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P31058

- YADC_ECOLI

UniProt

P31058 - YADC_ECOLI

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Protein
Uncharacterized fimbrial-like protein YadC
Gene
yadC, b0135, JW0131
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.1 Publication

GO - Biological processi

  1. cell adhesion involved in single-species biofilm formation Source: EcoCyc
  2. cellular response to DNA damage stimulus Source: EcoCyc
  3. response to antibiotic Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11678-MONOMER.
ECOL316407:JW0131-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YadC
Gene namesi
Name:yadC
Ordered Locus Names:b0135, JW0131
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11678. yadC.

Subcellular locationi

Fimbrium Reviewed prediction

GO - Cellular componenti

  1. pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 412390Uncharacterized fimbrial-like protein YadC
PRO_0000009253Add
BLAST

Proteomic databases

PRIDEiP31058.

Expressioni

Inductioni

Repressed by H-NS.1 Publication

Gene expression databases

GenevestigatoriP31058.

Interactioni

Protein-protein interaction databases

DIPiDIP-11181N.
STRINGi511145.b0135.

Structurei

3D structure databases

ProteinModelPortaliP31058.
SMRiP31058. Positions 247-412.

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG305823.
HOGENOMiHOG000116867.
OMAiIGVMIEG.
OrthoDBiEOG66HVBN.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
IPR017014. Fimbrial-like_YadC.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
PIRSFiPIRSF033053. UCP033503_fimbr. 1 hit.
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31058-1 [UniParc]FASTAAdd to Basket

« Hide

MKTIFRYILF LALYSCCNTV SAYTSFIVGN NAGVDNYRGP STAAQMTFNY    50
TSTASNLVFY KPTQLGPTGV KMYWSYLDTG TGGGILYCNT SGRANPGPIT 100
IENAMVYSGK DYGGHKLFNT SVPGLYYTML ISRVWSAYDT ITDIQSPGIY 150
IGDPSNQEFF FSVTDSDLQT KGCNKADDYD KFWAIGGIVH NITVEFYTDT 200
NFDPTLNQQV QLSSSSNYLY SFKAYSPGTK VVDHSNHIYV NFTLNNVKLT 250
LPTCFTSILT GPSVNGSTVR MGEYSSGTIK NGASPVPFDI SLQNCIRVRN 300
IETKLVTGKV GTQNTQLLGN TLTGSTAAKG VGVLIEGLAT SKNPLMTLKP 350
NDTNSVYIDY ETEDDTSDGV YPNQGNGTSQ PLHFQATLKQ DGNIAIEPGE 400
FKATSTFQVT YP 412
Length:412
Mass (Da):44,899
Last modified:June 1, 1994 - v2
Checksum:i3945450AD85EB5BE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2072LN → VT in X65538. 1 Publication
Sequence conflicti210 – 2112VQ → IK in X65538. 1 Publication
Sequence conflicti226 – 24520SPGTK…NFTLN → GAGQGINEHSYFIKIDFDLL in X65538. 1 Publication
Add
BLAST
Sequence conflicti251 – 2511L → N in X65538. 1 Publication
Sequence conflicti257 – 2626SILTGP → AMLSGT in X65538. 1 Publication
Sequence conflicti265 – 2651N → T in X65538. 1 Publication
Sequence conflicti270 – 2701R → K in X65538. 1 Publication
Sequence conflicti276 – 2805SGTIK → AEQKR in X65538. 1 Publication
Sequence conflicti284 – 2841S → T in X65538. 1 Publication
Sequence conflicti296 – 2961I → V in X65538. 1 Publication
Sequence conflicti299 – 2991R → T in X65538. 1 Publication
Sequence conflicti307 – 3082TG → ST in X65538. 1 Publication
Sequence conflicti313 – 3153QNT → ETG in X65538. 1 Publication
Sequence conflicti325 – 3262ST → ND in X65538. 1 Publication
Sequence conflicti353 – 3531T → S in X65538. 1 Publication
Sequence conflicti358 – 3581I → K in X65538. 1 Publication
Sequence conflicti361 – 3633ETE → DPRGK in X65538. 1 Publication
Sequence conflicti367 – 3682SD → TG in X65538. 1 Publication
Sequence conflicti373 – 3808NQGNGTSQ → DQDTGITY in X65538. 1 Publication
Sequence conflicti389 – 3891K → Q in X65538. 1 Publication
Sequence conflicti393 – 3931N → T in X65538. 1 Publication
Sequence conflicti395 – 3951A → P in X65538. 1 Publication
Sequence conflicti398 – 3981P → A in X65538. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC73246.1.
AP009048 Genomic DNA. Translation: BAB96712.1.
X65538 Genomic DNA. No translation available.
L17086 Genomic DNA. No translation available.
PIRiG64736.
RefSeqiNP_414677.1. NC_000913.3.
YP_488438.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73246; AAC73246; b0135.
BAB96712; BAB96712; BAB96712.
GeneIDi12933212.
944837.
KEGGiecj:Y75_p0132.
eco:b0135.
PATRICi32115375. VBIEscCol129921_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC73246.1 .
AP009048 Genomic DNA. Translation: BAB96712.1 .
X65538 Genomic DNA. No translation available.
L17086 Genomic DNA. No translation available.
PIRi G64736.
RefSeqi NP_414677.1. NC_000913.3.
YP_488438.1. NC_007779.1.

3D structure databases

ProteinModelPortali P31058.
SMRi P31058. Positions 247-412.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-11181N.
STRINGi 511145.b0135.

Proteomic databases

PRIDEi P31058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73246 ; AAC73246 ; b0135 .
BAB96712 ; BAB96712 ; BAB96712 .
GeneIDi 12933212.
944837.
KEGGi ecj:Y75_p0132.
eco:b0135.
PATRICi 32115375. VBIEscCol129921_0139.

Organism-specific databases

EchoBASEi EB1629.
EcoGenei EG11678. yadC.

Phylogenomic databases

eggNOGi NOG305823.
HOGENOMi HOG000116867.
OMAi IGVMIEG.
OrthoDBi EOG66HVBN.

Enzyme and pathway databases

BioCyci EcoCyc:EG11678-MONOMER.
ECOL316407:JW0131-MONOMER.

Miscellaneous databases

PROi P31058.

Gene expression databases

Genevestigatori P31058.

Family and domain databases

Gene3Di 2.60.40.1090. 1 hit.
InterProi IPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
IPR017014. Fimbrial-like_YadC.
[Graphical view ]
Pfami PF00419. Fimbrial. 1 hit.
[Graphical view ]
PIRSFi PIRSF033053. UCP033503_fimbr. 1 hit.
SUPFAMi SSF49401. SSF49401. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region."
    Fujita N., Mori H., Yura T., Ishihama A.
    Nucleic Acids Res. 22:1637-1639(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme."
    Jones C.E., Brook J.M., Buck D., Abell C., Smith A.G.
    J. Bacteriol. 175:2125-2130(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-412.
    Strain: K12.
  5. "Nucleotide sequence of the Escherichia coli panBCD gene cluster."
    Merkel W.K., Nichols B.P.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 354-412.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
    Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
    Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYADC_ECOLI
AccessioniPrimary (citable) accession number: P31058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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