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P31111

- ZIP1_YEAST

UniProt

P31111 - ZIP1_YEAST

Protein

Synaptonemal complex protein ZIP1

Gene

ZIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Required for meiotic chromosome synapsis and cell cycle progression. May act as a molecular zipper to bring homologous chromosomes in close apposition. ZIP1 may encode the transverse filaments of the synaptonemal complex.

    GO - Molecular functioni

    1. chromatin binding Source: SGD
    2. protein binding Source: IntAct
    3. SUMO polymer binding Source: SGD

    GO - Biological processi

    1. positive regulation of protein sumoylation Source: SGD
    2. reciprocal meiotic recombination Source: SGD
    3. synapsis Source: SGD

    Keywords - Biological processi

    Meiosis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29849-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptonemal complex protein ZIP1
    Gene namesi
    Name:ZIP1
    Ordered Locus Names:YDR285W
    ORF Names:D9819.9
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR285w.
    SGDiS000002693. ZIP1.

    Subcellular locationi

    Nucleus. Chromosome
    Note: Synapsed meiotic chromosomes.

    GO - Cellular componenti

    1. synaptonemal complex Source: SGD
    2. transverse filament Source: SGD

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 875875Synaptonemal complex protein ZIP1PRO_0000066584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei481 – 4811Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP31111.

    Expressioni

    Gene expression databases

    GenevestigatoriP31111.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CST9Q060323EBI-29645,EBI-30044

    Protein-protein interaction databases

    BioGridi32338. 68 interactions.
    DIPiDIP-1240N.
    IntActiP31111. 4 interactions.
    MINTiMINT-439827.
    STRINGi4932.YDR285W.

    Structurei

    3D structure databases

    ProteinModelPortaliP31111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili177 – 333157Sequence AnalysisAdd
    BLAST
    Coiled coili397 – 43842Sequence AnalysisAdd
    BLAST
    Coiled coili456 – 752297Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG145618.
    KOiK12768.
    OMAiIKHEHER.
    OrthoDBiEOG7PS1RN.

    Sequencei

    Sequence statusi: Complete.

    P31111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNFFRDSSM GFKPRPNIFA KLRVRDVDSD SSANTVVENS SNCLDVGSSI    50
    EGDDTFKKPH KTSTEQELIT SMSLSQRNHG YSDDMEIGSP KKTTSTDQYN 100
    RILKNDVAAI ENDTDEDFEI TEVREVSEGV AKETKESHGD PNDSETTLKD 150
    SKMHEYTMTN GKAPLHTSIN NSSTSSNDVL LEAFTNTQRI CSNLKQELQK 200
    QQQDNAKLKV RLQSYASNSD KINEKVGKYK SCLETLQERI ATLTSHKNNQ 250
    ETKLKDLRQN HQLYQRRISG FKTSIENLNK TINDLGKNKK EADAELMKKG 300
    KEIEYLKREL DDCSGQLSEE KIKNSSLIQE MGKNREEMIK SIENFFSEDK 350
    AHHLLQFNKF EERVHDLFEK KLQKHFDVAK DTLNVGLRNT TVELSSNTET 400
    MLKQQYEDIK ENLEQKMSSS KDEMAKTINE LSVTQKGLIM GVQEELLTSS 450
    GNIQTALVSE MNNTRQELLD DASQTAKNYA SLENLVKAYK AEIVQSNEYE 500
    ERIKHLESER STLSSQKNQI ISSLGTKEAQ YEDLVKKLEA KNIEISQISG 550
    KEQSLTEKNE NLSNELKKVQ DQLEKLNNLN ITTKSNYENK ISSQNEIVKA 600
    LVSENDTLKQ RIQQLVEIKE NEQKDHTTKL EAFQKNNEQL QKLNVEVVQL 650
    KAHELELEEQ NRHLKNCLEK KETGVEESLS DVKTLKQQVI VLKSEKQDIT 700
    AEKLELQDNL ESLEEVTKNL QQKVQSQKRE LEQKIKELEE IKNHKRNEPS 750
    KKGTQNFTKP SDSPKKNATT SNLFPNNSAA IHSPMKKCPK VDHISKSRIN 800
    SSKETSKFND EFDLSSSSND DLELTNPSPI QIKPVRGKIK KGSNCMKPPI 850
    SSRKKLLLVE DEDQSLKISK KRRRK 875
    Length:875
    Mass (Da):100,035
    Last modified:October 1, 1996 - v2
    Checksum:i674F12625CD9DDFD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551T → A in AAA35239. (PubMed:7916652)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06487 Genomic DNA. Translation: AAA35239.1.
    U51031 Genomic DNA. Translation: AAB64474.1.
    BK006938 Genomic DNA. Translation: DAA12125.1.
    PIRiS70115.
    RefSeqiNP_010571.1. NM_001180593.1.

    Genome annotation databases

    EnsemblFungiiYDR285W; YDR285W; YDR285W.
    GeneIDi851879.
    KEGGisce:YDR285W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06487 Genomic DNA. Translation: AAA35239.1 .
    U51031 Genomic DNA. Translation: AAB64474.1 .
    BK006938 Genomic DNA. Translation: DAA12125.1 .
    PIRi S70115.
    RefSeqi NP_010571.1. NM_001180593.1.

    3D structure databases

    ProteinModelPortali P31111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32338. 68 interactions.
    DIPi DIP-1240N.
    IntActi P31111. 4 interactions.
    MINTi MINT-439827.
    STRINGi 4932.YDR285W.

    Proteomic databases

    PaxDbi P31111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR285W ; YDR285W ; YDR285W .
    GeneIDi 851879.
    KEGGi sce:YDR285W.

    Organism-specific databases

    CYGDi YDR285w.
    SGDi S000002693. ZIP1.

    Phylogenomic databases

    eggNOGi NOG145618.
    KOi K12768.
    OMAi IKHEHER.
    OrthoDBi EOG7PS1RN.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29849-MONOMER.

    Miscellaneous databases

    NextBioi 969844.
    PROi P31111.

    Gene expression databases

    Genevestigatori P31111.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis."
      Sym M., Engebrecht J.A., Roeder G.S.
      Cell 72:365-378(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BR1824-3B.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZIP1_YEAST
    AccessioniPrimary (citable) accession number: P31111
    Secondary accession number(s): D6VSR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 391 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3