Superoxide dismutase [Mn] 1, mitochondrial precursor

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P31161 (SODM1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn] 1, mitochondrial
EC=1.15.1.1

Gene names

Name:	sod-2
Synonyms:	sdm-1
ORF Names:	F10D11.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H⁺ = O₂ + H₂O₂.
Cofactor	Binds 1 manganese ion per subunit By similarity.
Subunit structure	Homotetramer.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Manganese Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 20188671. Source: WormBase
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 24

Mitochondrion By similarity

Chain

25 – 221

197

Superoxide dismutase [Mn] 1, mitochondrial

PRO_0000032876

Sites

Metal binding

Manganese By similarity

Metal binding

Manganese By similarity

Metal binding

182

Manganese By similarity

Metal binding

186

Manganese By similarity

Secondary structure

221

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P31161 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: EEA518B2800379F7
Show »

FASTA

221

24,537

        10         20         30         40         50         60 
MLQNTVRCVS KLVQPITGVA AVRSKHSLPD LPYDYADLEP VISHEIMQLH HQKHHATYVN 

        70         80         90        100        110        120 
NLNQIEEKLH EAVSKGNVKE AIALQPALKF NGGGHINHSI FWTNLAKDGG EPSAELLTAI 

       130        140        150        160        170        180 
KSDFGSLDNL QKQLSASTVA VQGSGWGWLG YCPKGKILKV ATCANQDPLE ATTGLVPLFG 

       190        200        210        220 
IDVWEHAYYL QYKNVRPDYV NAIWKIANWK NVSERFAKAQ Q

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of manganese superoxide dismutase gene in C.elegans." Suzuki N., Ishii N., Suzuki K. Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning, sequencing and mapping of a manganese superoxide dismutase gene of the nematode Caenorhabditis elegans." Suzuki N., Inokuma K., Yasuda K., Ishii N. DNA Res. 3:171-174(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D12984 mRNA. Translation: BAA02363.1.
D85499 Genomic DNA. Translation: BAA12821.1.
Z81057 Genomic DNA. Translation: CAB02913.1.

PIR

JC5122.

RefSeq

NP_492290.1. NM_059889.4.

UniGene

Cel.112.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DC6	X-ray	1.80	A/C	25-221	[»]

ProteinModelPortal

P31161.

SMR

P31161. Positions 25-221.

ModBase

Search...

Protein-protein interaction databases

STRING

6239.F10D11.1.1.

Proteomic databases

PaxDb

P31161.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

F10D11.1.1; F10D11.1.1; F10D11.1.
F10D11.1.2; F10D11.1.2; F10D11.1.

GeneID

172632.

KEGG

cel:CELE_F10D11.1.

UCSC

F10D11.1.1. c. elegans.

Organism-specific databases

CTD

172632.

WormBase

F10D11.1; CE09323; WBGene00004931; sod-2.

Phylogenomic databases

eggNOG

COG0605.

GeneTree

ENSGT00390000011877.

HOGENOM

HOG000013583.

InParanoid

P31161.

K04564.

OMA

MAPPGKG.

Family and domain databases

InterPro

IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]

PANTHER

PTHR11404. PTHR11404. 1 hit.

Pfam

PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000349. SODismutase. 1 hit.

PRINTS

PR01703. MNSODISMTASE.

SUPFAM

SSF46609. SODismutase. 1 hit.
SSF54719. SODismutase. 1 hit.

PROSITE

PS00088. SOD_MN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P31161.

NextBio

876347.

Entry information

Entry name

SODM1_CAEEL

Accession

Primary (citable) accession number: P31161

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents