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P31259

- HXB1_CHICK

UniProt

P31259 - HXB1_CHICK

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Protein

Homeobox protein Hox-B1

Gene

HOXB1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi213 – 27260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B1
Alternative name(s):
Ghox-lab
Gene namesi
Name:HOXB1
Synonyms:GHOX-LAB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Homeobox protein Hox-B1PRO_0000200109Add
BLAST

Proteomic databases

PaxDbiP31259.
PRIDEiP31259.

Structurei

3D structure databases

ProteinModelPortaliP31259.
SMRiP31259. Positions 186-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi188 – 1936Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG321520.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiP31259.
PhylomeDBiP31259.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31259-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNTRMNSFL EYAICNRGTG AYHHLEQSSP SFPSCSGSPS SDTFHGEGAY
60 70 80 90 100
GAGGSPVAAA HLPPQSPGFF PAPPGAPSLR GRCPERRVPN PKLQPRLRHH
110 120 130 140 150
QLYLGQQDAD AVYFQAAGYS SSTGPHLGSL AEGYCGAVGQ YQQQQHLYGQ
160 170 180 190 200
EQPSYLPGVY GNLSPSLNED KDPACPSEPC PNASRARTFD WMKVKRNPPK
210 220 230 240 250
TAKVSEYGLL GQPNTIRTNF TTKQLTELEK EFHFNKYLTR ARRVEIAATL
260 270 280 290 300
ELNETQVKIW FQNRRMKQKK REKEGLAPPA ASRSAKEASE ASDQSNCTSP

EASPSSVSS
Length:309
Mass (Da):33,833
Last modified:July 1, 1993 - v1
Checksum:i7F229226B51D607D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68352, X68353 Genomic DNA. Translation: CAA48418.1.
PIRiA60096.
UniGeneiGga.533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68352 , X68353 Genomic DNA. Translation: CAA48418.1 .
PIRi A60096.
UniGenei Gga.533.

3D structure databases

ProteinModelPortali P31259.
SMRi P31259. Positions 186-274.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P31259.
PRIDEi P31259.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG321520.
HOGENOMi HOG000247020.
HOVERGENi HBG006089.
InParanoidi P31259.
PhylomeDBi P31259.

Miscellaneous databases

NextBioi 20815965.
PROi P31259.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Region-specific expression in early chick and mouse embryos of Ghox-lab and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila labial."
    Sundin O.H., Busse H.G., Rogers M.B., Gudas L.J., Eichele G.
    Development 108:47-58(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXB1_CHICK
AccessioniPrimary (citable) accession number: P31259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3