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Protein

Modification methylase NgoMIV

Gene

ngoMIVM

Organism
Neisseria gonorrhoeae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GCCGGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the ngomIV endonuclease.

Caution

Was originally known as M.nGmomI.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase NgoMIV (EC:2.1.1.37)
Short name:
M.NgoMIV
Alternative name(s):
Cytosine-specific methyltransferase NgoMIV
Gene namesi
Name:ngoMIVM
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878991 – 312Modification methylase NgoMIVAdd BLAST312

Structurei

3D structure databases

ProteinModelPortaliP31033
SMRiP31033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 311SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST309

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P31033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFTSLEICA GAGGQALGLE RAGFSHVALI EIEPSACQTL RLNRPDWNVI
60 70 80 90 100
EGDVRLFQGE GYDGIDLLAG GVPCPPFSKA GKQLGKDDER DLFPEAIRLA
110 120 130 140 150
KETDPKAIML ENVRGLLDPK FENYRNHITE QFAKLGYLGQ WKLLYAADYG
160 170 180 190 200
VSQLRPRVLF VALKNEYTNF FKWPEPNSEQ PKTVGELLFD LMSENNWQGA
210 220 230 240 250
HNWRLKAAQI APTLVAVQKN TAVLTWDLHD PNAHGRSWVW MVQVCGIVRR
260 270 280 290 300
LKTFTGMPRL TVRMTARIQG FPDDWQFFGK KTPMYRQIGN AFPPPVAEAV
310
GRQIIKALKK EN
Length:312
Mass (Da):35,226
Last modified:July 1, 1993 - v1
Checksum:i319E20242B873452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86915 Genomic DNA No translation available.
PIRiA42709

Similar proteinsi

Entry informationi

Entry nameiMTM4_NEIGO
AccessioniPrimary (citable) accession number: P31033
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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