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P31146

- COR1A_HUMAN

UniProt

P31146 - COR1A_HUMAN

Protein

Coronin-1A

Gene

CORO1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.1 Publication

    GO - Molecular functioni

    1. actin filament binding Source: UniProtKB
    2. cytoskeletal protein binding Source: UniProtKB
    3. phosphatidylinositol 3-kinase binding Source: UniProtKB
    4. poly(A) RNA binding Source: UniProtKB
    5. protein binding Source: UniProtKB
    6. protein C-terminus binding Source: UniProtKB
    7. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton organization Source: UniProtKB
    2. actin filament organization Source: Ensembl
    3. calcium ion transport Source: Ensembl
    4. cell-substrate adhesion Source: UniProtKB
    5. cellular component movement Source: UniProtKB
    6. cellular response to interleukin-4 Source: Ensembl
    7. homeostasis of number of cells within a tissue Source: Ensembl
    8. innate immune response Source: UniProtKB
    9. leukocyte chemotaxis Source: RefGenome
    10. negative regulation of actin nucleation Source: UniProtKB
    11. phagocytosis Source: UniProtKB
    12. phagolysosome assembly Source: UniProtKB
    13. positive chemotaxis Source: UniProtKB
    14. positive regulation of cell migration Source: Ensembl
    15. positive regulation of T cell proliferation Source: Ensembl
    16. regulation of actin filament polymerization Source: Ensembl
    17. regulation of cell shape Source: RefGenome
    18. T cell homeostasis Source: Ensembl
    19. uropod organization Source: RefGenome

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    SignaLinkiP31146.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coronin-1A
    Alternative name(s):
    Coronin-like protein A
    Short name:
    Clipin-A
    Coronin-like protein p57
    Tryptophan aspartate-containing coat protein
    Short name:
    TACO
    Gene namesi
    Name:CORO1A
    Synonyms:CORO1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:2252. CORO1A.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cytoplasmcell cortex By similarity. Cytoplasmic vesiclephagosome membrane By similarity
    Note: In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification By similarity.By similarity

    GO - Cellular componenti

    1. actin filament Source: UniProtKB
    2. cortical actin cytoskeleton Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. immunological synapse Source: Ensembl
    6. lamellipodium Source: UniProtKB
    7. membrane Source: UniProtKB
    8. phagocytic cup Source: UniProtKB
    9. phagocytic vesicle Source: UniProtKB
    10. phagocytic vesicle membrane Source: UniProtKB-SubCell
    11. plasma membrane Source: UniProtKB
    12. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Immunodeficiency 8 (IMD8) [MIM:615401]: A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti134 – 1341V → M in IMD8; the mutation causes a decrease in protein stability; patient T-cell blasts show delayed activation of signaling molecules MAPK3 and MAPK1. 1 Publication
    VAR_070447

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi615401. phenotype.
    Orphaneti228003. Severe combined immunodeficiency due to CORO1A deficiency.
    PharmGKBiPA26768.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 461460Coronin-1APRO_0000050920Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei2 – 21Phosphoserine; by PKC1 Publication
    Modified residuei412 – 4121Phosphothreonine; by PKC1 Publication
    Modified residuei449 – 4491N6-acetyllysine1 Publication

    Post-translational modificationi

    phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.1 Publication
    Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP31146.
    PaxDbiP31146.
    PeptideAtlasiP31146.
    PRIDEiP31146.

    2D gel databases

    OGPiP31146.
    UCD-2DPAGEP31146.

    PTM databases

    PhosphoSiteiP31146.

    Expressioni

    Tissue specificityi

    Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

    Gene expression databases

    ArrayExpressiP31146.
    BgeeiP31146.
    CleanExiHS_CORO1A.
    GenevestigatoriP31146.

    Organism-specific databases

    HPAiCAB046473.
    HPA051132.

    Interactioni

    Subunit structurei

    Binds actin.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    STAT3P407632EBI-1046676,EBI-518675

    Protein-protein interaction databases

    BioGridi116322. 16 interactions.
    IntActiP31146. 18 interactions.
    MINTiMINT-263387.
    STRINGi9606.ENSP00000219150.

    Structurei

    3D structure databases

    ProteinModelPortaliP31146.
    SMRiP31146. Positions 9-394, 430-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati13 – 6351WD 1Add
    BLAST
    Repeati73 – 11038WD 2Add
    BLAST
    Repeati123 – 16038WD 3Add
    BLAST
    Repeati164 – 20441WD 4Add
    BLAST
    Repeati207 – 25145WD 5Add
    BLAST
    Repeati258 – 29639WD 6Add
    BLAST
    Repeati302 – 34948WD 7Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili424 – 46037Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat coronin family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000166356.
    HOVERGENiHBG059978.
    InParanoidiP31146.
    KOiK13882.
    OMAiFMALICE.
    PhylomeDBiP31146.
    TreeFamiTF314280.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR029508. CORO1A.
    IPR015505. Coronin.
    IPR015048. DUF1899.
    IPR015049. DUF1900.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR10856. PTHR10856. 1 hit.
    PTHR10856:SF18. PTHR10856:SF18. 1 hit.
    PfamiPF08953. DUF1899. 1 hit.
    PF08954. DUF1900. 1 hit.
    PF00400. WD40. 3 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31146-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI    50
    CEASGGGAFL VLPLGKTGRV DKNAPTVCGH TAPVLDIAWC PHNDNVIASG 100
    SEDCTVMVWE IPDGGLMLPL REPVVTLEGH TKRVGIVAWH TTAQNVLLSA 150
    GCDNVIMVWD VGTGAAMLTL GPEVHPDTIY SVDWSRDGGL ICTSCRDKRV 200
    RIIEPRKGTV VAEKDRPHEG TRPVRAVFVS EGKILTTGFS RMSERQVALW 250
    DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE 300
    APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERRCEPIAM 350
    TVPRKSDLFQ EDLYPPTAGP DPALTAEEWL GGRDAGPLLI SLKDGYVPPK 400
    SRELRVNRGL DTGRRRAAPE ASGTPSSDAV SRLEEEMRKL QATVQELQKR 450
    LDRLEETVQA K 461
    Length:461
    Mass (Da):51,026
    Last modified:January 23, 2007 - v4
    Checksum:iDE3FEDA57041515E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81S → T in AAA77058. 1 PublicationCurated
    Sequence conflicti245 – 2451R → W in AAA77058. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti134 – 1341V → M in IMD8; the mutation causes a decrease in protein stability; patient T-cell blasts show delayed activation of signaling molecules MAPK3 and MAPK1. 1 Publication
    VAR_070447
    Natural varianti415 – 4151R → K.
    Corresponds to variant rs1804109 [ dbSNP | Ensembl ].
    VAR_011956
    Natural varianti443 – 4431T → P.
    Corresponds to variant rs1053574 [ dbSNP | Ensembl ].
    VAR_011957

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D44497 mRNA. Translation: BAA07940.1.
    X89109 mRNA. Translation: CAA61482.1.
    U34690 mRNA. Translation: AAA77058.1.
    AF495470 mRNA. Translation: AAM18516.1.
    AK314714 mRNA. Translation: BAG37258.1.
    CH471238 Genomic DNA. Translation: EAW79906.1.
    BC110374 mRNA. Translation: AAI10375.1.
    BC126385 mRNA. Translation: AAI26386.1.
    BC126387 mRNA. Translation: AAI26388.1.
    CCDSiCCDS10673.1.
    PIRiS65665.
    RefSeqiNP_001180262.1. NM_001193333.2.
    NP_009005.1. NM_007074.3.
    UniGeneiHs.415067.

    Genome annotation databases

    EnsembliENST00000219150; ENSP00000219150; ENSG00000102879.
    ENST00000570045; ENSP00000455552; ENSG00000102879.
    GeneIDi11151.
    KEGGihsa:11151.
    UCSCiuc002dww.3. human.

    Polymorphism databases

    DMDMi1706004.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D44497 mRNA. Translation: BAA07940.1 .
    X89109 mRNA. Translation: CAA61482.1 .
    U34690 mRNA. Translation: AAA77058.1 .
    AF495470 mRNA. Translation: AAM18516.1 .
    AK314714 mRNA. Translation: BAG37258.1 .
    CH471238 Genomic DNA. Translation: EAW79906.1 .
    BC110374 mRNA. Translation: AAI10375.1 .
    BC126385 mRNA. Translation: AAI26386.1 .
    BC126387 mRNA. Translation: AAI26388.1 .
    CCDSi CCDS10673.1.
    PIRi S65665.
    RefSeqi NP_001180262.1. NM_001193333.2.
    NP_009005.1. NM_007074.3.
    UniGenei Hs.415067.

    3D structure databases

    ProteinModelPortali P31146.
    SMRi P31146. Positions 9-394, 430-461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116322. 16 interactions.
    IntActi P31146. 18 interactions.
    MINTi MINT-263387.
    STRINGi 9606.ENSP00000219150.

    PTM databases

    PhosphoSitei P31146.

    Polymorphism databases

    DMDMi 1706004.

    2D gel databases

    OGPi P31146.
    UCD-2DPAGE P31146.

    Proteomic databases

    MaxQBi P31146.
    PaxDbi P31146.
    PeptideAtlasi P31146.
    PRIDEi P31146.

    Protocols and materials databases

    DNASUi 11151.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219150 ; ENSP00000219150 ; ENSG00000102879 .
    ENST00000570045 ; ENSP00000455552 ; ENSG00000102879 .
    GeneIDi 11151.
    KEGGi hsa:11151.
    UCSCi uc002dww.3. human.

    Organism-specific databases

    CTDi 11151.
    GeneCardsi GC16P030194.
    HGNCi HGNC:2252. CORO1A.
    HPAi CAB046473.
    HPA051132.
    MIMi 605000. gene.
    615401. phenotype.
    neXtProti NX_P31146.
    Orphaneti 228003. Severe combined immunodeficiency due to CORO1A deficiency.
    PharmGKBi PA26768.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000166356.
    HOVERGENi HBG059978.
    InParanoidi P31146.
    KOi K13882.
    OMAi FMALICE.
    PhylomeDBi P31146.
    TreeFami TF314280.

    Enzyme and pathway databases

    SignaLinki P31146.

    Miscellaneous databases

    GeneWikii CORO1A.
    GenomeRNAii 11151.
    NextBioi 42396.
    PROi P31146.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P31146.
    Bgeei P31146.
    CleanExi HS_CORO1A.
    Genevestigatori P31146.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR029508. CORO1A.
    IPR015505. Coronin.
    IPR015048. DUF1899.
    IPR015049. DUF1900.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR10856. PTHR10856. 1 hit.
    PTHR10856:SF18. PTHR10856:SF18. 1 hit.
    Pfami PF08953. DUF1899. 1 hit.
    PF08954. DUF1900. 1 hit.
    PF00400. WD40. 3 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif."
      Suzuki K., Nishihata J., Arai Y., Honma N., Yamamoto K., Irimura T., Toyoshima S.
      FEBS Lett. 364:283-288(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood leukocyte.
    2. Grogan A., Keep N.H., Reeves E., Segal A.W.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. Liau G., Popa I., Argraves K., Argraves W.S.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    4. "A new therapeutic strategy of mycobacterium infection by use of anti-TACO sequence."
      Kohchi C., Inagawa H., Makino K., Terada H., Soma G.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.
      Submitted (MAY-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-9; 50-65; 242-252; 433-448 AND 453-460, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: T-cell.
    9. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
      Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 355-374.
      Tissue: Keratinocyte.
    10. "A coat protein on phagosomes involved in the intracellular survival of mycobacteria."
      Ferrari G., Langen H., Naito M., Pieters J.
      Cell 97:435-447(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: ROLE IN PHAGOSOME TRAFFICKING.
    11. "Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion."
      Shiow L.R., Paris K., Akana M.C., Cyster J.G., Sorensen R.U., Puck J.M.
      Clin. Immunol. 131:24-30(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN IMD8.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-449, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A."
      Ichikawa D., Mizuno M., Yamamura T., Miyake S.
      J. Biol. Chem. 286:43465-43474(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY RNF128.
    16. "Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin."
      Oku T., Nakano M., Kaneko Y., Ando Y., Kenmotsu H., Itoh S., Tsuiji M., Seyama Y., Toyoshima S., Tsuji T.
      J. Biol. Chem. 287:42910-42920(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-2 AND THR-412, INTERACTION WITH ACTIN.
    17. "Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation."
      Moshous D., Martin E., Carpentier W., Lim A., Callebaut I., Canioni D., Hauck F., Majewski J., Schwartzentruber J., Nitschke P., Sirvent N., Frange P., Picard C., Blanche S., Revy P., Fischer A., Latour S., Jabado N., de Villartay J.P.
      J. Allergy Clin. Immunol. 131:1594-1603(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT IMD8 MET-134, CHARACTERIZATION OF VARIANT IMD8 MET-134.

    Entry informationi

    Entry nameiCOR1A_HUMAN
    AccessioniPrimary (citable) accession number: P31146
    Secondary accession number(s): B2RBL1, Q2YD73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 142 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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