Reviewed,
UniProtKB/Swiss-Prot P31152 (MK04_HUMAN)
Last modified
June 16, 2009.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mitogen-activated protein kinase 4 EC=2.7.11.24 Alternative name(s): Extracellular signal-regulated kinase 4 Short name=ERK-4 MAP kinase isoform p63 p63-MAPK | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 587 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Cofactor | Magnesium By similarity. |
| Tissue specificity | High expression in heart and brain. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. |
| Sequence caution | The sequence CAA42411.1 differs from that shown. Reason: Frameshift at several positions. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle |
| Coding sequence diversity | Polymorphism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylationTraceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase activityTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 587 | 587 | Mitogen-activated protein kinase 4 | PRO_0000186254 | |||||
Regions | |||||||||
| Domain | 20 – 312 | 293 | Protein kinase | ||||||
| Nucleotide binding | 26 – 34 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 149 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 49 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 186 | 1 | Phosphoserine Ref.4 | ||||||
Natural variations | |||||||||
| Natural variant | 38 | 1 | V → M: dbSNP rs3752087. Ref.5 | VAR_042254 | |||||
| Natural variant | 371 | 1 | R → P Ref.5 | VAR_042255 | |||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| X59727 mRNA. Translation: CAA42411.1. Frameshift. AK295058 mRNA. No translation available. AC012433 Genomic DNA. No translation available. AC090395 Genomic DNA. No translation available. | |
| IPI | IPI00010156. |
| PIR | S23429. |
| RefSeq | NP_002738.2. |
| UniGene | Hs.433728 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KV1 based on UniProtKB Q16539. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P31152. |
Genome annotation databases | |
| Ensembl | ENSG00000141639. Homo sapiens. [Contig view] |
| GeneID | 5596. |
| KEGG | hsa:5596. |
Organism-specific databases | |
| GeneCards | GC18P046340. |
| HGNC | HGNC:6878. MAPK4. |
| HPA | HPA007461. |
| MIM | 176949. gene. |
| PharmGKB | PA30623. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P31152. |
| OMA | P31152. PDRCQDA. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.24. 247. |
Gene expression databases | |
| ArrayExpress | P31152. |
| Bgee | P31152. |
| CleanEx | HS_MAPK4. |
| GermOnline | ENSG00000141639. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008350. Erk_3_4_MAPK. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| PRINTS | PR01771. ERK3ERK4MAPK. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | MK04_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P31152 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 18 Human chromosome 18: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


