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Protein

Polyadenylate-binding protein, cytoplasmic and nuclear

Gene

pab1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).By similarity1 Publication

GO - Molecular functioni

  • poly(A) binding Source: PomBase

GO - Biological processi

  • mRNA export from nucleus Source: PomBase
  • mRNA processing Source: UniProtKB-KW
  • regulation of translation Source: UniProtKB-KW

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA transport, Translation regulation, Transport

Enzyme and pathway databases

ReactomeiR-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SPO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein, cytoplasmic and nuclear
Short name:
PABP
Short name:
Poly(A)-binding protein
Alternative name(s):
Polyadenylate tail-binding protein
Gene namesi
Name:pab1
Synonyms:pabp
ORF Names:SPAC57A7.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC57A7.04c
PomBaseiSPAC57A7.04c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817181 – 653Polyadenylate-binding protein, cytoplasmic and nuclearAdd BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP31209
PaxDbiP31209
PRIDEiP31209

PTM databases

iPTMnetiP31209

Interactioni

Subunit structurei

Interacts with cid13.1 Publication

Protein-protein interaction databases

BioGridi278007, 17 interactors
IntActiP31209, 1 interactor
STRINGi4896.SPAC57A7.04c.1

Structurei

3D structure databases

ProteinModelPortaliP31209
SMRiP31209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 158RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini168 – 245RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini261 – 338RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini364 – 441RRM 4PROSITE-ProRule annotationAdd BLAST78
Domaini569 – 646PABCPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi481 – 569Pro-richAdd BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000217922
InParanoidiP31209
KOiK13126
OMAiKKVYVGH
OrthoDBiEOG092C3SCB
PhylomeDBiP31209

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 4 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

Sequencei

Sequence statusi: Complete.

P31209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSTDLKKQA DAAVESDVNT NNEAVESSTK EESSNTPSTE TQPEKKAEEP
60 70 80 90 100
EAAAEPSEST STPTNASSVA TPSGTAPTSA SLYVGELDPS VTEAMLFELF
110 120 130 140 150
NSIGPVASIR VCRDAVTRRS LGYAYVNFHN MEDGEKALDE LNYTLIKGRP
160 170 180 190 200
CRIMWSQRDP SLRKMGTGNV FIKNLDPAID NKALHDTFSA FGKILSCKVA
210 220 230 240 250
VDELGNAKGY GFVHFDSVES ANAAIEHVNG MLLNDKKVYV GHHVSRRERQ
260 270 280 290 300
SKVEALKANF TNVYIKNLDT EITEQEFSDL FGQFGEITSL SLVKDQNDKP
310 320 330 340 350
RGFGFVNYAN HECAQKAVDE LNDKEYKGKK LYVGRAQKKH EREEELRKRY
360 370 380 390 400
EQMKLEKMNK YQGVNLFIKN LQDEVDDERL KAEFSAFGTI TSAKIMTDEQ
410 420 430 440 450
GKSKGFGFVC YTTPEEANKA VTEMNQRMLA GKPLYVALAQ RKEVRRSQLE
460 470 480 490 500
AQIQARNQFR LQQQVAAAAG IPAVQYGATG PLIYGPGGYP IPAAVNGRGM
510 520 530 540 550
PMVPGHNGPM PMYPGMPTQF PAGGPAPGYP GMNARGPVPA QGRPMMMPGS
560 570 580 590 600
VPSAGPAEAE AVPAVPGMPE RFTAADLAAV PEESRKQVLG ELLYPKVFVR
610 620 630 640 650
EEKLSGKITG MLLEMPNSEL LELLEDDSAL NERVNEAIGV LQEFVDQEPG

FTE
Length:653
Mass (Da):71,513
Last modified:July 15, 1998 - v2
Checksum:i7F8F5CAD69D0CFE1
GO

Sequence cautioni

The sequence AAA35320 differs from that shown. Reason: Frameshift at positions 518 and 526.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 34MPSTD…KEESS → MSLENSSTLSLCSNNTTHFW in AAA35320 (PubMed:1675426).CuratedAdd BLAST34
Sequence conflicti349R → A in AAA35320 (PubMed:1675426).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB08762.1
M64603 mRNA Translation: AAA35320.1 Frameshift.
PIRiT38950 DNZPPA
RefSeqiNP_593377.1, NM_001018809.2

Genome annotation databases

EnsemblFungiiSPAC57A7.04c.1; SPAC57A7.04c.1:pep; SPAC57A7.04c
GeneIDi2541505
KEGGispo:SPAC57A7.04c

Similar proteinsi

Entry informationi

Entry nameiPABP_SCHPO
AccessioniPrimary (citable) accession number: P31209
Secondary accession number(s): P87135
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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