 – 276 | 4 | Poly-Pro | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 316 | 316 | Missing in isoform 2. | VSP_002384 | |||||
| Alternative sequence | 317 – 319 | 3 | DSL → MCQ in isoform 2. | VSP_002385 | |||||
Experimental info | |||||||||
| Sequence conflict | 20 | 1 | C → S in CAB86198. Ref.1 | ||||||
| Sequence conflict | 75 | 1 | L → W in CAB86198. Ref.1 | ||||||
| Sequence conflict | 86 | 1 | G → R in CAB86198. Ref.1 | ||||||
| Sequence conflict | 153 – 154 | 2 | QA → HR in CAB86198. Ref.1 | ||||||
| Sequence conflict | 192 | 1 | P → R in CAB86198. Ref.1 | ||||||
| Sequence conflict | 216 | 1 | L → P in CAB86198. Ref.1 | ||||||
| Sequence conflict | 221 | 1 | G → A in CAB86198. Ref.1 | ||||||
| Sequence conflict | 231 | 1 | G → C in CAB86198. Ref.1 | ||||||
| Sequence conflict | 234 – 235 | 2 | QQ → HE in CAB86198. Ref.1 | ||||||
| Sequence conflict | 241 | 1 | F → V in CAB86198. Ref.1 | ||||||
| Sequence conflict | 248 | 1 | R → G in CAB86198. Ref.1 | ||||||
| Sequence conflict | 260 – 261 | 2 | SA → GS in CAB86198. Ref.1 | ||||||
| Sequence conflict | 292 | 1 | A → G in CAB86198. Ref.1 | ||||||
| Sequence conflict | 295 | 1 | S → R in CAB86198. Ref.1 | ||||||
| Sequence conflict | 349 | 1 | L → S in AAD14031. Ref.7 | ||||||
| Sequence conflict | 351 | 1 | L → F in AAD14031. Ref.7 | ||||||
| Sequence conflict | 356 | 1 | L → H in AAD14030. Ref.7 | ||||||
| Sequence conflict | 359 | 1 | M → R in AAD14030. Ref.7 | ||||||
| Sequence conflict | 364 | 1 | E → R in AAD14030. Ref.7 | ||||||
| Sequence conflict | 367 | 1 | L → I in AAD14030. Ref.7 | ||||||
| Sequence conflict | 370 – 374 | 5 | SRSVH → ANALC in AAD14030. Ref.7 | ||||||
| Sequence conflict | 377 | 1 | D → E in AAD14030. Ref.7 | ||||||
| Sequence conflict | 380 | 1 | V → S in AAD14030. Ref.7 | ||||||
| Sequence conflict | 387 | 1 | R → P in AAD14030. Ref.7 | ||||||
| Sequence conflict | 387 | 1 | R → P in AAD14031. Ref.7 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells." Lowney P., Corral J.C., Detmer K., Lebeau M.M., Deaven L., Lawrence H.J., Largman C. Nucleic Acids Res. 19:3443-3449(1991) [PubMed: 1676505] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING. |
| [2] | Mi X., Winters J.L., Stevens D.B., Fleischman R.A. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. Wilson R.K.Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-410 (ISOFORM 1). Tissue: Muscle and Salivary gland. |
| [5] | "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines." Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A., Simonitch T.A., Hack F.M., Lawrence H.J. Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989) [PubMed: 2573064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-400. |
| [6] | "The human HOX gene family." Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E. Nucleic Acids Res. 17:10385-10402(1989) [PubMed: 2574852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 336-396. |
| [7] | "Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype." Castronovo V., Kusaka M., Chariot A., Gielen J., Sobel M. Biochem. Pharmacol. 47:137-143(1994) [PubMed: 7906121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 349-387. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X58430 Genomic DNA. Translation: CAB86198.1. Frameshift. AF040714 Genomic DNA. Translation: AAB96917.1. Different initiation. AC004080 Genomic DNA. No translation available. BC013971 mRNA. Translation: AAH13971.1. Different initiation. BC071843 mRNA. Translation: AAH71843.1. M30599 mRNA. Translation: AAA36006.1. S69027 mRNA. Translation: AAD14030.1. S69029 mRNA. Translation: AAD14031.1. |
| IPI | IPI00170686. IPI00941400. |
| PIR | I65264. I65265. S26402. S28814. |
| RefSeq | NP_061824.3. NM_018951.3. |
| UniGene | Hs.110637. Hs.659350. |
3D structure databases | |
| ProteinModelPortal | P31260. |
| SMR | P31260. Positions 327-397. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P31260. 2 interactions. |
| STRING | P31260. |
PTM databases | |
| PhosphoSite | P31260. |
Polymorphism databases | |
| DMDM | 294862509. |
Proteomic databases | |
| PRIDE | P31260. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000283921; ENSP00000283921; ENSG00000078399. ENST00000421352; ENSP00000409641; ENSG00000078399. |
| GeneID | 3206. |
| KEGG | hsa:3206. |
| UCSC | uc003syv.1. human. |
Organism-specific databases | |
| CTD | 3206. |
| GeneCards | GC07M027210. |
| HGNC | HGNC:5100. HOXA10. |
| HPA | CAB019384. |
| MIM | 142957. gene. |
| neXtProt | NX_P31260. |
| PharmGKB | PA29377. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG05343. |
| GeneTree | ENSGT00560000076560. |
| HOGENOM | HBG445572. |
| HOVERGEN | HBG052934. |
| InParanoid | P31260. |
| OMA | PQATSCS. |
| PhylomeDB | P31260. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | hdac_classiii_pathway. Signaling events mediated by HDAC Class III. |
Gene expression databases | |
| ArrayExpress | P31260. |
| Bgee | P31260. |
| CleanEx | HS_HOXA10. |
| Genevestigator | P31260. |
| GermOnline | ENSG00000153807. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| KO | K09295. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| PRINTS | PR00024. HOMEOBOX. |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| SUPFAM | SSF46689. Homeodomain_like. 1 hit. |
| PROSITE | PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 12756. |
| SOURCE | Search... |
Entry information
| Entry name | HXA10_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P31260 Secondary accession number(s): O43370, O43605, Q15949 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Vertebrate homeotic Hox proteins Nomenclature of vertebrate homeotic Hox proteins and list of entries |
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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