ID   HXC10_MOUSE             Reviewed;         342 AA.
AC   P31257; P31312; Q7TMT7;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   24-JAN-2024, entry version 176.
DE   RecName: Full=Homeobox protein Hox-C10;
DE   AltName: Full=Homeobox protein Hox-3.6;
GN   Name=Hoxc10; Synonyms=Hox-3.6, Hoxc-10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CD-1;
RX   PubMed=1353983; DOI=10.1016/0925-4773(92)90077-w;
RA   Peterson R.L., Jacobs D.F., Awgulewitsch A.;
RT   "Hox-3.6: isolation and characterization of a new murine homeobox gene
RT   located in the 5' region of the Hox-3 cluster.";
RL   Mech. Dev. 37:151-166(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C3H/He; TISSUE=Mesenchymal stem cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE OF 268-327.
RX   PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA   Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA   Potter S.S.;
RT   "Identification of 10 murine homeobox genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-313.
RX   PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA   Murtha M.T., Leckman J.F., Ruddle F.H.;
RT   "Detection of homeobox genes in development and evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X63507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC053405; AAH53405.1; -; mRNA.
DR   EMBL; M81658; AAA63310.1; -; Genomic_DNA.
DR   CCDS; CCDS57014.1; -.
DR   PIR; A56552; A56552.
DR   RefSeq; NP_034592.2; NM_010462.5.
DR   AlphaFoldDB; P31257; -.
DR   SMR; P31257; -.
DR   BioGRID; 229079; 1.
DR   STRING; 10090.ENSMUSP00000001699; -.
DR   PhosphoSitePlus; P31257; -.
DR   jPOST; P31257; -.
DR   MaxQB; P31257; -.
DR   PaxDb; 10090-ENSMUSP00000001699; -.
DR   ProteomicsDB; 266931; -.
DR   Antibodypedia; 15311; 512 antibodies from 34 providers.
DR   DNASU; 209448; -.
DR   Ensembl; ENSMUST00000001699.8; ENSMUSP00000001699.8; ENSMUSG00000022484.8.
DR   GeneID; 209448; -.
DR   KEGG; mmu:209448; -.
DR   UCSC; uc007xwz.2; mouse.
DR   AGR; MGI:96192; -.
DR   CTD; 3226; -.
DR   MGI; MGI:96192; Hoxc10.
DR   VEuPathDB; HostDB:ENSMUSG00000022484; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000160855; -.
DR   HOGENOM; CLU_057871_0_0_1; -.
DR   InParanoid; P31257; -.
DR   OMA; QGMYMQS; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P31257; -.
DR   TreeFam; TF317819; -.
DR   BioGRID-ORCS; 209448; 0 hits in 80 CRISPR screens.
DR   PRO; PR:P31257; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; P31257; Protein.
DR   Bgee; ENSMUSG00000022484; Expressed in embryonic post-anal tail and 100 other cell types or tissues.
DR   GO; GO:0016604; C:nuclear body; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR   GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR   GO; GO:0050905; P:neuromuscular process; IGI:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001501; P:skeletal system development; IGI:MGI.
DR   GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IGI:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; HOMEOBOX PROTEIN ABDOMINAL-B; 1.
DR   PANTHER; PTHR45874:SF2; HOMEOBOX PROTEIN HOX-C10; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P31257; MM.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation.
FT   CHAIN           1..342
FT                   /note="Homeobox protein Hox-C10"
FT                   /id="PRO_0000200191"
FT   DNA_BIND        268..327
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..255
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         8
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT   MOD_RES         189
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT   CROSSLNK        106
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT   CROSSLNK        195
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT   CROSSLNK        254
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NYD6"
FT   CONFLICT        182
FT                   /note="P -> S (in Ref. 2; AAH53405)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   342 AA;  38196 MW;  7BB2E117A768F52B CRC64;
     MTCPRNVTPN SYAEPLAAPG GGERYNRNAG MYMQSGSDFN CGVMRGCGLA PSLSKRDEGG
     SPNLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS YPPSVKEENV CCMYSAEKRA
     KSGPEAALYS HPLPESCLGE HEVPVPSYYR ASPSYSALDK TPHCAGANEF EAPFEQRASL
     NPRTEHLESP QLGGKVSFPE TPKSDSQTPS PNEIKTEQSL AGPKASPSES EKERAKTADS
     SPDTSDNEAK EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE
     ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT
//