Homeobox protein Hox-C10 - Mus musculus (Mouse)

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P31257 (HXC10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 110. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C10

Alternative name(s):
Homeobox protein Hox-3.6

Gene names

Name:	Hoxc10
Synonyms:	Hox-3.6, Hoxc-10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from genetic interaction PubMed 12869760. Source: MGI embryonic limb morphogenesis Inferred from genetic interaction PubMed 12869760. Source: MGI neuromuscular process Inferred from genetic interaction PubMed 18065432. Source: MGI proximal/distal pattern formation Inferred from genetic interaction PubMed 12869760. Source: MGI skeletal system development Inferred from genetic interaction PubMed 12869760. Source: MGI spinal cord motor neuron cell fate specification Inferred from genetic interaction PubMed 18065432. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cyclin-dependent protein kinase activating kinase holoenzyme complex Inferred from electronic annotation. Source: Compara
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 342

342

Homeobox protein Hox-C10

PRO_0000200191

Regions

DNA binding

268 – 327

Homeobox

Amino acid modifications

Modified residue

189

Phosphoserine By similarity

Experimental info

Sequence conflict

182

P → S in AAH53405. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P31257 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 7BB2E117A768F52B
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FASTA

342

38,196

        10         20         30         40         50         60 
MTCPRNVTPN SYAEPLAAPG GGERYNRNAG MYMQSGSDFN CGVMRGCGLA PSLSKRDEGG 

        70         80         90        100        110        120 
SPNLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS YPPSVKEENV CCMYSAEKRA 

       130        140        150        160        170        180 
KSGPEAALYS HPLPESCLGE HEVPVPSYYR ASPSYSALDK TPHCAGANEF EAPFEQRASL 

       190        200        210        220        230        240 
NPRTEHLESP QLGGKVSFPE TPKSDSQTPS PNEIKTEQSL AGPKASPSES EKERAKTADS 

       250        260        270        280        290        300 
SPDTSDNEAK EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 

       310        320        330        340 
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox-3 cluster." Peterson R.L., Jacobs D.F., Awgulewitsch A. Mech. Dev. 37:151-166(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CD-1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C3H/He. Tissue: Mesenchymal stem cell.
[3]	"Identification of 10 murine homeobox genes." Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G., Potter S.S. Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 268-327.
[4]	"Detection of homeobox genes in development and evolution." Murtha M.T., Leckman J.F., Ruddle F.H. Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-313.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63507 Genomic DNA. No translation available. BC053405 mRNA. Translation: AAH53405.1. M81658 Genomic DNA. Translation: AAA63310.1.
IPI	IPI00132257.
PIR	A56552.
RefSeq	NP_034592.2. NM_010462.5.
UniGene	Mm.31665.
3D structure databases
ProteinModelPortal	P31257.
SMR	P31257. Positions 269-327.
ModBase	Search...
PTM databases
PhosphoSite	P31257.
Proteomic databases
PRIDE	P31257.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000001699; ENSMUSP00000001699; ENSMUSG00000022484.
GeneID	209448.
KEGG	mmu:209448.
Organism-specific databases
CTD	3226.
MGI	MGI:96192. Hoxc10.
Phylogenomic databases
eggNOG	NOG269631.
GeneTree	ENSGT00700000104054.
HOGENOM	HOG000231182.
HOVERGEN	HBG052934.
InParanoid	P31257.
KO	K09295.
OMA	CGVMRGC.
OrthoDB	EOG4F7NK9.
Gene expression databases
ArrayExpress	P31257.
Bgee	P31257.
CleanEx	MM_HOXC10.
Genevestigator	P31257.
GermOnline	ENSMUSG00000022484. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	372673.
SOURCE	Search...

Entry information

Entry name

HXC10_MOUSE

Accession

Primary (citable) accession number: P31257
Secondary accession number(s): P31312, Q7TMT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents