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Protein

40S ribosomal protein S2

Gene

RpS2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a specific developmental role during oogenesis and a general role in protein synthesis as a component of the small ribosomal subunit.1 Publication

GO - Molecular functioni

  • RNA binding Source: InterPro
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • multicellular organism development Source: UniProtKB-KW
  • oogenesis Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, Ribosomal protein
Biological processDifferentiation, Oogenesis

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-3214858. RMTs methylate histone arginines.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-8876725. Protein methylation.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S2
Alternative name(s):
Protein strings of pearls
Gene namesi
Name:RpS2
Synonyms:sop
ORF Names:CG5920
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0004867. RpS2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001316791 – 26740S ribosomal protein S2Add BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP31009.
PRIDEiP31009.

PTM databases

iPTMnetiP31009.

Expressioni

Gene expression databases

BgeeiFBgn0004867.
ExpressionAtlasiP31009. differential.
GenevisibleiP31009. DM.

Interactioni

Protein-protein interaction databases

BioGridi60403. 27 interactors.
DIPiDIP-18767N.
IntActiP31009. 25 interactors.
MINTiMINT-769241.
STRINGi7227.FBpp0079500.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AC1-267[»]
ProteinModelPortaliP31009.
SMRiP31009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 148S5 DRBMPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001433.
InParanoidiP31009.
KOiK02981.
OMAiPHTVPMK.
OrthoDBiEOG091G0LPC.
PhylomeDBiP31009.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
InterProiView protein in InterPro
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiView protein in Pfam
PF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.

Sequencei

Sequence statusi: Complete.

P31009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEAPARSG FRGGFGSRGG RGGRGRGRGR WARGRGKEDS KEWVPVTKLG
60 70 80 90 100
RLVREGKIKS LEEIYLYSLP IKEFEIIDFF LGSSLKDEVL KIMPVQKQTR
110 120 130 140 150
AGQRTRFKAF VAIGDNNGHI GLGVKCSKEV ATAIRGAIIL AKLSVVPVRR
160 170 180 190 200
GYWGNKIGKP HTVPCKVTGK CGSVSVRLIP APRGTGIVSA PVPKKLLTMA
210 220 230 240 250
GIEDCYTSAR GSTGTLGNFA KATYAAIAKT YAYLTPDLWK EMPLGSTPYQ
260
AYSDFLSKPT PRLHADA
Length:267
Mass (Da):28,900
Last modified:February 1, 1995 - v2
Checksum:iADA22CD28F100743
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 20GG → PP in CAA48872 (PubMed:8441641).Curated2
Sequence conflicti194K → R in CAA48872 (PubMed:8441641).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01334 mRNA. Translation: AAC34198.1.
U01335 Genomic DNA. Translation: AAA87053.1.
X69120 mRNA. Translation: CAA48872.1.
AE014134 Genomic DNA. Translation: AAF52822.1.
AY094799 mRNA. Translation: AAM11152.1.
PIRiS30395.
RefSeqiNP_001260303.1. NM_001273374.2.
NP_001285785.1. NM_001298856.1.
NP_476874.1. NM_057526.5.
UniGeneiDm.3451.

Genome annotation databases

EnsemblMetazoaiFBtr0079905; FBpp0079500; FBgn0004867.
FBtr0330682; FBpp0303531; FBgn0004867.
FBtr0345436; FBpp0311561; FBgn0004867.
GeneIDi34309.
KEGGidme:Dmel_CG5920.

Similar proteinsi

Entry informationi

Entry nameiRS2_DROME
AccessioniPrimary (citable) accession number: P31009
Secondary accession number(s): Q9VL74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1995
Last modified: September 27, 2017
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families