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Protein

Saxiphilin

Gene
N/A
Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to the neurotoxin saxitoxin. Its physiological role may be to transport or sequester an endogenous organic molecule other than Fe3+. It may participate in a detoxification mechanism for neutralizing a microbial toxin.

Names & Taxonomyi

Protein namesi
Recommended name:
Saxiphilin
Short name:
SAX
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003574920 – 844SaxiphilinAdd BLAST825

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 64By similarity
Disulfide bondi39 ↔ 55By similarity
Disulfide bondi110 ↔ 130By similarity
Disulfide bondi141 ↔ 148By similarity
Disulfide bondi150 ↔ 172By similarity
Disulfide bondi180 ↔ 202By similarity
Disulfide bondi222 ↔ 244By similarity
Disulfide bondi277 ↔ 360By similarity
Disulfide bondi322 ↔ 335By similarity
Disulfide bondi332 ↔ 343By similarity
Disulfide bondi388 ↔ 402By similarity
Disulfide bondi495 ↔ 527By similarity
Disulfide bondi505 ↔ 518By similarity
Disulfide bondi552 ↔ 839By similarity
Disulfide bondi570 ↔ 799By similarity
Disulfide bondi607 ↔ 685By similarity
Disulfide bondi641 ↔ 655By similarity
Disulfide bondi652 ↔ 668By similarity
Disulfide bondi725 ↔ 739By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP31226

Expressioni

Tissue specificityi

Plasma. Highest levels of transcripts found in the liver, the lung, the pancreas and the brain.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP31226
SMRiP31226
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 106Transferrin-like 1; first partPROSITE-ProRule annotationAdd BLAST81
Domaini107 – 172Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST66
Domaini177 – 244Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST68
Domaini245 – 482Transferrin-like 1; second partPROSITE-ProRule annotationAdd BLAST238
Domaini492 – 828Transferrin-like 2PROSITE-ProRule annotationAdd BLAST337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 249Absent in transferrinsAdd BLAST141

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG000055

Family and domain databases

CDDicd00191 TY, 2 hits
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR016357 Transferrin
IPR001156 Transferrin-like_dom
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 2 hits
PF00405 Transferrin, 3 hits
PIRSFiPIRSF002549 Transferrin, 1 hit
PRINTSiPR00422 TRANSFERRIN
SMARTiView protein in SMART
SM00094 TR_FER, 2 hits
SM00211 TY, 2 hits
SUPFAMiSSF57610 SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 2 hits
PS51408 TRANSFERRIN_LIKE_4, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTFQTALF FTIISLSFAA PNAKQVRWCA ISDLEQKKCN DLVGSCNVPD
60 70 80 90 100
ITLVCVLRSS TEDCMTAIKD GQADAMFLDS GEVYEASKDP YNLKPIIAEP
110 120 130 140 150
YSSNRDLQKC LKERQQALAK KMIGHYIPQC DEKGNYQPQQ CHGSTGHCWC
160 170 180 190 200
VNAMGEKISG TNTPPGQTRA TCERHELPKC LKERQVALGG DEKVLGRFVP
210 220 230 240 250
QCDEKGNYEP QQFHGSTGYS WCVNAIGEEI AGTKTPPGKI PATCQKHDLV
260 270 280 290 300
TTCHYAVAMV KKSSAFQFNQ LKGKRSCHSG VSKTDGWKAL VTVLVEKKLL
310 320 330 340 350
SWDGPAKESI QRAMSKFFSV SCIPGATQTN LCKQCKGEEG KNCKNSHDEP
360 370 380 390 400
YYGNYGAFRC LKEDMGDVAF LRSTALSDEH SEVYELLCPD NTRKPLNKYK
410 420 430 440 450
ECNLGTVPAG TVVTRKISDK TEDINNFLME AQKRQCKLFS SAHGKDLMFD
460 470 480 490 500
DSTLQLALLS SEVDAFLYLG VKLFHAMKAL TGDAHLPSKN KVRWCTINKL
510 520 530 540 550
EKMKCDDWSA VSGGAIACTE ASCPKGCVKQ ILKGEADAVK LEVQYMYEAL
560 570 580 590 600
MCGLLPAVEE YHNKDDFGPC KTPGSPYTDF GTLRAVALVK KSNKDINWNN
610 620 630 640 650
IKGKKSCHTG VGDIAGWVIP VSLIRRQNDN SDIDSFFGES CAPGSDTKSN
660 670 680 690 700
LCKLCIGDPK NSAANTKCSL SDKEAYYGNQ GAFRCLVEKG DVAFVPHTVV
710 720 730 740 750
FENTDGKNPA VWAKNLKSED FELLCLDGSR APVSNYKSCK LSGIPPPAIV
760 770 780 790 800
TREESISDVV RIVANQQSLY GRKGFEKDMF QLFSSNKGNN LLFNDNTQCL
810 820 830 840
ITFDRQPKDI MEDYFGKPYY TTVYGASRSA MSSELISACT IKHC
Length:844
Mass (Da):93,089
Last modified:February 1, 1996 - v3
Checksum:i162A765AD02C3C5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05246 mRNA Translation: AAA75440.1
PIRiA39426

Similar proteinsi

Entry informationi

Entry nameiSAX_LITCT
AccessioniPrimary (citable) accession number: P31226
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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