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P31112 (HEPS1_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heptaprenyl diphosphate synthase component 1

Short name=HepPP synthase subunit 1
EC=2.5.1.30
Alternative name(s):
Spore germination protein C1
Gene names
Name:hepS
Synonyms:gerC1, gerCA, hepA
Ordered Locus Names:BSU22760
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7). Ref.4

Catalytic activity

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

Subunit structure

Heterodimer of component I and II.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Heptaprenyl diphosphate synthase component 1
PRO_0000124002

Sequences

Sequence LengthMass (Da)Tools
P31112 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 25D9FF1B3BF6F482

FASTA25129,122
        10         20         30         40         50         60 
MQDIYGTLAN LNTKLKQKLS HPYLAKHISA PKIDEDKLLL FHALFEEADI KNNDRENYIV 

        70         80         90        100        110        120 
TAMLVQSALD THDEVTTARV IKRDENKNRQ LTVLAGDYFS GLYYSLLSEM KDIYMIRTLA 

       130        140        150        160        170        180 
TAIKEINEHK IRLYDRSFKD ENDFFESVGI VESALFHRVA EHFNLPRWKK LSSDFFVFKR 

       190        200        210        220        230        240 
LMNGNDAFLD VIGSFIQLGK TKEEILEDCF KKAKNSIESL LPLNSPIQNI LINRLKTISQ 

       250 
DQTYHQKVEE G 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of Bacillus subtilis dbpA, mtr(A,B), gerC(1-3), ndk, cheR, aro(B,E,F,H), trp(A-F), hisH, and tyrA genes."
Henner D.J.
Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Characterization and cloning of the gerC locus of Bacillus subtilis 168."
Yazdi M.A., Moir A.
J. Gen. Microbiol. 136:1335-1342(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF GERC LOCUS.
[4]"The gerC locus of Bacillus subtilis, required for menaquinone biosynthesis, is concerned only indirectly with spore germination."
Leatherbarrow A.J.H., Yazdi M.A., Curson J.P., Moir A.
Microbiology 144:2125-2130(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80245 Genomic DNA. Translation: AAA20854.1.
AL009126 Genomic DNA. Translation: CAB14192.1.
PIRC69630.
RefSeqNP_390157.1. NC_000964.3.

3D structure databases

ProteinModelPortalP31112.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU22760.

Protocols and materials databases

DNASU938998.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14192; CAB14192; BSU22760.
GeneID938998.
KEGGbsu:BSU22760.
PATRIC18976363. VBIBacSub10457_2372.

Organism-specific databases

GenoListBSU22760. [Micado]

Phylogenomic databases

HOGENOMHOG000086759.
KOK00805.
OMAYIDHCKE.
OrthoDBEOG6PP9Q3.
PhylomeDBP31112.

Enzyme and pathway databases

BioCycBSUB:BSU22760-MONOMER.
MetaCyc:MONOMER-13769.

Family and domain databases

InterProIPR009920. HEPPP_synth_su1.
[Graphical view]
PfamPF07307. HEPPP_synt_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEPS1_BACSU
AccessionPrimary (citable) accession number: P31112
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList