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P31039

- SDHA_BOVIN

UniProt

P31039 - SDHA_BOVIN

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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene
SDHA, SDH2, SDHFP1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei276 – 2761FAD By similarity
Binding sitei297 – 2971Substrate By similarity
Binding sitei309 – 3091Substrate By similarity
Active sitei341 – 3411Proton acceptor By similarity
Binding sitei408 – 4081Substrate By similarity
Binding sitei441 – 4411FAD By similarity
Binding sitei452 – 4521Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 746FAD By similarity
Nucleotide bindingi92 – 10716FAD By similarityAdd
BLAST
Nucleotide bindingi457 – 4582FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. oxidation-reduction process Source: AgBase
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
Fp
Gene namesi
Name:SDHA
Synonyms:SDH2, SDHFP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrial respiratory chain complex II Source: UniProtKB
  3. mitochondrion Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4444MitochondrionAdd
BLAST
Chaini45 – 665621Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000010334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001Tele-8alpha-FAD histidine By similarity
Modified residuei168 – 1681N6-acetyllysine By similarity
Modified residuei180 – 1801N6-acetyllysine; alternate By similarity
Modified residuei180 – 1801N6-succinyllysine; alternate By similarity
Modified residuei183 – 1831N6-acetyllysine By similarity
Modified residuei216 – 2161Phosphotyrosine; by SRC By similarity
Modified residuei336 – 3361N6-acetyllysine; alternate By similarity
Modified residuei336 – 3361N6-succinyllysine; alternate By similarity
Modified residuei481 – 4811N6-acetyllysine By similarity
Modified residuei486 – 4861N6-acetyllysine; alternate By similarity
Modified residuei486 – 4861N6-succinyllysine; alternate By similarity
Modified residuei499 – 4991N6-acetyllysine; alternate By similarity
Modified residuei499 – 4991N6-succinyllysine; alternate By similarity
Modified residuei518 – 5181N6-acetyllysine By similarity
Modified residuei539 – 5391N6-acetyllysine; alternate By similarity
Modified residuei539 – 5391N6-succinyllysine; alternate By similarity
Modified residuei551 – 5511N6-acetyllysine By similarity
Modified residuei599 – 5991N6-acetyllysine By similarity
Modified residuei609 – 6091N6-acetyllysine By similarity
Modified residuei616 – 6161N6-succinyllysine By similarity
Modified residuei625 – 6251N6-acetyllysine By similarity
Modified residuei634 – 6341N6-acetyllysine By similarity
Modified residuei637 – 6371N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylation at Tyr-216 is important for efficient electron transfer in complex II and the prevention of ROS generation By similarity.
Deacetylated by SIRT3 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP31039.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity. Interacts with TRAP1 By similarity.

Protein-protein interaction databases

IntActiP31039. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP31039.
SMRiP31039. Positions 53-665.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001461.
KOiK00234.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31039-1 [UniParc]FASTAAdd to Basket

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MSGVAAVSRL WRARRLALTC TKWSAAWQTG TRSFHFTVDG NKRSSAKVSD    50
AISAQYPVVD HEFDAVVVGA GGAGLRAAFG LSEAGFNTAC VTKLFPTRSH 100
TVAAQGGINA ALGNMEEDNW RWHFYDTVKG SDWLGDQDAI HYMTEQAPAS 150
VVELENYGMP FSRTEDGKIY QRAFGGQSLK FGKGGQAHRC CCVADRTGHS 200
LLHTLYGRSL RYDTSYFVEY FALDLLMESG ECRGVIALCI EDGSIHRIRA 250
RNTVIATGGY GRTYFSCTSA HTSTGDGTAM VTRAGLPCQD LEFVQFHPTG 300
IYGAGCLITE GCRGEGGILI NSQGERFMER YAPVAKDLAS RDVVSRSMTL 350
EIREGRGCGP EKDHVYLQLH HLPPAQLAMR LPGISETAMI FAGVDVTKEP 400
IPVLPTVHYN MGGIPTNYKG QVLRHVNGQD QGVPGLYACG EAACASVHGA 450
NRLGANSLLD LVVFGRACAL SIAESCRPGD KVPSIKPNAG EESVMNLDKL 500
RFANGSIRTS ELRLNMQKSM QSHAAVFRVG SVLQEGCEKI SSLYGDLRHL 550
KTFDRGMVWN TDLVETLELQ NLMLCALQTI YGAEARKESR GGPRREDFKE 600
RVDEYDYSKP IQGQQKKPFE QHWRKHTLSY VDIKTGKVTL EYRPVIDRTL 650
NETDCATVPP AIGSY 665
Length:665
Mass (Da):72,944
Last modified:August 16, 2004 - v3
Checksum:iFE51160F248D51BC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 25312DGSIH…RARNT → ERVHPPHQGQEH in AAD38150. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60879 mRNA. Translation: AAA30758.1. Sequence problems.
AF139922 Genomic DNA. Translation: AAD38150.1.
PIRiA42792.
RefSeqiNP_776603.1. NM_174178.2.
UniGeneiBt.24449.

Genome annotation databases

GeneIDi281480.
KEGGibta:281480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60879 mRNA. Translation: AAA30758.1 . Sequence problems.
AF139922 Genomic DNA. Translation: AAD38150.1 .
PIRi A42792.
RefSeqi NP_776603.1. NM_174178.2.
UniGenei Bt.24449.

3D structure databases

ProteinModelPortali P31039.
SMRi P31039. Positions 53-665.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P31039. 2 interactions.

Proteomic databases

PRIDEi P31039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281480.
KEGGi bta:281480.

Organism-specific databases

CTDi 6389.

Phylogenomic databases

HOVERGENi HBG001461.
KOi K00234.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .
Reactomei REACT_223064. Respiratory electron transport.

Miscellaneous databases

NextBioi 20805455.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the flavoprotein subunit of bovine heart succinate dehydrogenase."
    Birch-MacHin M.A., Farnsworth L., Ackrell B.A.C., Cochran B., Jackson S., Bindoff L.A., Aitken A., Diamond A.G., Turnbull D.M.
    J. Biol. Chem. 267:11553-11558(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Heart.
  2. "The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase."
    Morris A.A.M., Farnsworth L., Ackrell B.A.C., Turnbull D.M., Birch-MacHin M.A.
    Biochim. Biophys. Acta 1185:125-128(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Mapping of the SDHA locus to bovine chromosome 20."
    Sonstegard T.S., Kappes S.M.
    Anim. Genet. 30:473-473(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 153-253.
    Strain: Hereford X Nelore.

Entry informationi

Entry nameiSDHA_BOVIN
AccessioniPrimary (citable) accession number: P31039
Secondary accession number(s): Q9TUY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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