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P31167

- ADT1_ARATH

UniProt

P31167 - ADT1_ARATH

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Protein

ADP,ATP carrier protein 1, mitochondrial

Gene

AAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei153 – 1531NucleotideBy similarity

GO - Molecular functioni

  1. ATP:ADP antiporter activity Source: TAIR
  2. copper ion binding Source: TAIR

GO - Biological processi

  1. ADP transport Source: GOC
  2. ATP transport Source: GOC
  3. purine nucleotide transport Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.1.5. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 1, mitochondrial
Alternative name(s):
ADP/ATP translocase 1
Adenine nucleotide translocator 1
Short name:
ANT 1
Gene namesi
Name:AAC1
Synonyms:ANT1
Ordered Locus Names:At3g08580
ORF Names:F17O14.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G08580.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. cell wall Source: TAIR
  2. chloroplast Source: TAIR
  3. chloroplast envelope Source: TAIR
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: TAIR
  6. mitochondrial envelope Source: TAIR
  7. mitochondrial inner membrane Source: UniProtKB-KW
  8. mitochondrion Source: TAIR
  9. nucleolus Source: TAIR
  10. plasma membrane Source: TAIR
  11. vacuolar membrane Source: TAIR
  12. vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7070MitochondrionSequence AnalysisAdd
BLAST
Chaini71 – 381311ADP,ATP carrier protein 1, mitochondrialPRO_0000019245Add
BLAST

Proteomic databases

PaxDbiP31167.
PRIDEiP31167.

Expressioni

Gene expression databases

ExpressionAtlasiP31167. baseline and differential.
GenevestigatoriP31167.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi5340. 4 interactions.
IntActiP31167. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliP31167.
SMRiP31167. Positions 78-376.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei77 – 11135Helical; Name=1By similarityAdd
BLAST
Transmembranei148 – 17225Helical; Name=2By similarityAdd
BLAST
Transmembranei181 – 21535Helical; Name=3By similarityAdd
BLAST
Transmembranei251 – 27828Helical; Name=4By similarityAdd
BLAST
Transmembranei283 – 31735Helical; Name=5By similarityAdd
BLAST
Transmembranei346 – 37126Helical; Name=6By similarityAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati78 – 17194Solcar 1Add
BLAST
Repeati183 – 27694Solcar 2Add
BLAST
Repeati284 – 37087Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi311 – 3166Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238123.
HOGENOMiHOG000165727.
InParanoidiP31167.
KOiK05863.
OMAiDCIVKIF.
PhylomeDBiP31167.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31167-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDQVQHPTI AQKAAGQFMR SSVSKDVQVG YQRPSMYQRH ATYGNYSNAA
60 70 80 90 100
FQFPPTSRML ATTASPVFVQ TPGEKGFTNF ALDFLMGGVS AAVSKTAAAP
110 120 130 140 150
IERVKLLIQN QDEMIKAGRL SEPYKGIGDC FGRTIKDEGF GSLWRGNTAN
160 170 180 190 200
VIRYFPTQAL NFAFKDYFKR LFNFKKDRDG YWKWFAGNLA SGGAAGASSL
210 220 230 240 250
LFVYSLDYAR TRLANDAKAA KKGGGGRQFD GLVDVYRKTL KTDGIAGLYR
260 270 280 290 300
GFNISCVGII VYRGLYFGLY DSVKPVLLTG DLQDSFFASF ALGWVITNGA
310 320 330 340 350
GLASYPIDTV RRRMMMTSGE AVKYKSSLDA FKQILKNEGA KSLFKGAGAN
360 370 380
ILRAVAGAGV LSGYDKLQLI VFGKKYGSGG A
Length:381
Mass (Da):41,476
Last modified:December 1, 2000 - v2
Checksum:iFF39C3D1E1ED5B58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31D → H in CAA46518. (PubMed:16653021)Curated
Sequence conflicti319 – 3191G → N in CAA46518. (PubMed:16653021)Curated
Sequence conflicti368 – 3681Q → T in CAA46518. (PubMed:16653021)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012562 Genomic DNA. Translation: AAG51358.1.
CP002686 Genomic DNA. Translation: AEE74648.1.
CP002686 Genomic DNA. Translation: AEE74649.1.
AY034933 mRNA. Translation: AAK59440.1.
AY042814 mRNA. Translation: AAK68754.1.
AY054248 mRNA. Translation: AAL06907.1.
AY074529 mRNA. Translation: AAL69497.1.
BT000381 mRNA. Translation: AAN15700.1.
BT002387 mRNA. Translation: AAO00747.1.
X65549 mRNA. Translation: CAA46518.1.
Z26399 mRNA. Translation: CAA81237.1.
PIRiS21313.
RefSeqiNP_187470.1. NM_111692.3.
NP_850541.1. NM_180210.1.
UniGeneiAt.15439.
At.23909.
At.67047.

Genome annotation databases

EnsemblPlantsiAT3G08580.1; AT3G08580.1; AT3G08580.
AT3G08580.2; AT3G08580.2; AT3G08580.
GeneIDi820005.
KEGGiath:AT3G08580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012562 Genomic DNA. Translation: AAG51358.1 .
CP002686 Genomic DNA. Translation: AEE74648.1 .
CP002686 Genomic DNA. Translation: AEE74649.1 .
AY034933 mRNA. Translation: AAK59440.1 .
AY042814 mRNA. Translation: AAK68754.1 .
AY054248 mRNA. Translation: AAL06907.1 .
AY074529 mRNA. Translation: AAL69497.1 .
BT000381 mRNA. Translation: AAN15700.1 .
BT002387 mRNA. Translation: AAO00747.1 .
X65549 mRNA. Translation: CAA46518.1 .
Z26399 mRNA. Translation: CAA81237.1 .
PIRi S21313.
RefSeqi NP_187470.1. NM_111692.3.
NP_850541.1. NM_180210.1.
UniGenei At.15439.
At.23909.
At.67047.

3D structure databases

ProteinModelPortali P31167.
SMRi P31167. Positions 78-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 5340. 4 interactions.
IntActi P31167. 7 interactions.

Protein family/group databases

TCDBi 2.A.29.1.5. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbi P31167.
PRIDEi P31167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G08580.1 ; AT3G08580.1 ; AT3G08580 .
AT3G08580.2 ; AT3G08580.2 ; AT3G08580 .
GeneIDi 820005.
KEGGi ath:AT3G08580.

Organism-specific databases

GeneFarmi 3730. 374.
TAIRi AT3G08580.

Phylogenomic databases

eggNOGi NOG238123.
HOGENOMi HOG000165727.
InParanoidi P31167.
KOi K05863.
OMAi DCIVKIF.
PhylomeDBi P31167.

Gene expression databases

ExpressionAtlasi P31167. baseline and differential.
Genevestigatori P31167.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Complementary DNA sequence of an adenylate translocator from Arabidopsis thaliana."
    Saint-Guily A., Lim P.Y., Chevalier C., Yamaguchi J., Akazawa T.
    Plant Physiol. 100:1069-1071(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-381.
    Strain: cv. Columbia.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-190.
    Strain: cv. Columbia.
  6. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.
  7. "The growing family of mitochondrial carriers in Arabidopsis."
    Picault N., Hodges M., Palmieri L., Palmieri F.
    Trends Plant Sci. 9:138-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  8. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
    Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
    J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: cv. Columbia.

Entry informationi

Entry nameiADT1_ARATH
AccessioniPrimary (citable) accession number: P31167
Secondary accession number(s): Q9M9K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3