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Protein

Homeobox protein Hox-C10

Gene

Hoxc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi268 – 32760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • neuromuscular process Source: MGI
  • proximal/distal pattern formation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • skeletal system development Source: MGI
  • spinal cord motor neuron cell fate specification Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C10
Alternative name(s):
Homeobox protein Hox-3.6
Gene namesi
Name:Hoxc10
Synonyms:Hox-3.6, Hoxc-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96192. Hoxc10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Homeobox protein Hox-C10PRO_0000200191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP31257.
PRIDEiP31257.

PTM databases

PhosphoSiteiP31257.

Expressioni

Gene expression databases

BgeeiP31257.
CleanExiMM_HOXC10.
ExpressionAtlasiP31257. baseline and differential.
GenevestigatoriP31257.

Structurei

3D structure databases

ProteinModelPortaliP31257.
SMRiP31257. Positions 269-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG269631.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiP31257.
KOiK17444.
OMAiCPRNVTP.
OrthoDBiEOG7VDXPP.
PhylomeDBiP31257.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCPRNVTPN SYAEPLAAPG GGERYNRNAG MYMQSGSDFN CGVMRGCGLA
60 70 80 90 100
PSLSKRDEGG SPNLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS
110 120 130 140 150
YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR
160 170 180 190 200
ASPSYSALDK TPHCAGANEF EAPFEQRASL NPRTEHLESP QLGGKVSFPE
210 220 230 240 250
TPKSDSQTPS PNEIKTEQSL AGPKASPSES EKERAKTADS SPDTSDNEAK
260 270 280 290 300
EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE
310 320 330 340
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT
Length:342
Mass (Da):38,196
Last modified:July 1, 1993 - v1
Checksum:i7BB2E117A768F52B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821P → S in AAH53405 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63507 Genomic DNA. No translation available.
BC053405 mRNA. Translation: AAH53405.1.
M81658 Genomic DNA. Translation: AAA63310.1.
CCDSiCCDS57014.1.
PIRiA56552.
RefSeqiNP_034592.2. NM_010462.5.
UniGeneiMm.31665.

Genome annotation databases

EnsembliENSMUST00000001699; ENSMUSP00000001699; ENSMUSG00000022484.
GeneIDi209448.
KEGGimmu:209448.
UCSCiuc007xwz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63507 Genomic DNA. No translation available.
BC053405 mRNA. Translation: AAH53405.1.
M81658 Genomic DNA. Translation: AAA63310.1.
CCDSiCCDS57014.1.
PIRiA56552.
RefSeqiNP_034592.2. NM_010462.5.
UniGeneiMm.31665.

3D structure databases

ProteinModelPortaliP31257.
SMRiP31257. Positions 269-327.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP31257.

Proteomic databases

MaxQBiP31257.
PRIDEiP31257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001699; ENSMUSP00000001699; ENSMUSG00000022484.
GeneIDi209448.
KEGGimmu:209448.
UCSCiuc007xwz.2. mouse.

Organism-specific databases

CTDi3226.
MGIiMGI:96192. Hoxc10.

Phylogenomic databases

eggNOGiNOG269631.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiP31257.
KOiK17444.
OMAiCPRNVTP.
OrthoDBiEOG7VDXPP.
PhylomeDBiP31257.
TreeFamiTF317819.

Miscellaneous databases

NextBioi372673.
PROiP31257.
SOURCEiSearch...

Gene expression databases

BgeeiP31257.
CleanExiMM_HOXC10.
ExpressionAtlasiP31257. baseline and differential.
GenevestigatoriP31257.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox-3 cluster."
    Peterson R.L., Jacobs D.F., Awgulewitsch A.
    Mech. Dev. 37:151-166(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CD-1.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Mesenchymal stem cell.
  3. Cited for: NUCLEOTIDE SEQUENCE OF 268-327.
  4. "Detection of homeobox genes in development and evolution."
    Murtha M.T., Leckman J.F., Ruddle F.H.
    Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-313.

Entry informationi

Entry nameiHXC10_MOUSE
AccessioniPrimary (citable) accession number: P31257
Secondary accession number(s): P31312, Q7TMT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 27, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.