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Protein

Coronin-1A

Gene

CORO1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • actin monomer binding Source: UniProtKB
  • cytoskeletal protein binding Source: UniProtKB
  • myosin heavy chain binding Source: UniProtKB
  • phosphatidylinositol 3-kinase binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • actin filament organization Source: Ensembl
  • calcium ion transport Source: Ensembl
  • cell-substrate adhesion Source: UniProtKB
  • cellular response to interleukin-4 Source: Ensembl
  • early endosome to recycling endosome transport Source: Ensembl
  • homeostasis of number of cells within a tissue Source: Ensembl
  • innate immune response Source: UniProtKB
  • leukocyte chemotaxis Source: Ensembl
  • movement of cell or subcellular component Source: UniProtKB
  • natural killer cell degranulation Source: UniProtKB
  • negative regulation of actin nucleation Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: Ensembl
  • negative regulation of vesicle fusion Source: Ensembl
  • nerve growth factor signaling pathway Source: Ensembl
  • phagocytosis Source: UniProtKB
  • phagolysosome assembly Source: UniProtKB
  • positive chemotaxis Source: UniProtKB
  • positive regulation of cell migration Source: Ensembl
  • positive regulation of T cell proliferation Source: Ensembl
  • regulation of actin cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: Ensembl
  • regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  • T cell homeostasis Source: Ensembl
  • uropod organization Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102879-MONOMER.
SignaLinkiP31146.
SIGNORiP31146.

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1A
Alternative name(s):
Coronin-like protein A
Short name:
Clipin-A
Coronin-like protein p57
Tryptophan aspartate-containing coat protein
Short name:
TACO
Gene namesi
Name:CORO1A
Synonyms:CORO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2252. CORO1A.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cytoplasmcell cortex By similarity
  • Cytoplasmic vesiclephagosome membrane By similarity

  • Note: In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).By similarity

GO - Cellular componenti

  • actin filament Source: UniProtKB
  • axon Source: Ensembl
  • cell-cell junction Source: Ensembl
  • cortical actin cytoskeleton Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: GOC
  • early endosome Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • immunological synapse Source: UniProtKB
  • lamellipodium Source: UniProtKB
  • membrane Source: UniProtKB
  • phagocytic cup Source: UniProtKB
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 8 (IMD8)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection.
See also OMIM:615401
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070447134V → M in IMD8; the mutation causes a decrease in protein stability; patient T-cell blasts show delayed activation of signaling molecules MAPK3 and MAPK1. 1 PublicationCorresponds to variant rs397514755dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi11151.
MalaCardsiCORO1A.
MIMi615401. phenotype.
OpenTargetsiENSG00000102879.
Orphaneti228003. Severe combined immunodeficiency due to CORO1A deficiency.
PharmGKBiPA26768.

Polymorphism and mutation databases

BioMutaiCORO1A.
DMDMi1706004.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000509202 – 461Coronin-1AAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2Phosphoserine; by PKC1 Publication1
Modified residuei412Phosphothreonine; by PKC1 Publication1
Modified residuei422PhosphoserineBy similarity1
Modified residuei449N6-acetyllysineCombined sources1

Post-translational modificationi

phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.1 Publication
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP31146.
MaxQBiP31146.
PaxDbiP31146.
PeptideAtlasiP31146.
PRIDEiP31146.
TopDownProteomicsiP31146.

2D gel databases

OGPiP31146.
UCD-2DPAGEP31146.

PTM databases

iPTMnetiP31146.
PhosphoSitePlusiP31146.
SwissPalmiP31146.

Expressioni

Tissue specificityi

Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Gene expression databases

BgeeiENSG00000102879.
CleanExiHS_CORO1A.
ExpressionAtlasiP31146. baseline and differential.
GenevisibleiP31146. HS.

Organism-specific databases

HPAiCAB046473.
HPA051132.

Interactioni

Subunit structurei

Binds actin.

Binary interactionsi

WithEntry#Exp.IntActNotes
FSD2A1L4K15EBI-1046676,EBI-5661036
GOLGA2Q083793EBI-1046676,EBI-618309
STAT3P407632EBI-1046676,EBI-518675

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • actin monomer binding Source: UniProtKB
  • cytoskeletal protein binding Source: UniProtKB
  • myosin heavy chain binding Source: UniProtKB
  • phosphatidylinositol 3-kinase binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi116322. 48 interactors.
IntActiP31146. 24 interactors.
MINTiMINT-263387.
STRINGi9606.ENSP00000219150.

Structurei

3D structure databases

ProteinModelPortaliP31146.
SMRiP31146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 63WD 1Add BLAST51
Repeati73 – 110WD 2Add BLAST38
Repeati123 – 160WD 3Add BLAST38
Repeati164 – 204WD 4Add BLAST41
Repeati207 – 251WD 5Add BLAST45
Repeati258 – 296WD 6Add BLAST39
Repeati302 – 349WD 7Add BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili424 – 460Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiP31146.
KOiK13882.
OMAiHAVFVSE.
OrthoDBiEOG091G03H5.
PhylomeDBiP31146.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR029508. CORO1A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. Trimer_CC.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF18. PTHR10856:SF18. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF08954. Trimer_CC. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI
60 70 80 90 100
CEASGGGAFL VLPLGKTGRV DKNAPTVCGH TAPVLDIAWC PHNDNVIASG
110 120 130 140 150
SEDCTVMVWE IPDGGLMLPL REPVVTLEGH TKRVGIVAWH TTAQNVLLSA
160 170 180 190 200
GCDNVIMVWD VGTGAAMLTL GPEVHPDTIY SVDWSRDGGL ICTSCRDKRV
210 220 230 240 250
RIIEPRKGTV VAEKDRPHEG TRPVRAVFVS EGKILTTGFS RMSERQVALW
260 270 280 290 300
DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE
310 320 330 340 350
APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERRCEPIAM
360 370 380 390 400
TVPRKSDLFQ EDLYPPTAGP DPALTAEEWL GGRDAGPLLI SLKDGYVPPK
410 420 430 440 450
SRELRVNRGL DTGRRRAAPE ASGTPSSDAV SRLEEEMRKL QATVQELQKR
460
LDRLEETVQA K
Length:461
Mass (Da):51,026
Last modified:January 23, 2007 - v4
Checksum:iDE3FEDA57041515E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → T in AAA77058 (Ref. 3) Curated1
Sequence conflicti245R → W in AAA77058 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070447134V → M in IMD8; the mutation causes a decrease in protein stability; patient T-cell blasts show delayed activation of signaling molecules MAPK3 and MAPK1. 1 PublicationCorresponds to variant rs397514755dbSNPEnsembl.1
Natural variantiVAR_011956415R → K.Corresponds to variant rs1804109dbSNPEnsembl.1
Natural variantiVAR_011957443T → P.Corresponds to variant rs1053574dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44497 mRNA. Translation: BAA07940.1.
X89109 mRNA. Translation: CAA61482.1.
U34690 mRNA. Translation: AAA77058.1.
AF495470 mRNA. Translation: AAM18516.1.
AK314714 mRNA. Translation: BAG37258.1.
CH471238 Genomic DNA. Translation: EAW79906.1.
BC110374 mRNA. Translation: AAI10375.1.
BC126385 mRNA. Translation: AAI26386.1.
BC126387 mRNA. Translation: AAI26388.1.
CCDSiCCDS10673.1.
PIRiS65665.
RefSeqiNP_001180262.1. NM_001193333.2.
NP_009005.1. NM_007074.3.
XP_011544016.1. XM_011545714.2.
UniGeneiHs.415067.

Genome annotation databases

EnsembliENST00000219150; ENSP00000219150; ENSG00000102879.
ENST00000570045; ENSP00000455552; ENSG00000102879.
GeneIDi11151.
KEGGihsa:11151.
UCSCiuc002dww.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44497 mRNA. Translation: BAA07940.1.
X89109 mRNA. Translation: CAA61482.1.
U34690 mRNA. Translation: AAA77058.1.
AF495470 mRNA. Translation: AAM18516.1.
AK314714 mRNA. Translation: BAG37258.1.
CH471238 Genomic DNA. Translation: EAW79906.1.
BC110374 mRNA. Translation: AAI10375.1.
BC126385 mRNA. Translation: AAI26386.1.
BC126387 mRNA. Translation: AAI26388.1.
CCDSiCCDS10673.1.
PIRiS65665.
RefSeqiNP_001180262.1. NM_001193333.2.
NP_009005.1. NM_007074.3.
XP_011544016.1. XM_011545714.2.
UniGeneiHs.415067.

3D structure databases

ProteinModelPortaliP31146.
SMRiP31146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116322. 48 interactors.
IntActiP31146. 24 interactors.
MINTiMINT-263387.
STRINGi9606.ENSP00000219150.

PTM databases

iPTMnetiP31146.
PhosphoSitePlusiP31146.
SwissPalmiP31146.

Polymorphism and mutation databases

BioMutaiCORO1A.
DMDMi1706004.

2D gel databases

OGPiP31146.
UCD-2DPAGEP31146.

Proteomic databases

EPDiP31146.
MaxQBiP31146.
PaxDbiP31146.
PeptideAtlasiP31146.
PRIDEiP31146.
TopDownProteomicsiP31146.

Protocols and materials databases

DNASUi11151.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219150; ENSP00000219150; ENSG00000102879.
ENST00000570045; ENSP00000455552; ENSG00000102879.
GeneIDi11151.
KEGGihsa:11151.
UCSCiuc002dww.4. human.

Organism-specific databases

CTDi11151.
DisGeNETi11151.
GeneCardsiCORO1A.
HGNCiHGNC:2252. CORO1A.
HPAiCAB046473.
HPA051132.
MalaCardsiCORO1A.
MIMi605000. gene.
615401. phenotype.
neXtProtiNX_P31146.
OpenTargetsiENSG00000102879.
Orphaneti228003. Severe combined immunodeficiency due to CORO1A deficiency.
PharmGKBiPA26768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiP31146.
KOiK13882.
OMAiHAVFVSE.
OrthoDBiEOG091G03H5.
PhylomeDBiP31146.
TreeFamiTF314280.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102879-MONOMER.
SignaLinkiP31146.
SIGNORiP31146.

Miscellaneous databases

GeneWikiiCORO1A.
GenomeRNAii11151.
PROiP31146.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102879.
CleanExiHS_CORO1A.
ExpressionAtlasiP31146. baseline and differential.
GenevisibleiP31146. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR029508. CORO1A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. Trimer_CC.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF18. PTHR10856:SF18. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF08954. Trimer_CC. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOR1A_HUMAN
AccessioniPrimary (citable) accession number: P31146
Secondary accession number(s): B2RBL1, Q2YD73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 165 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.