Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transgelin

Gene

Tagln

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actin cross-linking/gelling protein.

GO - Molecular functioni

  • actin filament binding Source: RGD
  • protein binding, bridging Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin
Alternative name(s):
Smooth muscle protein 22-alpha
Short name:
SM22-alpha
Gene namesi
Name:Tagln
Synonyms:Sm22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3723. Tagln.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002047832 – 201TransgelinAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineSequence analysisBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei172N6-acetyllysineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei183Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP31232.
PRIDEiP31232.

PTM databases

iPTMnetiP31232.
PhosphoSitePlusiP31232.

Expressioni

Tissue specificityi

Smooth muscle and mesenchymal cells but not in skeletal muscle or lymphocytes.

Gene expression databases

BgeeiENSRNOG00000017628.
ExpressionAtlasiP31232. baseline and differential.
GenevisibleiP31232. RN.

Interactioni

GO - Molecular functioni

  • actin filament binding Source: RGD
  • protein binding, bridging Source: RGD

Protein-protein interaction databases

BioGridi247194. 3 interactors.
IntActiP31232. 1 interactor.
STRINGi10116.ENSRNOP00000024030.

Structurei

3D structure databases

ProteinModelPortaliP31232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 137CHPROSITE-ProRule annotationAdd BLAST114
Repeati175 – 200Calponin-likeAdd BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 161Could be involved in actin-binding8

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 1 calponin-like repeat.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP31232.
KOiK20526.
PhylomeDBiP31232.
TreeFamiTF313921.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIVMQCGP DVGRPDRGRL
60 70 80 90 100
GFQVWLKNGV ILSKLVNSLY PEGSKPVKVP ENPPSMVFKQ MEQVAQFLKA
110 120 130 140 150
AEDYGVTKTD MFQTVDLFEG KDMAAVQRTV MALGSLAVTK NDGHYRGDPN
160 170 180 190 200
WFMKKAQEHK REFTDSQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII

S
Length:201
Mass (Da):22,603
Last modified:January 23, 2007 - v2
Checksum:i0D49B5296D9A125B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71070 mRNA. Translation: CAA50396.1.
M83107 mRNA. Translation: AAA40762.1.
X64422 mRNA. Translation: CAA45769.1.
BC061770 mRNA. Translation: AAH61770.1.
PIRiJN0774.
RefSeqiNP_113737.1. NM_031549.2.
UniGeneiRn.34397.

Genome annotation databases

EnsembliENSRNOT00000024030; ENSRNOP00000024030; ENSRNOG00000017628.
GeneIDi25123.
KEGGirno:25123.
UCSCiRGD:3723. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71070 mRNA. Translation: CAA50396.1.
M83107 mRNA. Translation: AAA40762.1.
X64422 mRNA. Translation: CAA45769.1.
BC061770 mRNA. Translation: AAH61770.1.
PIRiJN0774.
RefSeqiNP_113737.1. NM_031549.2.
UniGeneiRn.34397.

3D structure databases

ProteinModelPortaliP31232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247194. 3 interactors.
IntActiP31232. 1 interactor.
STRINGi10116.ENSRNOP00000024030.

PTM databases

iPTMnetiP31232.
PhosphoSitePlusiP31232.

Proteomic databases

PaxDbiP31232.
PRIDEiP31232.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024030; ENSRNOP00000024030; ENSRNOG00000017628.
GeneIDi25123.
KEGGirno:25123.
UCSCiRGD:3723. rat.

Organism-specific databases

CTDi6876.
RGDi3723. Tagln.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP31232.
KOiK20526.
PhylomeDBiP31232.
TreeFamiTF313921.

Miscellaneous databases

PROiP31232.

Gene expression databases

BgeeiENSRNOG00000017628.
ExpressionAtlasiP31232. baseline and differential.
GenevisibleiP31232. RN.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL_RAT
AccessioniPrimary (citable) accession number: P31232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.