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Reviewed, UniProtKB/Swiss-Prot P31155 (METK1_PETCR)

Last modified September 22, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    S-adenosylmethionine synthetase 1
      Short name=AdoMet synthetase 1
    EC=2.5.1.6
Alternative name(s):
    Methionine adenosyltransferase 1
      Short name=MAT 1
Gene names
Name: SMS-1
OrganismPetroselinum crispum (Parsley) (Petroselinum hortense)
Taxonomic identifier4043 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsasteridscampanulidsApialesApiaceaeApioideaeapioid supercladeApium cladePetroselinum

Protein attributes

Sequence length234 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme By similarity.

Catalytic activity

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.

Cofactor

Binds 2 divalent ions per subunit. Magnesium or cobalt By similarity.

Binds 1 potassium ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Mainly in floral buds and roots.

Induction

By fungal elicitor.

Sequence similarities

Belongs to the AdoMet synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 234›234S-adenosylmethionine synthetase 1
PRO_0000174474

Regions

Nucleotide binding110 – 1178ATP Potential

Sites

Metal binding1141Potassium By similarity
Metal binding1221Magnesium By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P31155-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 8491086FA5D16BDA

FASTA23425,652
        10         20         30         40         50         60 
NGTCAWLRPD GKTQVTVEYQ NDHGAMVPIR VHTILISTQH DETVTNDEIA ADLKEHVIKP 

        70         80         90        100        110        120 
VVPENYLDEK TIFHLNPSGR FVIGGPHGDA GLTGRKIIID TYGGWGAHGG GAFSGKDPTK 

       130        140        150        160        170        180 
VDRSGAYIVR QAAKSIVASG LARRCIVQVS YAIGVPEPLS VFVDTYGTGK IPDREILKIV 

       190        200        210        220        230 
KETFDFRPGM ISINLDLKRG GNGRFLKTAA YGHFGREDPD FTWEVVKPLK WEKA 

« Hide

References

[1]"Induction by fungal elicitor of S-adenosyl-L-methionine synthetase and S-adenosyl-L-homocysteine hydrolase mRNAs in cultured cells and leaves of Petroselinum crispum."
Kawalleck P., Plesch G., Hahlbrock K., Somssich I.E.
Proc. Natl. Acad. Sci. U.S.A. 89:4713-4717(1992) [PubMed: 1374911] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leaf.

Cross-references

Sequence databases

M62758 mRNA. Translation: AAA33857.1.

3D structure databases

HSSPHSSP built from PDB template 1QM4 based on UniProtKB P13444.
ModBaseSearch...

Genome annotation databases

UCSCH21P03.3a. c. elegans.

Enzyme and pathway databases

BRENDA2.5.1.6. 2662.

Family and domain databases

InterProIPR002133. S-AdoMet_synthetase.
[Graphical view]
PANTHERPTHR11964. S-AdoMet_synt. 1 hit.
PfamPF02773. S-AdoMet_synt_C. 1 hit.
PF02772. S-AdoMet_synt_M. 1 hit.
[Graphical view]
PROSITEPS00376. ADOMET_SYNTHETASE_1. Partial match.
PS00377. ADOMET_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMETK1_PETCR
AccessionPrimary (citable) accession number: P31155
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 22, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents