ID   HXB1_CHICK              Reviewed;         309 AA.
AC   P31259;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   24-JAN-2024, entry version 135.
DE   RecName: Full=Homeobox protein Hox-B1;
DE   AltName: Full=Ghox-lab;
GN   Name=HOXB1; Synonyms=GHOX-LAB;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1693558; DOI=10.1242/dev.108.supplement.47;
RA   Sundin O.H., Busse H.G., Rogers M.B., Gudas L.J., Eichele G.;
RT   "Region-specific expression in early chick and mouse embryos of Ghox-lab
RT   and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila
RT   labial.";
RL   Development 108:47-58(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Acts on the
CC       anterior body structures.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X68352; CAA48418.1; -; Genomic_DNA.
DR   EMBL; X68353; CAA48418.1; JOINED; Genomic_DNA.
DR   PIR; A60096; A60096.
DR   AlphaFoldDB; P31259; -.
DR   SMR; P31259; -.
DR   PaxDb; 9031-ENSGALP00000021895; -.
DR   VEuPathDB; HostDB:geneid_395900; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P31259; -.
DR   PhylomeDB; P31259; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946:SF5; HOMEOBOX PROTEIN HOX-B1; 1.
DR   PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..309
FT                   /note="Homeobox protein Hox-B1"
FT                   /id="PRO_0000200109"
FT   DNA_BIND        213..272
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          28..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           188..193
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        28..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  33833 MW;  7F229226B51D607D CRC64;
     MDNTRMNSFL EYAICNRGTG AYHHLEQSSP SFPSCSGSPS SDTFHGEGAY GAGGSPVAAA
     HLPPQSPGFF PAPPGAPSLR GRCPERRVPN PKLQPRLRHH QLYLGQQDAD AVYFQAAGYS
     SSTGPHLGSL AEGYCGAVGQ YQQQQHLYGQ EQPSYLPGVY GNLSPSLNED KDPACPSEPC
     PNASRARTFD WMKVKRNPPK TAKVSEYGLL GQPNTIRTNF TTKQLTELEK EFHFNKYLTR
     ARRVEIAATL ELNETQVKIW FQNRRMKQKK REKEGLAPPA ASRSAKEASE ASDQSNCTSP
     EASPSSVSS
//