Reviewed,
UniProtKB/Swiss-Prot P31166 (APT1_ARATH)
Last modified
February 9, 2010.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adenine phosphoribosyltransferase 1 Short name=APRT 1 EC=2.4.2.7 | ||||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 243 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. |
| Catalytic activity | AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| Pathway | Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the purine/pyrimidine phosphoribosyltransferase family. |
| Sequence caution | The sequence AAF99737.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine salvage |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative splicing |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | adenine salvage Traceable author statement. Source: TAIR purine ribonucleoside salvageInferred from electronic annotation. Source: UniProtKB-KW response to cadmium ionInferred from expression pattern. Source: TAIR |
| Cellular component | chloroplast Inferred from direct assay. Source: TAIR cytosolInferred from direct assay. Source: TAIR plant-type cell wallInferred from direct assay. Source: TAIR plasma membraneInferred from direct assay. Source: TAIR |
| Molecular function | adenine phosphoribosyltransferase activity Inferred from direct assay. Source: TAIR |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P31166-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 2 (identifier: P31166-2) The sequence of this isoform differs from the canonical sequence as follows: 1-60: Missing. |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A complete cDNA for adenine phosphoribosyltransferase from Arabidopsis thaliana." Moffatt B.A., McWhinnie E.A., Burkhart W.E., Pasternak J.J., Rothstein S.J. Plant Mol. Biol. 18:653-662(1992) [PubMed: 1558943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: cv. Columbia. |
| [2] | "The adenine phosphoribosyltransferase-encoding gene of Arabidopsis thaliana." Moffatt B.A., McWhinnie E.A., Agarwal S.K., Schaff D.A. Gene 143:211-216(1994) [PubMed: 8206375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2). Strain: cv. Columbia. |
| [3] | "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W.Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: cv. Columbia. |
| [5] | "Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X58640 mRNA. Translation: CAA41497.1. L19637 Genomic DNA. Translation: AAA20677.1. AC004557 Genomic DNA. Translation: AAF99737.1. Sequence problems. AF325045 mRNA. Translation: AAG40397.1. AY128377 mRNA. Translation: AAM91580.1. BT000370 mRNA. Translation: AAN15689.1. AY084300 mRNA. Translation: AAM60891.1. |
| IPI | IPI00517864. IPI00542898. |
| PIR | G86399. S20867. |
| RefSeq | NP_564284.1. NP_849714.1. |
| UniGene | At.25013 Rra.8977 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P31166. 1 interaction. |
| STRING | P31166. |
Proteomic databases | |
| PRIDE | P31166. |
Genome annotation databases | |
| GeneID | 839636. |
| GenomeReviews | Gene locus AT1G27450 in contig CT485782_GR. |
| KEGG | ath:AT1G27450. |
| NMPDR | fig|3702.1.peg.3072. |
Organism-specific databases | |
| TAIR | At1g27450. |
Phylogenomic databases | |
| eggNOG | KOG1712. |
| HOGENOM | HBG703830. |
| InParanoid | P31166. |
| OMA | VIPDFPK. |
| PhylomeDB | P31166. |
Enzyme and pathway databases | |
| BRENDA | 2.4.2.7. 302. |
Gene expression databases | |
| ArrayExpress | P31166. |
| Genevestigator | P31166. |
| GermOnline | AT1G27450. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view] |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01090. apt. 1 hit. |
| PROSITE | PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | APT1_ARATH | ||||||||
| Accession | Primary (citable) accession number: P31166 Secondary accession number(s): Q8LGF6, Q9FZJ0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


