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P31122

- SOTB_ECOLI

UniProt

P31122 - SOTB_ECOLI

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Protein
Sugar efflux transporter
Gene
sotB, ydeA, b1528, JW1521
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon.UniRule annotation

GO - Molecular functioni

  1. carbohydrate transmembrane transporter activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    BioCyciEcoCyc:YDEA-MONOMER.
    ECOL316407:JW1521-MONOMER.
    MetaCyc:YDEA-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.2.15. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar efflux transporter
    Gene namesi
    Name:sotB
    Synonyms:ydeA
    Ordered Locus Names:b1528, JW1521
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11636. sotB.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1414Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei15 – 3521Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini36 – 4914Periplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei50 – 7021Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini71 – 8010Cytoplasmic Reviewed prediction
    Transmembranei81 – 10121Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini102 – 1021Periplasmic Reviewed prediction
    Transmembranei103 – 12321Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini124 – 13512Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei136 – 15621Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini157 – 16913Periplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei170 – 19021Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini191 – 20818Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei209 – 22921Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini230 – 24516Periplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei246 – 26621Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini267 – 2748Cytoplasmic Reviewed prediction
    Transmembranei275 – 29521Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini296 – 2983Periplasmic Reviewed prediction
    Transmembranei299 – 31921Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini320 – 33213Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei333 – 35321Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini354 – 36310Periplasmic Reviewed prediction
    Transmembranei364 – 38421Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini385 – 39612Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Sugar efflux transporterUniRule annotation
    PRO_0000209323Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP31122.

    Interactioni

    Protein-protein interaction databases

    STRINGi511145.b1528.

    Structurei

    3D structure databases

    ProteinModelPortaliP31122.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2814.
    HOGENOMiHOG000268498.
    KOiK08159.
    OMAiGNDIRAN.
    OrthoDBiEOG6TJ7VJ.
    PhylomeDBiP31122.

    Family and domain databases

    HAMAPiMF_00517. MFS_SotB.
    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR023495. Sugar_effux_transptr_put.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31122-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTNTVSRKV AWLRVVTLAV AAFIFNTTEF VPVGLLSDIA QSFHMQTAQV    50
    GIMLTIYAWV VALMSLPFML MTSQVERRKL LICLFVVFIA SHVLSFLSWS 100
    FTVLVISRIG VAFAHAIFWS ITASLAIRMA PAGKRAQALS LIATGTALAM 150
    VLGLPLGRIV GQYFGWRMTF FAIGIGALIT LLCLIKLLPL LPSEHSGSLK 200
    SLPLLFRRPA LMSIYLLTVV VVTAHYTAYS YIEPFVQNIA GFSANFATAL 250
    LLLLGGAGII GSVIFGKLGN QYASALVSTA IALLLVCLAL LLPAANSEIH 300
    LGVLSIFWGI AMMIIGLGMQ VKVLALAPDA TDVAMALFSG IFNIGIGAGA 350
    LVGNQVSLHW SMSMIGYVGA VPAFAALIWS IIIFRRWPVT LEEQTQ 396
    Length:396
    Mass (Da):42,538
    Last modified:November 1, 1997 - v2
    Checksum:iCB6A34CA4EE6D4F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC74601.1.
    AP009048 Genomic DNA. Translation: BAA15210.1.
    M96235 Genomic DNA. No translation available.
    PIRiC64907.
    RefSeqiNP_416045.1. NC_000913.3.
    YP_489791.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74601; AAC74601; b1528.
    BAA15210; BAA15210; BAA15210.
    GeneIDi12930477.
    947218.
    KEGGiecj:Y75_p1503.
    eco:b1528.
    PATRICi32118354. VBIEscCol129921_1597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC74601.1 .
    AP009048 Genomic DNA. Translation: BAA15210.1 .
    M96235 Genomic DNA. No translation available.
    PIRi C64907.
    RefSeqi NP_416045.1. NC_000913.3.
    YP_489791.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P31122.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 511145.b1528.

    Protein family/group databases

    TCDBi 2.A.1.2.15. the major facilitator superfamily (mfs).

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74601 ; AAC74601 ; b1528 .
    BAA15210 ; BAA15210 ; BAA15210 .
    GeneIDi 12930477.
    947218.
    KEGGi ecj:Y75_p1503.
    eco:b1528.
    PATRICi 32118354. VBIEscCol129921_1597.

    Organism-specific databases

    EchoBASEi EB1592.
    EcoGenei EG11636. sotB.

    Phylogenomic databases

    eggNOGi COG2814.
    HOGENOMi HOG000268498.
    KOi K08159.
    OMAi GNDIRAN.
    OrthoDBi EOG6TJ7VJ.
    PhylomeDBi P31122.

    Enzyme and pathway databases

    BioCyci EcoCyc:YDEA-MONOMER.
    ECOL316407:JW1521-MONOMER.
    MetaCyc:YDEA-MONOMER.

    Miscellaneous databases

    PROi P31122.

    Gene expression databases

    Genevestigatori P31122.

    Family and domain databases

    HAMAPi MF_00517. MFS_SotB.
    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR023495. Sugar_effux_transptr_put.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli."
      Cohen S.P., Haechler H., Levy S.B.
      J. Bacteriol. 175:1484-1492(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 217-396.
    5. "Transcriptional activation of ydeA, which encodes a member of the major facilitator superfamily, interferes with arabinose accumulation and induction of the Escherichia coli arabinose PBAD promoter."
      Bost S., Silva F., Belin D.
      J. Bacteriol. 181:2185-2191(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Strain: SB0.
    6. "Escherichia coli gene ydeA encodes a major facilitator pump which exports L-arabinose and isopropyl-beta-D-thiogalactopyranoside."
      Carole S., Pichoff S., Bouche J.-P.
      J. Bacteriol. 181:5123-5125(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Strain: JS219.
    7. "Global topology analysis of the Escherichia coli inner membrane proteome."
      Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
      Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiSOTB_ECOLI
    AccessioniPrimary (citable) accession number: P31122
    Secondary accession number(s): P76883, P77353
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1997
    Last modified: July 9, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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