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P31257

- HXC10_MOUSE

UniProt

P31257 - HXC10_MOUSE

Protein

Homeobox protein Hox-C10

Gene

Hoxc10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi268 – 32760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. embryonic limb morphogenesis Source: MGI
    3. neuromuscular process Source: MGI
    4. proximal/distal pattern formation Source: MGI
    5. skeletal system development Source: MGI
    6. spinal cord motor neuron cell fate specification Source: MGI
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C10
    Alternative name(s):
    Homeobox protein Hox-3.6
    Gene namesi
    Name:Hoxc10
    Synonyms:Hox-3.6, Hoxc-10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96192. Hoxc10.

    Subcellular locationi

    GO - Cellular componenti

    1. cyclin-dependent protein kinase activating kinase holoenzyme complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Homeobox protein Hox-C10PRO_0000200191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei189 – 1891PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP31257.

    PTM databases

    PhosphoSiteiP31257.

    Expressioni

    Gene expression databases

    BgeeiP31257.
    CleanExiMM_HOXC10.
    GenevestigatoriP31257.

    Structurei

    3D structure databases

    ProteinModelPortaliP31257.
    SMRiP31257. Positions 269-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG269631.
    GeneTreeiENSGT00750000117229.
    HOGENOMiHOG000231182.
    HOVERGENiHBG052934.
    InParanoidiP31257.
    KOiK17444.
    OMAiCPRNVTP.
    OrthoDBiEOG7VDXPP.
    PhylomeDBiP31257.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31257-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTCPRNVTPN SYAEPLAAPG GGERYNRNAG MYMQSGSDFN CGVMRGCGLA    50
    PSLSKRDEGG SPNLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS 100
    YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR 150
    ASPSYSALDK TPHCAGANEF EAPFEQRASL NPRTEHLESP QLGGKVSFPE 200
    TPKSDSQTPS PNEIKTEQSL AGPKASPSES EKERAKTADS SPDTSDNEAK 250
    EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 300
    ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT 342
    Length:342
    Mass (Da):38,196
    Last modified:July 1, 1993 - v1
    Checksum:i7BB2E117A768F52B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti182 – 1821P → S in AAH53405. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63507 Genomic DNA. No translation available.
    BC053405 mRNA. Translation: AAH53405.1.
    M81658 Genomic DNA. Translation: AAA63310.1.
    CCDSiCCDS57014.1.
    PIRiA56552.
    RefSeqiNP_034592.2. NM_010462.5.
    UniGeneiMm.31665.

    Genome annotation databases

    EnsembliENSMUST00000001699; ENSMUSP00000001699; ENSMUSG00000022484.
    GeneIDi209448.
    KEGGimmu:209448.
    UCSCiuc007xwz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63507 Genomic DNA. No translation available.
    BC053405 mRNA. Translation: AAH53405.1 .
    M81658 Genomic DNA. Translation: AAA63310.1 .
    CCDSi CCDS57014.1.
    PIRi A56552.
    RefSeqi NP_034592.2. NM_010462.5.
    UniGenei Mm.31665.

    3D structure databases

    ProteinModelPortali P31257.
    SMRi P31257. Positions 269-327.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P31257.

    Proteomic databases

    PRIDEi P31257.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001699 ; ENSMUSP00000001699 ; ENSMUSG00000022484 .
    GeneIDi 209448.
    KEGGi mmu:209448.
    UCSCi uc007xwz.2. mouse.

    Organism-specific databases

    CTDi 3226.
    MGIi MGI:96192. Hoxc10.

    Phylogenomic databases

    eggNOGi NOG269631.
    GeneTreei ENSGT00750000117229.
    HOGENOMi HOG000231182.
    HOVERGENi HBG052934.
    InParanoidi P31257.
    KOi K17444.
    OMAi CPRNVTP.
    OrthoDBi EOG7VDXPP.
    PhylomeDBi P31257.
    TreeFami TF317819.

    Miscellaneous databases

    NextBioi 372673.
    PROi P31257.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31257.
    CleanExi MM_HOXC10.
    Genevestigatori P31257.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hox-3.6: isolation and characterization of a new murine homeobox gene located in the 5' region of the Hox-3 cluster."
      Peterson R.L., Jacobs D.F., Awgulewitsch A.
      Mech. Dev. 37:151-166(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CD-1.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/He.
      Tissue: Mesenchymal stem cell.
    3. Cited for: NUCLEOTIDE SEQUENCE OF 268-327.
    4. "Detection of homeobox genes in development and evolution."
      Murtha M.T., Leckman J.F., Ruddle F.H.
      Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 289-313.

    Entry informationi

    Entry nameiHXC10_MOUSE
    AccessioniPrimary (citable) accession number: P31257
    Secondary accession number(s): P31312, Q7TMT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3