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P31227

- SMOD_LITCT

UniProt

P31227 - SMOD_LITCT

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Protein
S-modulin
Gene
N/A
Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-dependent regulator of light sensitivity of cGMP phosphodiesterase in rod outer segments. Control rhodopsin phosphorylation in a Ca2+-dependent manner.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi74 – 85121 Reviewed prediction
Add
BLAST
Calcium bindingi110 – 121122 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. response to stimulus Source: UniProtKB-KW
  2. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S-modulin
Alternative name(s):
Sensitivity-modulating protein
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi


Note: The binding target of the Ca2+/S-modulin complex is possibly ROS membrane lipid(s).

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 202201S-modulin
PRO_0000073799Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Lipoprotein, Myristate

Structurei

3D structure databases

ProteinModelPortaliP31227.
SMRiP31227. Positions 2-191.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 6036EF-hand 1
Add
BLAST
Domaini61 – 9636EF-hand 2
Add
BLAST
Domaini97 – 13236EF-hand 3
Add
BLAST
Domaini147 – 18236EF-hand 4
Add
BLAST

Sequence similaritiesi

Belongs to the recoverin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG108179.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31227-1 [UniParc]FASTAAdd to Basket

« Hide

MGNTKSGALS KEILEELQLN TKFTQEELCT WYQSFLKECP SGRISKKQFE    50
SIYSKFFPDA DPKAYAQHVF RSFDANNDGT LDFKEYMIAL MMTSSGKANQ 100
KLEWAFCLYD VDGNGTINKK EVLEIITAIF KMINAEDQKH LPEDENTPEK 150
RTNKIWVYFG KKDDDKLTEG EFIQGIVKNK EILRLIQYEP QKVKDKLKEK 200
KH 202
Length:202
Mass (Da):23,527
Last modified:January 23, 2007 - v4
Checksum:i5FFE379649904A2B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911M → H in BAA19728. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83641 mRNA. Translation: BAA19728.1.
PIRiJC1107.
T10531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83641 mRNA. Translation: BAA19728.1 .
PIRi JC1107.
T10531.

3D structure databases

ProteinModelPortali P31227.
SMRi P31227. Positions 2-191.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108179.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
Pfami PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Recoverin has S-modulin activity in frog rods."
    Kawamura S., Hisatomi O., Kayada S., Tokunaga F., Kuo C.-H.
    J. Biol. Chem. 268:14579-14582(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Purification and characterization of S-modulin, a calcium-dependent regulator on cGMP phosphodiesterase in frog rod photoreceptors."
    Kawamura S., Takamatsu K., Kitamura K.
    Biochem. Biophys. Res. Commun. 186:411-417(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-28; 47-55; 63-97; 131-150; 154-162; 167-177 AND 180-192.
    Tissue: Retina.

Entry informationi

Entry nameiSMOD_LITCT
AccessioniPrimary (citable) accession number: P31227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 80 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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