Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P31041 (CD28_MOUSE)

Last modified January 19, 2010. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    T-cell-specific surface glycoprotein CD28
Alternative name(s):
    CD_antigen=CD28
Gene names
Name: Cd28
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Possibly involved in T-cell activation.

Subunit structure

Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 218199T-cell-specific surface glycoprotein CD28
PRO_0000014653

Regions

Topological domain20 – 150131Extracellular Potential
Transmembrane151 – 17727 Potential
Topological domain178 – 21841Cytoplasmic Potential
Domain29 – 138110Ig-like V-type

Amino acid modifications

Modified residue2071Phosphotyrosine By similarity
Modified residue2161Phosphotyrosine By similarity
Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation931N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 113 By similarity
Disulfide bond67 ↔ 87 By similarity

Experimental info

Sequence conflict187 – 1893VTT → SDY in AAA37396. Ref.2

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P31041-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: A491439DD7E8FD7F

FASTA21825,179
        10         20         30         40         50         60 
MTLRLLFLAL NFFSVQVTEN KILVKQSPLL VVDSNEVSLS CRYSYNLLAK EFRASLYKGV 

        70         80         90        100        110        120 
NSDVEVCVGN GNFTYQPQFR SNAEFNCDGD FDNETVTFRL WNLHVNHTDI YFCKIEFMYP 

       130        140        150        160        170        180 
PPYLDNERSN GTIIHIKEKH LCHTQSSPKL FWALVVVAGV LFCYGLLVTV ALCVIWTNSR 

       190        200        210 
RNRLLQVTTM NMTPRRPGLT RKPYQPYAPA RDFAAYRP

« Hide

Hide | Top

References

[1]"The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression."
Gross J.A., St John T., Allison J.P.
J. Immunol. 144:3201-3210(1990) [PubMed: 2157764] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location."
Harper K., Balzano C., Rouvier E., Mattei M.-G., Luciani M.-F., Golstein P.
J. Immunol. 147:1037-1044(1991) [PubMed: 1713603] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-218.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M34563 mRNA. Translation: AAA37395.1.
M74361 mRNA. Translation: AAA37396.1.
IPIIPI00318069.
PIRA43523.
I49584.
UniGeneMm.255003

3D structure databases

SMRP31041. Positions 20-137.
ModBaseSearch...

Protein-protein interaction databases

STRINGP31041.

PTM databases

PhosphoSiteP31041.

Proteomic databases

PRIDEP31041.

Genome annotation databases

EnsemblENSMUST00000027165; ENSMUSP00000027165; ENSMUSG00000026012; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:88327. Cd28.

Phylogenomic databases

eggNOGroNOG12814.
HOGENOMHBG280303.
HOVERGENP31041.
InParanoidP31041.

Gene expression databases

ArrayExpressP31041.
BgeeP31041.
CleanExMM_CD28.
GenevestigatorP31041.
GermOnlineENSMUSG00000026012. Mus musculus.

Family and domain databases

InterProIPR008093. CD28.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01717. CD28ANTIGEN.
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Hide | Top

Entry information

Entry nameCD28_MOUSE
AccessionPrimary (citable) accession number: P31041
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: January 19, 2010
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents