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P31038 (SDHA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase flavoprotein subunit

EC=1.3.5.1
Gene names
Name:sdhA
Ordered Locus Names:RP128
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

FAD.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Succinate dehydrogenase flavoprotein subunit
PRO_0000158657

Regions

Nucleotide binding18 – 236FAD By similarity
Nucleotide binding41 – 5616FAD By similarity
Nucleotide binding407 – 4082FAD By similarity

Sites

Active site2901Proton acceptor By similarity
Binding site2251FAD By similarity
Binding site2461Substrate By similarity
Binding site2581Substrate By similarity
Binding site3571Substrate By similarity
Binding site3911FAD By similarity
Binding site4021Substrate By similarity

Amino acid modifications

Modified residue491Tele-8alpha-FAD histidine By similarity

Sequences

Sequence LengthMass (Da)Tools
P31038 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: E5CAA5DFE9426EC4

FASTA59665,445
        10         20         30         40         50         60 
MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT VAAQGGISAA 

        70         80         90        100        110        120 
LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI LELEHYGVPF SRTVDGKIYQ 

       130        140        150        160        170        180 
RPFGGMTTEY GKGKAAQRTC AAADRTGHAI LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE 

       190        200        210        220        230        240 
CRGVVAWNLD DGSLHCFRAH NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM 

       250        260        270        280        290        300 
EFVQFHPTGI YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 

       310        320        330        340        350        360 
IREGRGVGEH KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI PVLPTVHYNM 

       370        380        390        400        410        420 
GGIPTNYQGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA NRLGSNSLLD LVVFGRSSAL 

       430        440        450        460        470        480 
KAAELIKPAS PHKPLQKETL EKIINRFDKV RYANGNILVA DLRLKMQRTM QSHVSVFRTQ 

       490        500        510        520        530        540 
KLLDEGVGMI SEIRNRYKDI KINDKSLIWN SDLVEALELD NLLDQALVTV CSAAARKESR 

       550        560        570        580        590 
GAHAREDYPD RNDRDWIKHT LSSIDDSGKV VLDYKPVTLT TLTDAISAIP PVKRVY 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the Rickettsia prowazekii gene encoding the flavoprotein subunit of succinate dehydrogenase."
Aliabadi Z., Winkler H.H., Wood D.O.
Gene 133:135-140(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Madrid E.
[2]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M88696 Unassigned DNA. Translation: AAA16097.1.
U02603 Unassigned DNA. Translation: AAA18327.1.
AJ235270 Genomic DNA. Translation: CAA14597.1.
PIRJN0895.
RefSeqNP_220520.1. NC_000963.1.

3D structure databases

ProteinModelPortalP31038.
SMRP31038. Positions 5-596.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP128.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14597; CAA14597; CAA14597.
GeneID883752.
KEGGrpr:RP128.
PATRIC17900996. VBIRicPro72556_0130.

Phylogenomic databases

eggNOGCOG1053.
HOGENOMHOG000160475.
KOK00239.
OMAHGQVIIK.
OrthoDBEOG6M3PC4.
ProtClustDBPRK09078.

Enzyme and pathway databases

UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHA_RICPR
AccessionPrimary (citable) accession number: P31038
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways