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Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase iron-sulfur subunit (sdhB), Succinate dehydrogenase flavoprotein subunit (sdhA)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei225FADBy similarity1
Binding sitei246SubstrateBy similarity1
Binding sitei258SubstrateBy similarity1
Active sitei290Proton acceptorBy similarity1
Binding sitei357SubstrateBy similarity1
Binding sitei391FADBy similarity1
Binding sitei402SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 23FADBy similarity6
Nucleotide bindingi41 – 56FADBy similarityAdd BLAST16
Nucleotide bindingi407 – 408FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1By similarity)
Gene namesi
Name:sdhA
Ordered Locus Names:RP128
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586571 – 596Succinate dehydrogenase flavoprotein subunitAdd BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Tele-8alpha-FAD histidineBy similarity1

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.By similarity

Protein-protein interaction databases

STRINGi272947.RP128.

Structurei

3D structure databases

ProteinModelPortaliP31038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108J01. Bacteria.
COG1053. LUCA.
HOGENOMiHOG000160475.
KOiK00239.
OMAiGKNHNSV.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT
60 70 80 90 100
VAAQGGISAA LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI
110 120 130 140 150
LELEHYGVPF SRTVDGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI
160 170 180 190 200
LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE CRGVVAWNLD DGSLHCFRAH
210 220 230 240 250
NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM EFVQFHPTGI
260 270 280 290 300
YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE
310 320 330 340 350
IREGRGVGEH KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI
360 370 380 390 400
PVLPTVHYNM GGIPTNYQGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA
410 420 430 440 450
NRLGSNSLLD LVVFGRSSAL KAAELIKPAS PHKPLQKETL EKIINRFDKV
460 470 480 490 500
RYANGNILVA DLRLKMQRTM QSHVSVFRTQ KLLDEGVGMI SEIRNRYKDI
510 520 530 540 550
KINDKSLIWN SDLVEALELD NLLDQALVTV CSAAARKESR GAHAREDYPD
560 570 580 590
RNDRDWIKHT LSSIDDSGKV VLDYKPVTLT TLTDAISAIP PVKRVY
Length:596
Mass (Da):65,445
Last modified:July 1, 1993 - v1
Checksum:iE5CAA5DFE9426EC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88696 Unassigned DNA. Translation: AAA16097.1.
U02603 Unassigned DNA. Translation: AAA18327.1.
AJ235270 Genomic DNA. Translation: CAA14597.1.
PIRiJN0895.
RefSeqiNP_220520.1. NC_000963.1.
WP_004597170.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14597; CAA14597; CAA14597.
GeneIDi883752.
KEGGirpr:RP128.
PATRICi17900996. VBIRicPro72556_0130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88696 Unassigned DNA. Translation: AAA16097.1.
U02603 Unassigned DNA. Translation: AAA18327.1.
AJ235270 Genomic DNA. Translation: CAA14597.1.
PIRiJN0895.
RefSeqiNP_220520.1. NC_000963.1.
WP_004597170.1. NC_000963.1.

3D structure databases

ProteinModelPortaliP31038.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272947.RP128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA14597; CAA14597; CAA14597.
GeneIDi883752.
KEGGirpr:RP128.
PATRICi17900996. VBIRicPro72556_0130.

Phylogenomic databases

eggNOGiENOG4108J01. Bacteria.
COG1053. LUCA.
HOGENOMiHOG000160475.
KOiK00239.
OMAiGKNHNSV.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDHA_RICPR
AccessioniPrimary (citable) accession number: P31038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 5, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.