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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei225UniRule annotation1
Active sitei227UniRule annotation1
Active sitei232UniRule annotation1
Active sitei399UniRule annotation1
Active sitei401UniRule annotation1
Active sitei406UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalUniRule annotationAdd BLAST21
Transmembranei40 – 60HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012611 – 481Cardiolipin synthase AAdd BLAST481

Structurei

3D structure databases

ProteinModelPortaliP31048.
SMRiP31048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 247PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini394 – 421PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX. Bacteria.
COG1502. LUCA.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiView protein in InterPro
IPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
PfamiView protein in Pfam
PF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
SMARTiView protein in SMART
SM00155. PLDc. 2 hits.
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiView protein in PROSITE
PS50035. PLD. 2 hits.

Sequencei

Sequence statusi: Complete.

P31048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHMDYHSPYF FGYLLGLIHL LGVVAALHAL FTVRTAQGAI AWAMPLFFIP
60 70 80 90 100
YLTLIPYLIF GARSFYAYIK ARRQANQEMH VAMANLNWRP WVEEALTARE
110 120 130 140 150
SESYAALRAM PKLGRMPCLA NNQVKLLVNG KATFDAIFAA IEKARDVVLV
160 170 180 190 200
QFFIIHDDTL GKALQQLLLR KAAEGVQVFV LYDRVGSHAL PASYSQQLRN
210 220 230 240 250
GGVQIHAFAT RRGWFNRFQV NFRNHRKIVV VDGLLGFIGG HNVGDEYLGG
260 270 280 290 300
HPQLSPWRDT HVQISGPVLA CLQESFAEDW YWATRQLPPL ILPDAYPDNG
310 320 330 340 350
VLCQALASGP ADPQETCSLF FLEAIHSATR RVWITSPYFI PDEAVFAALR
360 370 380 390 400
LAVLRGVDVR VLIPSRPDHR IVYAASSLFA FEAVRAGVRM FRYQPGFLHQ
410 420 430 440 450
KVVLVDDEVS AIGSANLDNR SFRLNFEITL LTVDRNFADQ VEHMLIKDFE
460 470 480
QAREITAEDS RDTHRLQQLG MRIARLISPI L
Length:481
Mass (Da):54,329
Last modified:July 1, 1993 - v1
Checksum:iB23A61677AE6D83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55704 Genomic DNA. Translation: CAA39233.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCLSA_PSEPU
AccessioniPrimary (citable) accession number: P31048
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 5, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families