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P31041

- CD28_MOUSE

UniProt

P31041 - CD28_MOUSE

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Protein
T-cell-specific surface glycoprotein CD28
Gene
Cd28
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival By similarity.

GO - Biological processi

  1. T cell costimulation Source: MGI
  2. T cell receptor signaling pathway Source: MGI
  3. apoptotic signaling pathway Source: MGI
  4. immune response Source: InterPro
  5. negative thymic T cell selection Source: MGI
  6. positive regulation of T cell proliferation Source: UniProtKB
  7. positive regulation of alpha-beta T cell proliferation Source: MGI
  8. positive regulation of inflammatory response to antigenic stimulus Source: MGI
  9. positive regulation of interleukin-2 biosynthetic process Source: UniProtKB
  10. positive regulation of isotype switching to IgG isotypes Source: MGI
  11. positive regulation of mitosis Source: UniProtKB
  12. positive regulation of signal transduction Source: GOC
  13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  14. regulatory T cell differentiation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_204081. CD28 co-stimulation.
REACT_226151. CD28 dependent PI3K/Akt signaling.
REACT_226341. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell-specific surface glycoprotein CD28
Alternative name(s):
CD_antigen: CD28
Gene namesi
Name:Cd28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:88327. Cd28.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 150131Extracellular Reviewed prediction
Add
BLAST
Transmembranei151 – 17727Helical; Reviewed prediction
Add
BLAST
Topological domaini178 – 21841Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. immunological synapse Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 218199T-cell-specific surface glycoprotein CD28
PRO_0000014653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 113 By similarity
Disulfide bondi67 ↔ 87 By similarity
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi93 – 931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Modified residuei187 – 1871Phosphoserine By similarity
Modified residuei189 – 1891Phosphotyrosine By similarity
Modified residuei207 – 2071Phosphotyrosine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP31041.

PTM databases

PhosphoSiteiP31041.

Expressioni

Gene expression databases

CleanExiMM_CD28.
GenevestigatoriP31041.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2 By similarity.

Protein-protein interaction databases

IntActiP31041. 1 interaction.
STRINGi10090.ENSMUSP00000027165.

Structurei

3D structure databases

ProteinModelPortaliP31041.
SMRiP31041. Positions 20-137.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 138110Ig-like V-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG48152.
GeneTreeiENSGT00530000063873.
HOGENOMiHOG000276892.
HOVERGENiHBG004094.
InParanoidiP31041.
KOiK06470.
OMAiVNGNYSH.
OrthoDBiEOG7W6WMJ.
TreeFamiTF335679.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008093. CD28.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01717. CD28ANTIGEN.
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31041-1 [UniParc]FASTAAdd to Basket

« Hide

MTLRLLFLAL NFFSVQVTEN KILVKQSPLL VVDSNEVSLS CRYSYNLLAK    50
EFRASLYKGV NSDVEVCVGN GNFTYQPQFR SNAEFNCDGD FDNETVTFRL 100
WNLHVNHTDI YFCKIEFMYP PPYLDNERSN GTIIHIKEKH LCHTQSSPKL 150
FWALVVVAGV LFCYGLLVTV ALCVIWTNSR RNRLLQSDYM NMTPRRPGLT 200
RKPYQPYAPA RDFAAYRP 218
Length:218
Mass (Da):25,243
Last modified:October 3, 2012 - v2
Checksum:iC8E1339DD7E53CA6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1893SDY → VTT in AAA37395. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34563 mRNA. Translation: AAA37395.1.
AL646054 Genomic DNA. Translation: CAI24197.1.
AL672024 Genomic DNA. Translation: CAI26227.1.
CR936842 Genomic DNA. Translation: CAM13249.1.
CH466548 Genomic DNA. Translation: EDL00156.1.
BC064058 mRNA. Translation: AAH64058.1.
M74361 mRNA. Translation: AAA37396.1.
CCDSiCCDS14992.1.
PIRiA43523.
I49584.
RefSeqiNP_031668.3. NM_007642.4.
UniGeneiMm.255003.

Genome annotation databases

EnsembliENSMUST00000027165; ENSMUSP00000027165; ENSMUSG00000026012.
GeneIDi12487.
KEGGimmu:12487.
UCSCiuc007bev.2. mouse.
uc007bew.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34563 mRNA. Translation: AAA37395.1 .
AL646054 Genomic DNA. Translation: CAI24197.1 .
AL672024 Genomic DNA. Translation: CAI26227.1 .
CR936842 Genomic DNA. Translation: CAM13249.1 .
CH466548 Genomic DNA. Translation: EDL00156.1 .
BC064058 mRNA. Translation: AAH64058.1 .
M74361 mRNA. Translation: AAA37396.1 .
CCDSi CCDS14992.1.
PIRi A43523.
I49584.
RefSeqi NP_031668.3. NM_007642.4.
UniGenei Mm.255003.

3D structure databases

ProteinModelPortali P31041.
SMRi P31041. Positions 20-137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P31041. 1 interaction.
STRINGi 10090.ENSMUSP00000027165.

PTM databases

PhosphoSitei P31041.

Proteomic databases

PRIDEi P31041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027165 ; ENSMUSP00000027165 ; ENSMUSG00000026012 .
GeneIDi 12487.
KEGGi mmu:12487.
UCSCi uc007bev.2. mouse.
uc007bew.2. mouse.

Organism-specific databases

CTDi 940.
MGIi MGI:88327. Cd28.

Phylogenomic databases

eggNOGi NOG48152.
GeneTreei ENSGT00530000063873.
HOGENOMi HOG000276892.
HOVERGENi HBG004094.
InParanoidi P31041.
KOi K06470.
OMAi VNGNYSH.
OrthoDBi EOG7W6WMJ.
TreeFami TF335679.

Enzyme and pathway databases

Reactomei REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_204081. CD28 co-stimulation.
REACT_226151. CD28 dependent PI3K/Akt signaling.
REACT_226341. PIP3 activates AKT signaling.

Miscellaneous databases

NextBioi 281396.
PROi P31041.
SOURCEi Search...

Gene expression databases

CleanExi MM_CD28.
Genevestigatori P31041.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR008093. CD28.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR01717. CD28ANTIGEN.
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression."
    Gross J.A., St John T., Allison J.P.
    J. Immunol. 144:3201-3210(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. "CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location."
    Harper K., Balzano C., Rouvier E., Mattei M.-G., Luciani M.-F., Golstein P.
    J. Immunol. 147:1037-1044(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-218.

Entry informationi

Entry nameiCD28_MOUSE
AccessioniPrimary (citable) accession number: P31041
Secondary accession number(s): Q6GSH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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