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Protein

Protein S100-A7

Gene

S100A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Zinc1
Metal bindingi25Zinc1
Metal bindingi87Zinc1
Metal bindingi91Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 742; high affinityAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • RAGE receptor binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • epidermis development Source: ProtInc
  • innate immune response Source: UniProtKB
  • keratinocyte differentiation Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of granulocyte chemotaxis Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • positive regulation of T cell chemotaxis Source: UniProtKB
  • response to lipopolysaccharide Source: UniProtKB
  • response to reactive oxygen species Source: UniProtKB
  • sequestering of metal ion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143556-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-6799990. Metal sequestration by antimicrobial proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A7
Alternative name(s):
Psoriasin
S100 calcium-binding protein A7
Gene namesi
Name:S100A7
Synonyms:PSOR1, S100A7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10497. S100A7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6278.
OpenTargetsiENSG00000143556.
PharmGKBiPA34909.

Polymorphism and mutation databases

BioMutaiS100A7.
DMDMi172046820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001439902 – 101Protein S100-A7Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Disulfide bondi47 ↔ 96

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP31151.
MaxQBiP31151.
PaxDbiP31151.
PeptideAtlasiP31151.
PRIDEiP31151.
TopDownProteomicsiP31151.

2D gel databases

UCD-2DPAGEP31151.

PTM databases

iPTMnetiP31151.
PhosphoSitePlusiP31151.

Expressioni

Tissue specificityi

Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.1 Publication

Gene expression databases

BgeeiENSG00000143556.
CleanExiHS_S100A7.
GenevisibleiP31151. HS.

Organism-specific databases

HPAiCAB001453.
CAB033766.
HPA006997.

Interactioni

Subunit structurei

Interacts with RANBP9.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RANBP9Q96S593EBI-357520,EBI-636085

GO - Molecular functioni

  • RAGE receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112186. 45 interactors.
IntActiP31151. 20 interactors.
MINTiMINT-1156620.
STRINGi9606.ENSP00000357711.

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15
Helixi29 – 39Combined sources11
Helixi41 – 49Combined sources9
Helixi54 – 56Combined sources3
Helixi58 – 62Combined sources5
Beta strandi67 – 70Combined sources4
Helixi72 – 89Combined sources18
Turni90 – 92Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PSRX-ray1.05A/B2-101[»]
2PSRX-ray2.05A2-101[»]
2WNDX-ray1.60A2-97[»]
2WORX-ray1.70A2-101[»]
2WOSX-ray1.70A2-101[»]
3PSRX-ray2.50A/B2-101[»]
4AQJX-ray1.60A1-101[»]
ProteinModelPortaliP31151.
SMRiP31151.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31151.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiP31151.
OMAiSHGAPAC.
OrthoDBiEOG091G0Y5T.
PhylomeDBiP31151.
TreeFamiTF341148.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028477. S100A7.
[Graphical view]
PANTHERiPTHR11639:SF64. PTHR11639:SF64. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK
60 70 80 90 100
GTNYLADVFE KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS

Q
Length:101
Mass (Da):11,471
Last modified:February 26, 2008 - v4
Checksum:i02C4CE39BF140971
GO

Mass spectrometryi

Molecular mass is 11365±0.7 Da from positions 2 - 101. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03911828E → D.4 PublicationsCorresponds to variant rs3014837dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86757 mRNA. Translation: AAA60210.1.
CR542164 mRNA. Translation: CAG46961.1.
AL591704 Genomic DNA. Translation: CAI19502.1.
BC034687 mRNA. Translation: AAH34687.1.
AJ012825 Genomic DNA. Translation: CAC20409.1.
BR000043 Genomic DNA. Translation: FAA00017.1.
CCDSiCCDS1039.1.
PIRiA54327.
RefSeqiNP_002954.2. NM_002963.3.
UniGeneiHs.112408.

Genome annotation databases

EnsembliENST00000368722; ENSP00000357711; ENSG00000143556.
ENST00000368723; ENSP00000357712; ENSG00000143556.
GeneIDi6278.
KEGGihsa:6278.
UCSCiuc001fbv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86757 mRNA. Translation: AAA60210.1.
CR542164 mRNA. Translation: CAG46961.1.
AL591704 Genomic DNA. Translation: CAI19502.1.
BC034687 mRNA. Translation: AAH34687.1.
AJ012825 Genomic DNA. Translation: CAC20409.1.
BR000043 Genomic DNA. Translation: FAA00017.1.
CCDSiCCDS1039.1.
PIRiA54327.
RefSeqiNP_002954.2. NM_002963.3.
UniGeneiHs.112408.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PSRX-ray1.05A/B2-101[»]
2PSRX-ray2.05A2-101[»]
2WNDX-ray1.60A2-97[»]
2WORX-ray1.70A2-101[»]
2WOSX-ray1.70A2-101[»]
3PSRX-ray2.50A/B2-101[»]
4AQJX-ray1.60A1-101[»]
ProteinModelPortaliP31151.
SMRiP31151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112186. 45 interactors.
IntActiP31151. 20 interactors.
MINTiMINT-1156620.
STRINGi9606.ENSP00000357711.

PTM databases

iPTMnetiP31151.
PhosphoSitePlusiP31151.

Polymorphism and mutation databases

BioMutaiS100A7.
DMDMi172046820.

2D gel databases

UCD-2DPAGEP31151.

Proteomic databases

EPDiP31151.
MaxQBiP31151.
PaxDbiP31151.
PeptideAtlasiP31151.
PRIDEiP31151.
TopDownProteomicsiP31151.

Protocols and materials databases

DNASUi6278.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368722; ENSP00000357711; ENSG00000143556.
ENST00000368723; ENSP00000357712; ENSG00000143556.
GeneIDi6278.
KEGGihsa:6278.
UCSCiuc001fbv.2. human.

Organism-specific databases

CTDi6278.
DisGeNETi6278.
GeneCardsiS100A7.
H-InvDBHIX0200006.
HGNCiHGNC:10497. S100A7.
HPAiCAB001453.
CAB033766.
HPA006997.
MIMi600353. gene.
neXtProtiNX_P31151.
OpenTargetsiENSG00000143556.
PharmGKBiPA34909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiP31151.
OMAiSHGAPAC.
OrthoDBiEOG091G0Y5T.
PhylomeDBiP31151.
TreeFamiTF341148.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143556-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-6799990. Metal sequestration by antimicrobial proteins.

Miscellaneous databases

EvolutionaryTraceiP31151.
GeneWikiiS100A7.
GenomeRNAii6278.
PROiP31151.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143556.
CleanExiHS_S100A7.
GenevisibleiP31151. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028477. S100A7.
[Graphical view]
PANTHERiPTHR11639:SF64. PTHR11639:SF64. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10A7_HUMAN
AccessioniPrimary (citable) accession number: P31151
Secondary accession number(s): Q5SY67, Q6FGE3, Q9H1E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 170 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.