P31098 (OSTK_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Osteopontin-K
Organism	Bos taurus (Bovine) [Reference proteome]
Taxonomic identifier	9913 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably involved in cell adhesion.
Subcellular location	Secreted.
Tissue specificity	Kidney, liver and heart. Weak in bone.
Sequence similarities	Belongs to the osteopontin family.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Secreted
Domain	Signal
Ligand	Sialic acid
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW ossification Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	By similarity
	Chain	17 – 277	261	Osteopontin-K		PRO_0000020328
Regions
	Motif	152 – 154	3	Cell attachment site
Amino acid modifications
	Glycosylation	101	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P31098 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 0943B831CDC18DF2	FASTA	277	30,969
	10 20 30 40 50 60 MRIAVICFCL LGIASALPVK PTSSGSSEEK QLNNKYPDAV ATWLKPDPSQ KQTFLAPQNS 70 80 90 100 110 120 VSSEETDDNK QNTLPSKSNE DPEQTDDLDD DDDNSQDVNS NDSDDAETTD DPDHSDESHH 130 140 150 160 170 180 SDESHQVHFP TDIPTIAVFT PFIPTESAND GRGDRCGLRT EVKIIEVPPI NVQSPDATEE 190 200 210 220 230 240 DFTSHIESER CMSTKKTSRL TDHSKETNRC ELSKELMPKA KDKNKHSNLI ESQENSKLSQ 250 260 270 EFHSLEDKLD LDHKSEEDKH LKIRISHELD SASSEVN

References

[1]	"Isolation and characterization of a cDNA for osteopontin-k: a kidney cell adhesion molecule with high homology to osteopontins." Crivello J.F., Delvin E. J. Bone Miner. Res. 7:693-699(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S45840 mRNA. Translation: AAB23593.2.
IPI	IPI00696774.
UniGene	Bt.10536.
3D structure databases
ModBase	Search...
Proteomic databases
PaxDb	P31098.
PRIDE	P31098.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG73598.
HOGENOM	HOG000059656.
HOVERGEN	HBG001731.
Enzyme and pathway databases
BioCyc	CATTLE:281499-MONOMER.
Family and domain databases
InterPro	IPR002038. Osteopontin. IPR019841. Osteopontin_CS. [Graphical view]
PANTHER	PTHR10607. PTHR10607. 1 hit.
Pfam	PF00865. Osteopontin. 1 hit. [Graphical view]
PRINTS	PR00216. OSTEOPONTIN.
SMART	SM00017. OSTEO. 1 hit. [Graphical view]
PROSITE	PS00884. OSTEOPONTIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OSTK_BOVIN

Accession

Primary (citable) accession number: P31098

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 29, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program