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Protein

Homeobox protein Hox-A2

Gene

Hoxa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 19860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. brain segmentation Source: MGI
  3. cell fate commitment Source: MGI
  4. cell fate determination Source: MGI
  5. cellular response to retinoic acid Source: MGI
  6. dorsal/ventral pattern formation Source: MGI
  7. embryonic skeletal system morphogenesis Source: MGI
  8. embryonic viscerocranium morphogenesis Source: MGI
  9. middle ear morphogenesis Source: MGI
  10. motor neuron axon guidance Source: MGI
  11. negative regulation of neuron differentiation Source: MGI
  12. negative regulation of osteoblast differentiation Source: MGI
  13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  14. osteoblast development Source: MGI
  15. pattern specification process Source: MGI
  16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  17. rhombomere 2 development Source: MGI
  18. rhombomere 3 development Source: MGI
  19. rhombomere 3 morphogenesis Source: MGI
  20. segment specification Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Alternative name(s):
Homeobox protein Hox-1.11
Short name:
Hox1.11
Gene namesi
Name:Hoxa2
Synonyms:Hox-1.11, Hoxa-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96174. Hoxa2.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Homeobox protein Hox-A2PRO_0000200037Add
BLAST

Proteomic databases

PRIDEiP31245.

PTM databases

PhosphoSiteiP31245.

Expressioni

Gene expression databases

BgeeiP31245.
CleanExiMM_HOXA2.
ExpressionAtlasiP31245. baseline and differential.
GenevestigatoriP31245.

Interactioni

Protein-protein interaction databases

BioGridi200367. 13 interactions.
IntActiP31245. 1 interaction.
STRINGi10090.ENSMUSP00000014848.

Structurei

3D structure databases

ProteinModelPortaliP31245.
SMRiP31245. Positions 141-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi96 – 1016Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG321520.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP31245.
KOiK09302.
OMAiNCGSGLN.
OrthoDBiEOG73RBBF.
PhylomeDBiP31245.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM
110 120 130 140 150
KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ
160 170 180 190 200
LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC
210 220 230 240 250
KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN
260 270 280 290 300
ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN
310 320 330 340 350
CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI
360 370
SADSFDFFTD TLTTIDLQHL NY
Length:372
Mass (Da):40,793
Last modified:July 1, 1993 - v1
Checksum:i0ADA79113DB72726
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95599 mRNA. Translation: AAA37827.1.
M93148 Genomic DNA. Translation: AAA37835.1.
M93292 mRNA. Translation: AAA37836.1.
BC117105 mRNA. Translation: AAI17106.1.
BC117107 mRNA. Translation: AAI17108.1.
M87801 Genomic DNA. Translation: AAA37834.1.
AB039191 Genomic DNA. Translation: BAB68715.1.
CCDSiCCDS20139.1.
PIRiA42694.
A46037.
RefSeqiNP_034581.1. NM_010451.2.
UniGeneiMm.131.

Genome annotation databases

EnsembliENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704.
GeneIDi15399.
KEGGimmu:15399.
UCSCiuc009bxz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95599 mRNA. Translation: AAA37827.1.
M93148 Genomic DNA. Translation: AAA37835.1.
M93292 mRNA. Translation: AAA37836.1.
BC117105 mRNA. Translation: AAI17106.1.
BC117107 mRNA. Translation: AAI17108.1.
M87801 Genomic DNA. Translation: AAA37834.1.
AB039191 Genomic DNA. Translation: BAB68715.1.
CCDSiCCDS20139.1.
PIRiA42694.
A46037.
RefSeqiNP_034581.1. NM_010451.2.
UniGeneiMm.131.

3D structure databases

ProteinModelPortaliP31245.
SMRiP31245. Positions 141-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200367. 13 interactions.
IntActiP31245. 1 interaction.
STRINGi10090.ENSMUSP00000014848.

PTM databases

PhosphoSiteiP31245.

Proteomic databases

PRIDEiP31245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704.
GeneIDi15399.
KEGGimmu:15399.
UCSCiuc009bxz.1. mouse.

Organism-specific databases

CTDi3199.
MGIiMGI:96174. Hoxa2.

Phylogenomic databases

eggNOGiNOG321520.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP31245.
KOiK09302.
OMAiNCGSGLN.
OrthoDBiEOG73RBBF.
PhylomeDBiP31245.
TreeFamiTF317730.

Miscellaneous databases

NextBioi288090.
PROiP31245.
SOURCEiSearch...

Gene expression databases

BgeeiP31245.
CleanExiMM_HOXA2.
ExpressionAtlasiP31245. baseline and differential.
GenevestigatoriP31245.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse Hox 1-11."
    Gridley T.
    Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: ICR X Swiss Webster.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231.
    Strain: ICR X Swiss Webster.
  5. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
    Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372.
    Strain: HMI/Msf.

Entry informationi

Entry nameiHXA2_MOUSE
AccessioniPrimary (citable) accession number: P31245
Secondary accession number(s): Q149U3, Q920T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.