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P31245

- HXA2_MOUSE

UniProt

P31245 - HXA2_MOUSE

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Protein

Homeobox protein Hox-A2

Gene

Hoxa2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 19860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. brain segmentation Source: MGI
  3. cell fate commitment Source: MGI
  4. cell fate determination Source: MGI
  5. cellular response to retinoic acid Source: MGI
  6. dorsal/ventral pattern formation Source: MGI
  7. embryonic skeletal system morphogenesis Source: MGI
  8. embryonic viscerocranium morphogenesis Source: MGI
  9. middle ear morphogenesis Source: MGI
  10. motor neuron axon guidance Source: MGI
  11. negative regulation of neuron differentiation Source: MGI
  12. negative regulation of osteoblast differentiation Source: MGI
  13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  14. osteoblast development Source: MGI
  15. pattern specification process Source: MGI
  16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  17. rhombomere 2 development Source: MGI
  18. rhombomere 3 development Source: MGI
  19. rhombomere 3 morphogenesis Source: MGI
  20. segment specification Source: MGI
  21. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A2
Alternative name(s):
Homeobox protein Hox-1.11
Short name:
Hox1.11
Gene namesi
Name:Hoxa2
Synonyms:Hox-1.11, Hoxa-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96174. Hoxa2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Homeobox protein Hox-A2PRO_0000200037Add
BLAST

Proteomic databases

PRIDEiP31245.

PTM databases

PhosphoSiteiP31245.

Expressioni

Gene expression databases

BgeeiP31245.
CleanExiMM_HOXA2.
ExpressionAtlasiP31245. baseline and differential.
GenevestigatoriP31245.

Interactioni

Protein-protein interaction databases

BioGridi200367. 13 interactions.
IntActiP31245. 1 interaction.
STRINGi10090.ENSMUSP00000014848.

Structurei

3D structure databases

ProteinModelPortaliP31245.
SMRiP31245. Positions 141-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi96 – 1016Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG321520.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP31245.
KOiK09302.
OMAiNCGSGLN.
OrthoDBiEOG73RBBF.
PhylomeDBiP31245.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31245-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
60 70 80 90 100
PFEQTIPSLN PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM
110 120 130 140 150
KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ
160 170 180 190 200
LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC
210 220 230 240 250
KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN
260 270 280 290 300
ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN
310 320 330 340 350
CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI
360 370
SADSFDFFTD TLTTIDLQHL NY
Length:372
Mass (Da):40,793
Last modified:July 1, 1993 - v1
Checksum:i0ADA79113DB72726
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95599 mRNA. Translation: AAA37827.1.
M93148 Genomic DNA. Translation: AAA37835.1.
M93292 mRNA. Translation: AAA37836.1.
BC117105 mRNA. Translation: AAI17106.1.
BC117107 mRNA. Translation: AAI17108.1.
M87801 Genomic DNA. Translation: AAA37834.1.
AB039191 Genomic DNA. Translation: BAB68715.1.
CCDSiCCDS20139.1.
PIRiA42694.
A46037.
RefSeqiNP_034581.1. NM_010451.2.
UniGeneiMm.131.

Genome annotation databases

EnsembliENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704.
GeneIDi15399.
KEGGimmu:15399.
UCSCiuc009bxz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95599 mRNA. Translation: AAA37827.1 .
M93148 Genomic DNA. Translation: AAA37835.1 .
M93292 mRNA. Translation: AAA37836.1 .
BC117105 mRNA. Translation: AAI17106.1 .
BC117107 mRNA. Translation: AAI17108.1 .
M87801 Genomic DNA. Translation: AAA37834.1 .
AB039191 Genomic DNA. Translation: BAB68715.1 .
CCDSi CCDS20139.1.
PIRi A42694.
A46037.
RefSeqi NP_034581.1. NM_010451.2.
UniGenei Mm.131.

3D structure databases

ProteinModelPortali P31245.
SMRi P31245. Positions 141-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200367. 13 interactions.
IntActi P31245. 1 interaction.
STRINGi 10090.ENSMUSP00000014848.

PTM databases

PhosphoSitei P31245.

Proteomic databases

PRIDEi P31245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014848 ; ENSMUSP00000014848 ; ENSMUSG00000014704 .
GeneIDi 15399.
KEGGi mmu:15399.
UCSCi uc009bxz.1. mouse.

Organism-specific databases

CTDi 3199.
MGIi MGI:96174. Hoxa2.

Phylogenomic databases

eggNOGi NOG321520.
GeneTreei ENSGT00760000118940.
HOGENOMi HOG000063664.
HOVERGENi HBG006088.
InParanoidi P31245.
KOi K09302.
OMAi NCGSGLN.
OrthoDBi EOG73RBBF.
PhylomeDBi P31245.
TreeFami TF317730.

Miscellaneous databases

NextBioi 288090.
PROi P31245.
SOURCEi Search...

Gene expression databases

Bgeei P31245.
CleanExi MM_HOXA2.
ExpressionAtlasi P31245. baseline and differential.
Genevestigatori P31245.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse Hox 1-11."
    Gridley T.
    Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: ICR X Swiss Webster.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231.
    Strain: ICR X Swiss Webster.
  5. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
    Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372.
    Strain: HMI/Msf.

Entry informationi

Entry nameiHXA2_MOUSE
AccessioniPrimary (citable) accession number: P31245
Secondary accession number(s): Q149U3, Q920T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3