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Protein

Synaptobrevin homolog 1

Gene

SNC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion.

GO - Molecular functioni

  • SNAP receptor activity Source: SGD

GO - Biological processi

  • endocytosis Source: SGD
  • exocytosis Source: SGD
  • Golgi to plasma membrane transport Source: SGD
  • vesicle fusion Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28841-MONOMER.
ReactomeiR-SCE-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog 1
Gene namesi
Name:SNC1
Ordered Locus Names:YAL030W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL030W.
SGDiS000000028. SNC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9494CytoplasmicSequence analysisAdd
BLAST
Transmembranei95 – 11117Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini112 – 1176VesicularSequence analysis

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • endosome Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
  • SNARE complex Source: SGD
  • trans-Golgi network Source: SGD
  • transport vesicle membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117Synaptobrevin homolog 1PRO_0000206744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki63 – 63Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Lipidationi95 – 951S-palmitoyl cysteine1 Publication

Post-translational modificationi

Palmitoylated by SWF1.1 Publication

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

MaxQBiP31109.
PeptideAtlasiP31109.

PTM databases

iPTMnetiP31109.
SwissPalmiP31109.

Interactioni

GO - Molecular functioni

  • SNAP receptor activity Source: SGD

Protein-protein interaction databases

BioGridi31736. 59 interactions.
DIPiDIP-2495N.
IntActiP31109. 2 interactions.

Structurei

Secondary structure

1
117
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi27 – 8559Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B5NX-ray1.60A/E/I27-86[»]
DisProtiDP00113.
ProteinModelPortaliP31109.
SMRiP31109. Positions 27-86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31109.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 8861v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
InParanoidiP31109.
KOiK08513.
OMAiCRNIKLT.
OrthoDBiEOG7W9S5V.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSTPFDPY ALSEHDEERP QNVQSKSRTA ELQAEIDDTV GIMRDNINKV
60 70 80 90 100
AERGERLTSI EDKADNLAVS AQGFKRGANR VRKAMWYKDL KMKMCLALVI
110
IILLVVIIVP IAVHFSR
Length:117
Mass (Da):13,201
Last modified:July 1, 1993 - v1
Checksum:i662C3DB5C8D44A94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91157 Genomic DNA. Translation: AAA35069.1.
U12980 Genomic DNA. Translation: AAC05002.1.
BK006935 Genomic DNA. Translation: DAA06958.1.
PIRiS31250.
RefSeqiNP_009372.1. NM_001178175.1.

Genome annotation databases

EnsemblFungiiYAL030W; YAL030W; YAL030W.
GeneIDi851203.
KEGGisce:YAL030W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91157 Genomic DNA. Translation: AAA35069.1.
U12980 Genomic DNA. Translation: AAC05002.1.
BK006935 Genomic DNA. Translation: DAA06958.1.
PIRiS31250.
RefSeqiNP_009372.1. NM_001178175.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B5NX-ray1.60A/E/I27-86[»]
DisProtiDP00113.
ProteinModelPortaliP31109.
SMRiP31109. Positions 27-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31736. 59 interactions.
DIPiDIP-2495N.
IntActiP31109. 2 interactions.

PTM databases

iPTMnetiP31109.
SwissPalmiP31109.

Proteomic databases

MaxQBiP31109.
PeptideAtlasiP31109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL030W; YAL030W; YAL030W.
GeneIDi851203.
KEGGisce:YAL030W.

Organism-specific databases

EuPathDBiFungiDB:YAL030W.
SGDiS000000028. SNC1.

Phylogenomic databases

GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
InParanoidiP31109.
KOiK08513.
OMAiCRNIKLT.
OrthoDBiEOG7W9S5V.

Enzyme and pathway databases

BioCyciYEAST:G3O-28841-MONOMER.
ReactomeiR-SCE-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

EvolutionaryTraceiP31109.
PROiP31109.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes."
    Gerst J.E., Rodgers L., Riggs M., Wigler M.
    Proc. Natl. Acad. Sci. U.S.A. 89:4338-4342(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Erratum
    Gerst J.E., Rodgers L., Riggs M., Wigler M.
    Proc. Natl. Acad. Sci. U.S.A. 89:7287-7287(1992)
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-63.
    Strain: SUB592.
  6. "Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation."
    Valdez-Taubas J., Pelham H.R.B.
    EMBO J. 24:2524-2532(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-95.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNC1_YEAST
AccessioniPrimary (citable) accession number: P31109
Secondary accession number(s): D6VPI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 8, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.