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P31038

- SDHA_RICPR

UniProt

P31038 - SDHA_RICPR

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Protein

Succinate dehydrogenase flavoprotein subunit

Gene
sdhA, RP128
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251FAD By similarity
Binding sitei246 – 2461Substrate By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei290 – 2901Proton acceptor By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei391 – 3911FAD By similarity
Binding sitei402 – 4021Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 236FAD By similarity
Nucleotide bindingi41 – 5616FAD By similarityAdd
BLAST
Nucleotide bindingi407 – 4082FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
Gene namesi
Name:sdhA
Ordered Locus Names:RP128
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Succinate dehydrogenase flavoprotein subunitPRO_0000158657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Tele-8alpha-FAD histidine By similarity

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Protein-protein interaction databases

STRINGi272947.RP128.

Structurei

3D structure databases

ProteinModelPortaliP31038.
SMRiP31038. Positions 5-596.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
KOiK00239.
OMAiSYRPVHV.
OrthoDBiEOG6M3PC4.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31038-1 [UniParc]FASTAAdd to Basket

« Hide

MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT    50
VAAQGGISAA LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI 100
LELEHYGVPF SRTVDGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI 150
LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE CRGVVAWNLD DGSLHCFRAH 200
NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM EFVQFHPTGI 250
YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 300
IREGRGVGEH KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI 350
PVLPTVHYNM GGIPTNYQGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA 400
NRLGSNSLLD LVVFGRSSAL KAAELIKPAS PHKPLQKETL EKIINRFDKV 450
RYANGNILVA DLRLKMQRTM QSHVSVFRTQ KLLDEGVGMI SEIRNRYKDI 500
KINDKSLIWN SDLVEALELD NLLDQALVTV CSAAARKESR GAHAREDYPD 550
RNDRDWIKHT LSSIDDSGKV VLDYKPVTLT TLTDAISAIP PVKRVY 596
Length:596
Mass (Da):65,445
Last modified:July 1, 1993 - v1
Checksum:iE5CAA5DFE9426EC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88696 Unassigned DNA. Translation: AAA16097.1.
U02603 Unassigned DNA. Translation: AAA18327.1.
AJ235270 Genomic DNA. Translation: CAA14597.1.
PIRiJN0895.
RefSeqiNP_220520.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14597; CAA14597; CAA14597.
GeneIDi883752.
KEGGirpr:RP128.
PATRICi17900996. VBIRicPro72556_0130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88696 Unassigned DNA. Translation: AAA16097.1 .
U02603 Unassigned DNA. Translation: AAA18327.1 .
AJ235270 Genomic DNA. Translation: CAA14597.1 .
PIRi JN0895.
RefSeqi NP_220520.1. NC_000963.1.

3D structure databases

ProteinModelPortali P31038.
SMRi P31038. Positions 5-596.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP128.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14597 ; CAA14597 ; CAA14597 .
GeneIDi 883752.
KEGGi rpr:RP128.
PATRICi 17900996. VBIRicPro72556_0130.

Phylogenomic databases

eggNOGi COG1053.
HOGENOMi HOG000160475.
KOi K00239.
OMAi SYRPVHV.
OrthoDBi EOG6M3PC4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the Rickettsia prowazekii gene encoding the flavoprotein subunit of succinate dehydrogenase."
    Aliabadi Z., Winkler H.H., Wood D.O.
    Gene 133:135-140(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Madrid E.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiSDHA_RICPR
AccessioniPrimary (citable) accession number: P31038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 14, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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