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Protein

Uncharacterized MFS-type transporter YdeE

Gene

ydeE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed:20067529). Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide (PubMed:20067529).1 Publication

GO - Molecular functioni

  • dipeptide transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • dipeptide transmembrane transport Source: EcoCyc
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YDEF-MONOMER

Protein family/group databases

TCDBi2.A.1.2.55 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized MFS-type transporter YdeE
Gene namesi
Name:ydeE
Synonyms:ydeF
Ordered Locus Names:b1534, JW1527
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11640 ydeE

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Transmembranei44 – 66HelicalSequence analysisAdd BLAST23
Transmembranei75 – 94HelicalSequence analysisAdd BLAST20
Transmembranei99 – 121HelicalSequence analysisAdd BLAST23
Transmembranei134 – 156HelicalSequence analysisAdd BLAST23
Transmembranei160 – 182HelicalSequence analysisAdd BLAST23
Transmembranei208 – 230HelicalSequence analysisAdd BLAST23
Transmembranei245 – 264HelicalSequence analysisAdd BLAST20
Transmembranei271 – 293HelicalSequence analysisAdd BLAST23
Transmembranei298 – 320HelicalSequence analysisAdd BLAST23
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Transmembranei364 – 381HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848961 – 395Uncharacterized MFS-type transporter YdeEAdd BLAST395

Proteomic databases

PaxDbiP31126
PRIDEiP31126

Interactioni

Protein-protein interaction databases

BioGridi4259113, 150 interactors
STRINGi316385.ECDH10B_1665

Structurei

3D structure databases

ProteinModelPortaliP31126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E5W Bacteria
ENOG410ZDMF LUCA
HOGENOMiHOG000120784
InParanoidiP31126
OMAiWESNLSV
PhylomeDBiP31126

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P31126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSLRRSTS ALLASSLLLT IGRGATLPFM TIYLSRQYSL SVDLIGYAMT
60 70 80 90 100
IALTIGVVFS LGFGILADKF DKKRYMLLAI TAFASGFIAI TLVNNVTLVV
110 120 130 140 150
LFFALINCAY SVFATVLKAW FADNLSSTSK TKIFSINYTM LNIGWTIGPP
160 170 180 190 200
LGTLLVMQSI NLPFWLAAIC SAFPMLFIQI WVKRSEKIIA TETGSVWSPK
210 220 230 240 250
VLLQDKALLW FTCSGFLASF VSGAFASCIS QYVMVIADGD FAEKVVAVVL
260 270 280 290 300
PVNAAMVVTL QYSVGRRLNP ANIRALMTAG TLCFVIGLVG FIFSGNSLLL
310 320 330 340 350
WGMSAAVFTV GEIIYAPGEY MLIDHIAPPE MKASYFSAQS LGWLGAAINP
360 370 380 390
LVSGVVLTSL PPSSLFVILA LVIIAAWVLM LKGIRARPWG QPALC
Length:395
Mass (Da):42,659
Last modified:November 1, 1997 - v2
Checksum:i223F27AE18AC4F48
GO

Sequence cautioni

The sequence M96235 differs from that shown. Reason: Frameshift at position 145. Produces two separate ORFS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27L → V in M96235 (PubMed:8383113).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA No translation available.
U00096 Genomic DNA Translation: AAC74607.1
AP009048 Genomic DNA Translation: BAA15224.2
PIRiA64908
RefSeqiNP_416051.1, NC_000913.3
WP_001054204.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74607; AAC74607; b1534
BAA15224; BAA15224; BAA15224
GeneIDi946083
KEGGiecj:JW1527
eco:b1534
PATRICifig|1411691.4.peg.732

Similar proteinsi

Entry informationi

Entry nameiYDEE_ECOLI
AccessioniPrimary (citable) accession number: P31126
Secondary accession number(s): P31127, P76151
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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