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P31245

- HXA2_MOUSE

UniProt

P31245 - HXA2_MOUSE

Protein

Homeobox protein Hox-A2

Gene

Hoxa2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi139 – 19860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. brain segmentation Source: MGI
    3. cell fate commitment Source: MGI
    4. cell fate determination Source: MGI
    5. dorsal/ventral pattern formation Source: MGI
    6. embryonic skeletal system morphogenesis Source: MGI
    7. embryonic viscerocranium morphogenesis Source: MGI
    8. middle ear morphogenesis Source: MGI
    9. motor neuron axon guidance Source: MGI
    10. negative regulation of neuron differentiation Source: MGI
    11. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    12. osteoblast development Source: MGI
    13. pattern specification process Source: MGI
    14. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    15. rhombomere 2 development Source: MGI
    16. rhombomere 3 development Source: MGI
    17. rhombomere 3 morphogenesis Source: MGI
    18. segment specification Source: MGI
    19. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A2
    Alternative name(s):
    Homeobox protein Hox-1.11
    Short name:
    Hox1.11
    Gene namesi
    Name:Hoxa2
    Synonyms:Hox-1.11, Hoxa-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96174. Hoxa2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Homeobox protein Hox-A2PRO_0000200037Add
    BLAST

    Proteomic databases

    PRIDEiP31245.

    PTM databases

    PhosphoSiteiP31245.

    Expressioni

    Gene expression databases

    BgeeiP31245.
    CleanExiMM_HOXA2.
    GenevestigatoriP31245.

    Interactioni

    Protein-protein interaction databases

    BioGridi200367. 13 interactions.
    IntActiP31245. 1 interaction.
    STRINGi10090.ENSMUSP00000014848.

    Structurei

    3D structure databases

    ProteinModelPortaliP31245.
    SMRiP31245. Positions 141-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi96 – 1016Antp-type hexapeptide

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG321520.
    GeneTreeiENSGT00750000117389.
    HOGENOMiHOG000063664.
    HOVERGENiHBG006088.
    InParanoidiP31245.
    KOiK09302.
    OMAiNCGSGLN.
    OrthoDBiEOG73RBBF.
    PhylomeDBiP31245.
    TreeFamiTF317730.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31245-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP    50
    PFEQTIPSLN PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM 100
    KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ 150
    LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC 200
    KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN 250
    ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 300
    CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI 350
    SADSFDFFTD TLTTIDLQHL NY 372
    Length:372
    Mass (Da):40,793
    Last modified:July 1, 1993 - v1
    Checksum:i0ADA79113DB72726
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95599 mRNA. Translation: AAA37827.1.
    M93148 Genomic DNA. Translation: AAA37835.1.
    M93292 mRNA. Translation: AAA37836.1.
    BC117105 mRNA. Translation: AAI17106.1.
    BC117107 mRNA. Translation: AAI17108.1.
    M87801 Genomic DNA. Translation: AAA37834.1.
    AB039191 Genomic DNA. Translation: BAB68715.1.
    CCDSiCCDS20139.1.
    PIRiA42694.
    A46037.
    RefSeqiNP_034581.1. NM_010451.2.
    UniGeneiMm.131.

    Genome annotation databases

    EnsembliENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704.
    GeneIDi15399.
    KEGGimmu:15399.
    UCSCiuc009bxz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95599 mRNA. Translation: AAA37827.1 .
    M93148 Genomic DNA. Translation: AAA37835.1 .
    M93292 mRNA. Translation: AAA37836.1 .
    BC117105 mRNA. Translation: AAI17106.1 .
    BC117107 mRNA. Translation: AAI17108.1 .
    M87801 Genomic DNA. Translation: AAA37834.1 .
    AB039191 Genomic DNA. Translation: BAB68715.1 .
    CCDSi CCDS20139.1.
    PIRi A42694.
    A46037.
    RefSeqi NP_034581.1. NM_010451.2.
    UniGenei Mm.131.

    3D structure databases

    ProteinModelPortali P31245.
    SMRi P31245. Positions 141-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200367. 13 interactions.
    IntActi P31245. 1 interaction.
    STRINGi 10090.ENSMUSP00000014848.

    PTM databases

    PhosphoSitei P31245.

    Proteomic databases

    PRIDEi P31245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014848 ; ENSMUSP00000014848 ; ENSMUSG00000014704 .
    GeneIDi 15399.
    KEGGi mmu:15399.
    UCSCi uc009bxz.1. mouse.

    Organism-specific databases

    CTDi 3199.
    MGIi MGI:96174. Hoxa2.

    Phylogenomic databases

    eggNOGi NOG321520.
    GeneTreei ENSGT00750000117389.
    HOGENOMi HOG000063664.
    HOVERGENi HBG006088.
    InParanoidi P31245.
    KOi K09302.
    OMAi NCGSGLN.
    OrthoDBi EOG73RBBF.
    PhylomeDBi P31245.
    TreeFami TF317730.

    Miscellaneous databases

    NextBioi 288090.
    PROi P31245.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31245.
    CleanExi MM_HOXA2.
    Genevestigatori P31245.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse Hox 1-11."
      Gridley T.
      Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: ICR X Swiss Webster.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231.
      Strain: ICR X Swiss Webster.
    5. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
      Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372.
      Strain: HMI/Msf.

    Entry informationi

    Entry nameiHXA2_MOUSE
    AccessioniPrimary (citable) accession number: P31245
    Secondary accession number(s): Q149U3, Q920T8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3