Reviewed, UniProtKB/Swiss-Prot P31007 (DLG1_DROME)

Names and origin

Protein names

Recommended name:
    Disks large 1 tumor suppressor protein

Gene names

Name:	dlg1
Synonyms:	l(1)dlg1
ORF Names:	CG1725

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	970 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. Ref.1 Ref.2 Ref.6
Subcellular location	Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Cell junction › septate junction. Note: Cytoskeleton- and membrane-associated. Located at the cytoplasmic face of the membrane in the cellular blastoderm and becomes associated with septate junctions which begin to form between epithelial cells at the time of dorsal closure. In adult flies, located at the apical-lateral membrane boundary of epithelial cells. Ref.1 Ref.2 Ref.6
Tissue specificity	During the cellular blastoderm stage, isoform B, isoform F, isoform H, isoform I and isoform S97 expression is localized to the cell borders. From stage 11 onwards, expression is found predominantly in the developing nervous system: axon bundles in the ventral cord and the brain. Stage 14 and 15 embryos exhibit expression in the developing body wall muscle. Expression in neuropil regions of the CNS and at NMJs persists through to larval development. Other isoforms show expression in embryonic epithelial cells. In larvae, expression is seen as a belt around salivary glands, imaginal disks and proventriculus. Expressed in adult reproductive tissues. In epithelia, coexpressed with scrib throughout development. Ref.1 Ref.2 Ref.6
Developmental stage	Expressed both maternally and zygotically throughout development. Ref.1
Sequence similarities	Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 1 L27 domain. Contains 3 PDZ (DHR) domains. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Cell adhesion Differentiation Neurogenesis
Cellular component	Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat SH3 domain
Molecular function	Developmental protein Transducer
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asymmetric protein localization involved in cell fate determination Traceable author statement. Source: FlyBase basal protein localization Inferred from mutant phenotype. Source: FlyBase cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Ref.6 Traceable author statement. Source: FlyBase central nervous system development Ref.2 Inferred from mutant phenotype. Source: FlyBase dorsal closure Traceable author statement. Source: FlyBase establishment of spindle orientation Inferred from mutant phenotype. Source: FlyBase establishment or maintenance of epithelial cell apical/basal polarity Traceable author statement. Source: FlyBase establishment or maintenance of neuroblast polarity Traceable author statement. Source: FlyBase establishment or maintenance of polarity of embryonic epithelium Traceable author statement. Source: FlyBase establishment or maintenance of polarity of follicular epithelium Ref.6 Inferred from genetic interaction. Source: FlyBase establishment or maintenance of polarity of larval imaginal disc epithelium Ref.6 Traceable author statement. Source: FlyBase morphogenesis of a polarized epithelium Traceable author statement. Source: FlyBase negative regulation of cell proliferation Traceable author statement. Source: FlyBase neuron differentiation Ref.2 Inferred from mutant phenotype. Source: FlyBase peripheral nervous system development Ref.2 Inferred from mutant phenotype. Source: FlyBase regulation of border follicle cell delamination Traceable author statement. Source: FlyBase regulation of cell cycle Non-traceable author statement. Source: FlyBase septate junction assembly Traceable author statement. Source: FlyBase signal transduction Inferred from electronic annotation. Source: UniProtKB-KW synaptic transmission Inferred from mutant phenotype. Source: FlyBase zonula adherens assembly Traceable author statement. Source: FlyBase
Cellular component	apical cortex Inferred from direct assay. Source: FlyBase basolateral plasma membrane Traceable author statement. Source: FlyBase cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from direct assay. Source: FlyBase septate junction Traceable author statement. Source: FlyBase terminal button Inferred from direct assay. Source: FlyBase
Molecular function	epidermal growth factor receptor binding Traceable author statement. Source: FlyBase guanylate kinase activity Traceable author statement. Source: FlyBase signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW structural molecule activity Traceable author statement. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9W4I9	1	EBI-389374,EBI-109489
EG:BACR37P7.5	Q9V3G9	1	EBI-389374,EBI-162998
Miro	Q8IMX7	1	EBI-389374,EBI-167586

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]
Isoform B (identifier: P31007-2) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Contains the N-terminal domain essential for correct neuronal development.
Isoform A (identifier: P31007-3) The sequence of this isoform differs from the canonical sequence as follows:      1-37: MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERV → MTTRKKKRDGGGSGGGFIKKVSSLFNLDSLHKASSTK      38-205: Missing.      473-473: E → GALNSMGQTV...NRSQSPQPRQ      747-761: FMLCYTQDDANAEGA → NGVVSSTSEIDINNVNNNQSNEPQP
Note: No experimental confirmation available.
Isoform E (identifier: P31007-1) Also known as: Dlg-A; D; The sequence of this isoform differs from the canonical sequence as follows:      1-29: MPVKKQEAHRALELLEDYHARLSEPQDRA → MTTRKKKRDGGGSGGGFIKKVSSLFNLDS      30-205: Missing.      473-473: E → GALNSMGQTV...NRSQSPQPRQ      747-761: FMLCYTQDDANAEGA → NGVVSSTSEIDINNVNNNQSNEPQP
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	355	1	S → D in AAA28468. Ref.1
Isoform F (identifier: P31007-4) The sequence of this isoform differs from the canonical sequence as follows:      1-7: MPVKKQE → MDSDTDSERE...EEERIADIQK      473-519: EPGSRYASTN...QKGPQGLGFN → AFMLCYTQDD...NDADYRKSSI      520-970: Missing.
Note: Contains the N-terminal domain essential for correct neuronal development.
Isoform G (identifier: P31007-5) The sequence of this isoform differs from the canonical sequence as follows:      1-29: MPVKKQEAHRALELLEDYHARLSEPQDRA → MTTRKKKRDGGGSGGGFIKKVSSLFNLDS      30-205: Missing.      473-473: E → GALNSMGQTV...NRSQSPQPRQ      746-746: P → PNGVVSSTSEIDINNVNNNQSNEPQP
Note: No experimental confirmation available.
Isoform H (identifier: P31007-6) The sequence of this isoform differs from the canonical sequence as follows:      93-151: Missing.
Note: Contains the N-terminal domain essential for correct neuronal development.
Isoform I (identifier: P31007-7) Also known as: C; The sequence of this isoform differs from the canonical sequence as follows:      93-151: Missing.      206-267: VNGDDSWLYE...ADGRLSINDI → SQIQIQSLTQ...KMLKRAFEST      268-970: Missing.
Note: Contains the N-terminal domain essential for correct neuronal development.
Isoform S97 (identifier: P31007-8) The sequence of this isoform differs from the canonical sequence as follows:      93-151: Missing.      205-205: T → TLHKASSTK      761-761: A → GEIIYRVELPDMEQITLIYLENNDADYP
Note: Contains the N-terminal domain essential for correct neuronal development.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 970	970	Disks large 1 tumor suppressor protein		PRO_0000094538
Regions
	Domain	4 – 64	61	L27
	Domain	216 – 303	88	PDZ 1
	Domain	330 – 421	92	PDZ 2
	Domain	506 – 587	82	PDZ 3
	Domain	620 – 690	71	SH3
	Domain	780 – 955	176	Guanylate kinase-like
Amino acid modifications
	Modified residue	496	1	Phosphoserine Ref.7
	Modified residue	714	1	Phosphothreonine Ref.7
Natural variations
	Alternative sequence	1 – 37	37	MPVKK…AIERV → MTTRKKKRDGGGSGGGFIKK VSSLFNLDSLHKASSTK in isoform A.		VSP_011403
	Alternative sequence	1 – 29	29	MPVKK…PQDRA → MTTRKKKRDGGGSGGGFIKK VSSLFNLDS in isoform E and isoform G.		VSP_011402
	Alternative sequence	1 – 7	7	MPVKKQE → MDSDTDSEREKSSDPNEGLL SSDDKTFHDDDEPAEDSSPA DDEEEPEEEECLLPQKKAQI RCDQDQPPLVVLVQPSAEAI EVRQEIDDTNPVAVAAKASD MDGDSQLEVMEHQMETVTEP DPEPPKCPTSLRDSVRESVE CFYSAQDLLEYGHMLSSTSM VRTPDVESGYFEKSESDASR DEWEGPSSSSSGAARCRLLS GISGLSVSSSSRHSAEGLRM ELSRFRTMIETLERESLEKS QSELQLKAKSKAKPKPKQRS HVQDAAGESGSEQGSERGFW STIFGQAGLAISQDEEERIA DIQK in isoform F.		VSP_011401
	Alternative sequence	30 – 205	176	Missing in isoform E and isoform G.		VSP_011404
	Alternative sequence	38 – 205	168	Missing in isoform A.		VSP_011405
	Alternative sequence	93 – 151	59	Missing in isoform I, isoform H and isoform S97.		VSP_011406
	Alternative sequence	205	1	T → TLHKASSTK in isoform S97.		VSP_011407
	Alternative sequence	206 – 267	62	VNGDD…SINDI → SQIQIQSLTQTYPNAHQRKR VLVSLHPHQHQHQSQIQHQH HYQLRHNNGIQAKMLKRAFE ST in isoform I.		VSP_011408
	Alternative sequence	268 – 970	703	Missing in isoform I.		VSP_011409
	Alternative sequence	473 – 519	47	EPGSR…GLGFN → AFMLCYTQDDANAEGGEIIY RVELPDMEQITLIYLENNDA DYRKSSI in isoform F.		VSP_011411
	Alternative sequence	473	1	E → GALNSMGQTVVDSPSIPQAA AAVAAAANASASASVIASNN TISNTTVTTVTATATASNSS SKLPPSLGANSSISISNSNS NSNSNNINNINSINNNNSSS SSTTATVAAATPTAASAAAA AASSPPANSFYNNASMPALP VESNQTNNRSQSPQPRQ in isoform A, isoform E and isoform G.		VSP_011410
	Alternative sequence	520 – 970	451	Missing in isoform F.		VSP_011412
	Alternative sequence	746	1	P → PNGVVSSTSEIDINNVNNNQ SNEPQP in isoform G.		VSP_011413
	Alternative sequence	747 – 761	15	FMLCY…NAEGA → NGVVSSTSEIDINNVNNNQS NEPQP in isoform A and isoform E.		VSP_011414
	Alternative sequence	761	1	A → GEIIYRVELPDMEQITLIYL ENNDADYP in isoform S97.		VSP_011415
Experimental info
	Sequence conflict	365	1	M → T Ref.1
	Sequence conflict	365	1	M → T Ref.2
	Sequence conflict	369	1	A → R Ref.1
	Sequence conflict	369	1	A → R Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified August 31, 2004. Version 2. Checksum: 544D1E1AD03B0674	FASTA	970	106,673
	10 20 30 40 50 60 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 70 80 90 100 110 120 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADFIKSSNLN RNCAYEFNND ASSNQTNQSA 130 140 150 160 170 180 LNQNPIANNV SAQAQAEALS RTFKSELEEI LNQRMRIESD TENAKEPTVE QQQKQQQAQQ 190 200 210 220 230 240 RSSRSPQQQN PQQQQGSKSR SGSQTVNGDD SWLYEDIQLE RGNSGLGFSI AGGTDNPHIG 250 260 270 280 290 300 TDTSIYITKL ISGGAAAADG RLSINDIIVS VNDVSVVDVP HASAVDALKK AGNVVKLHVK 310 320 330 340 350 360 RKRGTATTPA AGSAAGDARD SAASGPKVIE IDLVKGGKGL GFSIAGGIGN QHIPGDNGIY 370 380 390 400 410 420 VTKLMDGGAA QVDGRLSIGD KLIAVRTNGS EKNLENVTHE LAVATLKSIT DKVTLIIGKT 430 440 450 460 470 480 QHLTTSASGG GGGGLSSGQQ LSQSQSQLAT SQSQSQVHQQ QHATPMVNSQ STEPGSRYAS 490 500 510 520 530 540 TNVLAAVPPG TPRAVSTEDI TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA 550 560 570 580 590 600 DLGSELKRGD QLLSVNNVNL THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL 610 620 630 640 650 660 KQQAALGAGG SGTLLRTTQK RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD 670 680 690 700 710 720 EWWQARRVLG DNEDEQIGIV PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK 730 740 750 760 770 780 NFTFSRKFPF MKSRDEKNED GSDQEPFMLC YTQDDANAEG ASEENVLSYE AVQRLSINYT 790 800 810 820 830 840 RPVIILGPLK DRINDDLISE YPDKFGSCVP HTTRPKREYE VDGRDYHFVS SREQMERDIQ 850 860 870 880 890 900 NHLFIEAGQY NDNLYGTSVA SVREVAEKGK HCILDVSGNA IKRLQVAQLY PVAVFIKPKS 910 920 930 940 950 960 VDSVMEMNRR MTEEQAKKTY ERAIKMEQEF GEYFTGVVQG DTIEEIYSKV KSMIWSQSGP 970 TIWVPSKESL
	Isoform A. Checksum: E641D9BE7669331C	FASTA	968	103,239
	10 20 30 40 50 60 MTTRKKKRDG GGSGGGFIKK VSSLFNLDSL HKASSTKVNG DDSWLYEDIQ LERGNSGLGF 70 80 90 100 110 120 SIAGGTDNPH IGTDTSIYIT KLISGGAAAA DGRLSINDII VSVNDVSVVD VPHASAVDAL 130 140 150 160 170 180 KKAGNVVKLH VKRKRGTATT PAAGSAAGDA RDSAASGPKV IEIDLVKGGK GLGFSIAGGI 190 200 210 220 230 240 GNQHIPGDNG IYVTKLMDGG AAQVDGRLSI GDKLIAVRTN GSEKNLENVT HELAVATLKS 250 260 270 280 290 300 ITDKVTLIIG KTQHLTTSAS GGGGGGLSSG QQLSQSQSQL ATSQSQSQVH QQQHATPMVN 310 320 330 340 350 360 SQSTGALNSM GQTVVDSPSI PQAAAAVAAA ANASASASVI ASNNTISNTT VTTVTATATA 370 380 390 400 410 420 SNSSSKLPPS LGANSSISIS NSNSNSNSNN INNINSINNN NSSSSSTTAT VAAATPTAAS 430 440 450 460 470 480 AAAAAASSPP ANSFYNNASM PALPVESNQT NNRSQSPQPR QPGSRYASTN VLAAVPPGTP 490 500 510 520 530 540 RAVSTEDITR EPRTITIQKG PQGLGFNIVG GEDGQGIYVS FILAGGPADL GSELKRGDQL 550 560 570 580 590 600 LSVNNVNLTH ATHEEAAQAL KTSGGVVTLL AQYRPEEYNR FEARIQELKQ QAALGAGGSG 610 620 630 640 650 660 TLLRTTQKRS LYVRALFDYD PNRDDGLPSR GLPFKHGDIL HVTNASDDEW WQARRVLGDN 670 680 690 700 710 720 EDEQIGIVPS KRRWERKMRA RDRSVKFQGH AAANNNLDKQ STLDRKKKNF TFSRKFPFMK 730 740 750 760 770 780 SRDEKNEDGS DQEPNGVVSS TSEIDINNVN NNQSNEPQPS EENVLSYEAV QRLSINYTRP 790 800 810 820 830 840 VIILGPLKDR INDDLISEYP DKFGSCVPHT TRPKREYEVD GRDYHFVSSR EQMERDIQNH 850 860 870 880 890 900 LFIEAGQYND NLYGTSVASV REVAEKGKHC ILDVSGNAIK RLQVAQLYPV AVFIKPKSVD 910 920 930 940 950 960 SVMEMNRRMT EEQAKKTYER AIKMEQEFGE YFTGVVQGDT IEEIYSKVKS MIWSQSGPTI WVPSKESL
	Isoform E (Dlg-A) (D). Checksum: 26E9B6026226BDA3	FASTA	960	102,386
	10 20 30 40 50 60 MTTRKKKRDG GGSGGGFIKK VSSLFNLDSV NGDDSWLYED IQLERGNSGL GFSIAGGTDN 70 80 90 100 110 120 PHIGTDTSIY ITKLISGGAA AADGRLSIND IIVSVNDVSV VDVPHASAVD ALKKAGNVVK 130 140 150 160 170 180 LHVKRKRGTA TTPAAGSAAG DARDSAASGP KVIEIDLVKG GKGLGFSIAG GIGNQHIPGD 190 200 210 220 230 240 NGIYVTKLMD GGAAQVDGRL SIGDKLIAVR TNGSEKNLEN VTHELAVATL KSITDKVTLI 250 260 270 280 290 300 IGKTQHLTTS ASGGGGGGLS SGQQLSQSQS QLATSQSQSQ VHQQQHATPM VNSQSTGALN 310 320 330 340 350 360 SMGQTVVDSP SIPQAAAAVA AAANASASAS VIASNNTISN TTVTTVTATA TASNSSSKLP 370 380 390 400 410 420 PSLGANSSIS ISNSNSNSNS NNINNINSIN NNNSSSSSTT ATVAAATPTA ASAAAAAASS 430 440 450 460 470 480 PPANSFYNNA SMPALPVESN QTNNRSQSPQ PRQPGSRYAS TNVLAAVPPG TPRAVSTEDI 490 500 510 520 530 540 TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA DLGSELKRGD QLLSVNNVNL 550 560 570 580 590 600 THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL KQQAALGAGG SGTLLRTTQK 610 620 630 640 650 660 RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD EWWQARRVLG DNEDEQIGIV 670 680 690 700 710 720 PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK NFTFSRKFPF MKSRDEKNED 730 740 750 760 770 780 GSDQEPNGVV SSTSEIDINN VNNNQSNEPQ PSEENVLSYE AVQRLSINYT RPVIILGPLK 790 800 810 820 830 840 DRINDDLISE YPDKFGSCVP HTTRPKREYE VDGRDYHFVS SREQMERDIQ NHLFIEAGQY 850 860 870 880 890 900 NDNLYGTSVA SVREVAEKGK HCILDVSGNA IKRLQVAQLY PVAVFIKPKS VDSVMEMNRR 910 920 930 940 950 960 MTEEQAKKTY ERAIKMEQEF GEYFTGVVQG DTIEEIYSKV KSMIWSQSGP TIWVPSKESL
	Isoform F. Checksum: 35894E1555DE5AAE	FASTA	816	88,662
	10 20 30 40 50 60 MDSDTDSERE KSSDPNEGLL SSDDKTFHDD DEPAEDSSPA DDEEEPEEEE CLLPQKKAQI 70 80 90 100 110 120 RCDQDQPPLV VLVQPSAEAI EVRQEIDDTN PVAVAAKASD MDGDSQLEVM EHQMETVTEP 130 140 150 160 170 180 DPEPPKCPTS LRDSVRESVE CFYSAQDLLE YGHMLSSTSM VRTPDVESGY FEKSESDASR 190 200 210 220 230 240 DEWEGPSSSS SGAARCRLLS GISGLSVSSS SRHSAEGLRM ELSRFRTMIE TLERESLEKS 250 260 270 280 290 300 QSELQLKAKS KAKPKPKQRS HVQDAAGESG SEQGSERGFW STIFGQAGLA ISQDEEERIA 310 320 330 340 350 360 DIQKAHRALE LLEDYHARLS EPQDRALRIA IERVIRIFKS RLFQALLDIQ EFYELTLLDD 370 380 390 400 410 420 SKSIQQKTAE TLQIATKWEK DGQAVKIADF IKSSNLNRNC AYEFNNDASS NQTNQSALNQ 430 440 450 460 470 480 NPIANNVSAQ AQAEALSRTF KSELEEILNQ RMRIESDTEN AKEPTVEQQQ KQQQAQQRSS 490 500 510 520 530 540 RSPQQQNPQQ QQGSKSRSGS QTVNGDDSWL YEDIQLERGN SGLGFSIAGG TDNPHIGTDT 550 560 570 580 590 600 SIYITKLISG GAAAADGRLS INDIIVSVND VSVVDVPHAS AVDALKKAGN VVKLHVKRKR 610 620 630 640 650 660 GTATTPAAGS AAGDARDSAA SGPKVIEIDL VKGGKGLGFS IAGGIGNQHI PGDNGIYVTK 670 680 690 700 710 720 LMDGGAAQVD GRLSIGDKLI AVRTNGSEKN LENVTHELAV ATLKSITDKV TLIIGKTQHL 730 740 750 760 770 780 TTSASGGGGG GLSSGQQLSQ SQSQLATSQS QSQVHQQQHA TPMVNSQSTA FMLCYTQDDA 790 800 810 NAEGGEIIYR VELPDMEQIT LIYLENNDAD YRKSSI
	Isoform G. Checksum: 15D466336AA4194C	FASTA	975	104,016
	10 20 30 40 50 60 MTTRKKKRDG GGSGGGFIKK VSSLFNLDSV NGDDSWLYED IQLERGNSGL GFSIAGGTDN 70 80 90 100 110 120 PHIGTDTSIY ITKLISGGAA AADGRLSIND IIVSVNDVSV VDVPHASAVD ALKKAGNVVK 130 140 150 160 170 180 LHVKRKRGTA TTPAAGSAAG DARDSAASGP KVIEIDLVKG GKGLGFSIAG GIGNQHIPGD 190 200 210 220 230 240 NGIYVTKLMD GGAAQVDGRL SIGDKLIAVR TNGSEKNLEN VTHELAVATL KSITDKVTLI 250 260 270 280 290 300 IGKTQHLTTS ASGGGGGGLS SGQQLSQSQS QLATSQSQSQ VHQQQHATPM VNSQSTGALN 310 320 330 340 350 360 SMGQTVVDSP SIPQAAAAVA AAANASASAS VIASNNTISN TTVTTVTATA TASNSSSKLP 370 380 390 400 410 420 PSLGANSSIS ISNSNSNSNS NNINNINSIN NNNSSSSSTT ATVAAATPTA ASAAAAAASS 430 440 450 460 470 480 PPANSFYNNA SMPALPVESN QTNNRSQSPQ PRQPGSRYAS TNVLAAVPPG TPRAVSTEDI 490 500 510 520 530 540 TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA DLGSELKRGD QLLSVNNVNL 550 560 570 580 590 600 THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL KQQAALGAGG SGTLLRTTQK 610 620 630 640 650 660 RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD EWWQARRVLG DNEDEQIGIV 670 680 690 700 710 720 PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK NFTFSRKFPF MKSRDEKNED 730 740 750 760 770 780 GSDQEPNGVV SSTSEIDINN VNNNQSNEPQ PFMLCYTQDD ANAEGASEEN VLSYEAVQRL 790 800 810 820 830 840 SINYTRPVII LGPLKDRIND DLISEYPDKF GSCVPHTTRP KREYEVDGRD YHFVSSREQM 850 860 870 880 890 900 ERDIQNHLFI EAGQYNDNLY GTSVASVREV AEKGKHCILD VSGNAIKRLQ VAQLYPVAVF 910 920 930 940 950 960 IKPKSVDSVM EMNRRMTEEQ AKKTYERAIK MEQEFGEYFT GVVQGDTIEE IYSKVKSMIW 970 SQSGPTIWVP SKESL
	Isoform H. Checksum: 47ACCA6E52AD1168	FASTA	911	100,171
	10 20 30 40 50 60 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 70 80 90 100 110 120 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADNQRMRIES DTENAKEPTV EQQQKQQQAQ 130 140 150 160 170 180 QRSSRSPQQQ NPQQQQGSKS RSGSQTVNGD DSWLYEDIQL ERGNSGLGFS IAGGTDNPHI 190 200 210 220 230 240 GTDTSIYITK LISGGAAAAD GRLSINDIIV SVNDVSVVDV PHASAVDALK KAGNVVKLHV 250 260 270 280 290 300 KRKRGTATTP AAGSAAGDAR DSAASGPKVI EIDLVKGGKG LGFSIAGGIG NQHIPGDNGI 310 320 330 340 350 360 YVTKLMDGGA AQVDGRLSIG DKLIAVRTNG SEKNLENVTH ELAVATLKSI TDKVTLIIGK 370 380 390 400 410 420 TQHLTTSASG GGGGGLSSGQ QLSQSQSQLA TSQSQSQVHQ QQHATPMVNS QSTEPGSRYA 430 440 450 460 470 480 STNVLAAVPP GTPRAVSTED ITREPRTITI QKGPQGLGFN IVGGEDGQGI YVSFILAGGP 490 500 510 520 530 540 ADLGSELKRG DQLLSVNNVN LTHATHEEAA QALKTSGGVV TLLAQYRPEE YNRFEARIQE 550 560 570 580 590 600 LKQQAALGAG GSGTLLRTTQ KRSLYVRALF DYDPNRDDGL PSRGLPFKHG DILHVTNASD 610 620 630 640 650 660 DEWWQARRVL GDNEDEQIGI VPSKRRWERK MRARDRSVKF QGHAAANNNL DKQSTLDRKK 670 680 690 700 710 720 KNFTFSRKFP FMKSRDEKNE DGSDQEPFML CYTQDDANAE GASEENVLSY EAVQRLSINY 730 740 750 760 770 780 TRPVIILGPL KDRINDDLIS EYPDKFGSCV PHTTRPKREY EVDGRDYHFV SSREQMERDI 790 800 810 820 830 840 QNHLFIEAGQ YNDNLYGTSV ASVREVAEKG KHCILDVSGN AIKRLQVAQL YPVAVFIKPK 850 860 870 880 890 900 SVDSVMEMNR RMTEEQAKKT YERAIKMEQE FGEYFTGVVQ GDTIEEIYSK VKSMIWSQSG 910 PTIWVPSKES L
	Isoform I (C). Checksum: BB8F4B44E9DE2562	FASTA	208	24,378
	10 20 30 40 50 60 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 70 80 90 100 110 120 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADNQRMRIES DTENAKEPTV EQQQKQQQAQ 130 140 150 160 170 180 QRSSRSPQQQ NPQQQQGSKS RSGSQTSQIQ IQSLTQTYPN AHQRKRVLVS LHPHQHQHQS 190 200 QIQHQHHYQL RHNNGIQAKM LKRAFEST
	Isoform S97. Checksum: 6BAFDD6BE66191B7	FASTA	946	104,263
	10 20 30 40 50 60 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 70 80 90 100 110 120 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADNQRMRIES DTENAKEPTV EQQQKQQQAQ 130 140 150 160 170 180 QRSSRSPQQQ NPQQQQGSKS RSGSQTLHKA SSTKVNGDDS WLYEDIQLER GNSGLGFSIA 190 200 210 220 230 240 GGTDNPHIGT DTSIYITKLI SGGAAAADGR LSINDIIVSV NDVSVVDVPH ASAVDALKKA 250 260 270 280 290 300 GNVVKLHVKR KRGTATTPAA GSAAGDARDS AASGPKVIEI DLVKGGKGLG FSIAGGIGNQ 310 320 330 340 350 360 HIPGDNGIYV TKLMDGGAAQ VDGRLSIGDK LIAVRTNGSE KNLENVTHEL AVATLKSITD 370 380 390 400 410 420 KVTLIIGKTQ HLTTSASGGG GGGLSSGQQL SQSQSQLATS QSQSQVHQQQ HATPMVNSQS 430 440 450 460 470 480 TEPGSRYAST NVLAAVPPGT PRAVSTEDIT REPRTITIQK GPQGLGFNIV GGEDGQGIYV 490 500 510 520 530 540 SFILAGGPAD LGSELKRGDQ LLSVNNVNLT HATHEEAAQA LKTSGGVVTL LAQYRPEEYN 550 560 570 580 590 600 RFEARIQELK QQAALGAGGS GTLLRTTQKR SLYVRALFDY DPNRDDGLPS RGLPFKHGDI 610 620 630 640 650 660 LHVTNASDDE WWQARRVLGD NEDEQIGIVP SKRRWERKMR ARDRSVKFQG HAAANNNLDK 670 680 690 700 710 720 QSTLDRKKKN FTFSRKFPFM KSRDEKNEDG SDQEPFMLCY TQDDANAEGG EIIYRVELPD 730 740 750 760 770 780 MEQITLIYLE NNDADYPSEE NVLSYEAVQR LSINYTRPVI ILGPLKDRIN DDLISEYPDK 790 800 810 820 830 840 FGSCVPHTTR PKREYEVDGR DYHFVSSREQ MERDIQNHLF IEAGQYNDNL YGTSVASVRE 850 860 870 880 890 900 VAEKGKHCIL DVSGNAIKRL QVAQLYPVAV FIKPKSVDSV MEMNRRMTEE QAKKTYERAI 910 920 930 940 KMEQEFGEYF TGVVQGDTIE EIYSKVKSMI WSQSGPTIWV PSKESL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions." Woods D.F., Bryant P.J. Cell 66:451-464(1991) [PubMed: 1651169] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: Oregon-R. Tissue: Embryo.
[2]	"Novel isoforms of Dlg are fundamental for neuronal development in Drosophila." Mendoza C., Olguin P., Lafferte G., Thomas U., Ebitsch S., Gundelfinger E.D., Kukuljan M., Sierralta J. J. Neurosci. 23:2093-2101(2003) [PubMed: 12657668] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS B; F; H; I AND S97), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Embryo.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS F AND I), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 711-970 (ISOFORM G). Strain: Berkeley. Tissue: Embryo and Head.
[6]	"Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors." Bilder D., Li M., Perrimon N. Science 289:113-116(2000) [PubMed: 10884224] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND THR-714, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M73529 mRNA. Translation: AAA28468.1. AY332243 mRNA. Translation: AAQ01226.1. AE014298 Genomic DNA. Translation: AAF48037.2. AE014298 Genomic DNA. Translation: AAF48038.2. AE014298 Genomic DNA. Translation: AAF48039.2. AE014298 Genomic DNA. Translation: AAN09630.1. AE014298 Genomic DNA. Translation: AAS65308.1. AE014298 Genomic DNA. Translation: AAS65309.1. AE014298 Genomic DNA. Translation: AAS65312.1. AY059433 mRNA. Translation: AAL13339.1. AY069408 mRNA. Translation: AAL39553.1. Different initiation. AY075410 mRNA. Translation: AAL68235.1.
PIR	A39651.
RefSeq	NP_511120.2. NP_727518.1. NP_727519.1. NP_727520.1. NP_996404.1. NP_996405.1. NP_996406.1.
UniGene	Dm.4352
3D structure databases
HSSP	HSSP built from PDB template 1JXO based on UniProtKB P31016.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31007. 32 interactions.
Genome annotation databases
Ensembl	FBgn0001624. Drosophila melanogaster. [Contig view]
GeneID	32083.
NMPDR	fig|7227.3.peg.17410.
Organism-specific databases
FlyBase	FBgn0001624. dlg1.
Gene expression databases
ArrayExpress	P31007.
GermOnline	CG1725. Drosophila melanogaster.
Family and domain databases
InterPro	IPR019586. Gua_kin_assoc_C. IPR008144. Guanylate_kin. IPR008145. Guanylt/Ca. IPR004172. L27. IPR015143. L27_1. IPR001478. PDZ/DHR/GLGF. IPR001452. SH3_domain. [Graphical view]
Pfam	PF10603. Gua_kin_assoc_C. 1 hit. PF00625. Guanylate_kin. 1 hit. PF09058. L27_1. 1 hit. PF00595. PDZ. 3 hits. PF00018. SH3_1. 1 hit. [Graphical view]
ProDom	PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00072. GuKc. 1 hit. SM00569. L27. 1 hit. SM00228. PDZ. 3 hits. SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. PS51022. L27. 1 hit. PS50106. PDZ. 3 hits. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	776723.

Entry information

Entry name

DLG1_DROME

Accession

Primary (citable) accession number: P31007
Secondary accession number(s): Q7KV38 , Q7KV39, Q7KV40, Q7YXH8, Q8SY37, Q8T0C6, Q95TF5, Q9VYZ4, Q9VYZ5, Q9VYZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	August 31, 2004
Last modified:	June 16, 2009
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project