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Protein

T-cell-specific surface glycoprotein CD28

Gene

Cd28

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.By similarity

GO - Molecular functioni

  • coreceptor activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • immune response Source: RGD
  • positive regulation of interleukin-10 production Source: UniProtKB
  • positive regulation of interleukin-2 biosynthetic process Source: UniProtKB
  • positive regulation of interleukin-4 production Source: UniProtKB
  • positive regulation of mitotic nuclear division Source: UniProtKB
  • positive regulation of T cell proliferation Source: UniProtKB
  • T cell activation Source: RGD
  • T cell costimulation Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell-specific surface glycoprotein CD28
Alternative name(s):
CD_antigen: CD28
Gene namesi
Name:Cd28
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2299. Cd28.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 150ExtracellularSequence analysisAdd BLAST131
Transmembranei151 – 177HelicalSequence analysisAdd BLAST27
Topological domaini178 – 218CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001465420 – 218T-cell-specific surface glycoprotein CD28Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 113By similarity
Disulfide bondi67 ↔ 87By similarity
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Modified residuei187PhosphoserineBy similarity1
Modified residuei189PhosphotyrosineBy similarity1
Modified residuei207PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31042.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2 (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013701.

Structurei

3D structure databases

ProteinModelPortaliP31042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 138Ig-like V-typeAdd BLAST110

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXMM. Eukaryota.
ENOG410Z063. LUCA.
HOGENOMiHOG000276892.
HOVERGENiHBG004094.
InParanoidiP31042.
KOiK06470.
PhylomeDBiP31042.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008093. CD28.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF15910. V-set_2. 1 hit.
[Graphical view]
PRINTSiPR01717. CD28ANTIGEN.
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRLLFLAL SFFSVQVTEN KILVKQSPLL VVDNNEVSLS CRYSYNLLAK
60 70 80 90 100
EFRASLYKGV NSDVEVCVGN GNFTYQPQFR PNVGFNCDGN FDNETVTFRL
110 120 130 140 150
WNLDVNHTDI YFCKIEVMYP PPYLDNEKSN GTIIHIKEKH LCHAQTSPKL
160 170 180 190 200
FWPLVVVAGV LLCYGLLVTV TLCIIWTNSR RNRLLQSDYM NMTPRRLGPT
210
RKHYQPYAPA RDFAAYRP
Length:218
Mass (Da):25,170
Last modified:July 1, 1993 - v1
Checksum:i2E151C8F324C0B6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55288 mRNA. Translation: CAA39003.1.
PIRiS24413.
RefSeqiNP_037253.1. NM_013121.1.
UniGeneiRn.10327.

Genome annotation databases

GeneIDi25660.
KEGGirno:25660.
UCSCiRGD:2299. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55288 mRNA. Translation: CAA39003.1.
PIRiS24413.
RefSeqiNP_037253.1. NM_013121.1.
UniGeneiRn.10327.

3D structure databases

ProteinModelPortaliP31042.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013701.

Proteomic databases

PaxDbiP31042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25660.
KEGGirno:25660.
UCSCiRGD:2299. rat.

Organism-specific databases

CTDi940.
RGDi2299. Cd28.

Phylogenomic databases

eggNOGiENOG410IXMM. Eukaryota.
ENOG410Z063. LUCA.
HOGENOMiHOG000276892.
HOVERGENiHBG004094.
InParanoidiP31042.
KOiK06470.
PhylomeDBiP31042.

Miscellaneous databases

PROiP31042.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008093. CD28.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF15910. V-set_2. 1 hit.
[Graphical view]
PRINTSiPR01717. CD28ANTIGEN.
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCD28_RAT
AccessioniPrimary (citable) accession number: P31042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 5, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.