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Protein

Homeobox protein Hox-A2

Gene

Hoxa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi139 – 198HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Alternative name(s):
Homeobox protein Hox-1.11
Gene namesi
Name:Hoxa2
Synonyms:Hox-1.11, Hoxa-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi11468112. Hoxa2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000381 – 372Homeobox protein Hox-A2Add BLAST372

Proteomic databases

PaxDbiP31246.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064446.

Structurei

3D structure databases

ProteinModelPortaliP31246.
SMRiP31246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 101Antp-type hexapeptide6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP31246.
KOiK09302.
PhylomeDBiP31246.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P31246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PGSHPRQSAG AGGRPKSSPA GSRGSPVPAR ALQPPEYPWM
110 120 130 140 150
KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ
160 170 180 190 200
LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC
210 220 230 240 250
KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN
260 270 280 290 300
ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN
310 320 330 340 350
CGAGLNNDSP EALEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLGSPVDI
360 370
SADSFDFFTD TLTTIDLQHL NY
Length:372
Mass (Da):40,827
Last modified:July 1, 1993 - v1
Checksum:iFDBBD71D55A9F19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91802 mRNA. Translation: AAA67846.1.
PIRiI52196.
RefSeqiNP_036713.2. NM_012581.2.
UniGeneiRn.91077.

Genome annotation databases

GeneIDi103690123.
KEGGirno:103690123.
UCSCiRGD:2813. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHXA2_RAT
AccessioniPrimary (citable) accession number: P31246
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 7, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families