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Protein

Homeobox protein Hox-A2

Gene

Hoxa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi139 – 198HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: RGD
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Alternative name(s):
Homeobox protein Hox-1.11
Gene namesi
Name:Hoxa2
Synonyms:Hox-1.11, Hoxa-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi11468112 Hoxa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000381 – 372Homeobox protein Hox-A2Add BLAST372

Proteomic databases

PaxDbiP31246

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064446

Structurei

3D structure databases

ProteinModelPortaliP31246
SMRiP31246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 101Antp-type hexapeptide6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
HOGENOMiHOG000063664
HOVERGENiHBG006088
InParanoidiP31246
KOiK09302
PhylomeDBiP31246

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PGSHPRQSAG AGGRPKSSPA GSRGSPVPAR ALQPPEYPWM
110 120 130 140 150
KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ
160 170 180 190 200
LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC
210 220 230 240 250
KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN
260 270 280 290 300
ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN
310 320 330 340 350
CGAGLNNDSP EALEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLGSPVDI
360 370
SADSFDFFTD TLTTIDLQHL NY
Length:372
Mass (Da):40,827
Last modified:July 1, 1993 - v1
Checksum:iFDBBD71D55A9F19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91802 mRNA Translation: AAA67846.1
PIRiI52196
RefSeqiNP_036713.2, NM_012581.2
UniGeneiRn.91077

Genome annotation databases

GeneIDi103690123
KEGGirno:103690123
UCSCiRGD:2813 rat

Similar proteinsi

Entry informationi

Entry nameiHXA2_RAT
AccessioniPrimary (citable) accession number: P31246
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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