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P31038

- SDHA_RICPR

UniProt

P31038 - SDHA_RICPR

Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei225 – 2251FADBy similarity
    Binding sitei246 – 2461SubstrateBy similarity
    Binding sitei258 – 2581SubstrateBy similarity
    Active sitei290 – 2901Proton acceptorBy similarity
    Binding sitei357 – 3571SubstrateBy similarity
    Binding sitei391 – 3911FADBy similarity
    Binding sitei402 – 4021SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 236FADBy similarity
    Nucleotide bindingi41 – 5616FADBy similarityAdd
    BLAST
    Nucleotide bindingi407 – 4082FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
    Gene namesi
    Name:sdhA
    Ordered Locus Names:RP128
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 596596Succinate dehydrogenase flavoprotein subunitPRO_0000158657Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491Tele-8alpha-FAD histidineBy similarity

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

    Protein-protein interaction databases

    STRINGi272947.RP128.

    Structurei

    3D structure databases

    ProteinModelPortaliP31038.
    SMRiP31038. Positions 5-596.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1053.
    HOGENOMiHOG000160475.
    KOiK00239.
    OMAiSYRPVHV.
    OrthoDBiEOG6M3PC4.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT    50
    VAAQGGISAA LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI 100
    LELEHYGVPF SRTVDGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI 150
    LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE CRGVVAWNLD DGSLHCFRAH 200
    NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM EFVQFHPTGI 250
    YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 300
    IREGRGVGEH KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI 350
    PVLPTVHYNM GGIPTNYQGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA 400
    NRLGSNSLLD LVVFGRSSAL KAAELIKPAS PHKPLQKETL EKIINRFDKV 450
    RYANGNILVA DLRLKMQRTM QSHVSVFRTQ KLLDEGVGMI SEIRNRYKDI 500
    KINDKSLIWN SDLVEALELD NLLDQALVTV CSAAARKESR GAHAREDYPD 550
    RNDRDWIKHT LSSIDDSGKV VLDYKPVTLT TLTDAISAIP PVKRVY 596
    Length:596
    Mass (Da):65,445
    Last modified:July 1, 1993 - v1
    Checksum:iE5CAA5DFE9426EC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88696 Unassigned DNA. Translation: AAA16097.1.
    U02603 Unassigned DNA. Translation: AAA18327.1.
    AJ235270 Genomic DNA. Translation: CAA14597.1.
    PIRiJN0895.
    RefSeqiNP_220520.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14597; CAA14597; CAA14597.
    GeneIDi883752.
    KEGGirpr:RP128.
    PATRICi17900996. VBIRicPro72556_0130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88696 Unassigned DNA. Translation: AAA16097.1 .
    U02603 Unassigned DNA. Translation: AAA18327.1 .
    AJ235270 Genomic DNA. Translation: CAA14597.1 .
    PIRi JN0895.
    RefSeqi NP_220520.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali P31038.
    SMRi P31038. Positions 5-596.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14597 ; CAA14597 ; CAA14597 .
    GeneIDi 883752.
    KEGGi rpr:RP128.
    PATRICi 17900996. VBIRicPro72556_0130.

    Phylogenomic databases

    eggNOGi COG1053.
    HOGENOMi HOG000160475.
    KOi K00239.
    OMAi SYRPVHV.
    OrthoDBi EOG6M3PC4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01005 .

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the Rickettsia prowazekii gene encoding the flavoprotein subunit of succinate dehydrogenase."
      Aliabadi Z., Winkler H.H., Wood D.O.
      Gene 133:135-140(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Madrid E.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiSDHA_RICPR
    AccessioniPrimary (citable) accession number: P31038
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3