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Protein

Homeobox protein Hox-A11

Gene

HOXA11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi225 – 28460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A11
Alternative name(s):
Ghox-1I
Homeobox protein Hox-1.9
Short name:
Chox-1.9
Gene namesi
Name:HOXA11
Synonyms:GHOX1I
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Homeobox protein Hox-A11PRO_0000200097Add
BLAST

Proteomic databases

PaxDbiP31258.

Expressioni

Gene expression databases

ExpressionAtlasiP31258. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037025.

Structurei

3D structure databases

ProteinModelPortaliP31258.
SMRiP31258. Positions 222-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiP31258.
KOiK09296.
PhylomeDBiP31258.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDFDERVPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS
60 70 80 90 100
NLPQVQPVRE VTFREYAIDP SSKWHPRNNL PHCYSAEEIM HRDCLPSTTT
110 120 130 140 150
ASMGEVFGKS TANVYHHPSA NVSSNFYSTV GRNGVLPQAF DQFFETAYGT
160 170 180 190 200
AENPSSADYP PDKSGEKAPA AAGATAATSS SEGGCGGAAA AAGKERRRRP
210 220 230 240 250
ESGSSPESSS GNNEEKSGSS SGQRTRKKRC PYTKYQIREL EREFFFSVYI
260 270 280 290
NKEKRLQLSR MLNLTDRQVK IWFQNRRMKE KKINRDRLQY YSANPLL
Length:297
Mass (Da):33,273
Last modified:July 1, 1993 - v1
Checksum:i943B19F9CF3F7C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81250 mRNA. Translation: AAA48823.1.
RefSeqiNP_989950.1. NM_204619.1.
UniGeneiGga.957.

Genome annotation databases

EnsembliENSGALT00000018032; ENSGALP00000018010; ENSGALG00000023130.
ENSGALT00000037817; ENSGALP00000037023; ENSGALG00000023130.
ENSGALT00000037819; ENSGALP00000037025; ENSGALG00000023130.
ENSGALT00000045349; ENSGALP00000042845; ENSGALG00000023130.
GeneIDi395327.
KEGGigga:395327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81250 mRNA. Translation: AAA48823.1.
RefSeqiNP_989950.1. NM_204619.1.
UniGeneiGga.957.

3D structure databases

ProteinModelPortaliP31258.
SMRiP31258. Positions 222-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037025.

Proteomic databases

PaxDbiP31258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000018032; ENSGALP00000018010; ENSGALG00000023130.
ENSGALT00000037817; ENSGALP00000037023; ENSGALG00000023130.
ENSGALT00000037819; ENSGALP00000037025; ENSGALG00000023130.
ENSGALT00000045349; ENSGALP00000042845; ENSGALG00000023130.
GeneIDi395327.
KEGGigga:395327.

Organism-specific databases

CTDi3207.

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiP31258.
KOiK09296.
PhylomeDBiP31258.

Miscellaneous databases

NextBioi20815412.
PROiP31258.

Gene expression databases

ExpressionAtlasiP31258. baseline and differential.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The pattern of expression of the chicken homolog of HOX1I in the developing limb suggests a possible role in the ectodermal inhibition of chondrogenesis."
    Rogina B., Coelho C.N., Kosher R.A., Upholt W.B.
    Dev. Dyn. 193:92-101(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHXA11_CHICK
AccessioniPrimary (citable) accession number: P31258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.