P31010 (TX3_PHONI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: U7-ctenitoxin-Pn1b Short name=U7-CNTX-Pn1b Alternative name(s): Neurotoxin Tx3
Organism	Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Taxonomic identifier	6918 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Araneae › Araneomorphae › Entelegynae › Lycosoidea › Ctenidae › Phoneutria

Protein attributes

Sequence length	19 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Antagonist of L-type calcium channels (Cav1/CACNA1) By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the plectoxin superfamily. Tx3 family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Calcium channel inhibitor Ionic channel inhibitor Neurotoxin Toxin
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›19	›19	U7-ctenitoxin-Pn1b		PRO_0000087642
Experimental info
	Non-terminal residue	19	1

Sequences

	Sequence		Length	Mass (Da)
	P31010 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 3214E89CF10F7587	FASTA	19	2,244
	10 GCIGRNESQK KDNVYKFKE

References

[1]	"Isolation of neurotoxic peptides from the venom of the 'armed' spider Phoneutria nigriventer." Rezende L. Jr., Cordeiro M.N., Oliveira E.B., Diniz C.R. Toxicon 29:1225-1233(1991) [PubMed: 1801316] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	C39305.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ArachnoServer	AS000275. U7-ctenitoxin-Pn1b (N-terminal fragment).
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

TX3_PHONI

Accession

Primary (citable) accession number: P31010

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program