P31245 (HXA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A2

Alternative name(s):
Homeobox protein Hox-1.11
Short name=Hox1.11

Gene names

Name:	Hoxa2
Synonyms:	Hox-1.11, Hoxa-2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from mutant phenotype PubMed 9367425. Source: MGI brain segmentation Inferred from mutant phenotype PubMed 9367425. Source: MGI cell fate determination Inferred from mutant phenotype PubMed 16221728. Source: MGI dorsal/ventral pattern formation Inferred from mutant phenotype PubMed 10230789. Source: MGI embryonic viscerocranium morphogenesis Inferred from mutant phenotype PubMed 16221728. Source: MGI middle ear morphogenesis Inferred from mutant phenotype PubMed 15861402PubMed 16221728. Source: MGI motor neuron axon guidance Inferred from mutant phenotype PubMed 9367425. Source: MGI negative regulation of neuron differentiation Inferred from mutant phenotype PubMed 18164701. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 15634706. Source: MGI osteoblast development Inferred from genetic interaction PubMed 16751105. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 18787068. Source: MGI rhombomere 2 development Inferred from mutant phenotype PubMed 7508007. Source: MGI rhombomere 3 morphogenesis Inferred from mutant phenotype PubMed 10230789. Source: MGI segment specification Inferred from mutant phenotype PubMed 9367425. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 10536059PubMed 11209945. Source: MGI
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 15634706. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Homeobox protein Hox-A2		PRO_0000200037
Regions
	DNA binding	139 – 198	60	Homeobox
	Motif	96 – 101	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	P31245 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 0ADA79113DB72726	FASTA	372	40,793
	10 20 30 40 50 60 MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM KEKKAAKKTA LPPAAASTGP 130 140 150 160 170 180 ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE 190 200 210 220 230 240 RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL 250 260 270 280 290 300 EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 310 320 330 340 350 360 CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI SADSFDFFTD 370 TLTTIDLQHL NY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of mouse Hox 1-11." Gridley T. Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Murine Hox-1.11 homeobox gene structure and expression." Tan D.P., Ferrante J., Nazarali A., Shao X., Kozak C.A., Guo V., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:6280-6284(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: ICR X Swiss Webster.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[4]	"Hox-1.11 and Hox-4.9 homeobox genes." Nazarali A., Kim Y., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231. Strain: ICR X Swiss Webster.
[5]	"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies." Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372. Strain: HMI/Msf.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M95599 mRNA. Translation: AAA37827.1. M93148 Genomic DNA. Translation: AAA37835.1. M93292 mRNA. Translation: AAA37836.1. BC117105 mRNA. Translation: AAI17106.1. BC117107 mRNA. Translation: AAI17108.1. M87801 Genomic DNA. Translation: AAA37834.1. AB039191 Genomic DNA. Translation: BAB68715.1.
IPI	IPI00132242.
PIR	A42694. A46037.
RefSeq	NP_034581.1. NM_010451.2.
UniGene	Mm.131.
3D structure databases
ProteinModelPortal	P31245.
SMR	P31245. Positions 141-197.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31245. 1 interaction.
STRING	10090.ENSMUSP00000014848.
PTM databases
PhosphoSite	P31245.
Proteomic databases
PRIDE	P31245.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000014848; ENSMUSP00000014848; ENSMUSG00000014704.
GeneID	15399.
KEGG	mmu:15399.
UCSC	uc009bxz.1. mouse.
Organism-specific databases
CTD	3199.
MGI	MGI:96174. Hoxa2.
Phylogenomic databases
eggNOG	NOG321520.
GeneTree	ENSGT00700000104446.
HOGENOM	HOG000063664.
HOVERGEN	HBG006088.
InParanoid	P31245.
KO	K09302.
OMA	NCGSGLN.
OrthoDB	EOG43TZVT.
Gene expression databases
ArrayExpress	P31245.
Bgee	P31245.
CleanEx	MM_HOXA2.
Genevestigator	P31245.
GermOnline	ENSMUSG00000014704. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288090.
SOURCE	Search...

Entry information

Entry name

HXA2_MOUSE

Accession

Primary (citable) accession number: P31245
Secondary accession number(s): Q149U3, Q920T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 29, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program