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Protein

Superoxide dismutase [Mn] 1, mitochondrial

Gene

sod-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50ManganeseBy similarity1
Metal bindingi98ManganeseBy similarity1
Metal bindingi182ManganeseBy similarity1
Metal bindingi186ManganeseBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: WormBase
  • superoxide dismutase activity Source: WormBase

GO - Biological processi

  • removal of superoxide radicals Source: WormBase

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] 1, mitochondrial (EC:1.15.1.1)
Gene namesi
Name:sod-2
Synonyms:sdm-1
ORF Names:F10D11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF10D11.1 ; CE09323 ; WBGene00004931 ; sod-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionBy similarityAdd BLAST24
ChainiPRO_000003287625 – 221Superoxide dismutase [Mn] 1, mitochondrialAdd BLAST197

Proteomic databases

EPDiP31161
PaxDbiP31161
PeptideAtlasiP31161
PRIDEiP31161

PTM databases

iPTMnetiP31161

Expressioni

Gene expression databases

BgeeiWBGene00004931

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

  • protein homodimerization activity Source: WormBase

Protein-protein interaction databases

STRINGi6239.F10D11.1.2

Structurei

Secondary structure

1221
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni35 – 41Combined sources7
Helixi44 – 52Combined sources9
Helixi54 – 74Combined sources21
Helixi78 – 83Combined sources6
Helixi85 – 103Combined sources19
Helixi114 – 124Combined sources11
Helixi127 – 139Combined sources13
Beta strandi143 – 152Combined sources10
Turni153 – 156Combined sources4
Beta strandi157 – 164Combined sources8
Helixi169 – 173Combined sources5
Beta strandi176 – 182Combined sources7
Helixi185 – 187Combined sources3
Helixi189 – 192Combined sources4
Helixi196 – 202Combined sources7
Helixi203 – 206Combined sources4
Helixi209 – 219Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DC6X-ray1.80A/C25-221[»]
ProteinModelPortaliP31161
SMRiP31161
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31161

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
GeneTreeiENSGT00390000011877
HOGENOMiHOG000013583
InParanoidiP31161
KOiK04564
OMAiKWGSFDK
OrthoDBiEOG091G0MVL
PhylomeDBiP31161

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQNTVRCVS KLVQPITGVA AVRSKHSLPD LPYDYADLEP VISHEIMQLH
60 70 80 90 100
HQKHHATYVN NLNQIEEKLH EAVSKGNVKE AIALQPALKF NGGGHINHSI
110 120 130 140 150
FWTNLAKDGG EPSAELLTAI KSDFGSLDNL QKQLSASTVA VQGSGWGWLG
160 170 180 190 200
YCPKGKILKV ATCANQDPLE ATTGLVPLFG IDVWEHAYYL QYKNVRPDYV
210 220
NAIWKIANWK NVSERFAKAQ Q
Length:221
Mass (Da):24,537
Last modified:July 1, 1993 - v1
Checksum:iEEA518B2800379F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12984 mRNA Translation: BAA02363.1
D85499 Genomic DNA Translation: BAA12821.1
Z81057 Genomic DNA Translation: CAB02913.1
PIRiJC5122
RefSeqiNP_492290.1, NM_059889.4
UniGeneiCel.112

Genome annotation databases

EnsemblMetazoaiF10D11.1.1; F10D11.1.1; WBGene00004931
F10D11.1.2; F10D11.1.2; WBGene00004931
F10D11.1.3; F10D11.1.3; WBGene00004931
GeneIDi172632
KEGGicel:CELE_F10D11.1
UCSCiF10D11.1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSODM1_CAEEL
AccessioniPrimary (citable) accession number: P31161
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health