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Protein

Tyrosine phenol-lyase

Gene

tpl

Organism
Citrobacter intermedius (Escherichia intermedia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-tyrosine + H2O = phenol + pyruvate + NH3.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine phenol-lyase (EC:4.1.99.2)
Alternative name(s):
Beta-tyrosinase
Gene namesi
Name:tpl
OrganismiCitrobacter intermedius (Escherichia intermedia)
Taxonomic identifieri66695 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacter

Pathology & Biotechi

Chemistry databases

DrugBankiDB03897 Hydroxyphenyl Propionic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956341 – 456Tyrosine phenol-lyaseAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP31012

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP31012
SMRiP31012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-eliminating lyase family.Curated

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00543 Tyr_phenol_lyase, 1 hit
InterProiView protein in InterPro
IPR001597 ArAA_b-elim_lyase/Thr_aldolase
IPR011166 Beta-eliminating_lyase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR018176 Tryptophanase_CS
IPR013441 Tyr_phenol_ly
PfamiView protein in Pfam
PF01212 Beta_elim_lyase, 1 hit
PIRSFiPIRSF001386 Trpase, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR02618 tyr_phenol_ly, 1 hit
PROSITEiView protein in PROSITE
PS00853 BETA_ELIM_LYASE, 1 hit

Sequencei

Sequence statusi: Complete.

P31012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYPAEPFRI KSVETVSMIP RDERLKKMQE AGYNTFLLNS KDIYIDLLTD
60 70 80 90 100
SGTNAMSDKQ WAGMMMGDEA YAGSENFYHL ERTVQELFGF KHIVPTHQGR
110 120 130 140 150
GAENLLSQLA IKPGQYVAGN MYFTTTRYHQ EKNGAVFVDI VRDEAHDAGL
160 170 180 190 200
NIAFKGDIDL KKLQKLIDEK GAENIAYICL AVTVNLAGGQ PVSMANMRAV
210 220 230 240 250
RELTAAHGIK VFYDATRCVE NAYFIKEQEQ GFENKSIAEI VHEMFSYADG
260 270 280 290 300
CTMSGKKDCL VNIGGFLCMN DDEMFSSAKE LVVVYEGMPS YGGLAGRDME
310 320 330 340 350
AMAIGLREAM QYEYIEHRVK QVRYLGDKLK AAGVPIVEPV GGHAVFLDAR
360 370 380 390 400
RFCEHLTQDE FPAQSLAASI YVETGVRSME RGIISAGRNN VTGEHHRPKL
410 420 430 440 450
ETVRLTIPRR VYTYAHMDVV ADGIIKLYQH KEDIRGLKFI YEPKQLRFFT

ARFDYI
Length:456
Mass (Da):51,442
Last modified:July 1, 1993 - v1
Checksum:i037AB58327C22476
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00918 Genomic DNA Translation: BAA00763.1
PIRiI52555

Similar proteinsi

Entry informationi

Entry nameiTPL_CITIN
AccessioniPrimary (citable) accession number: P31012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health