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Protein

Sugar efflux transporter

Gene

sotB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YDEA-MONOMER.
ECOL316407:JW1521-MONOMER.
MetaCyc:YDEA-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.15. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar efflux transporter
Gene namesi
Name:sotB
Synonyms:ydeA
Ordered Locus Names:b1528, JW1521
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11636. sotB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 49PeriplasmicSequence analysisAdd BLAST14
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 80CytoplasmicSequence analysis10
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102PeriplasmicSequence analysis1
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 135CytoplasmicSequence analysisAdd BLAST12
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 169PeriplasmicSequence analysisAdd BLAST13
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 208CytoplasmicSequence analysisAdd BLAST18
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 245PeriplasmicSequence analysisAdd BLAST16
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 274CytoplasmicSequence analysis8
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 298PeriplasmicSequence analysis3
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 332CytoplasmicSequence analysisAdd BLAST13
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 363PeriplasmicSequence analysis10
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385 – 396CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093231 – 396Sugar efflux transporterAdd BLAST396

Proteomic databases

PaxDbiP31122.
PRIDEiP31122.

Interactioni

Protein-protein interaction databases

BioGridi4259471. 243 interactors.
STRINGi511145.b1528.

Structurei

3D structure databases

ProteinModelPortaliP31122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F27. Bacteria.
COG2814. LUCA.
HOGENOMiHOG000268498.
InParanoidiP31122.
KOiK08159.
OMAiHMESAQA.
PhylomeDBiP31122.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_00517. MFS_SotB. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023495. Sugar_effux_transptr_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNTVSRKV AWLRVVTLAV AAFIFNTTEF VPVGLLSDIA QSFHMQTAQV
60 70 80 90 100
GIMLTIYAWV VALMSLPFML MTSQVERRKL LICLFVVFIA SHVLSFLSWS
110 120 130 140 150
FTVLVISRIG VAFAHAIFWS ITASLAIRMA PAGKRAQALS LIATGTALAM
160 170 180 190 200
VLGLPLGRIV GQYFGWRMTF FAIGIGALIT LLCLIKLLPL LPSEHSGSLK
210 220 230 240 250
SLPLLFRRPA LMSIYLLTVV VVTAHYTAYS YIEPFVQNIA GFSANFATAL
260 270 280 290 300
LLLLGGAGII GSVIFGKLGN QYASALVSTA IALLLVCLAL LLPAANSEIH
310 320 330 340 350
LGVLSIFWGI AMMIIGLGMQ VKVLALAPDA TDVAMALFSG IFNIGIGAGA
360 370 380 390
LVGNQVSLHW SMSMIGYVGA VPAFAALIWS IIIFRRWPVT LEEQTQ
Length:396
Mass (Da):42,538
Last modified:November 1, 1997 - v2
Checksum:iCB6A34CA4EE6D4F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74601.1.
AP009048 Genomic DNA. Translation: BAA15210.1.
M96235 Genomic DNA. No translation available.
PIRiC64907.
RefSeqiNP_416045.1. NC_000913.3.
WP_000210799.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74601; AAC74601; b1528.
BAA15210; BAA15210; BAA15210.
GeneIDi947218.
KEGGiecj:JW1521.
eco:b1528.
PATRICi32118354. VBIEscCol129921_1597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74601.1.
AP009048 Genomic DNA. Translation: BAA15210.1.
M96235 Genomic DNA. No translation available.
PIRiC64907.
RefSeqiNP_416045.1. NC_000913.3.
WP_000210799.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP31122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259471. 243 interactors.
STRINGi511145.b1528.

Protein family/group databases

TCDBi2.A.1.2.15. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP31122.
PRIDEiP31122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74601; AAC74601; b1528.
BAA15210; BAA15210; BAA15210.
GeneIDi947218.
KEGGiecj:JW1521.
eco:b1528.
PATRICi32118354. VBIEscCol129921_1597.

Organism-specific databases

EchoBASEiEB1592.
EcoGeneiEG11636. sotB.

Phylogenomic databases

eggNOGiENOG4105F27. Bacteria.
COG2814. LUCA.
HOGENOMiHOG000268498.
InParanoidiP31122.
KOiK08159.
OMAiHMESAQA.
PhylomeDBiP31122.

Enzyme and pathway databases

BioCyciEcoCyc:YDEA-MONOMER.
ECOL316407:JW1521-MONOMER.
MetaCyc:YDEA-MONOMER.

Miscellaneous databases

PROiP31122.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_00517. MFS_SotB. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023495. Sugar_effux_transptr_put.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOTB_ECOLI
AccessioniPrimary (citable) accession number: P31122
Secondary accession number(s): P76883, P77353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.