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Protein

T-cell-specific surface glycoprotein CD28

Gene

Cd28

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.By similarity

GO - Molecular functioni

  • coreceptor activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • immune response Source: RGD
  • positive regulation of interleukin-10 production Source: UniProtKB
  • positive regulation of interleukin-2 biosynthetic process Source: UniProtKB
  • positive regulation of interleukin-4 production Source: UniProtKB
  • positive regulation of mitotic nuclear division Source: UniProtKB
  • positive regulation of T cell proliferation Source: UniProtKB
  • T cell activation Source: RGD
  • T cell costimulation Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell-specific surface glycoprotein CD28
Alternative name(s):
CD_antigen: CD28
Gene namesi
Name:Cd28
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2299 Cd28

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 150ExtracellularSequence analysisAdd BLAST131
Transmembranei151 – 177HelicalSequence analysisAdd BLAST27
Topological domaini178 – 218CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001465420 – 218T-cell-specific surface glycoprotein CD28Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 113By similarity
Disulfide bondi67 ↔ 87By similarity
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei187PhosphoserineBy similarity1
Modified residuei189PhosphotyrosineBy similarity1
Modified residuei207PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31042
PRIDEiP31042

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2 (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013701

Structurei

3D structure databases

ProteinModelPortaliP31042
SMRiP31042
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 138Ig-like V-typeAdd BLAST110

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXMM Eukaryota
ENOG410Z063 LUCA
HOGENOMiHOG000276892
HOVERGENiHBG004094
InParanoidiP31042
KOiK06470
PhylomeDBiP31042

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008093 CD28
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF15910 V-set_2, 1 hit
PRINTSiPR01717 CD28ANTIGEN
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRLLFLAL SFFSVQVTEN KILVKQSPLL VVDNNEVSLS CRYSYNLLAK
60 70 80 90 100
EFRASLYKGV NSDVEVCVGN GNFTYQPQFR PNVGFNCDGN FDNETVTFRL
110 120 130 140 150
WNLDVNHTDI YFCKIEVMYP PPYLDNEKSN GTIIHIKEKH LCHAQTSPKL
160 170 180 190 200
FWPLVVVAGV LLCYGLLVTV TLCIIWTNSR RNRLLQSDYM NMTPRRLGPT
210
RKHYQPYAPA RDFAAYRP
Length:218
Mass (Da):25,170
Last modified:July 1, 1993 - v1
Checksum:i2E151C8F324C0B6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55288 mRNA Translation: CAA39003.1
PIRiS24413
RefSeqiNP_037253.1, NM_013121.1
UniGeneiRn.10327

Genome annotation databases

GeneIDi25660
KEGGirno:25660
UCSCiRGD:2299 rat

Similar proteinsi

Entry informationi

Entry nameiCD28_RAT
AccessioniPrimary (citable) accession number: P31042
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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