Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P31112

- HEPS1_BACSU

UniProt

P31112 - HEPS1_BACSU

Protein

Heptaprenyl diphosphate synthase component 1

Gene

hepS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).1 Publication

    Catalytic activityi

    (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

    GO - Molecular functioni

    1. heptaprenyl diphosphate synthase activity Source: UniProtKB-EC
    2. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: UniProtKB

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW
    2. menaquinone biosynthetic process Source: UniProtKB
    3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Sporulation

    Enzyme and pathway databases

    BioCyciBSUB:BSU22760-MONOMER.
    MetaCyc:MONOMER-13769.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heptaprenyl diphosphate synthase component 1 (EC:2.5.1.30)
    Short name:
    HepPP synthase subunit 1
    Alternative name(s):
    Spore germination protein C1
    Gene namesi
    Name:hepS
    Synonyms:gerC1, gerCA, hepA
    Ordered Locus Names:BSU22760
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU22760. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Heptaprenyl diphosphate synthase component 1PRO_0000124002Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of component I and II.

    Protein-protein interaction databases

    STRINGi224308.BSU22760.

    Structurei

    3D structure databases

    ProteinModelPortaliP31112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000086759.
    KOiK00805.
    OMAiYIDHCKE.
    OrthoDBiEOG6PP9Q3.
    PhylomeDBiP31112.

    Family and domain databases

    InterProiIPR009920. HEPPP_synth_su1.
    [Graphical view]
    PfamiPF07307. HEPPP_synt_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31112-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDIYGTLAN LNTKLKQKLS HPYLAKHISA PKIDEDKLLL FHALFEEADI    50
    KNNDRENYIV TAMLVQSALD THDEVTTARV IKRDENKNRQ LTVLAGDYFS 100
    GLYYSLLSEM KDIYMIRTLA TAIKEINEHK IRLYDRSFKD ENDFFESVGI 150
    VESALFHRVA EHFNLPRWKK LSSDFFVFKR LMNGNDAFLD VIGSFIQLGK 200
    TKEEILEDCF KKAKNSIESL LPLNSPIQNI LINRLKTISQ DQTYHQKVEE 250
    G 251
    Length:251
    Mass (Da):29,122
    Last modified:July 1, 1993 - v1
    Checksum:i25D9FF1B3BF6F482
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80245 Genomic DNA. Translation: AAA20854.1.
    AL009126 Genomic DNA. Translation: CAB14192.1.
    PIRiC69630.
    RefSeqiNP_390157.1. NC_000964.3.
    WP_004398550.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB14192; CAB14192; BSU22760.
    GeneIDi938998.
    KEGGibsu:BSU22760.
    PATRICi18976363. VBIBacSub10457_2372.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80245 Genomic DNA. Translation: AAA20854.1 .
    AL009126 Genomic DNA. Translation: CAB14192.1 .
    PIRi C69630.
    RefSeqi NP_390157.1. NC_000964.3.
    WP_004398550.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali P31112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU22760.

    Protocols and materials databases

    DNASUi 938998.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB14192 ; CAB14192 ; BSU22760 .
    GeneIDi 938998.
    KEGGi bsu:BSU22760.
    PATRICi 18976363. VBIBacSub10457_2372.

    Organism-specific databases

    GenoListi BSU22760. [Micado ]

    Phylogenomic databases

    HOGENOMi HOG000086759.
    KOi K00805.
    OMAi YIDHCKE.
    OrthoDBi EOG6PP9Q3.
    PhylomeDBi P31112.

    Enzyme and pathway databases

    BioCyci BSUB:BSU22760-MONOMER.
    MetaCyc:MONOMER-13769.

    Family and domain databases

    InterProi IPR009920. HEPPP_synth_su1.
    [Graphical view ]
    Pfami PF07307. HEPPP_synt_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of Bacillus subtilis dbpA, mtr(A,B), gerC(1-3), ndk, cheR, aro(B,E,F,H), trp(A-F), hisH, and tyrA genes."
      Henner D.J.
      Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Characterization and cloning of the gerC locus of Bacillus subtilis 168."
      Yazdi M.A., Moir A.
      J. Gen. Microbiol. 136:1335-1342(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF GERC LOCUS.
    4. "The gerC locus of Bacillus subtilis, required for menaquinone biosynthesis, is concerned only indirectly with spore germination."
      Leatherbarrow A.J.H., Yazdi M.A., Curson J.P., Moir A.
      Microbiology 144:2125-2130(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHEPS1_BACSU
    AccessioniPrimary (citable) accession number: P31112
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

    External Data

    Dasty 3