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P31150

- GDIA_HUMAN

UniProt

P31150 - GDIA_HUMAN

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Protein

Rab GDP dissociation inhibitor alpha

Gene

GDI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.1 Publication

GO - Molecular functioni

  1. GDP-dissociation inhibitor activity Source: ProtInc
  2. GTPase activator activity Source: UniProtKB-KW
  3. Rab GDP-dissociation inhibitor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of axonogenesis Source: UniProtKB
  2. negative regulation of protein targeting to membrane Source: UniProtKB
  3. protein transport Source: InterPro
  4. Rab protein signal transduction Source: UniProtKB
  5. regulation of catalytic activity Source: GOC
  6. regulation of small GTPase mediated signal transduction Source: Reactome
  7. response to calcium ion Source: Ensembl
  8. signal transduction Source: ProtInc
  9. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor alpha
Short name:
Rab GDI alpha
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 1
Short name:
GDI-1
Oligophrenin-2
Protein XAP-4
Gene namesi
Name:GDI1
Synonyms:GDIL, OPHN2, RABGDIA, XAP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:4226. GDI1.

Subcellular locationi

Cytoplasm 1 Publication. Golgi apparatustrans-Golgi network 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. cytosol Source: Reactome
  3. Golgi apparatus Source: UniProtKB-KW
  4. midbody Source: UniProtKB
  5. neuron projection Source: Ensembl
  6. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 41 (MRX41) [MIM:300849]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921L → P in MRX41; causes reduced binding and recycling of RAB3A. 1 Publication
VAR_008130
Natural varianti423 – 4231R → P in MRX41. 1 Publication
VAR_008131

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi300849. phenotype.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA28641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Rab GDP dissociation inhibitor alphaPRO_0000056671Add
BLAST

Proteomic databases

MaxQBiP31150.
PaxDbiP31150.
PeptideAtlasiP31150.
PRIDEiP31150.

2D gel databases

OGPiP31150.
REPRODUCTION-2DPAGEIPI00010154.
UCD-2DPAGEP31150.

PTM databases

PhosphoSiteiP31150.

Expressioni

Tissue specificityi

Brain; predominant in neural and sensory tissues.1 Publication

Gene expression databases

BgeeiP31150.
CleanExiHS_GDI1.
ExpressionAtlasiP31150. baseline and differential.
GenevestigatoriP31150.

Organism-specific databases

HPAiCAB012979.
HPA049290.

Interactioni

Subunit structurei

Interacts with RHOH. Interacts with RAB1A, RAB3A, RAB5A and RAB10.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Rab10P610273EBI-946999,EBI-911581From a different organism.
RAB4AP203382EBI-946999,EBI-722284

Protein-protein interaction databases

BioGridi108932. 31 interactions.
IntActiP31150. 11 interactions.
MINTiMINT-2859157.
STRINGi9606.ENSP00000394071.

Structurei

3D structure databases

ProteinModelPortaliP31150.
SMRiP31150. Positions 1-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiCOG5044.
GeneTreeiENSGT00530000063044.
HOVERGENiHBG000839.
InParanoidiP31150.
KOiK17255.
OMAiKTWKDFD.
PhylomeDBiP31150.
TreeFamiTF300449.

Family and domain databases

InterProiIPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
[Graphical view]
PfamiPF00996. GDI. 1 hit.
[Graphical view]
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.

Sequencei

Sequence statusi: Complete.

P31150-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE
60 70 80 90 100
ELYKRFQLLE GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVVEGSFV YKGGKIYKVP STETEALASN LMGMFEKRRF RKFLVFVANF
160 170 180 190 200
DENDPKTFEG VDPQTTSMRD VYRKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCLETVNRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI
360 370 380 390 400
AIASTTVETT DPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGCESQVFC
410 420 430 440
SCSYDATTHF ETTCNDIKDI YKRMAGTAFD FENMKRKQND VFGEAEQ
Length:447
Mass (Da):50,583
Last modified:October 1, 1996 - v2
Checksum:iBC283A445E50A652
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341D → G in BAA08078. (PubMed:7585614)Curated
Sequence conflicti36 – 361N → K in BAA08078. (PubMed:7585614)Curated
Sequence conflicti149 – 1513NFD → GTY in BAA08078. (PubMed:7585614)Curated
Sequence conflicti347 – 3471G → V in AAC15851. 1 PublicationCurated
Sequence conflicti409 – 4091H → Q in AAC15851. 1 PublicationCurated
Sequence conflicti416 – 4161D → G in AAC15851. 1 PublicationCurated
Sequence conflicti442 – 4421F → S in BAA08078. (PubMed:7585614)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921L → P in MRX41; causes reduced binding and recycling of RAB3A. 1 Publication
VAR_008130
Natural varianti423 – 4231R → P in MRX41. 1 Publication
VAR_008131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79353 mRNA. Translation: CAA55908.1.
X79354
, X79355, X79356, X79357, X79358, X79359, X79360, X79364, X79361, X79362, X79363 Genomic DNA. Translation: CAA55909.1.
D45021 mRNA. Translation: BAA08078.1.
L44140 Genomic DNA. Translation: AAA92648.1.
AF400433 mRNA. Translation: AAK92482.1.
AB101741 Genomic DNA. Translation: BAC80330.1.
AB101742 Genomic DNA. Translation: BAC80331.1.
AB101743 Genomic DNA. Translation: BAC80332.1.
AB101744 Genomic DNA. Translation: BAC80333.1.
AB101745 Genomic DNA. Translation: BAC80334.1.
AB101746 Genomic DNA. Translation: BAC80335.1.
AB101747 Genomic DNA. Translation: BAC80336.1.
AB101748 Genomic DNA. Translation: BAC80337.1.
AB101749 Genomic DNA. Translation: BAC80338.1.
AB101750 Genomic DNA. Translation: BAC80339.1.
AB101751 Genomic DNA. Translation: BAC80340.1.
AB101752 Genomic DNA. Translation: BAC80341.1.
AB101753 Genomic DNA. Translation: BAC80342.1.
AB101754 Genomic DNA. Translation: BAC80343.1.
AB101755 Genomic DNA. Translation: BAC80344.1.
AB101756 Genomic DNA. Translation: BAC80345.1.
AB101757 Genomic DNA. Translation: BAC80346.1.
AB101758 Genomic DNA. Translation: BAC80347.1.
AB101759 Genomic DNA. Translation: BAC80348.1.
AB101760 Genomic DNA. Translation: BAC80349.1.
AB101771 Genomic DNA. Translation: BAC80360.1.
AB101772 Genomic DNA. Translation: BAC80361.1.
AB101773 Genomic DNA. Translation: BAC80362.1.
AB101774 Genomic DNA. Translation: BAC80363.1.
AB101775 Genomic DNA. Translation: BAC80364.1.
AB101776 Genomic DNA. Translation: BAC80365.1.
AB101777 Genomic DNA. Translation: BAC80366.1.
AB101778 Genomic DNA. Translation: BAC80367.1.
AB101779 Genomic DNA. Translation: BAC80368.1.
AB101780 Genomic DNA. Translation: BAC80369.1.
AB101781 Genomic DNA. Translation: BAC80370.1.
AB101782 Genomic DNA. Translation: BAC80371.1.
AB101783 Genomic DNA. Translation: BAC80372.1.
AB101784 Genomic DNA. Translation: BAC80373.1.
AB101785 Genomic DNA. Translation: BAC80374.1.
AB101786 Genomic DNA. Translation: BAC80375.1.
AB101787 Genomic DNA. Translation: BAC80376.1.
AB101788 Genomic DNA. Translation: BAC80377.1.
AB101789 Genomic DNA. Translation: BAC80378.1.
AB101790 Genomic DNA. Translation: BAC80379.1.
AB101801 Genomic DNA. Translation: BAC80390.1.
AB101802 Genomic DNA. Translation: BAC80391.1.
AB101803 Genomic DNA. Translation: BAC80392.1.
AB101804 Genomic DNA. Translation: BAC80393.1.
AB101805 Genomic DNA. Translation: BAC80394.1.
AB101806 Genomic DNA. Translation: BAC80395.1.
AB101807 Genomic DNA. Translation: BAC80396.1.
AB101808 Genomic DNA. Translation: BAC80397.1.
AB101809 Genomic DNA. Translation: BAC80398.1.
AB101810 Genomic DNA. Translation: BAC80399.1.
AB101811 Genomic DNA. Translation: BAC80400.1.
AB101812 Genomic DNA. Translation: BAC80401.1.
AB101813 Genomic DNA. Translation: BAC80402.1.
AB101814 Genomic DNA. Translation: BAC80403.1.
AB101815 Genomic DNA. Translation: BAC80404.1.
AB101816 Genomic DNA. Translation: BAC80405.1.
AB101817 Genomic DNA. Translation: BAC80406.1.
AB101818 Genomic DNA. Translation: BAC80407.1.
AB101819 Genomic DNA. Translation: BAC80408.1.
AB101820 Genomic DNA. Translation: BAC80409.1.
AB101831 Genomic DNA. Translation: BAC80420.1.
AB101832 Genomic DNA. Translation: BAC80421.1.
AB101833 Genomic DNA. Translation: BAC80422.1.
AB101834 Genomic DNA. Translation: BAC80423.1.
AB101835 Genomic DNA. Translation: BAC80424.1.
AB101836 Genomic DNA. Translation: BAC80425.1.
AB101837 Genomic DNA. Translation: BAC80426.1.
AB101838 Genomic DNA. Translation: BAC80427.1.
AB101839 Genomic DNA. Translation: BAC80428.1.
AB101840 Genomic DNA. Translation: BAC80429.1.
AB101841 Genomic DNA. Translation: BAC80430.1.
AB101842 Genomic DNA. Translation: BAC80431.1.
AB101843 Genomic DNA. Translation: BAC80432.1.
AB101844 Genomic DNA. Translation: BAC80433.1.
AB101845 Genomic DNA. Translation: BAC80434.1.
AB101846 Genomic DNA. Translation: BAC80435.1.
AB101847 Genomic DNA. Translation: BAC80436.1.
AB101848 Genomic DNA. Translation: BAC80437.1.
AB101849 Genomic DNA. Translation: BAC80438.1.
AB101850 Genomic DNA. Translation: BAC80439.1.
AB102647 mRNA. Translation: BAC81116.1.
CR542258 mRNA. Translation: CAG47054.1.
CR542276 mRNA. Translation: CAG47072.1.
BT019884 mRNA. Translation: AAV38687.1.
BX936385 Genomic DNA. Translation: CAI95780.1.
CH471172 Genomic DNA. Translation: EAW72710.1.
BC000317 mRNA. Translation: AAH00317.1.
BC012201 mRNA. Translation: AAH12201.1.
U14623 Genomic DNA. Translation: AAA21558.1.
L05086 mRNA. Translation: AAC15851.1.
CCDSiCCDS35452.1.
PIRiI37082.
RefSeqiNP_001484.1. NM_001493.2.
UniGeneiHs.595950.
Hs.74576.

Genome annotation databases

EnsembliENST00000447750; ENSP00000394071; ENSG00000203879.
GeneIDi2664.
KEGGihsa:2664.
UCSCiuc004fli.4. human.

Polymorphism databases

DMDMi1707886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79353 mRNA. Translation: CAA55908.1 .
X79354
, X79355 , X79356 , X79357 , X79358 , X79359 , X79360 , X79364 , X79361 , X79362 , X79363 Genomic DNA. Translation: CAA55909.1 .
D45021 mRNA. Translation: BAA08078.1 .
L44140 Genomic DNA. Translation: AAA92648.1 .
AF400433 mRNA. Translation: AAK92482.1 .
AB101741 Genomic DNA. Translation: BAC80330.1 .
AB101742 Genomic DNA. Translation: BAC80331.1 .
AB101743 Genomic DNA. Translation: BAC80332.1 .
AB101744 Genomic DNA. Translation: BAC80333.1 .
AB101745 Genomic DNA. Translation: BAC80334.1 .
AB101746 Genomic DNA. Translation: BAC80335.1 .
AB101747 Genomic DNA. Translation: BAC80336.1 .
AB101748 Genomic DNA. Translation: BAC80337.1 .
AB101749 Genomic DNA. Translation: BAC80338.1 .
AB101750 Genomic DNA. Translation: BAC80339.1 .
AB101751 Genomic DNA. Translation: BAC80340.1 .
AB101752 Genomic DNA. Translation: BAC80341.1 .
AB101753 Genomic DNA. Translation: BAC80342.1 .
AB101754 Genomic DNA. Translation: BAC80343.1 .
AB101755 Genomic DNA. Translation: BAC80344.1 .
AB101756 Genomic DNA. Translation: BAC80345.1 .
AB101757 Genomic DNA. Translation: BAC80346.1 .
AB101758 Genomic DNA. Translation: BAC80347.1 .
AB101759 Genomic DNA. Translation: BAC80348.1 .
AB101760 Genomic DNA. Translation: BAC80349.1 .
AB101771 Genomic DNA. Translation: BAC80360.1 .
AB101772 Genomic DNA. Translation: BAC80361.1 .
AB101773 Genomic DNA. Translation: BAC80362.1 .
AB101774 Genomic DNA. Translation: BAC80363.1 .
AB101775 Genomic DNA. Translation: BAC80364.1 .
AB101776 Genomic DNA. Translation: BAC80365.1 .
AB101777 Genomic DNA. Translation: BAC80366.1 .
AB101778 Genomic DNA. Translation: BAC80367.1 .
AB101779 Genomic DNA. Translation: BAC80368.1 .
AB101780 Genomic DNA. Translation: BAC80369.1 .
AB101781 Genomic DNA. Translation: BAC80370.1 .
AB101782 Genomic DNA. Translation: BAC80371.1 .
AB101783 Genomic DNA. Translation: BAC80372.1 .
AB101784 Genomic DNA. Translation: BAC80373.1 .
AB101785 Genomic DNA. Translation: BAC80374.1 .
AB101786 Genomic DNA. Translation: BAC80375.1 .
AB101787 Genomic DNA. Translation: BAC80376.1 .
AB101788 Genomic DNA. Translation: BAC80377.1 .
AB101789 Genomic DNA. Translation: BAC80378.1 .
AB101790 Genomic DNA. Translation: BAC80379.1 .
AB101801 Genomic DNA. Translation: BAC80390.1 .
AB101802 Genomic DNA. Translation: BAC80391.1 .
AB101803 Genomic DNA. Translation: BAC80392.1 .
AB101804 Genomic DNA. Translation: BAC80393.1 .
AB101805 Genomic DNA. Translation: BAC80394.1 .
AB101806 Genomic DNA. Translation: BAC80395.1 .
AB101807 Genomic DNA. Translation: BAC80396.1 .
AB101808 Genomic DNA. Translation: BAC80397.1 .
AB101809 Genomic DNA. Translation: BAC80398.1 .
AB101810 Genomic DNA. Translation: BAC80399.1 .
AB101811 Genomic DNA. Translation: BAC80400.1 .
AB101812 Genomic DNA. Translation: BAC80401.1 .
AB101813 Genomic DNA. Translation: BAC80402.1 .
AB101814 Genomic DNA. Translation: BAC80403.1 .
AB101815 Genomic DNA. Translation: BAC80404.1 .
AB101816 Genomic DNA. Translation: BAC80405.1 .
AB101817 Genomic DNA. Translation: BAC80406.1 .
AB101818 Genomic DNA. Translation: BAC80407.1 .
AB101819 Genomic DNA. Translation: BAC80408.1 .
AB101820 Genomic DNA. Translation: BAC80409.1 .
AB101831 Genomic DNA. Translation: BAC80420.1 .
AB101832 Genomic DNA. Translation: BAC80421.1 .
AB101833 Genomic DNA. Translation: BAC80422.1 .
AB101834 Genomic DNA. Translation: BAC80423.1 .
AB101835 Genomic DNA. Translation: BAC80424.1 .
AB101836 Genomic DNA. Translation: BAC80425.1 .
AB101837 Genomic DNA. Translation: BAC80426.1 .
AB101838 Genomic DNA. Translation: BAC80427.1 .
AB101839 Genomic DNA. Translation: BAC80428.1 .
AB101840 Genomic DNA. Translation: BAC80429.1 .
AB101841 Genomic DNA. Translation: BAC80430.1 .
AB101842 Genomic DNA. Translation: BAC80431.1 .
AB101843 Genomic DNA. Translation: BAC80432.1 .
AB101844 Genomic DNA. Translation: BAC80433.1 .
AB101845 Genomic DNA. Translation: BAC80434.1 .
AB101846 Genomic DNA. Translation: BAC80435.1 .
AB101847 Genomic DNA. Translation: BAC80436.1 .
AB101848 Genomic DNA. Translation: BAC80437.1 .
AB101849 Genomic DNA. Translation: BAC80438.1 .
AB101850 Genomic DNA. Translation: BAC80439.1 .
AB102647 mRNA. Translation: BAC81116.1 .
CR542258 mRNA. Translation: CAG47054.1 .
CR542276 mRNA. Translation: CAG47072.1 .
BT019884 mRNA. Translation: AAV38687.1 .
BX936385 Genomic DNA. Translation: CAI95780.1 .
CH471172 Genomic DNA. Translation: EAW72710.1 .
BC000317 mRNA. Translation: AAH00317.1 .
BC012201 mRNA. Translation: AAH12201.1 .
U14623 Genomic DNA. Translation: AAA21558.1 .
L05086 mRNA. Translation: AAC15851.1 .
CCDSi CCDS35452.1.
PIRi I37082.
RefSeqi NP_001484.1. NM_001493.2.
UniGenei Hs.595950.
Hs.74576.

3D structure databases

ProteinModelPortali P31150.
SMRi P31150. Positions 1-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108932. 31 interactions.
IntActi P31150. 11 interactions.
MINTi MINT-2859157.
STRINGi 9606.ENSP00000394071.

PTM databases

PhosphoSitei P31150.

Polymorphism databases

DMDMi 1707886.

2D gel databases

OGPi P31150.
REPRODUCTION-2DPAGE IPI00010154.
UCD-2DPAGE P31150.

Proteomic databases

MaxQBi P31150.
PaxDbi P31150.
PeptideAtlasi P31150.
PRIDEi P31150.

Protocols and materials databases

DNASUi 2664.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000447750 ; ENSP00000394071 ; ENSG00000203879 .
GeneIDi 2664.
KEGGi hsa:2664.
UCSCi uc004fli.4. human.

Organism-specific databases

CTDi 2664.
GeneCardsi GC0XP153665.
H-InvDB HIX0056464.
HGNCi HGNC:4226. GDI1.
HPAi CAB012979.
HPA049290.
MIMi 300104. gene.
300849. phenotype.
neXtProti NX_P31150.
Orphaneti 777. X-linked non-syndromic intellectual disability.
PharmGKBi PA28641.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5044.
GeneTreei ENSGT00530000063044.
HOVERGENi HBG000839.
InParanoidi P31150.
KOi K17255.
OMAi KTWKDFD.
PhylomeDBi P31150.
TreeFami TF300449.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi GDI1. human.
GeneWikii GDI1.
GenomeRNAii 2664.
NextBioi 10512.
PROi P31150.
SOURCEi Search...

Gene expression databases

Bgeei P31150.
CleanExi HS_GDI1.
ExpressionAtlasi P31150. baseline and differential.
Genevestigatori P31150.

Family and domain databases

InterProi IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
[Graphical view ]
Pfami PF00996. GDI. 1 hit.
[Graphical view ]
PRINTSi PR00892. RABGDI.
PR00891. RABGDIREP.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI)."
    Sedlacek Z., Konecki D.S., Korn B., Klauck S.M., Poustka A.
    Mamm. Genome 5:633-639(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens."
    Nishimura N., Goji J., Nakamura H., Orita S., Takai Y., Sano K.
    Cancer Res. 55:5445-5450(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  3. "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."
    Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L., Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M.
    Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. Feng Z., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees."
    Kitano T., Schwarz C., Nickel B., Paeaebo S.
    Mol. Biol. Evol. 20:1281-1289(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  11. "Rapid identification of gene sequences for transcriptional map assembly by direct cDNA screening of genomic reference libraries."
    Hochgeschwender U.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-181.
  12. Lubec G., Vishwanath V.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 143-156; 174-193 AND 222-240, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Cajal-Retzius cell.
  13. Bhat K.S.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 328-436.
  14. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
    Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
    Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 349-361.
    Tissue: Keratinocyte.
  15. "Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport."
    Bachner D., Sedlacek Z., Korn B., Hameister H., Poustka A.
    Hum. Mol. Genet. 4:701-708(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  16. "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function."
    Li X., Bu X., Lu B., Avraham H., Flavell R.A., Lim B.
    Mol. Cell. Biol. 22:1158-1171(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RHOH.
  17. "GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation."
    Chen Y., Deng Y., Zhang J., Yang L., Xie X., Xu T.
    Biochem. J. 422:229-235(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB10, SUBCELLULAR LOCATION.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy."
    Kirsten M.L., Baron R.A., Seabra M.C., Ces O.
    Mol. Membr. Biol. 30:303-314(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB1A AND RAB5A, FUNCTION.
  20. Cited for: VARIANT MRX41 PRO-92.
  21. Cited for: VARIANT MRX41 PRO-423.

Entry informationi

Entry nameiGDIA_HUMAN
AccessioniPrimary (citable) accession number: P31150
Secondary accession number(s): P50394
, Q6FG50, Q7Z2G6, Q7Z2G9, Q7Z2H5, Q7Z2I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3