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Protein

Uncharacterized fimbrial-like protein YadC

Gene

yadC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.1 Publication

GO - Biological processi

  • cell adhesion involved in single-species biofilm formation Source: EcoCyc
  • cellular response to DNA damage stimulus Source: EcoCyc
  • response to antibiotic Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11678-MONOMER.
ECOL316407:JW0131-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YadC
Gene namesi
Name:yadC
Ordered Locus Names:b0135, JW0131
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11678. yadC.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 412390Uncharacterized fimbrial-like protein YadCPRO_0000009253Add
BLAST

Proteomic databases

PRIDEiP31058.

Expressioni

Inductioni

Repressed by H-NS.1 Publication

Interactioni

Protein-protein interaction databases

DIPiDIP-11181N.
STRINGi511145.b0135.

Structurei

3D structure databases

ProteinModelPortaliP31058.
SMRiP31058. Positions 247-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG305823.
HOGENOMiHOG000116867.
OMAiIGVMIEG.
OrthoDBiEOG66HVBN.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
IPR017014. Fimbrial-like_YadC.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
PIRSFiPIRSF033053. UCP033503_fimbr. 1 hit.
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIFRYILF LALYSCCNTV SAYTSFIVGN NAGVDNYRGP STAAQMTFNY
60 70 80 90 100
TSTASNLVFY KPTQLGPTGV KMYWSYLDTG TGGGILYCNT SGRANPGPIT
110 120 130 140 150
IENAMVYSGK DYGGHKLFNT SVPGLYYTML ISRVWSAYDT ITDIQSPGIY
160 170 180 190 200
IGDPSNQEFF FSVTDSDLQT KGCNKADDYD KFWAIGGIVH NITVEFYTDT
210 220 230 240 250
NFDPTLNQQV QLSSSSNYLY SFKAYSPGTK VVDHSNHIYV NFTLNNVKLT
260 270 280 290 300
LPTCFTSILT GPSVNGSTVR MGEYSSGTIK NGASPVPFDI SLQNCIRVRN
310 320 330 340 350
IETKLVTGKV GTQNTQLLGN TLTGSTAAKG VGVLIEGLAT SKNPLMTLKP
360 370 380 390 400
NDTNSVYIDY ETEDDTSDGV YPNQGNGTSQ PLHFQATLKQ DGNIAIEPGE
410
FKATSTFQVT YP
Length:412
Mass (Da):44,899
Last modified:June 1, 1994 - v2
Checksum:i3945450AD85EB5BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2072LN → VT in X65538 (PubMed:8096212).Curated
Sequence conflicti210 – 2112VQ → IK in X65538 (PubMed:8096212).Curated
Sequence conflicti226 – 24520SPGTK…NFTLN → GAGQGINEHSYFIKIDFDLL in X65538 (PubMed:8096212).CuratedAdd
BLAST
Sequence conflicti251 – 2511L → N in X65538 (PubMed:8096212).Curated
Sequence conflicti257 – 2626SILTGP → AMLSGT in X65538 (PubMed:8096212).Curated
Sequence conflicti265 – 2651N → T in X65538 (PubMed:8096212).Curated
Sequence conflicti270 – 2701R → K in X65538 (PubMed:8096212).Curated
Sequence conflicti276 – 2805SGTIK → AEQKR in X65538 (PubMed:8096212).Curated
Sequence conflicti284 – 2841S → T in X65538 (PubMed:8096212).Curated
Sequence conflicti296 – 2961I → V in X65538 (PubMed:8096212).Curated
Sequence conflicti299 – 2991R → T in X65538 (PubMed:8096212).Curated
Sequence conflicti307 – 3082TG → ST in X65538 (PubMed:8096212).Curated
Sequence conflicti313 – 3153QNT → ETG in X65538 (PubMed:8096212).Curated
Sequence conflicti325 – 3262ST → ND in X65538 (PubMed:8096212).Curated
Sequence conflicti353 – 3531T → S in X65538 (PubMed:8096212).Curated
Sequence conflicti358 – 3581I → K in X65538 (PubMed:8096212).Curated
Sequence conflicti361 – 3633ETE → DPRGK in X65538 (PubMed:8096212).Curated
Sequence conflicti367 – 3682SD → TG in X65538 (PubMed:8096212).Curated
Sequence conflicti373 – 3808NQGNGTSQ → DQDTGITY in X65538 (PubMed:8096212).Curated
Sequence conflicti389 – 3891K → Q in X65538 (PubMed:8096212).Curated
Sequence conflicti393 – 3931N → T in X65538 (PubMed:8096212).Curated
Sequence conflicti395 – 3951A → P in X65538 (PubMed:8096212).Curated
Sequence conflicti398 – 3981P → A in X65538 (PubMed:8096212).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73246.1.
AP009048 Genomic DNA. Translation: BAB96712.1.
X65538 Genomic DNA. No translation available.
L17086 Genomic DNA. No translation available.
PIRiG64736.
RefSeqiNP_414677.1. NC_000913.3.
WP_000848455.1. NZ_CP010445.1.

Genome annotation databases

EnsemblBacteriaiAAC73246; AAC73246; b0135.
BAB96712; BAB96712; BAB96712.
GeneIDi944837.
KEGGieco:b0135.
PATRICi32115375. VBIEscCol129921_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73246.1.
AP009048 Genomic DNA. Translation: BAB96712.1.
X65538 Genomic DNA. No translation available.
L17086 Genomic DNA. No translation available.
PIRiG64736.
RefSeqiNP_414677.1. NC_000913.3.
WP_000848455.1. NZ_CP010445.1.

3D structure databases

ProteinModelPortaliP31058.
SMRiP31058. Positions 247-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-11181N.
STRINGi511145.b0135.

Proteomic databases

PRIDEiP31058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73246; AAC73246; b0135.
BAB96712; BAB96712; BAB96712.
GeneIDi944837.
KEGGieco:b0135.
PATRICi32115375. VBIEscCol129921_0139.

Organism-specific databases

EchoBASEiEB1629.
EcoGeneiEG11678. yadC.

Phylogenomic databases

eggNOGiNOG305823.
HOGENOMiHOG000116867.
OMAiIGVMIEG.
OrthoDBiEOG66HVBN.

Enzyme and pathway databases

BioCyciEcoCyc:EG11678-MONOMER.
ECOL316407:JW0131-MONOMER.

Miscellaneous databases

PROiP31058.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
IPR017014. Fimbrial-like_YadC.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
PIRSFiPIRSF033053. UCP033503_fimbr. 1 hit.
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region."
    Fujita N., Mori H., Yura T., Ishihama A.
    Nucleic Acids Res. 22:1637-1639(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme."
    Jones C.E., Brook J.M., Buck D., Abell C., Smith A.G.
    J. Bacteriol. 175:2125-2130(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-412.
    Strain: K12.
  5. "Nucleotide sequence of the Escherichia coli panBCD gene cluster."
    Merkel W.K., Nichols B.P.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 354-412.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
    Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
    Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYADC_ECOLI
AccessioniPrimary (citable) accession number: P31058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 1, 1994
Last modified: July 22, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.