Reviewed,
UniProtKB/Swiss-Prot P31246 (HXA2_RAT)
Last modified
October 13, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homeobox protein Hox-A2 Alternative name(s): Hox-1.11 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 372 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Subcellular location | |
| Sequence similarities | Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Homeobox |
| Ligand | DNA-binding |
| Molecular function | Developmental protein |
| Gene Ontology (GO) | |
| Biological process | transcription Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | transcription factor activity Ref.1 Traceable author statement. Source: RGD |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Molecular cloning of a homeobox transcription factor from adult aortic smooth muscle." Patel C.V., Gorski D.H., Lepage D.F., Lincecum J., Walsh K. J. Biol. Chem. 267:26085-26090(1992) [PubMed: 1361191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aorta. |
| [2] | "Cloning and sequence analysis of homeobox transcription factor cDNAs with an inosine-containing probe." Gorski D.H., LePage D.F., Walsh K. BioTechniques 16:856-858(1994) [PubMed: 7915120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| M91802 mRNA. Translation: AAA67846.1. | |
| IPI | IPI00210902. |
| PIR | I52196. |
| RefSeq | NP_036713.2. |
| UniGene | Rn.91077 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B72 based on UniProtKB P14653. |
| SMR | P31246. Positions 141-197. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P31246. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000008023; ENSRNOP00000008023; ENSRNOG00000005968; Rattus norvegicus. [Genome view] |
| GeneID | 24452. |
| KEGG | rno:24452. |
| UCSC | NM_012581. rat. |
Organism-specific databases | |
| CTD | 24452. |
| RGD | 2813. Hoxa2. |
Phylogenomic databases | |
| HOVERGEN | P31246. |
Gene expression databases | |
| ArrayExpress | P31246. |
| Genevestigator | P31246. |
| GermOnline | ENSRNOG00000005968. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR012287. Homeodomain-rel. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| PRINTS | PR00024. HOMEOBOX. |
| ProDom | PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| PROSITE | PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 603363. |
Entry information
| Entry name | HXA2_RAT | ||||||||
| Accession | Primary (citable) accession number: P31246 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Vertebrate homeotic Hox proteins Nomenclature of vertebrate homeotic Hox proteins and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


