Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-A2

Gene

Hoxa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 19860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Alternative name(s):
Homeobox protein Hox-1.11
Gene namesi
Name:Hoxa2
Synonyms:Hox-1.11, Hoxa-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2813. Hoxa2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Homeobox protein Hox-A2PRO_0000200038Add
BLAST

Proteomic databases

PaxDbiP31246.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064446.

Structurei

3D structure databases

ProteinModelPortaliP31246.
SMRiP31246. Positions 139-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi96 – 1016Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP31246.
KOiK09302.
PhylomeDBiP31246.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PGSHPRQSAG AGGRPKSSPA GSRGSPVPAR ALQPPEYPWM
110 120 130 140 150
KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ
160 170 180 190 200
LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC
210 220 230 240 250
KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN
260 270 280 290 300
ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN
310 320 330 340 350
CGAGLNNDSP EALEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLGSPVDI
360 370
SADSFDFFTD TLTTIDLQHL NY
Length:372
Mass (Da):40,827
Last modified:July 1, 1993 - v1
Checksum:iFDBBD71D55A9F19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91802 mRNA. Translation: AAA67846.1.
PIRiI52196.
RefSeqiNP_036713.2. NM_012581.2.
UniGeneiRn.91077.

Genome annotation databases

GeneIDi103690123.
KEGGirno:103690123.
UCSCiRGD:2813. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91802 mRNA. Translation: AAA67846.1.
PIRiI52196.
RefSeqiNP_036713.2. NM_012581.2.
UniGeneiRn.91077.

3D structure databases

ProteinModelPortaliP31246.
SMRiP31246. Positions 139-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064446.

Proteomic databases

PaxDbiP31246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103690123.
KEGGirno:103690123.
UCSCiRGD:2813. rat.

Organism-specific databases

CTDi3199.
RGDi2813. Hoxa2.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP31246.
KOiK09302.
PhylomeDBiP31246.

Miscellaneous databases

NextBioi603363.
PROiP31246.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a homeobox transcription factor from adult aortic smooth muscle."
    Patel C.V., Gorski D.H., Lepage D.F., Lincecum J., Walsh K.
    J. Biol. Chem. 267:26085-26090(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aorta.
  2. "Cloning and sequence analysis of homeobox transcription factor cDNAs with an inosine-containing probe."
    Gorski D.H., LePage D.F., Walsh K.
    BioTechniques 16:856-858(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHXA2_RAT
AccessioniPrimary (citable) accession number: P31246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.