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P31245 (HXA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A2
Alternative name(s):
Homeobox protein Hox-1.11
Short name=Hox1.11
Gene names
Name:Hoxa2
Synonyms:Hox-1.11, Hoxa-2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Proboscipedia subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype PubMed 9367425. Source: MGI

brain segmentation

Inferred from mutant phenotype PubMed 9367425. Source: MGI

cell fate commitment

Inferred from mutant phenotype PubMed 7903600PubMed 7903601. Source: MGI

cell fate determination

Inferred from mutant phenotype PubMed 16221728. Source: MGI

dorsal/ventral pattern formation

Inferred from mutant phenotype PubMed 10230789. Source: MGI

embryonic skeletal system morphogenesis

Inferred from genetic interaction PubMed 15634706. Source: MGI

embryonic viscerocranium morphogenesis

Inferred from mutant phenotype PubMed 16221728. Source: MGI

middle ear morphogenesis

Inferred from mutant phenotype PubMed 15861402PubMed 16221728. Source: MGI

motor neuron axon guidance

Inferred from mutant phenotype PubMed 9367425. Source: MGI

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 18164701. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15634706. Source: MGI

osteoblast development

Inferred from genetic interaction PubMed 16751105. Source: MGI

pattern specification process

Inferred from mutant phenotype PubMed 7903600PubMed 7903601. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18787068. Source: MGI

rhombomere 2 development

Inferred from mutant phenotype PubMed 7508007. Source: MGI

rhombomere 3 development

Inferred from genetic interaction PubMed 7508007. Source: MGI

rhombomere 3 morphogenesis

Inferred from mutant phenotype PubMed 10230789. Source: MGI

segment specification

Inferred from mutant phenotype PubMed 9367425. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 10536059PubMed 11209945. Source: MGI

   Molecular_functionsequence-specific DNA binding

Inferred from direct assay PubMed 15634706. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Homeobox protein Hox-A2
PRO_0000200037

Regions

DNA binding139 – 19860Homeobox
Motif96 – 1016Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
P31245 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 0ADA79113DB72726

FASTA37240,793
        10         20         30         40         50         60 
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 

        70         80         90        100        110        120 
PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM KEKKAAKKTA LPPAAASTGP 

       130        140        150        160        170        180 
ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE 

       190        200        210        220        230        240 
RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL 

       250        260        270        280        290        300 
EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 

       310        320        330        340        350        360 
CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI SADSFDFFTD 

       370 
TLTTIDLQHL NY 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of mouse Hox 1-11."
Gridley T.
Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Murine Hox-1.11 homeobox gene structure and expression."
Tan D.P., Ferrante J., Nazarali A., Shao X., Kozak C.A., Guo V., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 89:6280-6284(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: ICR X Swiss Webster.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[4]"Hox-1.11 and Hox-4.9 homeobox genes."
Nazarali A., Kim Y., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231.
Strain: ICR X Swiss Webster.
[5]"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372.
Strain: HMI/Msf.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95599 mRNA. Translation: AAA37827.1.
M93148 Genomic DNA. Translation: AAA37835.1.
M93292 mRNA. Translation: AAA37836.1.
BC117105 mRNA. Translation: AAI17106.1.
BC117107 mRNA. Translation: AAI17108.1.
M87801 Genomic DNA. Translation: AAA37834.1.
AB039191 Genomic DNA. Translation: BAB68715.1.
CCDSCCDS20139.1.
PIRA42694.
A46037.
RefSeqNP_034581.1. NM_010451.2.
UniGeneMm.131.

3D structure databases

ProteinModelPortalP31245.
SMRP31245. Positions 141-197.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200367. 13 interactions.
IntActP31245. 1 interaction.
STRING10090.ENSMUSP00000014848.

PTM databases

PhosphoSiteP31245.

Proteomic databases

PRIDEP31245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704.
GeneID15399.
KEGGmmu:15399.
UCSCuc009bxz.1. mouse.

Organism-specific databases

CTD3199.
MGIMGI:96174. Hoxa2.

Phylogenomic databases

eggNOGNOG321520.
GeneTreeENSGT00750000117389.
HOGENOMHOG000063664.
HOVERGENHBG006088.
InParanoidP31245.
KOK09302.
OMANCGSGLN.
OrthoDBEOG73RBBF.
PhylomeDBP31245.
TreeFamTF317730.

Gene expression databases

BgeeP31245.
CleanExMM_HOXA2.
GenevestigatorP31245.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288090.
PROP31245.
SOURCESearch...

Entry information

Entry nameHXA2_MOUSE
AccessionPrimary (citable) accession number: P31245
Secondary accession number(s): Q149U3, Q920T8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries