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Protein

Sialidase

Gene

nanH

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sialidases have been suggested to be pathogenic factors in microbial infections.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei399Sequence analysis1
Binding sitei415SubstrateBy similarity1
Binding sitei479SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase (EC:3.2.1.18)
Alternative name(s):
Neuraminidase
Gene namesi
Name:nanH
Ordered Locus Names:BF1729
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002197 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001202923 – 544SialidaseAdd BLAST522

Structurei

3D structure databases

ProteinModelPortaliP31206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati239 – 250BNR 1Add BLAST12
Repeati318 – 329BNR 2Add BLAST12
Repeati378 – 389BNR 3Add BLAST12
Repeati425 – 436BNR 4Add BLAST12
Repeati485 – 496BNR 5Add BLAST12

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated
Contains 5 BNR repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000252336.
KOiK01186.
OMAiTWSAPIN.
OrthoDBiPOG091H0EBR.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
PF14873. BNR_assoc_N. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKAVILFSL FCFLCAIPVV QAADTIFVRE TRIPILIERQ DNVLFYLRLD
60 70 80 90 100
AKESQTLNDV VLNLGEGVNL SEIQSIKLYY GGTEALQDSG KKRFAPVGYI
110 120 130 140 150
SSNTPGKTLA ANPSYSIKKS EVTNPGNQVV LKGDQKLFPG INYFWISLQM
160 170 180 190 200
KPGTSLTSKV TADIASITLD GKKALLDVVS ENGIEHRMGV GVRHAGDDNS
210 220 230 240 250
AAFRIPGLVT TNKGTLLGVY DVRYNSSVDL QEHVDVGLSR STDGGKTWEK
260 270 280 290 300
MRLPLAFGEF GGLPAGQNGV GDPSILVDTK TNNVWVVAAW THGMGNQRAW
310 320 330 340 350
WSSHPGMDMN HTAQLVLAKS TDDGKTWSAP INITEQVKDP SWYFLLQGPG
360 370 380 390 400
RGITMSDGTL VFPTQFIDST RVPNAGIMYS KDGGKNWKMH NYARTNTTEA
410 420 430 440 450
QVAEVEPGVL MLNMRDNRGG SRAVAITKDL GKTWTEHESS RKALPESVCM
460 470 480 490 500
ASLISVKAKD NVLGKDLLIF SNPNTTKGRY NTTIKISLDG GVTWSPEHQL
510 520 530 540
LLDEGNNWGY SCLSMIDKET IGILYESSVA HMTFQAVKLK DIIK
Length:544
Mass (Da):59,556
Last modified:November 23, 2004 - v2
Checksum:i6D1D185AB15FA822
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197D → A in BAA05853 (PubMed:8093075).Curated1
Sequence conflicti405V → A in AAA22912 (PubMed:2158974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28493 Genomic DNA. Translation: BAA05853.1.
AB102772 Genomic DNA. Translation: BAC56895.2.
AP006841 Genomic DNA. Translation: BAD48476.1.
M31663 Genomic DNA. Translation: AAA22912.1.
PIRiJC2500.
RefSeqiWP_005786655.1. NC_006347.1.
YP_099010.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD48476; BAD48476; BF1729.
GeneIDi3082956.
KEGGibfr:BF1729.
PATRICi21049123. VBIBacFra17906_1678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28493 Genomic DNA. Translation: BAA05853.1.
AB102772 Genomic DNA. Translation: BAC56895.2.
AP006841 Genomic DNA. Translation: BAD48476.1.
M31663 Genomic DNA. Translation: AAA22912.1.
PIRiJC2500.
RefSeqiWP_005786655.1. NC_006347.1.
YP_099010.1. NC_006347.1.

3D structure databases

ProteinModelPortaliP31206.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD48476; BAD48476; BF1729.
GeneIDi3082956.
KEGGibfr:BF1729.
PATRICi21049123. VBIBacFra17906_1678.

Phylogenomic databases

HOGENOMiHOG000252336.
KOiK01186.
OMAiTWSAPIN.
OrthoDBiPOG091H0EBR.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
PF14873. BNR_assoc_N. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNANH_BACFR
AccessioniPrimary (citable) accession number: P31206
Secondary accession number(s): Q45145, Q64VK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 23, 2004
Last modified: October 5, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.