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Protein

Lipocalin-1

Gene

LCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

  • long-chain fatty acid transport Source: Reactome
  • proteolysis Source: ProtInc
  • response to stimulus Source: UniProtKB-KW
  • retina homeostasis Source: UniProtKB
  • sensory perception of taste Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Taste, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160349-MONOMER.
ReactomeiR-HSA-804914. Transport of fatty acids.

Chemistry databases

SwissLipidsiSLP:000001525.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipocalin-1
Alternative name(s):
Tear lipocalin
Short name:
Tlc
Tear prealbumin
Short name:
TP
Von Ebner gland protein
Short name:
VEG protein
Gene namesi
Name:LCN1
Synonyms:VEGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:6525. LCN1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3933.
OpenTargetsiENSG00000160349.
PharmGKBiPA30308.

Protein family/group databases

Allergomei3990. Hom s TL.

Polymorphism and mutation databases

BioMutaiLCN1.
DMDMi401346.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000001797419 – 176Lipocalin-1Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 171

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP31025.
MaxQBiP31025.
PaxDbiP31025.
PeptideAtlasiP31025.
PRIDEiP31025.
TopDownProteomicsiP31025.

2D gel databases

UCD-2DPAGEP31025.

PTM databases

iPTMnetiP31025.
PhosphoSitePlusiP31025.

Expressioni

Tissue specificityi

Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.

Gene expression databases

BgeeiENSG00000160349.
CleanExiHS_LCN1.
ExpressionAtlasiP31025. baseline and differential.
GenevisibleiP31025. HS.

Interactioni

Subunit structurei

Homodimer (By similarity). Binds to LMBR1L which may mediate its endocytosis.By similarity

Protein-protein interaction databases

BioGridi110125. 11 interactors.
IntActiP31025. 3 interactors.
STRINGi9606.ENSP00000263598.

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 42Combined sources10
Beta strandi49 – 54Combined sources6
Beta strandi57 – 61Combined sources5
Beta strandi67 – 73Combined sources7
Beta strandi75 – 78Combined sources4
Beta strandi80 – 88Combined sources9
Beta strandi94 – 97Combined sources4
Helixi98 – 100Combined sources3
Beta strandi102 – 108Combined sources7
Beta strandi111 – 113Combined sources3
Beta strandi114 – 121Combined sources8
Beta strandi128 – 139Combined sources12
Helixi145 – 154Combined sources10
Beta strandi160 – 163Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKIX-ray1.80A23-176[»]
3EYCX-ray2.60A/B/C/D23-176[»]
4QAFX-ray1.80A/B23-174[»]
DisProtiDP00647.
ProteinModelPortaliP31025.
SMRiP31025.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31025.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1KM. Eukaryota.
ENOG4111BH9. LUCA.
GeneTreeiENSGT00440000033563.
HOGENOMiHOG000231562.
HOVERGENiHBG101411.
InParanoidiP31025.
OMAiQCQEVKV.
OrthoDBiEOG091G0PIH.
PhylomeDBiP31025.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01175. VNEBNERGLAND.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLLLAVSL GLIAALQAHH LLASDEEIQD VSGTWYLKAM TVDREFPEMN
60 70 80 90 100
LESVTPMTLT TLEGGNLEAK VTMLISGRCQ EVKAVLEKTD EPGKYTADGG
110 120 130 140 150
KHVAYIIRSH VKDHYIFYCE GELHGKPVRG VKLVGRDPKN NLEALEDFEK
160 170
AAGARGLSTE SILIPRQSET CSPGSD
Length:176
Mass (Da):19,250
Last modified:July 1, 1993 - v1
Checksum:i0DDBF124C8C78CB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62418 mRNA. Translation: CAA44284.1.
M90424 mRNA. Translation: AAA61845.1.
X67647 mRNA. Translation: CAA47889.1.
L14927 Genomic DNA. Translation: AAA18633.1.
AL161452 Genomic DNA. Translation: CAI14045.1.
CH471090 Genomic DNA. Translation: EAW88156.1.
BC065721 mRNA. Translation: AAH65721.1.
BC074925 mRNA. Translation: AAH74925.1.
BC074926 mRNA. Translation: AAH74926.1.
CCDSiCCDS6991.1.
PIRiA44029. LCHUL.
RefSeqiNP_001239546.1. NM_001252617.1.
NP_001239547.1. NM_001252618.1.
NP_001239548.1. NM_001252619.1.
NP_002288.1. NM_002297.3.
UniGeneiHs.530311.

Genome annotation databases

EnsembliENST00000263598; ENSP00000263598; ENSG00000160349.
ENST00000371781; ENSP00000360846; ENSG00000160349.
GeneIDi3933.
KEGGihsa:3933.
UCSCiuc004cfz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62418 mRNA. Translation: CAA44284.1.
M90424 mRNA. Translation: AAA61845.1.
X67647 mRNA. Translation: CAA47889.1.
L14927 Genomic DNA. Translation: AAA18633.1.
AL161452 Genomic DNA. Translation: CAI14045.1.
CH471090 Genomic DNA. Translation: EAW88156.1.
BC065721 mRNA. Translation: AAH65721.1.
BC074925 mRNA. Translation: AAH74925.1.
BC074926 mRNA. Translation: AAH74926.1.
CCDSiCCDS6991.1.
PIRiA44029. LCHUL.
RefSeqiNP_001239546.1. NM_001252617.1.
NP_001239547.1. NM_001252618.1.
NP_001239548.1. NM_001252619.1.
NP_002288.1. NM_002297.3.
UniGeneiHs.530311.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKIX-ray1.80A23-176[»]
3EYCX-ray2.60A/B/C/D23-176[»]
4QAFX-ray1.80A/B23-174[»]
DisProtiDP00647.
ProteinModelPortaliP31025.
SMRiP31025.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110125. 11 interactors.
IntActiP31025. 3 interactors.
STRINGi9606.ENSP00000263598.

Chemistry databases

SwissLipidsiSLP:000001525.

Protein family/group databases

Allergomei3990. Hom s TL.

PTM databases

iPTMnetiP31025.
PhosphoSitePlusiP31025.

Polymorphism and mutation databases

BioMutaiLCN1.
DMDMi401346.

2D gel databases

UCD-2DPAGEP31025.

Proteomic databases

EPDiP31025.
MaxQBiP31025.
PaxDbiP31025.
PeptideAtlasiP31025.
PRIDEiP31025.
TopDownProteomicsiP31025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263598; ENSP00000263598; ENSG00000160349.
ENST00000371781; ENSP00000360846; ENSG00000160349.
GeneIDi3933.
KEGGihsa:3933.
UCSCiuc004cfz.3. human.

Organism-specific databases

CTDi3933.
DisGeNETi3933.
GeneCardsiLCN1.
HGNCiHGNC:6525. LCN1.
MIMi151675. gene.
neXtProtiNX_P31025.
OpenTargetsiENSG00000160349.
PharmGKBiPA30308.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1KM. Eukaryota.
ENOG4111BH9. LUCA.
GeneTreeiENSGT00440000033563.
HOGENOMiHOG000231562.
HOVERGENiHBG101411.
InParanoidiP31025.
OMAiQCQEVKV.
OrthoDBiEOG091G0PIH.
PhylomeDBiP31025.
TreeFamiTF338197.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160349-MONOMER.
ReactomeiR-HSA-804914. Transport of fatty acids.

Miscellaneous databases

ChiTaRSiLCN1. human.
EvolutionaryTraceiP31025.
GeneWikiiLCN1.
GenomeRNAii3933.
PROiP31025.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160349.
CleanExiHS_LCN1.
ExpressionAtlasiP31025. baseline and differential.
GenevisibleiP31025. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01175. VNEBNERGLAND.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLCN1_HUMAN
AccessioniPrimary (citable) accession number: P31025
Secondary accession number(s): Q5T8A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.