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P31257 (HXC10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C10
Alternative name(s):
Homeobox protein Hox-3.6
Gene names
Name:Hoxc10
Synonyms:Hox-3.6, Hoxc-10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Homeobox protein Hox-C10
PRO_0000200191

Regions

DNA binding268 – 32760Homeobox

Amino acid modifications

Modified residue1891Phosphoserine By similarity

Experimental info

Sequence conflict1821P → S in AAH53405. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P31257 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 7BB2E117A768F52B

FASTA34238,196
        10         20         30         40         50         60 
MTCPRNVTPN SYAEPLAAPG GGERYNRNAG MYMQSGSDFN CGVMRGCGLA PSLSKRDEGG 

        70         80         90        100        110        120 
SPNLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS YPPSVKEENV CCMYSAEKRA 

       130        140        150        160        170        180 
KSGPEAALYS HPLPESCLGE HEVPVPSYYR ASPSYSALDK TPHCAGANEF EAPFEQRASL 

       190        200        210        220        230        240 
NPRTEHLESP QLGGKVSFPE TPKSDSQTPS PNEIKTEQSL AGPKASPSES EKERAKTADS 

       250        260        270        280        290        300 
SPDTSDNEAK EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 

       310        320        330        340 
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT 

« Hide

References

« Hide 'large scale' references
[1]"Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox-3 cluster."
Peterson R.L., Jacobs D.F., Awgulewitsch A.
Mech. Dev. 37:151-166(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CD-1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C3H/He.
Tissue: Mesenchymal stem cell.
[3]"Identification of 10 murine homeobox genes."
Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G., Potter S.S.
Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 268-327.
[4]"Detection of homeobox genes in development and evolution."
Murtha M.T., Leckman J.F., Ruddle F.H.
Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-313.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63507 Genomic DNA. No translation available.
BC053405 mRNA. Translation: AAH53405.1.
M81658 Genomic DNA. Translation: AAA63310.1.
CCDSCCDS57014.1.
PIRA56552.
RefSeqNP_034592.2. NM_010462.5.
UniGeneMm.31665.

3D structure databases

ProteinModelPortalP31257.
SMRP31257. Positions 269-327.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP31257.

Proteomic databases

PRIDEP31257.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001699; ENSMUSP00000001699; ENSMUSG00000022484.
GeneID209448.
KEGGmmu:209448.
UCSCuc007xwz.2. mouse.

Organism-specific databases

CTD3226.
MGIMGI:96192. Hoxc10.

Phylogenomic databases

eggNOGNOG269631.
GeneTreeENSGT00750000117229.
HOGENOMHOG000231182.
HOVERGENHBG052934.
InParanoidP31257.
KOK17444.
OMACPRNVTP.
OrthoDBEOG7VDXPP.
PhylomeDBP31257.
TreeFamTF317819.

Gene expression databases

BgeeP31257.
CleanExMM_HOXC10.
GenevestigatorP31257.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio372673.
PROP31257.
SOURCESearch...

Entry information

Entry nameHXC10_MOUSE
AccessionPrimary (citable) accession number: P31257
Secondary accession number(s): P31312, Q7TMT7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries