Reviewed,
UniProtKB/Swiss-Prot P31039 (DHSA_BOVIN)
Last modified
June 16, 2009.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial EC=1.3.5.1 Alternative name(s): Flavoprotein subunit of complex II Short name=Fp | ||||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 665 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). |
| Catalytic activity | Succinate + ubiquinone = fumarate + ubiquinol. |
| Cofactor | FAD. |
| Pathway | |
| Subunit structure | Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| Sequence similarities | Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport Tricarboxylic acid cycle |
| Cellular component | Membrane Mitochondrion Mitochondrion inner membrane |
| Domain | Transit peptide |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| PTM | Acetylation Phosphoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro succinate dehydrogenase (ubiquinone) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 44 | 44 | Mitochondrion | ||||||
| Chain | 45 – 665 | 621 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | PRO_0000010334 | |||||
Regions | |||||||||
| Nucleotide binding | 92 – 107 | 16 | FAD By similarity | ||||||
Sites | |||||||||
| Active site | 341 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 297 | 1 | Substrate By similarity | ||||||
| Binding site | 309 | 1 | Substrate By similarity | ||||||
| Binding site | 408 | 1 | Substrate By similarity | ||||||
| Binding site | 452 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 100 | 1 | Tele-8alpha-FAD histidine By similarity | ||||||
| Modified residue | 180 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 253 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 486 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 499 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 539 | 1 | N6-acetyllysine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 242 – 253 | 12 | DGSIH…RARNT → ERVHPPHQGQEH Ref.3 | ||||||
Sequences
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References
| [1] | "The sequence of the flavoprotein subunit of bovine heart succinate dehydrogenase." Birch-MacHin M.A., Farnsworth L., Ackrell B.A.C., Cochran B., Jackson S., Bindoff L.A., Aitken A., Diamond A.G., Turnbull D.M. J. Biol. Chem. 267:11553-11558(1992) [PubMed: 1375942] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Heart. |
| [2] | "The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase." Morris A.A.M., Farnsworth L., Ackrell B.A.C., Turnbull D.M., Birch-MacHin M.A. Biochim. Biophys. Acta 1185:125-128(1994) [PubMed: 8142412] [Abstract] Cited for: SEQUENCE REVISION. |
| [3] | "Mapping of the SDHA locus to bovine chromosome 20." Sonstegard T.S., Kappes S.M. Anim. Genet. 30:473-473(1999) [PubMed: 10612251] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 153-253. Strain: Hereford X Nelore. |
Cross-references
Sequence databases | |
|---|---|
| M60879 mRNA. Translation: AAA30758.1. Sequence problems. AF139922 Genomic DNA. Translation: AAD38150.1. | |
| IPI | IPI00686177. |
| PIR | A42792. |
| RefSeq | NP_776603.1. |
| UniGene | Bt.24449 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NEK based on UniProtKB P10444. |
| SMR | P31039. Positions 55-665. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 281480. |
| KEGG | bta:281480. |
Phylogenomic databases | |
| HOVERGEN | P31039. |
Enzyme and pathway databases | |
| BRENDA | 1.3.5.1. 251. |
Family and domain databases | |
| InterPro | IPR003953. FAD_bind2_N. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR003952. FRD_SDH_FAD_BS. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR011281. Succ_DH_flav_su_fwd. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view] |
| Pfam | PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view] |
| PRINTS | PR00368. FADPNR. |
| TIGRFAMs | TIGR01816. sdhA_forward. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit. |
| PROSITE | PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHSA_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P31039 Secondary accession number(s): Q9TUY8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


