Reviewed, UniProtKB/Swiss-Prot P31245 (HXA2_MOUSE)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A2
Alternative name(s):
    Hox-1.11
      Short name=Hox1.11

Gene names

Name:	Hoxa2
Synonyms:	Hox-1.11, Hoxa-2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	anterior/posterior pattern formation Inferred from mutant phenotype. Source: MGI brain segmentation Inferred from mutant phenotype. Source: MGI cell fate determination Inferred from mutant phenotype. Source: MGI dorsal/ventral pattern formation Inferred from genetic interaction. Source: MGI embryonic viscerocranium morphogenesis Inferred from mutant phenotype. Source: MGI middle ear morphogenesis Inferred from mutant phenotype. Source: MGI motor axon guidance Inferred from mutant phenotype. Source: MGI negative regulation of neuron differentiation Inferred from genetic interaction. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI osteoblast development Inferred from genetic interaction. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI rhombomere 2 development Inferred from mutant phenotype. Source: MGI rhombomere 3 morphogenesis Inferred from mutant phenotype. Source: MGI segment specification Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: MGI transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Homeobox protein Hox-A2		PRO_0000200037
Regions
	DNA binding	139 – 198	60	Homeobox
	Motif	96 – 101	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	P31245-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 0ADA79113DB72726	FASTA	372	40,793
	10 20 30 40 50 60 MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM KEKKAAKKTA LPPAAASTGP 130 140 150 160 170 180 ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE 190 200 210 220 230 240 RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL 250 260 270 280 290 300 EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 310 320 330 340 350 360 CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI SADSFDFFTD 370 TLTTIDLQHL NY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of mouse Hox 1-11." Gridley T. Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Murine Hox-1.11 homeobox gene structure and expression." Tan D.P., Ferrante J., Nazarali A., Shao X., Kozak C.A., Guo V., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:6280-6284(1992) [PubMed: 1352886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: ICR X Swiss Webster.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[4]	"Hox-1.11 and Hox-4.9 homeobox genes." Nazarali A., Kim Y., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992) [PubMed: 1348361] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231. Strain: ICR X Swiss Webster.
[5]	"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies." Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372. Strain: HMI/Msf.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M95599 mRNA. Translation: AAA37827.1. M93148 Genomic DNA. Translation: AAA37835.1. M93292 mRNA. Translation: AAA37836.1. BC117105 mRNA. Translation: AAI17106.1. BC117107 mRNA. Translation: AAI17108.1. M87801 Genomic DNA. Translation: AAA37834.1. AB039191 Genomic DNA. Translation: BAB68715.1.
IPI	IPI00132242.
PIR	A42694. A46037.
RefSeq	NP_034581.1.
UniGene	Mm.131
3D structure databases
SMR	P31245. Positions 141-197.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31245. 2 interactions.
STRING	P31245.
Proteomic databases
PRIDE	P31245.
Genome annotation databases
Ensembl	ENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704; Mus musculus. [Genome view]
GeneID	15399.
KEGG	mmu:15399.
UCSC	uc009bxz.1. mouse.
Organism-specific databases
CTD	15399.
MGI	MGI:96174. Hoxa2.
Phylogenomic databases
HOGENOM	P31245.
HOVERGEN	P31245.
OMA	NCGSGLN
OrthoDB	EOG9KWNC3
Gene expression databases
ArrayExpress	P31245.
Bgee	P31245.
CleanEx	MM_HOXA2.
Genevestigator	P31245.
GermOnline	ENSMUSG00000014704. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	288090.
SOURCE	Search...

Entry information

Entry name

HXA2_MOUSE

Accession

Primary (citable) accession number: P31245
Secondary accession number(s): Q149U3, Q920T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	November 24, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)