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Protein

Homeobox protein Hox-A11

Gene

HOXA11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi225 – 284HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A11
Alternative name(s):
Ghox-1I
Homeobox protein Hox-1.9
Short name:
Chox-1.9
Gene namesi
Name:HOXA11
Synonyms:GHOX1I
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000971 – 297Homeobox protein Hox-A11Add BLAST297

Proteomic databases

PaxDbiP31258.

Expressioni

Gene expression databases

BgeeiENSGALG00000023130.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037025.

Structurei

3D structure databases

ProteinModelPortaliP31258.
SMRiP31258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00900000140792.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiP31258.
KOiK21951.
OrthoDBiEOG091G0DZB.
PhylomeDBiP31258.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR021918. DUF3528.
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P31258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDFDERVPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS
60 70 80 90 100
NLPQVQPVRE VTFREYAIDP SSKWHPRNNL PHCYSAEEIM HRDCLPSTTT
110 120 130 140 150
ASMGEVFGKS TANVYHHPSA NVSSNFYSTV GRNGVLPQAF DQFFETAYGT
160 170 180 190 200
AENPSSADYP PDKSGEKAPA AAGATAATSS SEGGCGGAAA AAGKERRRRP
210 220 230 240 250
ESGSSPESSS GNNEEKSGSS SGQRTRKKRC PYTKYQIREL EREFFFSVYI
260 270 280 290
NKEKRLQLSR MLNLTDRQVK IWFQNRRMKE KKINRDRLQY YSANPLL
Length:297
Mass (Da):33,273
Last modified:July 1, 1993 - v1
Checksum:i943B19F9CF3F7C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81250 mRNA. Translation: AAA48823.1.
RefSeqiNP_989950.1. NM_204619.1.
UniGeneiGga.957.

Genome annotation databases

EnsembliENSGALT00000078475; ENSGALP00000046000; ENSGALG00000040021.
GeneIDi395327.
KEGGigga:395327.

Similar proteinsi

Entry informationi

Entry nameiHXA11_CHICK
AccessioniPrimary (citable) accession number: P31258
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families