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Reviewed, UniProtKB/Swiss-Prot P31245 (HXA2_MOUSE)

Last modified November 24, 2009. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Homeobox protein Hox-A2
Alternative name(s):
    Hox-1.11
      Short name=Hox1.11
Gene names
Name: Hoxa2
Synonyms: Hox-1.11, Hoxa-2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Proboscipedia subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological processanterior/posterior pattern formation

Inferred from mutant phenotype. Source: MGI

brain segmentation

Inferred from mutant phenotype. Source: MGI

cell fate determination

Inferred from mutant phenotype. Source: MGI

dorsal/ventral pattern formation

Inferred from genetic interaction. Source: MGI

embryonic viscerocranium morphogenesis

Inferred from mutant phenotype. Source: MGI

middle ear morphogenesis

Inferred from mutant phenotype. Source: MGI

motor axon guidance

Inferred from mutant phenotype. Source: MGI

negative regulation of neuron differentiation

Inferred from genetic interaction. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: MGI

osteoblast development

Inferred from genetic interaction. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: MGI

rhombomere 2 development

Inferred from mutant phenotype. Source: MGI

rhombomere 3 morphogenesis

Inferred from mutant phenotype. Source: MGI

segment specification

Inferred from mutant phenotype. Source: MGI

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from direct assay. Source: MGI

   Molecular functionsequence-specific DNA binding

Inferred from direct assay. Source: MGI

transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Homeobox protein Hox-A2
PRO_0000200037

Regions

DNA binding139 – 19860Homeobox
Motif96 – 1016Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
P31245-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 0ADA79113DB72726

FASTA37240,793
        10         20         30         40         50         60 
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 

        70         80         90        100        110        120 
PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM KEKKAAKKTA LPPAAASTGP 

       130        140        150        160        170        180 
ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE 

       190        200        210        220        230        240 
RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL 

       250        260        270        280        290        300 
EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 

       310        320        330        340        350        360 
CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI SADSFDFFTD 

       370 
TLTTIDLQHL NY 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of mouse Hox 1-11."
Gridley T.
Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Murine Hox-1.11 homeobox gene structure and expression."
Tan D.P., Ferrante J., Nazarali A., Shao X., Kozak C.A., Guo V., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 89:6280-6284(1992) [PubMed: 1352886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: ICR X Swiss Webster.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[4]"Hox-1.11 and Hox-4.9 homeobox genes."
Nazarali A., Kim Y., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992) [PubMed: 1348361] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231.
Strain: ICR X Swiss Webster.
[5]"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372.
Strain: HMI/Msf.
+Additional computationally mapped references.

Cross-references

Sequence databases

M95599 mRNA. Translation: AAA37827.1.
M93148 Genomic DNA. Translation: AAA37835.1.
M93292 mRNA. Translation: AAA37836.1.
BC117105 mRNA. Translation: AAI17106.1.
BC117107 mRNA. Translation: AAI17108.1.
M87801 Genomic DNA. Translation: AAA37834.1.
AB039191 Genomic DNA. Translation: BAB68715.1.
IPIIPI00132242.
PIRA42694.
A46037.
RefSeqNP_034581.1.
UniGeneMm.131

3D structure databases

SMRP31245. Positions 141-197.
ModBaseSearch...

Protein-protein interaction databases

IntActP31245. 2 interactions.
STRINGP31245.

Proteomic databases

PRIDEP31245.

Genome annotation databases

EnsemblENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704; Mus musculus. [Genome view]
GeneID15399.
KEGGmmu:15399.
UCSCuc009bxz.1. mouse.

Organism-specific databases

CTD15399.
MGIMGI:96174. Hoxa2.

Phylogenomic databases

HOGENOMP31245.
HOVERGENP31245.
OMANCGSGLN
OrthoDBEOG9KWNC3

Gene expression databases

ArrayExpressP31245.
BgeeP31245.
CleanExMM_HOXA2.
GenevestigatorP31245.
GermOnlineENSMUSG00000014704. Mus musculus.

Family and domain databases

InterProIPR001356. Homeobox.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_region.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio288090.
SOURCESearch...

Entry information

Entry nameHXA2_MOUSE
AccessionPrimary (citable) accession number: P31245
Secondary accession number(s): Q149U3, Q920T8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 24, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents