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Protein

Modification methylase CviAII

Gene

CVIAIIM

Organism
Paramecium bursaria Chlorella virus 1 (PBCV-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CATG, causes specific methylation on A-2 on both strands and protects the DNA from cleavage by the CviAII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3542. M.CviAII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase CviAII (EC:2.1.1.72)
Short name:
M.CviAII
Alternative name(s):
Adenine-specific methyltransferase CviAII
Gene namesi
Name:CVIAIIM
Ordered Locus Names:A251R
OrganismiParamecium bursaria Chlorella virus 1 (PBCV-1)
Taxonomic identifieri10506 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
Virus hostiChlorella [TaxID: 114049]
Proteomesi
  • UP000000862 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879501 – 326Modification methylase CviAIIAdd BLAST326

Structurei

3D structure databases

ProteinModelPortaliP31118.
SMRiP31118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF02086. MethyltransfD12. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiView protein in PROSITE
PS00092. N6_MTASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P31118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRIGYIGSK LKLKDWIFEE ISKRTDDTYT KFADLFAGSC IMTHEALEKK
60 70 80 90 100
YECISNDLET YSYVIMNGLK CPFSDKLQNI IETLDDLDTK DMVIPGFVTL
110 120 130 140 150
TYSPRGNRMY FTEDIAMRID IIRENIERMK ERVSTDEYNF LLASLLTSAD
160 170 180 190 200
SVKNTSVVYG AYLKKFKKTA LKRMVFAPLH TRSTTVTLET FNEDATELEI
210 220 230 240 250
KTDIAYVDPP YNSRQYGANY FVLNQILTPK EIGNGVTGLP EYKKSSFCRK
260 270 280 290 300
QEVAMSFHKM LKNVSARLFV ISYSSESLLS KGDMVALLSQ YGKCEVVVRN
310 320
HKRFKAQISA VGNDVEEYLF FVYIEQ
Length:326
Mass (Da):37,492
Last modified:December 15, 1998 - v2
Checksum:i8CC1FC75D85F0D89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86639 Genomic DNA. Translation: AAB92381.1.
JF411744 Genomic DNA. Translation: AAC96619.1.
PIRiS35442. S27901.
T17743.
RefSeqiNP_048600.2. NC_000852.5.

Genome annotation databases

GeneIDi918436.
KEGGivg:918436.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMTC2_PBCV1
AccessioniPrimary (citable) accession number: P31118
Secondary accession number(s): Q84569
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 15, 1998
Last modified: May 10, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families