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P31146

- COR1A_HUMAN

UniProt

P31146 - COR1A_HUMAN

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Protein
Coronin-1A
Gene
CORO1A, CORO1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.1 Publication

GO - Molecular functioni

  1. actin filament binding Source: UniProtKB
  2. cytoskeletal protein binding Source: UniProtKB
  3. phosphatidylinositol 3-kinase binding Source: UniProtKB
  4. poly(A) RNA binding Source: UniProtKB
  5. protein C-terminus binding Source: UniProtKB
  6. protein binding Source: UniProtKB
  7. protein homodimerization activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. T cell homeostasis Source: Ensembl
  2. actin cytoskeleton organization Source: UniProtKB
  3. actin filament organization Source: Ensembl
  4. calcium ion transport Source: Ensembl
  5. cell-substrate adhesion Source: UniProtKB
  6. cellular component movement Source: UniProtKB
  7. cellular response to interleukin-4 Source: Ensembl
  8. homeostasis of number of cells within a tissue Source: Ensembl
  9. innate immune response Source: UniProtKB
  10. leukocyte chemotaxis Source: RefGenome
  11. negative regulation of actin nucleation Source: UniProtKB
  12. phagocytosis Source: UniProtKB
  13. phagolysosome assembly Source: UniProtKB
  14. positive chemotaxis Source: UniProtKB
  15. positive regulation of T cell proliferation Source: Ensembl
  16. positive regulation of cell migration Source: Ensembl
  17. regulation of actin filament polymerization Source: Ensembl
  18. regulation of cell shape Source: RefGenome
  19. uropod organization Source: RefGenome
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiP31146.

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1A
Alternative name(s):
Coronin-like protein A
Short name:
Clipin-A
Coronin-like protein p57
Tryptophan aspartate-containing coat protein
Short name:
TACO
Gene namesi
Name:CORO1A
Synonyms:CORO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:2252. CORO1A.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cytoplasmcell cortex By similarity. Cytoplasmic vesiclephagosome membrane By similarity
Note: In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification By similarity.

GO - Cellular componenti

  1. actin filament Source: UniProtKB
  2. cortical actin cytoskeleton Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. immunological synapse Source: Ensembl
  6. lamellipodium Source: UniProtKB
  7. phagocytic cup Source: UniProtKB
  8. phagocytic vesicle Source: UniProtKB
  9. phagocytic vesicle membrane Source: UniProtKB-SubCell
  10. plasma membrane Source: UniProtKB
  11. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 8 (IMD8) [MIM:615401]: A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341V → M in IMD8; the mutation causes a decrease in protein stability; patient T-cell blasts show delayed activation of signaling molecules MAPK3 and MAPK1. 1 Publication
VAR_070447

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi615401. phenotype.
Orphaneti228003. Severe combined immunodeficiency due to CORO1A deficiency.
PharmGKBiPA26768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 461460Coronin-1A
PRO_0000050920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei2 – 21Phosphoserine; by PKC1 Publication
Modified residuei412 – 4121Phosphothreonine; by PKC1 Publication
Modified residuei449 – 4491N6-acetyllysine1 Publication

Post-translational modificationi

phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP31146.
PaxDbiP31146.
PeptideAtlasiP31146.
PRIDEiP31146.

2D gel databases

OGPiP31146.
UCD-2DPAGEP31146.

PTM databases

PhosphoSiteiP31146.

Expressioni

Tissue specificityi

Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Gene expression databases

ArrayExpressiP31146.
BgeeiP31146.
CleanExiHS_CORO1A.
GenevestigatoriP31146.

Organism-specific databases

HPAiCAB046473.
HPA051132.

Interactioni

Subunit structurei

Binds actin.

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-1046676,EBI-518675

Protein-protein interaction databases

BioGridi116322. 16 interactions.
IntActiP31146. 18 interactions.
MINTiMINT-263387.
STRINGi9606.ENSP00000219150.

Structurei

3D structure databases

ProteinModelPortaliP31146.
SMRiP31146. Positions 9-394, 430-461.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 6351WD 1
Add
BLAST
Repeati73 – 11038WD 2
Add
BLAST
Repeati123 – 16038WD 3
Add
BLAST
Repeati164 – 20441WD 4
Add
BLAST
Repeati207 – 25145WD 5
Add
BLAST
Repeati258 – 29639WD 6
Add
BLAST
Repeati302 – 34948WD 7
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili424 – 46037 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat coronin family.
Contains 7 WD repeats.

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiP31146.
KOiK13882.
OMAiFMALICE.
PhylomeDBiP31146.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR029508. CORO1A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF18. PTHR10856:SF18. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31146-1 [UniParc]FASTAAdd to Basket

« Hide

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI    50
CEASGGGAFL VLPLGKTGRV DKNAPTVCGH TAPVLDIAWC PHNDNVIASG 100
SEDCTVMVWE IPDGGLMLPL REPVVTLEGH TKRVGIVAWH TTAQNVLLSA 150
GCDNVIMVWD VGTGAAMLTL GPEVHPDTIY SVDWSRDGGL ICTSCRDKRV 200
RIIEPRKGTV VAEKDRPHEG TRPVRAVFVS EGKILTTGFS RMSERQVALW 250
DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE 300
APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERRCEPIAM 350
TVPRKSDLFQ EDLYPPTAGP DPALTAEEWL GGRDAGPLLI SLKDGYVPPK 400
SRELRVNRGL DTGRRRAAPE ASGTPSSDAV SRLEEEMRKL QATVQELQKR 450
LDRLEETVQA K 461
Length:461
Mass (Da):51,026
Last modified:January 23, 2007 - v4
Checksum:iDE3FEDA57041515E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341V → M in IMD8; the mutation causes a decrease in protein stability; patient T-cell blasts show delayed activation of signaling molecules MAPK3 and MAPK1. 1 Publication
VAR_070447
Natural varianti415 – 4151R → K.
Corresponds to variant rs1804109 [ dbSNP | Ensembl ].
VAR_011956
Natural varianti443 – 4431T → P.
Corresponds to variant rs1053574 [ dbSNP | Ensembl ].
VAR_011957

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81S → T in AAA77058. 1 Publication
Sequence conflicti245 – 2451R → W in AAA77058. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D44497 mRNA. Translation: BAA07940.1.
X89109 mRNA. Translation: CAA61482.1.
U34690 mRNA. Translation: AAA77058.1.
AF495470 mRNA. Translation: AAM18516.1.
AK314714 mRNA. Translation: BAG37258.1.
CH471238 Genomic DNA. Translation: EAW79906.1.
BC110374 mRNA. Translation: AAI10375.1.
BC126385 mRNA. Translation: AAI26386.1.
BC126387 mRNA. Translation: AAI26388.1.
CCDSiCCDS10673.1.
PIRiS65665.
RefSeqiNP_001180262.1. NM_001193333.2.
NP_009005.1. NM_007074.3.
UniGeneiHs.415067.

Genome annotation databases

EnsembliENST00000219150; ENSP00000219150; ENSG00000102879.
ENST00000570045; ENSP00000455552; ENSG00000102879.
GeneIDi11151.
KEGGihsa:11151.
UCSCiuc002dww.3. human.

Polymorphism databases

DMDMi1706004.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D44497 mRNA. Translation: BAA07940.1 .
X89109 mRNA. Translation: CAA61482.1 .
U34690 mRNA. Translation: AAA77058.1 .
AF495470 mRNA. Translation: AAM18516.1 .
AK314714 mRNA. Translation: BAG37258.1 .
CH471238 Genomic DNA. Translation: EAW79906.1 .
BC110374 mRNA. Translation: AAI10375.1 .
BC126385 mRNA. Translation: AAI26386.1 .
BC126387 mRNA. Translation: AAI26388.1 .
CCDSi CCDS10673.1.
PIRi S65665.
RefSeqi NP_001180262.1. NM_001193333.2.
NP_009005.1. NM_007074.3.
UniGenei Hs.415067.

3D structure databases

ProteinModelPortali P31146.
SMRi P31146. Positions 9-394, 430-461.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116322. 16 interactions.
IntActi P31146. 18 interactions.
MINTi MINT-263387.
STRINGi 9606.ENSP00000219150.

PTM databases

PhosphoSitei P31146.

Polymorphism databases

DMDMi 1706004.

2D gel databases

OGPi P31146.
UCD-2DPAGE P31146.

Proteomic databases

MaxQBi P31146.
PaxDbi P31146.
PeptideAtlasi P31146.
PRIDEi P31146.

Protocols and materials databases

DNASUi 11151.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219150 ; ENSP00000219150 ; ENSG00000102879 .
ENST00000570045 ; ENSP00000455552 ; ENSG00000102879 .
GeneIDi 11151.
KEGGi hsa:11151.
UCSCi uc002dww.3. human.

Organism-specific databases

CTDi 11151.
GeneCardsi GC16P030194.
HGNCi HGNC:2252. CORO1A.
HPAi CAB046473.
HPA051132.
MIMi 605000. gene.
615401. phenotype.
neXtProti NX_P31146.
Orphaneti 228003. Severe combined immunodeficiency due to CORO1A deficiency.
PharmGKBi PA26768.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000166356.
HOVERGENi HBG059978.
InParanoidi P31146.
KOi K13882.
OMAi FMALICE.
PhylomeDBi P31146.
TreeFami TF314280.

Enzyme and pathway databases

SignaLinki P31146.

Miscellaneous databases

GeneWikii CORO1A.
GenomeRNAii 11151.
NextBioi 42396.
PROi P31146.
SOURCEi Search...

Gene expression databases

ArrayExpressi P31146.
Bgeei P31146.
CleanExi HS_CORO1A.
Genevestigatori P31146.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR029508. CORO1A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR10856. PTHR10856. 1 hit.
PTHR10856:SF18. PTHR10856:SF18. 1 hit.
Pfami PF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif."
    Suzuki K., Nishihata J., Arai Y., Honma N., Yamamoto K., Irimura T., Toyoshima S.
    FEBS Lett. 364:283-288(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood leukocyte.
  2. Grogan A., Keep N.H., Reeves E., Segal A.W.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Liau G., Popa I., Argraves K., Argraves W.S.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  4. "A new therapeutic strategy of mycobacterium infection by use of anti-TACO sequence."
    Kohchi C., Inagawa H., Makino K., Terada H., Soma G.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.
    Submitted (MAY-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-9; 50-65; 242-252; 433-448 AND 453-460, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: T-cell.
  9. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
    Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
    Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 355-374.
    Tissue: Keratinocyte.
  10. "A coat protein on phagosomes involved in the intracellular survival of mycobacteria."
    Ferrari G., Langen H., Naito M., Pieters J.
    Cell 97:435-447(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN PHAGOSOME TRAFFICKING.
  11. "Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion."
    Shiow L.R., Paris K., Akana M.C., Cyster J.G., Sorensen R.U., Puck J.M.
    Clin. Immunol. 131:24-30(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN IMD8.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-449, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A."
    Ichikawa D., Mizuno M., Yamamura T., Miyake S.
    J. Biol. Chem. 286:43465-43474(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY RNF128.
  16. "Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin."
    Oku T., Nakano M., Kaneko Y., Ando Y., Kenmotsu H., Itoh S., Tsuiji M., Seyama Y., Toyoshima S., Tsuji T.
    J. Biol. Chem. 287:42910-42920(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-2 AND THR-412, INTERACTION WITH ACTIN.
  17. "Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation."
    Moshous D., Martin E., Carpentier W., Lim A., Callebaut I., Canioni D., Hauck F., Majewski J., Schwartzentruber J., Nitschke P., Sirvent N., Frange P., Picard C., Blanche S., Revy P., Fischer A., Latour S., Jabado N., de Villartay J.P.
    J. Allergy Clin. Immunol. 131:1594-1603(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT IMD8 MET-134, CHARACTERIZATION OF VARIANT IMD8 MET-134.

Entry informationi

Entry nameiCOR1A_HUMAN
AccessioniPrimary (citable) accession number: P31146
Secondary accession number(s): B2RBL1, Q2YD73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi