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P31167 (ADT1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 1, mitochondrial
Alternative name(s):
ADP/ATP translocase 1
Adenine nucleotide translocator 1
Short name=ANT 1
Gene names
Name:AAC1
Synonyms:ANT1
Ordered Locus Names:At3g08580
ORF Names:F17O14.5
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Ref.6.

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainRepeat
Transit peptide
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processADP transport

Inferred from direct assay PubMed 12084057. Source: GOC

ATP transport

Inferred from direct assay PubMed 12084057. Source: GOC

purine nucleotide transport

Inferred from direct assay PubMed 12084057. Source: TAIR

   Cellular_componentcell wall

Inferred from direct assay PubMed 16287169. Source: TAIR

chloroplast

Inferred from direct assay PubMed 15028209PubMed 18431481. Source: TAIR

chloroplast envelope

Inferred from direct assay PubMed 12938931. Source: TAIR

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from direct assay PubMed 17432890. Source: TAIR

mitochondrial envelope

Traceable author statement PubMed 12084057. Source: TAIR

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

mitochondrion

Inferred from direct assay Ref.6PubMed 15276431PubMed 22923678. Source: TAIR

nucleolus

Inferred from direct assay PubMed 15496452. Source: TAIR

plasma membrane

Inferred from direct assay PubMed 17644812. Source: TAIR

vacuolar membrane

Inferred from direct assay PubMed 17151019. Source: TAIR

vacuole

Inferred from direct assay PubMed 15215502. Source: TAIR

   Molecular_functionATP:ADP antiporter activity

Inferred from direct assay PubMed 12084057. Source: TAIR

copper ion binding

Inferred from direct assay PubMed 20018591. Source: TAIR

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 7070Mitochondrion Potential
Chain71 – 381311ADP,ATP carrier protein 1, mitochondrial
PRO_0000019245

Regions

Transmembrane77 – 11135Helical; Name=1; By similarity
Transmembrane148 – 17225Helical; Name=2; By similarity
Transmembrane181 – 21535Helical; Name=3; By similarity
Transmembrane251 – 27828Helical; Name=4; By similarity
Transmembrane283 – 31735Helical; Name=5; By similarity
Transmembrane346 – 37126Helical; Name=6; By similarity
Repeat78 – 17194Solcar 1
Repeat183 – 27694Solcar 2
Repeat284 – 37087Solcar 3
Motif311 – 3166Substrate recognition By similarity

Sites

Binding site1531Nucleotide By similarity

Experimental info

Sequence conflict31D → H in CAA46518. Ref.4
Sequence conflict3191G → N in CAA46518. Ref.4
Sequence conflict3681Q → T in CAA46518. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P31167 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: FF39C3D1E1ED5B58

FASTA38141,476
        10         20         30         40         50         60 
MVDQVQHPTI AQKAAGQFMR SSVSKDVQVG YQRPSMYQRH ATYGNYSNAA FQFPPTSRML 

        70         80         90        100        110        120 
ATTASPVFVQ TPGEKGFTNF ALDFLMGGVS AAVSKTAAAP IERVKLLIQN QDEMIKAGRL 

       130        140        150        160        170        180 
SEPYKGIGDC FGRTIKDEGF GSLWRGNTAN VIRYFPTQAL NFAFKDYFKR LFNFKKDRDG 

       190        200        210        220        230        240 
YWKWFAGNLA SGGAAGASSL LFVYSLDYAR TRLANDAKAA KKGGGGRQFD GLVDVYRKTL 

       250        260        270        280        290        300 
KTDGIAGLYR GFNISCVGII VYRGLYFGLY DSVKPVLLTG DLQDSFFASF ALGWVITNGA 

       310        320        330        340        350        360 
GLASYPIDTV RRRMMMTSGE AVKYKSSLDA FKQILKNEGA KSLFKGAGAN ILRAVAGAGV 

       370        380 
LSGYDKLQLI VFGKKYGSGG A 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Complementary DNA sequence of an adenylate translocator from Arabidopsis thaliana."
Saint-Guily A., Lim P.Y., Chevalier C., Yamaguchi J., Akazawa T.
Plant Physiol. 100:1069-1071(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-381.
Strain: cv. Columbia.
[5]"Further progress towards a catalogue of all Arabidopsis genes: analysis of a set of 5000 non-redundant ESTs."
Cooke R., Raynal M., Laudie M., Grellet F., Delseny M., Morris P.-C., Guerrier D., Giraudat J., Quigley F., Clabault G., Li Y.-F., Mache R., Krivitzky M., Gy I.J.-J., Kreis M., Lecharny A., Parmentier Y., Marbach J. expand/collapse author list , Fleck J., Clement B., Philipps G., Herve C., Bardet C., Tremousaygue D., Lescure B., Lacomme C., Roby D., Jourjon M.-F., Chabrier P., Charpenteau J.-L., Desprez T., Amselem J., Chiapello H., Hoefte H.
Plant J. 9:101-124(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-190.
Strain: cv. Columbia.
[6]"Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Strain: cv. Landsberg erecta.
[7]"The growing family of mitochondrial carriers in Arabidopsis."
Picault N., Hodges M., Palmieri L., Palmieri F.
Trends Plant Sci. 9:138-146(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
[8]"Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC012562 Genomic DNA. Translation: AAG51358.1.
CP002686 Genomic DNA. Translation: AEE74648.1.
CP002686 Genomic DNA. Translation: AEE74649.1.
AY034933 mRNA. Translation: AAK59440.1.
AY042814 mRNA. Translation: AAK68754.1.
AY054248 mRNA. Translation: AAL06907.1.
AY074529 mRNA. Translation: AAL69497.1.
BT000381 mRNA. Translation: AAN15700.1.
BT002387 mRNA. Translation: AAO00747.1.
X65549 mRNA. Translation: CAA46518.1.
Z26399 mRNA. Translation: CAA81237.1.
PIRS21313.
RefSeqNP_187470.1. NM_111692.3.
NP_850541.1. NM_180210.1.
UniGeneAt.15439.
At.23909.
At.67047.

3D structure databases

ProteinModelPortalP31167.
SMRP31167. Positions 78-376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid5340. 4 interactions.
IntActP31167. 7 interactions.

Protein family/group databases

TCDB2.A.29.1.5. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbP31167.
PRIDEP31167.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G08580.1; AT3G08580.1; AT3G08580.
AT3G08580.2; AT3G08580.2; AT3G08580.
GeneID820005.
KEGGath:AT3G08580.

Organism-specific databases

GeneFarm3730. 374.
TAIRAT3G08580.

Phylogenomic databases

eggNOGNOG238123.
HOGENOMHOG000165727.
InParanoidP31167.
KOK05863.
OMADCIVKIF.
PhylomeDBP31167.

Gene expression databases

GenevestigatorP31167.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADT1_ARATH
AccessionPrimary (citable) accession number: P31167
Secondary accession number(s): Q9M9K2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names