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Protein

Disks large homolog 4

Gene

Dlg4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.3 Publications

GO - Molecular functioni

  • acetylcholine receptor binding Source: RGD
  • beta-1 adrenergic receptor binding Source: UniProtKB
  • D1 dopamine receptor binding Source: RGD
  • glutamate receptor binding Source: BHF-UCL
  • guanylate kinase activity Source: GO_Central
  • ionotropic glutamate receptor binding Source: RGD
  • neuroligin family protein binding Source: BHF-UCL
  • P2Y1 nucleotide receptor binding Source: BHF-UCL
  • PDZ domain binding Source: RGD
  • protein complex binding Source: RGD
  • protein C-terminus binding Source: UniProtKB
  • protein kinase binding Source: RGD
  • protein phosphatase binding Source: BHF-UCL
  • receptor binding Source: UniProtKB
  • scaffold protein binding Source: BHF-UCL

GO - Biological processi

  • AMPA glutamate receptor clustering Source: BHF-UCL
  • dendritic spine morphogenesis Source: BHF-UCL
  • establishment of protein localization Source: BHF-UCL
  • establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
  • locomotory exploration behavior Source: BHF-UCL
  • negative regulation of receptor internalization Source: UniProtKB
  • neuromuscular process controlling balance Source: BHF-UCL
  • neuronal ion channel clustering Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of excitatory postsynaptic potential Source: BHF-UCL
  • positive regulation of synaptic transmission Source: BHF-UCL
  • protein complex assembly Source: BHF-UCL
  • protein localization to synapse Source: BHF-UCL
  • receptor localization to synapse Source: BHF-UCL
  • regulation of grooming behavior Source: BHF-UCL
  • regulation of long-term neuronal synaptic plasticity Source: BHF-UCL
  • regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: BHF-UCL
  • social behavior Source: BHF-UCL
  • synaptic vesicle maturation Source: BHF-UCL
  • vocalization behavior Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-399719. Trafficking of AMPA receptors.
R-RNO-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-RNO-442729. CREB phosphorylation through the activation of CaMKII.
R-RNO-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-RNO-451308. Activation of Ca-permeable Kainate Receptor.
R-RNO-5625900. RHO GTPases activate CIT.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-5682910. LGI-ADAM interactions.
R-RNO-8849932. SALM protein interactions at the synapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 4
Alternative name(s):
Postsynaptic density protein 95
Short name:
PSD-95
Synapse-associated protein 90
Short name:
SAP-90
Short name:
SAP90
Gene namesi
Name:Dlg4
Synonyms:Dlgh4, Psd95
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi68424. Dlg4.

Subcellular locationi

GO - Cellular componenti

  • AMPA glutamate receptor complex Source: BHF-UCL
  • basolateral plasma membrane Source: GO_Central
  • cell junction Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • dendrite cytoplasm Source: BHF-UCL
  • dendritic spine Source: ParkinsonsUK-UCL
  • endoplasmic reticulum Source: BHF-UCL
  • excitatory synapse Source: BHF-UCL
  • extrinsic component of cytoplasmic side of plasma membrane Source: BHF-UCL
  • juxtaparanode region of axon Source: UniProtKB
  • membrane Source: UniProtKB
  • neuron projection terminus Source: BHF-UCL
  • neuron spine Source: BHF-UCL
  • postsynaptic density Source: UniProtKB
  • postsynaptic membrane Source: MGI
  • synapse Source: MGI
  • synaptic vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi3 – 31C → S: Loss of palmitoylation and targeting to postsynaptic density. 1 Publication
Mutagenesisi5 – 51C → S: Loss of palmitoylation and targeting to postsynaptic density. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Disks large homolog 4PRO_0000094562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteine1 Publication
Lipidationi5 – 51S-palmitoyl cysteine1 Publication
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei142 – 1421PhosphoserineBy similarity
Modified residuei240 – 2401PhosphotyrosineCombined sources
Modified residuei295 – 2951PhosphoserineCombined sources
Modified residuei415 – 4151PhosphoserineBy similarity
Modified residuei418 – 4181PhosphoserineCombined sources
Modified residuei420 – 4201PhosphothreonineCombined sources
Modified residuei422 – 4221PhosphoserineCombined sources
Modified residuei425 – 4251PhosphoserineBy similarity
Modified residuei449 – 4491PhosphoserineCombined sources
Modified residuei480 – 4801PhosphoserineBy similarity
Modified residuei580 – 5801PhosphotyrosineBy similarity
Modified residuei606 – 6061PhosphoserineBy similarity
Modified residuei654 – 6541PhosphoserineCombined sources
Modified residuei715 – 7151PhosphotyrosineBy similarity

Post-translational modificationi

Palmitoylation of isoform 1 is required for targeting to postsynaptic density.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP31016.
PRIDEiP31016.

PTM databases

iPTMnetiP31016.
PhosphoSiteiP31016.
SwissPalmiP31016.

Expressioni

Tissue specificityi

Detected in juxtaparanodal zones in the central nervous system and at nerve terminal plexuses of basket cells in the cerebellum (PubMed:20089912). Detected in brain (at protein level). Brain. Highest levels of isoform 2 in cerebellum, cortex, hippocampus, and corpus striatum.3 Publications

Gene expression databases

BgeeiENSRNOG00000018526.
ExpressionAtlasiP31016. baseline and differential.
GenevisibleiP31016. RN.

Interactioni

Subunit structurei

Interacts through its PDZ domains with ANO2 and NETO1. Interacts with KCNJ4 (PubMed:11997254). Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ASIC3, certain splice forms of GRIN1, KCND2, CXADR, SYNGAP1, KCNA1, KCNA2, KCNA3, KCNA4, ERBB4, LRRC4; LRRC4B and SEMA4C. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. Interacts through its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN, SIPA1L1 and KIF13B (PubMed:9115257, PubMed:9756850). Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with ADR1B, ANKS1B and PRR7 (PubMed:15629447). May interact with HTR2A. Interacts with ADAM22, KLHL17 and LGI1. Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4, but not with LRFN3 nor LRFN5. Interacts (via N-terminal tandem pair of PDZ domains) with GPER1 (via C-terminus tail motif); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (PubMed:23300088). Interacts (via N-terminus tandem pair of PDZ domains) with NOS1 (via N-terminal domain) (PubMed:23300088). Interacts with SHANK3. Interacts with GPR85 (By similarity).By similarity21 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Adrb2P106082EBI-375655,EBI-7090342
ApcP704782EBI-375655,EBI-631663
Cacng2Q71RJ22EBI-375655,EBI-8538384
Cnksr2Q9Z1T44EBI-375655,EBI-8548356
CRIPTQ9P0212EBI-375655,EBI-946968From a different organism.
DgkiQ810C55EBI-375655,EBI-8523614
DgkzO085606EBI-375655,EBI-8570505
DLG1Q12959-29EBI-375655,EBI-357500From a different organism.
Dlg1Q626962EBI-375655,EBI-389325
Dlgap1P978369EBI-375655,EBI-80901
Dlgap2P978372EBI-375655,EBI-81025
GraspQ8R4T53EBI-375655,EBI-7361884
Grin1P354394EBI-375655,EBI-877897
GRIN2AQ128792EBI-375655,EBI-7249937From a different organism.
Grin2aQ009595EBI-375655,EBI-630970
GRIN2BQ132242EBI-375655,EBI-2256942From a different organism.
Grin2bQ009608EBI-375655,EBI-396905
GRIN2CQ149572EBI-375655,EBI-8285963From a different organism.
Gucy1a2Q9WVI47EBI-375655,EBI-7665590
Gucy1b3P205952EBI-375655,EBI-7980539
KCNA4P224593EBI-375655,EBI-631235From a different organism.
Klhl17Q8K4302EBI-375655,EBI-7713653
Lrfn2Q460M53EBI-375655,EBI-877185
Lrrc7P705875EBI-375655,EBI-7798464
Map1aP3492612EBI-375655,EBI-631571
PtenO548575EBI-375655,EBI-8074312
Shank1Q9WV483EBI-375655,EBI-80909
Slc6a9P285722EBI-375655,EBI-848783
Slc6a9P28572-24EBI-375655,EBI-848796
SrcP054809EBI-375655,EBI-298680From a different organism.
Sstr4P309373EBI-375655,EBI-7665959
Syngap1Q9QUH63EBI-375655,EBI-2310349
Vangl1Q80Z964EBI-375655,EBI-1750708From a different organism.
Vangl2Q91ZD46EBI-375655,EBI-1750744From a different organism.
Wipf1Q6IN365EBI-375655,EBI-6986245

GO - Molecular functioni

  • acetylcholine receptor binding Source: RGD
  • beta-1 adrenergic receptor binding Source: UniProtKB
  • D1 dopamine receptor binding Source: RGD
  • glutamate receptor binding Source: BHF-UCL
  • ionotropic glutamate receptor binding Source: RGD
  • neuroligin family protein binding Source: BHF-UCL
  • P2Y1 nucleotide receptor binding Source: BHF-UCL
  • PDZ domain binding Source: RGD
  • protein complex binding Source: RGD
  • protein C-terminus binding Source: UniProtKB
  • protein kinase binding Source: RGD
  • protein phosphatase binding Source: BHF-UCL
  • receptor binding Source: UniProtKB
  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi248135. 19 interactions.
DIPiDIP-29264N.
IntActiP31016. 352 interactions.
MINTiMINT-93329.
STRINGi10116.ENSRNOP00000059045.

Structurei

Secondary structure

1
724
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi61 – 699Combined sources
Beta strandi71 – 733Combined sources
Beta strandi74 – 807Combined sources
Beta strandi82 – 854Combined sources
Beta strandi88 – 914Combined sources
Beta strandi94 – 996Combined sources
Beta strandi101 – 1033Combined sources
Helixi104 – 1085Combined sources
Beta strandi116 – 1205Combined sources
Helixi125 – 1273Combined sources
Helixi130 – 1389Combined sources
Beta strandi142 – 15110Combined sources
Beta strandi156 – 16611Combined sources
Beta strandi172 – 1787Combined sources
Beta strandi189 – 1946Combined sources
Helixi199 – 2035Combined sources
Beta strandi211 – 2155Combined sources
Beta strandi221 – 2244Combined sources
Helixi225 – 2339Combined sources
Beta strandi237 – 24711Combined sources
Helixi302 – 3043Combined sources
Beta strandi312 – 3176Combined sources
Beta strandi325 – 3295Combined sources
Helixi331 – 3333Combined sources
Beta strandi336 – 3416Combined sources
Helixi346 – 3505Combined sources
Beta strandi357 – 3626Combined sources
Helixi372 – 3809Combined sources
Beta strandi384 – 3929Combined sources
Helixi394 – 3985Combined sources
Beta strandi414 – 4163Combined sources
Beta strandi431 – 4377Combined sources
Helixi441 – 4455Combined sources
Beta strandi449 – 4513Combined sources
Beta strandi459 – 4646Combined sources
Beta strandi467 – 4759Combined sources
Beta strandi486 – 4894Combined sources
Helixi491 – 4999Combined sources
Turni504 – 5074Combined sources
Beta strandi523 – 5308Combined sources
Beta strandi537 – 5415Combined sources
Helixi544 – 55411Combined sources
Turni556 – 5583Combined sources
Turni576 – 5783Combined sources
Helixi586 – 5949Combined sources
Beta strandi598 – 6047Combined sources
Beta strandi607 – 6126Combined sources
Helixi613 – 6219Combined sources
Beta strandi625 – 6284Combined sources
Helixi634 – 6407Combined sources
Beta strandi646 – 6505Combined sources
Helixi655 – 6617Combined sources
Beta strandi663 – 6653Combined sources
Helixi667 – 68418Combined sources
Helixi685 – 6873Combined sources
Beta strandi689 – 6924Combined sources
Helixi697 – 71115Combined sources
Beta strandi714 – 7196Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BE9X-ray1.82A302-430[»]
1BFEX-ray2.30A302-402[»]
1IU0NMR-A61-151[»]
1IU2NMR-A61-151[»]
1JXMX-ray2.00A430-724[»]
1JXOX-ray2.30A/B430-724[»]
1KJWX-ray1.80A430-724[»]
1QLCNMR-A155-249[»]
1RGRNMR-A62-154[»]
1TP3X-ray1.99A302-402[»]
1TP5X-ray1.54A302-402[»]
1TQ3X-ray1.89A302-402[»]
2KA9NMR-A61-249[»]
2MHONMR-A60-155[»]
2XKXOther22.90A/B1-724[»]
3GSLX-ray2.05A/B61-249[»]
3WP0X-ray2.04A531-713[»]
3WP1X-ray2.80B531-713[»]
ProteinModelPortaliP31016.
SMRiP31016. Positions 62-249, 306-402, 430-724.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31016.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 15187PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini160 – 24687PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini313 – 39381PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini428 – 49871SH3PROSITE-ProRule annotationAdd
BLAST
Domaini534 – 709176Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Domaini

The PDZ domain 3 mediates interaction with ADR1B.By similarity
The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.By similarity

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000232102.
HOVERGENiHBG107814.
InParanoidiP31016.
KOiK11828.
PhylomeDBiP31016.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR016313. DLG1.
IPR019590. DLG1_PEST_dom.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23119:SF33. PTHR23119:SF33. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM01277. MAGUK_N_PEST. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31016-1) [UniParc]FASTAAdd to basket
Also known as: PSD95-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDCLCIVTTK KYRYQDEDTP PLEHSPAHLP NQANSPPVIV NTDTLEAPGY
60 70 80 90 100
ELQVNGTEGE MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII
110 120 130 140 150
PGGAAAQDGR LRVNDSILFV NEVDVREVTH SAAVEALKEA GSIVRLYVMR
160 170 180 190 200
RKPPAEKVME IKLIKGPKGL GFSIAGGVGN QHIPGDNSIY VTKIIEGGAA
210 220 230 240 250
HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY LKVAKPSNAY
260 270 280 290 300
LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD
310 320 330 340 350
LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS
360 370 380 390 400
GELRKGDQIL SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF
410 420 430 440 450
EAKIHDLREQ LMNSSLGSGT ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ
460 470 480 490 500
ALSFRFGDVL HVIDAGDEEW WQARRVHSDS ETDDIGFIPS KRRVERREWS
510 520 530 540 550
RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL GPTKDRANDD
560 570 580 590 600
LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE
610 620 630 640 650
AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI
660 670 680 690 700
RPRSLENVLE INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI
710 720
YHKVKRVIED LSGPYIWVPA RERL
Length:724
Mass (Da):80,465
Last modified:July 1, 1993 - v1
Checksum:i7922D4E8E0F9AD85
GO
Isoform 2 (identifier: P31016-2)
Also known as: PSD95-beta
Sequence is not available
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611M → L in CAA47103 (PubMed:7680343).Curated
Sequence conflicti78 – 781S → T in CAA47103 (PubMed:7680343).Curated
Sequence conflicti177 – 1826GVGNQH → ALGTSI in CAA47103 (PubMed:7680343).Curated
Sequence conflicti200 – 2001A → G in CAA47103 (PubMed:7680343).Curated
Sequence conflicti254 – 2541S → T in CAA47103 (PubMed:7680343).Curated
Sequence conflicti540 – 55516LGPTK…LLSEF → SLDPPKTVPTMIFSPSS in CAA47103 (PubMed:7680343).CuratedAdd
BLAST
Sequence conflicti623 – 6253GKH → RDQ in AAB38270 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96853 mRNA. Translation: AAA41971.1.
X66474 mRNA. Translation: CAA47103.1.
U77090 mRNA. Translation: AAB38270.1.
PIRiA45436.
JH0800.
RefSeqiNP_062567.1. NM_019621.1. [P31016-1]
UniGeneiRn.9765.

Genome annotation databases

EnsembliENSRNOT00000068493; ENSRNOP00000059045; ENSRNOG00000018526. [P31016-1]
GeneIDi29495.
KEGGirno:29495.
UCSCiRGD:68424. rat. [P31016-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96853 mRNA. Translation: AAA41971.1.
X66474 mRNA. Translation: CAA47103.1.
U77090 mRNA. Translation: AAB38270.1.
PIRiA45436.
JH0800.
RefSeqiNP_062567.1. NM_019621.1. [P31016-1]
UniGeneiRn.9765.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BE9X-ray1.82A302-430[»]
1BFEX-ray2.30A302-402[»]
1IU0NMR-A61-151[»]
1IU2NMR-A61-151[»]
1JXMX-ray2.00A430-724[»]
1JXOX-ray2.30A/B430-724[»]
1KJWX-ray1.80A430-724[»]
1QLCNMR-A155-249[»]
1RGRNMR-A62-154[»]
1TP3X-ray1.99A302-402[»]
1TP5X-ray1.54A302-402[»]
1TQ3X-ray1.89A302-402[»]
2KA9NMR-A61-249[»]
2MHONMR-A60-155[»]
2XKXOther22.90A/B1-724[»]
3GSLX-ray2.05A/B61-249[»]
3WP0X-ray2.04A531-713[»]
3WP1X-ray2.80B531-713[»]
ProteinModelPortaliP31016.
SMRiP31016. Positions 62-249, 306-402, 430-724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248135. 19 interactions.
DIPiDIP-29264N.
IntActiP31016. 352 interactions.
MINTiMINT-93329.
STRINGi10116.ENSRNOP00000059045.

PTM databases

iPTMnetiP31016.
PhosphoSiteiP31016.
SwissPalmiP31016.

Proteomic databases

PaxDbiP31016.
PRIDEiP31016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068493; ENSRNOP00000059045; ENSRNOG00000018526. [P31016-1]
GeneIDi29495.
KEGGirno:29495.
UCSCiRGD:68424. rat. [P31016-1]

Organism-specific databases

CTDi1742.
RGDi68424. Dlg4.

Phylogenomic databases

eggNOGiKOG0708. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000232102.
HOVERGENiHBG107814.
InParanoidiP31016.
KOiK11828.
PhylomeDBiP31016.

Enzyme and pathway databases

ReactomeiR-RNO-399719. Trafficking of AMPA receptors.
R-RNO-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-RNO-442729. CREB phosphorylation through the activation of CaMKII.
R-RNO-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-RNO-451308. Activation of Ca-permeable Kainate Receptor.
R-RNO-5625900. RHO GTPases activate CIT.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-5682910. LGI-ADAM interactions.
R-RNO-8849932. SALM protein interactions at the synapse.

Miscellaneous databases

EvolutionaryTraceiP31016.
PROiP31016.

Gene expression databases

BgeeiENSRNOG00000018526.
ExpressionAtlasiP31016. baseline and differential.
GenevisibleiP31016. RN.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR016313. DLG1.
IPR019590. DLG1_PEST_dom.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23119:SF33. PTHR23119:SF33. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM01277. MAGUK_N_PEST. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLG4_RAT
AccessioniPrimary (citable) accession number: P31016
Secondary accession number(s): P97631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 185 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.