P31246 (HXA2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A2

Alternative name(s):
Homeobox protein Hox-1.11

Gene names

Name:	Hoxa2
Synonyms:	Hox-1.11, Hoxa-2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Homeobox protein Hox-A2		PRO_0000200038
Regions
	DNA binding	139 – 198	60	Homeobox
	Motif	96 – 101	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	P31246 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: FDBBD71D55A9F19A	FASTA	372	40,827
	10 20 30 40 50 60 MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGSHPRQSAG AGGRPKSSPA GSRGSPVPAR ALQPPEYPWM KEKKAAKKTA LPPAAASTGP 130 140 150 160 170 180 ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE 190 200 210 220 230 240 RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL 250 260 270 280 290 300 EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 310 320 330 340 350 360 CGAGLNNDSP EALEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLGSPVDI SADSFDFFTD 370 TLTTIDLQHL NY

References

[1]	"Molecular cloning of a homeobox transcription factor from adult aortic smooth muscle." Patel C.V., Gorski D.H., Lepage D.F., Lincecum J., Walsh K. J. Biol. Chem. 267:26085-26090(1992) [PubMed: 1361191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aorta.
[2]	"Cloning and sequence analysis of homeobox transcription factor cDNAs with an inosine-containing probe." Gorski D.H., LePage D.F., Walsh K. BioTechniques 16:856-858(1994) [PubMed: 7915120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M91802 mRNA. Translation: AAA67846.1.
IPI	IPI00210902.
PIR	I52196.
RefSeq	NP_036713.2. NM_012581.2.
UniGene	Rn.91077.
3D structure databases
ProteinModelPortal	P31246.
SMR	P31246. Positions 139-197.
ModBase	Search...
Protein-protein interaction databases
STRING	P31246.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	24452.
KEGG	rno:24452.
UCSC	NM_012581. rat.
Organism-specific databases
CTD	3199.
RGD	2813. Hoxa2.
Phylogenomic databases
eggNOG	roNOG12005.
GeneTree	ENSGT00600000084339.
HOVERGEN	HBG006088.
InParanoid	P31246.
OrthoDB	EOG43TZVT.
Gene expression databases
ArrayExpress	P31246.
Genevestigator	P31246.
GermOnline	ENSRNOG00000005968. Rattus norvegicus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09302.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	603363.

Entry information

Entry name

HXA2_RAT

Accession

Primary (citable) accession number: P31246

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	December 14, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program