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P31227

- SMOD_LITCT

UniProt

P31227 - SMOD_LITCT

Protein

S-modulin

Gene
N/A
Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Calcium-dependent regulator of light sensitivity of cGMP phosphodiesterase in rod outer segments. Control rhodopsin phosphorylation in a Ca2+-dependent manner.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi74 – 85121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi110 – 121122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW
    2. visual perception Source: UniProtKB-KW

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-modulin
    Alternative name(s):
    Sensitivity-modulating protein
    OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
    Taxonomic identifieri8400 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

    Subcellular locationi


    Note: The binding target of the Ca2+/S-modulin complex is possibly ROS membrane lipid(s).

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 202201S-modulinPRO_0000073799Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Post-translational modificationi

    The N-terminus is blocked.

    Keywords - PTMi

    Lipoprotein, Myristate

    Structurei

    3D structure databases

    ProteinModelPortaliP31227.
    SMRiP31227. Positions 2-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 6036EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini61 – 9636EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini97 – 13236EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini147 – 18236EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG108179.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PfamiPF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31227-1 [UniParc]FASTAAdd to Basket

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    MGNTKSGALS KEILEELQLN TKFTQEELCT WYQSFLKECP SGRISKKQFE    50
    SIYSKFFPDA DPKAYAQHVF RSFDANNDGT LDFKEYMIAL MMTSSGKANQ 100
    KLEWAFCLYD VDGNGTINKK EVLEIITAIF KMINAEDQKH LPEDENTPEK 150
    RTNKIWVYFG KKDDDKLTEG EFIQGIVKNK EILRLIQYEP QKVKDKLKEK 200
    KH 202
    Length:202
    Mass (Da):23,527
    Last modified:January 23, 2007 - v4
    Checksum:i5FFE379649904A2B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911M → H in BAA19728. (PubMed:8392055)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83641 mRNA. Translation: BAA19728.1.
    PIRiJC1107.
    T10531.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83641 mRNA. Translation: BAA19728.1 .
    PIRi JC1107.
    T10531.

    3D structure databases

    ProteinModelPortali P31227.
    SMRi P31227. Positions 2-191.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108179.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    Pfami PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recoverin has S-modulin activity in frog rods."
      Kawamura S., Hisatomi O., Kayada S., Tokunaga F., Kuo C.-H.
      J. Biol. Chem. 268:14579-14582(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. "Purification and characterization of S-modulin, a calcium-dependent regulator on cGMP phosphodiesterase in frog rod photoreceptors."
      Kawamura S., Takamatsu K., Kitamura K.
      Biochem. Biophys. Res. Commun. 186:411-417(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-28; 47-55; 63-97; 131-150; 154-162; 167-177 AND 180-192.
      Tissue: Retina.

    Entry informationi

    Entry nameiSMOD_LITCT
    AccessioniPrimary (citable) accession number: P31227
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3