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P31259

- HXB1_CHICK

UniProt

P31259 - HXB1_CHICK

Protein

Homeobox protein Hox-B1

Gene

HOXB1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi213 – 27260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B1
    Alternative name(s):
    Ghox-lab
    Gene namesi
    Name:HOXB1
    Synonyms:GHOX-LAB
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Homeobox protein Hox-B1PRO_0000200109Add
    BLAST

    Proteomic databases

    PaxDbiP31259.
    PRIDEiP31259.

    Structurei

    3D structure databases

    ProteinModelPortaliP31259.
    SMRiP31259. Positions 186-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi188 – 1936Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family. Labial subfamily.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG321520.
    HOGENOMiHOG000247020.
    HOVERGENiHBG006089.
    InParanoidiP31259.
    PhylomeDBiP31259.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31259-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNTRMNSFL EYAICNRGTG AYHHLEQSSP SFPSCSGSPS SDTFHGEGAY    50
    GAGGSPVAAA HLPPQSPGFF PAPPGAPSLR GRCPERRVPN PKLQPRLRHH 100
    QLYLGQQDAD AVYFQAAGYS SSTGPHLGSL AEGYCGAVGQ YQQQQHLYGQ 150
    EQPSYLPGVY GNLSPSLNED KDPACPSEPC PNASRARTFD WMKVKRNPPK 200
    TAKVSEYGLL GQPNTIRTNF TTKQLTELEK EFHFNKYLTR ARRVEIAATL 250
    ELNETQVKIW FQNRRMKQKK REKEGLAPPA ASRSAKEASE ASDQSNCTSP 300
    EASPSSVSS 309
    Length:309
    Mass (Da):33,833
    Last modified:July 1, 1993 - v1
    Checksum:i7F229226B51D607D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68352, X68353 Genomic DNA. Translation: CAA48418.1.
    PIRiA60096.
    UniGeneiGga.533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68352 , X68353 Genomic DNA. Translation: CAA48418.1 .
    PIRi A60096.
    UniGenei Gga.533.

    3D structure databases

    ProteinModelPortali P31259.
    SMRi P31259. Positions 186-274.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P31259.
    PRIDEi P31259.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG321520.
    HOGENOMi HOG000247020.
    HOVERGENi HBG006089.
    InParanoidi P31259.
    PhylomeDBi P31259.

    Miscellaneous databases

    NextBioi 20815965.
    PROi P31259.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Region-specific expression in early chick and mouse embryos of Ghox-lab and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila labial."
      Sundin O.H., Busse H.G., Rogers M.B., Gudas L.J., Eichele G.
      Development 108:47-58(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHXB1_CHICK
    AccessioniPrimary (citable) accession number: P31259
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3