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P31058

- YADC_ECOLI

UniProt

P31058 - YADC_ECOLI

Protein

Uncharacterized fimbrial-like protein YadC

Gene

yadC

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.1 Publication

    GO - Biological processi

    1. cell adhesion involved in single-species biofilm formation Source: EcoCyc
    2. cellular response to DNA damage stimulus Source: EcoCyc
    3. response to antibiotic Source: EcoCyc

    Enzyme and pathway databases

    BioCyciEcoCyc:EG11678-MONOMER.
    ECOL316407:JW0131-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized fimbrial-like protein YadC
    Gene namesi
    Name:yadC
    Ordered Locus Names:b0135, JW0131
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11678. yadC.

    Subcellular locationi

    Fimbrium Curated

    GO - Cellular componenti

    1. pilus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Fimbrium

    Pathology & Biotechi

    Disruption phenotypei

    Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 412390Uncharacterized fimbrial-like protein YadCPRO_0000009253Add
    BLAST

    Proteomic databases

    PRIDEiP31058.

    Expressioni

    Inductioni

    Repressed by H-NS.1 Publication

    Gene expression databases

    GenevestigatoriP31058.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-11181N.
    STRINGi511145.b0135.

    Structurei

    3D structure databases

    ProteinModelPortaliP31058.
    SMRiP31058. Positions 247-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the fimbrial protein family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG305823.
    HOGENOMiHOG000116867.
    OMAiIGVMIEG.
    OrthoDBiEOG66HVBN.

    Family and domain databases

    Gene3Di2.60.40.1090. 1 hit.
    InterProiIPR008966. Adhesion_dom.
    IPR000259. Adhesion_dom_fimbrial.
    IPR017014. Fimbrial-like_YadC.
    [Graphical view]
    PfamiPF00419. Fimbrial. 1 hit.
    [Graphical view]
    PIRSFiPIRSF033053. UCP033503_fimbr. 1 hit.
    SUPFAMiSSF49401. SSF49401. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31058-1 [UniParc]FASTAAdd to Basket

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    MKTIFRYILF LALYSCCNTV SAYTSFIVGN NAGVDNYRGP STAAQMTFNY    50
    TSTASNLVFY KPTQLGPTGV KMYWSYLDTG TGGGILYCNT SGRANPGPIT 100
    IENAMVYSGK DYGGHKLFNT SVPGLYYTML ISRVWSAYDT ITDIQSPGIY 150
    IGDPSNQEFF FSVTDSDLQT KGCNKADDYD KFWAIGGIVH NITVEFYTDT 200
    NFDPTLNQQV QLSSSSNYLY SFKAYSPGTK VVDHSNHIYV NFTLNNVKLT 250
    LPTCFTSILT GPSVNGSTVR MGEYSSGTIK NGASPVPFDI SLQNCIRVRN 300
    IETKLVTGKV GTQNTQLLGN TLTGSTAAKG VGVLIEGLAT SKNPLMTLKP 350
    NDTNSVYIDY ETEDDTSDGV YPNQGNGTSQ PLHFQATLKQ DGNIAIEPGE 400
    FKATSTFQVT YP 412
    Length:412
    Mass (Da):44,899
    Last modified:June 1, 1994 - v2
    Checksum:i3945450AD85EB5BE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2072LN → VT in X65538. (PubMed:8096212)Curated
    Sequence conflicti210 – 2112VQ → IK in X65538. (PubMed:8096212)Curated
    Sequence conflicti226 – 24520SPGTK…NFTLN → GAGQGINEHSYFIKIDFDLL in X65538. (PubMed:8096212)CuratedAdd
    BLAST
    Sequence conflicti251 – 2511L → N in X65538. (PubMed:8096212)Curated
    Sequence conflicti257 – 2626SILTGP → AMLSGT in X65538. (PubMed:8096212)Curated
    Sequence conflicti265 – 2651N → T in X65538. (PubMed:8096212)Curated
    Sequence conflicti270 – 2701R → K in X65538. (PubMed:8096212)Curated
    Sequence conflicti276 – 2805SGTIK → AEQKR in X65538. (PubMed:8096212)Curated
    Sequence conflicti284 – 2841S → T in X65538. (PubMed:8096212)Curated
    Sequence conflicti296 – 2961I → V in X65538. (PubMed:8096212)Curated
    Sequence conflicti299 – 2991R → T in X65538. (PubMed:8096212)Curated
    Sequence conflicti307 – 3082TG → ST in X65538. (PubMed:8096212)Curated
    Sequence conflicti313 – 3153QNT → ETG in X65538. (PubMed:8096212)Curated
    Sequence conflicti325 – 3262ST → ND in X65538. (PubMed:8096212)Curated
    Sequence conflicti353 – 3531T → S in X65538. (PubMed:8096212)Curated
    Sequence conflicti358 – 3581I → K in X65538. (PubMed:8096212)Curated
    Sequence conflicti361 – 3633ETE → DPRGK in X65538. (PubMed:8096212)Curated
    Sequence conflicti367 – 3682SD → TG in X65538. (PubMed:8096212)Curated
    Sequence conflicti373 – 3808NQGNGTSQ → DQDTGITY in X65538. (PubMed:8096212)Curated
    Sequence conflicti389 – 3891K → Q in X65538. (PubMed:8096212)Curated
    Sequence conflicti393 – 3931N → T in X65538. (PubMed:8096212)Curated
    Sequence conflicti395 – 3951A → P in X65538. (PubMed:8096212)Curated
    Sequence conflicti398 – 3981P → A in X65538. (PubMed:8096212)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC73246.1.
    AP009048 Genomic DNA. Translation: BAB96712.1.
    X65538 Genomic DNA. No translation available.
    L17086 Genomic DNA. No translation available.
    PIRiG64736.
    RefSeqiNP_414677.1. NC_000913.3.
    YP_488438.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73246; AAC73246; b0135.
    BAB96712; BAB96712; BAB96712.
    GeneIDi12933212.
    944837.
    KEGGiecj:Y75_p0132.
    eco:b0135.
    PATRICi32115375. VBIEscCol129921_0139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC73246.1 .
    AP009048 Genomic DNA. Translation: BAB96712.1 .
    X65538 Genomic DNA. No translation available.
    L17086 Genomic DNA. No translation available.
    PIRi G64736.
    RefSeqi NP_414677.1. NC_000913.3.
    YP_488438.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P31058.
    SMRi P31058. Positions 247-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-11181N.
    STRINGi 511145.b0135.

    Proteomic databases

    PRIDEi P31058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73246 ; AAC73246 ; b0135 .
    BAB96712 ; BAB96712 ; BAB96712 .
    GeneIDi 12933212.
    944837.
    KEGGi ecj:Y75_p0132.
    eco:b0135.
    PATRICi 32115375. VBIEscCol129921_0139.

    Organism-specific databases

    EchoBASEi EB1629.
    EcoGenei EG11678. yadC.

    Phylogenomic databases

    eggNOGi NOG305823.
    HOGENOMi HOG000116867.
    OMAi IGVMIEG.
    OrthoDBi EOG66HVBN.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG11678-MONOMER.
    ECOL316407:JW0131-MONOMER.

    Miscellaneous databases

    PROi P31058.

    Gene expression databases

    Genevestigatori P31058.

    Family and domain databases

    Gene3Di 2.60.40.1090. 1 hit.
    InterProi IPR008966. Adhesion_dom.
    IPR000259. Adhesion_dom_fimbrial.
    IPR017014. Fimbrial-like_YadC.
    [Graphical view ]
    Pfami PF00419. Fimbrial. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF033053. UCP033503_fimbr. 1 hit.
    SUPFAMi SSF49401. SSF49401. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region."
      Fujita N., Mori H., Yura T., Ishihama A.
      Nucleic Acids Res. 22:1637-1639(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme."
      Jones C.E., Brook J.M., Buck D., Abell C., Smith A.G.
      J. Bacteriol. 175:2125-2130(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-412.
      Strain: K12.
    5. "Nucleotide sequence of the Escherichia coli panBCD gene cluster."
      Merkel W.K., Nichols B.P.
      Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 354-412.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    6. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
      Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
      Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiYADC_ECOLI
    AccessioniPrimary (citable) accession number: P31058
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3