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Protein

Protein S100-A7

Gene

S100A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Zinc1
Metal bindingi25Zinc1
Metal bindingi87Zinc1
Metal bindingi91Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 742; high affinityAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • RAGE receptor binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • defense response to Gram-negative bacterium Source: UniProtKB
  • epidermis development Source: ProtInc
  • innate immune response Source: UniProtKB
  • keratinocyte differentiation Source: UniProtKB
  • neutrophil degranulation Source: Reactome
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of granulocyte chemotaxis Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • positive regulation of T cell chemotaxis Source: UniProtKB
  • response to lipopolysaccharide Source: UniProtKB
  • response to reactive oxygen species Source: UniProtKB
  • sequestering of metal ion Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6799990 Metal sequestration by antimicrobial proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A7
Alternative name(s):
Psoriasin
S100 calcium-binding protein A7
Gene namesi
Name:S100A7
Synonyms:PSOR1, S100A7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143556.8
HGNCiHGNC:10497 S100A7
MIMi600353 gene
neXtProtiNX_P31151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6278
OpenTargetsiENSG00000143556
PharmGKBiPA34909

Chemistry databases

DrugBankiDB04474 1-Anilino-8-Naphthalene Sulfonate

Polymorphism and mutation databases

BioMutaiS100A7
DMDMi172046820

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001439902 – 101Protein S100-A7Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Disulfide bondi47 ↔ 96

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP31151
MaxQBiP31151
PaxDbiP31151
PeptideAtlasiP31151
PRIDEiP31151
TopDownProteomicsiP31151

2D gel databases

UCD-2DPAGEiP31151

PTM databases

iPTMnetiP31151
PhosphoSitePlusiP31151

Expressioni

Tissue specificityi

Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.1 Publication

Gene expression databases

BgeeiENSG00000143556
CleanExiHS_S100A7
GenevisibleiP31151 HS

Organism-specific databases

HPAiCAB001453
CAB033766
HPA006997

Interactioni

Subunit structurei

Interacts with RANBP9.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • RAGE receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112186, 52 interactors
IntActiP31151, 23 interactors
STRINGi9606.ENSP00000357711

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15
Helixi29 – 39Combined sources11
Helixi41 – 49Combined sources9
Helixi54 – 56Combined sources3
Helixi58 – 62Combined sources5
Beta strandi67 – 70Combined sources4
Helixi72 – 89Combined sources18
Turni90 – 92Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PSRX-ray1.05A/B2-101[»]
2PSRX-ray2.05A2-101[»]
2WNDX-ray1.60A2-97[»]
2WORX-ray1.70A2-101[»]
2WOSX-ray1.70A2-101[»]
3PSRX-ray2.50A/B2-101[»]
4AQJX-ray1.60A1-101[»]
ProteinModelPortaliP31151
SMRiP31151
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31151

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JEQ8 Eukaryota
ENOG41114XT LUCA
GeneTreeiENSGT00910000144342
HOGENOMiHOG000154231
HOVERGENiHBG095357
InParanoidiP31151
KOiK21126
OMAiSHGAPAC
OrthoDBiEOG091G0Y5T
PhylomeDBiP31151
TreeFamiTF341148

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
IPR028477 S100A7
PANTHERiPTHR11639:SF64 PTHR11639:SF64, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK
60 70 80 90 100
GTNYLADVFE KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS

Q
Length:101
Mass (Da):11,471
Last modified:February 26, 2008 - v4
Checksum:i02C4CE39BF140971
GO

Mass spectrometryi

Molecular mass is 11365±0.7 Da from positions 2 - 101. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03911828E → D4 PublicationsCorresponds to variant dbSNP:rs3014837Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86757 mRNA Translation: AAA60210.1
CR542164 mRNA Translation: CAG46961.1
AL591704 Genomic DNA No translation available.
BC034687 mRNA Translation: AAH34687.1
AJ012825 Genomic DNA Translation: CAC20409.1
BR000043 Genomic DNA Translation: FAA00017.1
CCDSiCCDS1039.1
PIRiA54327
RefSeqiNP_002954.2, NM_002963.3
UniGeneiHs.112408

Genome annotation databases

EnsembliENST00000368722; ENSP00000357711; ENSG00000143556
ENST00000368723; ENSP00000357712; ENSG00000143556
GeneIDi6278
KEGGihsa:6278
UCSCiuc001fbv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS10A7_HUMAN
AccessioniPrimary (citable) accession number: P31151
Secondary accession number(s): Q5SY67, Q6FGE3, Q9H1E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 181 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health