Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P31259 (HXB1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B1
Alternative name(s):
Ghox-lab
Gene names
Name:HOXB1
Synonyms:GHOX-LAB
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Labial subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Homeobox protein Hox-B1
PRO_0000200109

Regions

DNA binding213 – 27260Homeobox
Motif188 – 1936Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
P31259 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 7F229226B51D607D

FASTA30933,833
        10         20         30         40         50         60 
MDNTRMNSFL EYAICNRGTG AYHHLEQSSP SFPSCSGSPS SDTFHGEGAY GAGGSPVAAA 

        70         80         90        100        110        120 
HLPPQSPGFF PAPPGAPSLR GRCPERRVPN PKLQPRLRHH QLYLGQQDAD AVYFQAAGYS 

       130        140        150        160        170        180 
SSTGPHLGSL AEGYCGAVGQ YQQQQHLYGQ EQPSYLPGVY GNLSPSLNED KDPACPSEPC 

       190        200        210        220        230        240 
PNASRARTFD WMKVKRNPPK TAKVSEYGLL GQPNTIRTNF TTKQLTELEK EFHFNKYLTR 

       250        260        270        280        290        300 
ARRVEIAATL ELNETQVKIW FQNRRMKQKK REKEGLAPPA ASRSAKEASE ASDQSNCTSP 


EASPSSVSS 

« Hide

References

[1]"Region-specific expression in early chick and mouse embryos of Ghox-lab and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila labial."
Sundin O.H., Busse H.G., Rogers M.B., Gudas L.J., Eichele G.
Development 108:47-58(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68352, X68353 Genomic DNA. Translation: CAA48418.1.
PIRA60096.
UniGeneGga.533.

3D structure databases

ProteinModelPortalP31259.
SMRP31259. Positions 186-274.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP31259.
PRIDEP31259.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG321520.
HOGENOMHOG000247020.
HOVERGENHBG006089.
InParanoidP31259.
PhylomeDBP31259.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815965.
PROP31259.

Entry information

Entry nameHXB1_CHICK
AccessionPrimary (citable) accession number: P31259
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries