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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei225 – 2251UniRule annotation
Active sitei227 – 2271UniRule annotation
Active sitei232 – 2321UniRule annotation
Active sitei399 – 3991UniRule annotation
Active sitei401 – 4011UniRule annotation
Active sitei406 – 4061UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalUniRule annotationAdd
BLAST
Transmembranei40 – 6021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Cardiolipin synthase APRO_0000201261Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_5364.

Structurei

3D structure databases

ProteinModelPortaliP31048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 24728PLD phosphodiesterase 1UniRule annotationAdd
BLAST
Domaini394 – 42128PLD phosphodiesterase 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX. Bacteria.
COG1502. LUCA.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHMDYHSPYF FGYLLGLIHL LGVVAALHAL FTVRTAQGAI AWAMPLFFIP
60 70 80 90 100
YLTLIPYLIF GARSFYAYIK ARRQANQEMH VAMANLNWRP WVEEALTARE
110 120 130 140 150
SESYAALRAM PKLGRMPCLA NNQVKLLVNG KATFDAIFAA IEKARDVVLV
160 170 180 190 200
QFFIIHDDTL GKALQQLLLR KAAEGVQVFV LYDRVGSHAL PASYSQQLRN
210 220 230 240 250
GGVQIHAFAT RRGWFNRFQV NFRNHRKIVV VDGLLGFIGG HNVGDEYLGG
260 270 280 290 300
HPQLSPWRDT HVQISGPVLA CLQESFAEDW YWATRQLPPL ILPDAYPDNG
310 320 330 340 350
VLCQALASGP ADPQETCSLF FLEAIHSATR RVWITSPYFI PDEAVFAALR
360 370 380 390 400
LAVLRGVDVR VLIPSRPDHR IVYAASSLFA FEAVRAGVRM FRYQPGFLHQ
410 420 430 440 450
KVVLVDDEVS AIGSANLDNR SFRLNFEITL LTVDRNFADQ VEHMLIKDFE
460 470 480
QAREITAEDS RDTHRLQQLG MRIARLISPI L
Length:481
Mass (Da):54,329
Last modified:July 1, 1993 - v1
Checksum:iB23A61677AE6D83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55704 Genomic DNA. Translation: CAA39233.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55704 Genomic DNA. Translation: CAA39233.1.

3D structure databases

ProteinModelPortaliP31048.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160488.PP_5364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CQX. Bacteria.
COG1502. LUCA.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLSA_PSEPU
AccessioniPrimary (citable) accession number: P31048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 11, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.