P31007 (DLG1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disks large 1 tumor suppressor protein

Gene names

Name:	dlg1
Synonyms:	l(1)dlg1
ORF Names:	CG1725

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	970 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. Ref.1 Ref.2 Ref.7
Subcellular location	Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Cell junction › septate junction. Note: Cytoskeleton- and membrane-associated. Located at the cytoplasmic face of the membrane in the cellular blastoderm and becomes associated with septate junctions which begin to form between epithelial cells at the time of dorsal closure. In adult flies, located at the apical-lateral membrane boundary of epithelial cells. Ref.1 Ref.2 Ref.7
Tissue specificity	During the cellular blastoderm stage, isoform B, isoform F, isoform H, isoform I and isoform L expression is localized to the cell borders. From stage 11 onwards, expression is found predominantly in the developing nervous system: axon bundles in the ventral cord and the brain. Stage 14 and 15 embryos exhibit expression in the developing body wall muscle. Expression in neuropil regions of the CNS and at NMJs persists through to larval development. Other isoforms show expression in embryonic epithelial cells. In larvae, expression is seen as a belt around salivary glands, imaginal disks and proventriculus. Expressed in adult reproductive tissues. In epithelia, coexpressed with scrib throughout development. Ref.1 Ref.2 Ref.7
Developmental stage	Expressed both maternally and zygotically throughout development. Ref.1
Sequence similarities	Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 1 L27 domain. Contains 3 PDZ (DHR) domains. Contains 1 SH3 domain.
Sequence caution	The sequence AAL39553.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Cell adhesion Differentiation Neurogenesis
Cellular component	Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat SH3 domain
Molecular function	Developmental protein Transducer
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior axis specification, follicular epithelium Inferred from mutant phenotype PubMed 19948068. Source: BHF-UCL asymmetric protein localization involved in cell fate determination Traceable author statement PubMed 15018932. Source: FlyBase basal protein localization Inferred from mutant phenotype PubMed 11117748. Source: FlyBase cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell fate commitment involved in pattern specification Inferred from mutant phenotype PubMed 19948068. Source: BHF-UCL cell fate specification Inferred from mutant phenotype PubMed 19948068. Source: BHF-UCL dorsal closure Non-traceable author statement PubMed 12147138. Source: FlyBase establishment of spindle orientation Inferred from mutant phenotype PubMed 16377571. Source: FlyBase establishment or maintenance of epithelial cell apical/basal polarity Non-traceable author statement PubMed 11782950. Source: FlyBase establishment or maintenance of neuroblast polarity Traceable author statement PubMed 11700298. Source: FlyBase establishment or maintenance of polarity of embryonic epithelium Traceable author statement PubMed 11117747PubMed 11117748. Source: FlyBase establishment or maintenance of polarity of larval imaginal disc epithelium Non-traceable author statement PubMed 11700298. Source: FlyBase locomotor rhythm Inferred from mutant phenotype PubMed 18171947. Source: FlyBase male courtship behavior Inferred from mutant phenotype PubMed 18171947. Source: FlyBase morphogenesis of a polarized epithelium Traceable author statement PubMed 14644201. Source: FlyBase negative regulation of cell proliferation Traceable author statement PubMed 12766944. Source: FlyBase negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 19948068. Source: BHF-UCL pole plasm protein localization Inferred from mutant phenotype PubMed 19948068. Source: BHF-UCL positive phototaxis Inferred from mutant phenotype PubMed 18171947. Source: FlyBase regulation of JAK-STAT cascade Inferred from mutant phenotype PubMed 19948068. Source: BHF-UCL regulation of Notch signaling pathway Inferred from mutant phenotype PubMed 19948068. Source: BHF-UCL regulation of border follicle cell delamination Traceable author statement PubMed 10822261. Source: FlyBase regulation of cell cycle Non-traceable author statement PubMed 12766944. Source: FlyBase regulation of epidermal growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 19948068. Source: BHF-UCL septate junction assembly Traceable author statement PubMed 12141438PubMed 12147138. Source: FlyBase synaptic growth at neuromuscular junction Inferred from mutant phenotype PubMed 17224403. Source: FlyBase synaptic transmission Inferred from mutant phenotype PubMed 10458610PubMed 12451127. Source: FlyBase
Cellular_component	apical cortex Inferred from direct assay PubMed 11117748PubMed 16377571. Source: FlyBase apicolateral plasma membrane Inferred from direct assay Ref.7. Source: FlyBase basolateral plasma membrane Traceable author statement PubMed 14644201. Source: FlyBase cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell lateral plasma membrane Inferred from direct assay PubMed 18501681. Source: FlyBase neuromuscular junction Inferred from direct assay PubMed 18070911. Source: FlyBase perinuclear region of cytoplasm Inferred from direct assay PubMed 18501681. Source: FlyBase postsynaptic membrane Inferred from direct assay PubMed 16413491. Source: FlyBase smooth septate junction Inferred from direct assay PubMed 22854041. Source: FlyBase terminal bouton Inferred from direct assay PubMed 11937021. Source: FlyBase
Molecular_function	epidermal growth factor receptor binding Traceable author statement PubMed 12766944. Source: FlyBase guanylate kinase activity Traceable author statement PubMed 10458610PubMed 11117747. Source: FlyBase signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW structural molecule activity Traceable author statement PubMed 11494317. Source: FlyBase
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: P31007-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Contains the N-terminal domain essential for correct neuronal development.

Isoform A (identifier: P31007-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERV → MTTRKKKRDGGGSGGGFIKKVSSLFNLDSLHKASSTK
     38-205: Missing.
     473-473: E → GALNSMGQTV...NRSQSPQPRQ
     747-761: FMLCYTQDDANAEGA → NGVVSSTSEIDINNVNNNQSNEPQP

Note: No experimental confirmation available.

Isoform E (identifier: P31007-1)

Also known as: Dlg-A; D;

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MPVKKQEAHRALELLEDYHARLSEPQDRA → MTTRKKKRDGGGSGGGFIKKVSSLFNLDS
     30-205: Missing.
     473-473: E → GALNSMGQTV...NRSQSPQPRQ
     747-761: FMLCYTQDDANAEGA → NGVVSSTSEIDINNVNNNQSNEPQP

Isoform F (identifier: P31007-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MPVKKQE → MDSDTDSERE...EEERIADIQK
     473-519: EPGSRYASTN...QKGPQGLGFN → AFMLCYTQDD...NDADYRKSSI
     520-970: Missing.

Note: Contains the N-terminal domain essential for correct neuronal development.

Isoform G (identifier: P31007-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MPVKKQEAHRALELLEDYHARLSEPQDRA → MTTRKKKRDGGGSGGGFIKKVSSLFNLDS
     30-205: Missing.
     473-473: E → GALNSMGQTV...NRSQSPQPRQ
     746-746: P → PNGVVSSTSEIDINNVNNNQSNEPQP

Note: No experimental confirmation available.

Isoform H (identifier: P31007-6)

The sequence of this isoform differs from the canonical sequence as follows:
     93-151: Missing.

Note: Contains the N-terminal domain essential for correct neuronal development.

Isoform I (identifier: P31007-7)

Also known as: C; J;

The sequence of this isoform differs from the canonical sequence as follows:
     93-151: Missing.
     206-267: VNGDDSWLYE...ADGRLSINDI → SQIQIQSLTQ...KMLKRAFEST
     268-970: Missing.

Note: Contains the N-terminal domain essential for correct neuronal development.

Isoform K (identifier: P31007-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MPVKKQEAHR...KDGQAVKIAD → MIDWVSIVRH...GSRYACCCAN
     93-151: Missing.

Note: No experimental confirmation available.

Isoform L (identifier: P31007-8)

Also known as: S97;

The sequence of this isoform differs from the canonical sequence as follows:
     93-151: Missing.
     205-205: T → TLHKASSTK
     761-761: A → GEIIYRVELPDMEQITLIYLENNDADYP

Note: Contains the N-terminal domain essential for correct neuronal development.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 970

970

Disks large 1 tumor suppressor protein

PRO_0000094538

Regions

Domain

4 – 64

61

L27

Domain

216 – 303

88

PDZ 1

Domain

330 – 421

92

PDZ 2

Domain

506 – 587

82

PDZ 3

Domain

620 – 690

71

SH3

Domain

780 – 955

176

Guanylate kinase-like

Amino acid modifications

Modified residue

496

1

Phosphoserine Ref.8

Modified residue

714

1

Phosphothreonine Ref.8

Natural variations

Alternative sequence

1 – 92

92

MPVKK…VKIAD → MIDWVSIVRHSRRRFSNYVG SRSPVRMRRRRRQLTAPPPQ QQQQQHYHQQQQQDQHQSRE RQKKDKEKEKETEKDNESGG GIGSRYACCCAN in isoform K.

VSP_039402

Alternative sequence

1 – 37

37

MPVKK…AIERV → MTTRKKKRDGGGSGGGFIKK VSSLFNLDSLHKASSTK in isoform A.

VSP_011403

Alternative sequence

1 – 29

29

MPVKK…PQDRA → MTTRKKKRDGGGSGGGFIKK VSSLFNLDS in isoform E and isoform G.

VSP_011402

Alternative sequence

1 – 7

7

MPVKKQE → MDSDTDSEREKSSDPNEGLL SSDDKTFHDDDEPAEDSSPA DDEEEPEEEECLLPQKKAQI RCDQDQPPLVVLVQPSAEAI EVRQEIDDTNPVAVAAKASD MDGDSQLEVMEHQMETVTEP DPEPPKCPTSLRDSVRESVE CFYSAQDLLEYGHMLSSTSM VRTPDVESGYFEKSESDASR DEWEGPSSSSSGAARCRLLS GISGLSVSSSSRHSAEGLRM ELSRFRTMIETLERESLEKS QSELQLKAKSKAKPKPKQRS HVQDAAGESGSEQGSERGFW STIFGQAGLAISQDEEERIA DIQK in isoform F.

VSP_011401

Alternative sequence

30 – 205

176

Missing in isoform E and isoform G.

VSP_011404

Alternative sequence

38 – 205

168

Missing in isoform A.

VSP_011405

Alternative sequence

93 – 151

59

Missing in isoform I, isoform H, isoform K and isoform L.

VSP_011406

Alternative sequence

205

1

T → TLHKASSTK in isoform L.

VSP_011407

Alternative sequence

206 – 267

62

VNGDD…SINDI → SQIQIQSLTQTYPNAHQRKR VLVSLHPHQHQHQSQIQHQH HYQLRHNNGIQAKMLKRAFE ST in isoform I.

VSP_011408

Alternative sequence

268 – 970

703

Missing in isoform I.

VSP_011409

Alternative sequence

473 – 519

47

EPGSR…GLGFN → AFMLCYTQDDANAEGGEIIY RVELPDMEQITLIYLENNDA DYRKSSI in isoform F.

VSP_011411

Alternative sequence

473

1

E → GALNSMGQTVVDSPSIPQAA AAVAAAANASASASVIASNN TISNTTVTTVTATATASNSS SKLPPSLGANSSISISNSNS NSNSNNINNINSINNNNSSS SSTTATVAAATPTAASAAAA AASSPPANSFYNNASMPALP VESNQTNNRSQSPQPRQ in isoform A, isoform E and isoform G.

VSP_011410

Alternative sequence

520 – 970

451

Missing in isoform F.

VSP_011412

Alternative sequence

746

1

P → PNGVVSSTSEIDINNVNNNQ SNEPQP in isoform G.

VSP_011413

Alternative sequence

747 – 761

15

FMLCY…NAEGA → NGVVSSTSEIDINNVNNNQS NEPQP in isoform A and isoform E.

VSP_011414

Alternative sequence

761

1

A → GEIIYRVELPDMEQITLIYL ENNDADYP in isoform L.

VSP_011415

Experimental info

Sequence conflict

365

1

M → T in AAA28468. Ref.1

Sequence conflict

365

1

M → T in AAQ01226. Ref.2

Sequence conflict

369

1

A → R in AAA28468. Ref.1

Sequence conflict

369

1

A → R in AAQ01226. Ref.2

Sequence conflict

395

1

E → G in ACV53090. Ref.6

Isoform E:

Sequence conflict

355

1

S → D in AAA28468. Ref.1

Secondary structure

1

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970

Helix Strand Turn

Details...

Beta strand

624 – 627

4

Beta strand

651 – 656

6

Beta strand

659 – 665

7

Beta strand

679 – 681

3

Helix

683 – 691

9

Beta strand

769 – 776

8

Beta strand

783 – 787

5

Helix

790 – 800

11

Turn

802 – 804

3

Turn

822 – 824

3

Helix

832 – 840

9

Beta strand

844 – 850

7

Beta strand

853 – 858

6

Helix

859 – 868

10

Beta strand

871 – 874

4

Helix

879 – 886

8

Beta strand

892 – 896

5

Helix

901 – 906

6

Helix

915 – 930

16

Turn

931 – 933

3

Beta strand

935 – 938

4

Helix

943 – 957

15

Beta strand

960 – 965

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified August 31, 2004. Version 2. Checksum: 544D1E1AD03B0674	FASTA	970	106,673
	10 20 30 40 50 60 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 70 80 90 100 110 120 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADFIKSSNLN RNCAYEFNND ASSNQTNQSA 130 140 150 160 170 180 LNQNPIANNV SAQAQAEALS RTFKSELEEI LNQRMRIESD TENAKEPTVE QQQKQQQAQQ 190 200 210 220 230 240 RSSRSPQQQN PQQQQGSKSR SGSQTVNGDD SWLYEDIQLE RGNSGLGFSI AGGTDNPHIG 250 260 270 280 290 300 TDTSIYITKL ISGGAAAADG RLSINDIIVS VNDVSVVDVP HASAVDALKK AGNVVKLHVK 310 320 330 340 350 360 RKRGTATTPA AGSAAGDARD SAASGPKVIE IDLVKGGKGL GFSIAGGIGN QHIPGDNGIY 370 380 390 400 410 420 VTKLMDGGAA QVDGRLSIGD KLIAVRTNGS EKNLENVTHE LAVATLKSIT DKVTLIIGKT 430 440 450 460 470 480 QHLTTSASGG GGGGLSSGQQ LSQSQSQLAT SQSQSQVHQQ QHATPMVNSQ STEPGSRYAS 490 500 510 520 530 540 TNVLAAVPPG TPRAVSTEDI TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA 550 560 570 580 590 600 DLGSELKRGD QLLSVNNVNL THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL 610 620 630 640 650 660 KQQAALGAGG SGTLLRTTQK RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD 670 680 690 700 710 720 EWWQARRVLG DNEDEQIGIV PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK 730 740 750 760 770 780 NFTFSRKFPF MKSRDEKNED GSDQEPFMLC YTQDDANAEG ASEENVLSYE AVQRLSINYT 790 800 810 820 830 840 RPVIILGPLK DRINDDLISE YPDKFGSCVP HTTRPKREYE VDGRDYHFVS SREQMERDIQ 850 860 870 880 890 900 NHLFIEAGQY NDNLYGTSVA SVREVAEKGK HCILDVSGNA IKRLQVAQLY PVAVFIKPKS 910 920 930 940 950 960 VDSVMEMNRR MTEEQAKKTY ERAIKMEQEF GEYFTGVVQG DTIEEIYSKV KSMIWSQSGP 970 TIWVPSKESL
	Isoform A [UniParc]. Checksum: E641D9BE7669331C	FASTA	968	103,239
	10 20 30 40 50 60 MTTRKKKRDG GGSGGGFIKK VSSLFNLDSL HKASSTKVNG DDSWLYEDIQ LERGNSGLGF 70 80 90 100 110 120 SIAGGTDNPH IGTDTSIYIT KLISGGAAAA DGRLSINDII VSVNDVSVVD VPHASAVDAL 130 140 150 160 170 180 KKAGNVVKLH VKRKRGTATT PAAGSAAGDA RDSAASGPKV IEIDLVKGGK GLGFSIAGGI 190 200 210 220 230 240 GNQHIPGDNG IYVTKLMDGG AAQVDGRLSI GDKLIAVRTN GSEKNLENVT HELAVATLKS 250 260 270 280 290 300 ITDKVTLIIG KTQHLTTSAS GGGGGGLSSG QQLSQSQSQL ATSQSQSQVH QQQHATPMVN 310 320 330 340 350 360 SQSTGALNSM GQTVVDSPSI PQAAAAVAAA ANASASASVI ASNNTISNTT VTTVTATATA 370 380 390 400 410 420 SNSSSKLPPS LGANSSISIS NSNSNSNSNN INNINSINNN NSSSSSTTAT VAAATPTAAS 430 440 450 460 470 480 AAAAAASSPP ANSFYNNASM PALPVESNQT NNRSQSPQPR QPGSRYASTN VLAAVPPGTP 490 500 510 520 530 540 RAVSTEDITR EPRTITIQKG PQGLGFNIVG GEDGQGIYVS FILAGGPADL GSELKRGDQL 550 560 570 580 590 600 LSVNNVNLTH ATHEEAAQAL KTSGGVVTLL AQYRPEEYNR FEARIQELKQ QAALGAGGSG 610 620 630 640 650 660 TLLRTTQKRS LYVRALFDYD PNRDDGLPSR GLPFKHGDIL HVTNASDDEW WQARRVLGDN 670 680 690 700 710 720 EDEQIGIVPS KRRWERKMRA RDRSVKFQGH AAANNNLDKQ STLDRKKKNF TFSRKFPFMK 730 740 750 760 770 780 SRDEKNEDGS DQEPNGVVSS TSEIDINNVN NNQSNEPQPS EENVLSYEAV QRLSINYTRP 790 800 810 820 830 840 VIILGPLKDR INDDLISEYP DKFGSCVPHT TRPKREYEVD GRDYHFVSSR EQMERDIQNH 850 860 870 880 890 900 LFIEAGQYND NLYGTSVASV REVAEKGKHC ILDVSGNAIK RLQVAQLYPV AVFIKPKSVD 910 920 930 940 950 960 SVMEMNRRMT EEQAKKTYER AIKMEQEFGE YFTGVVQGDT IEEIYSKVKS MIWSQSGPTI WVPSKESL
	Isoform E (Dlg-A) (D) [UniParc]. Checksum: 26E9B6026226BDA3	FASTA	960	102,386
	10 20 30 40 50 60 MTTRKKKRDG GGSGGGFIKK VSSLFNLDSV NGDDSWLYED IQLERGNSGL GFSIAGGTDN 70 80 90 100 110 120 PHIGTDTSIY ITKLISGGAA AADGRLSIND IIVSVNDVSV VDVPHASAVD ALKKAGNVVK 130 140 150 160 170 180 LHVKRKRGTA TTPAAGSAAG DARDSAASGP KVIEIDLVKG GKGLGFSIAG GIGNQHIPGD 190 200 210 220 230 240 NGIYVTKLMD GGAAQVDGRL SIGDKLIAVR TNGSEKNLEN VTHELAVATL KSITDKVTLI 250 260 270 280 290 300 IGKTQHLTTS ASGGGGGGLS SGQQLSQSQS QLATSQSQSQ VHQQQHATPM VNSQSTGALN 310 320 330 340 350 360 SMGQTVVDSP SIPQAAAAVA AAANASASAS VIASNNTISN TTVTTVTATA TASNSSSKLP 370 380 390 400 410 420 PSLGANSSIS ISNSNSNSNS NNINNINSIN NNNSSSSSTT ATVAAATPTA ASAAAAAASS 430 440 450 460 470 480 PPANSFYNNA SMPALPVESN QTNNRSQSPQ PRQPGSRYAS TNVLAAVPPG TPRAVSTEDI 490 500 510 520 530 540 TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA DLGSELKRGD QLLSVNNVNL 550 560 570 580 590 600 THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL KQQAALGAGG SGTLLRTTQK 610 620 630 640 650 660 RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD EWWQARRVLG DNEDEQIGIV 670 680 690 700 710 720 PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK NFTFSRKFPF MKSRDEKNED 730 740 750 760 770 780 GSDQEPNGVV SSTSEIDINN VNNNQSNEPQ PSEENVLSYE AVQRLSINYT RPVIILGPLK 790 800 810 820 830 840 DRINDDLISE YPDKFGSCVP HTTRPKREYE VDGRDYHFVS SREQMERDIQ NHLFIEAGQY 850 860 870 880 890 900 NDNLYGTSVA SVREVAEKGK HCILDVSGNA IKRLQVAQLY PVAVFIKPKS VDSVMEMNRR 910 920 930 940 950 960 MTEEQAKKTY ERAIKMEQEF GEYFTGVVQG DTIEEIYSKV KSMIWSQSGP TIWVPSKESL
	Isoform F [UniParc]. Checksum: 35894E1555DE5AAE	FASTA	816	88,662
	10 20 30 40 50 60 MDSDTDSERE KSSDPNEGLL SSDDKTFHDD DEPAEDSSPA DDEEEPEEEE CLLPQKKAQI 70 80 90 100 110 120 RCDQDQPPLV VLVQPSAEAI EVRQEIDDTN PVAVAAKASD MDGDSQLEVM EHQMETVTEP 130 140 150 160 170 180 DPEPPKCPTS LRDSVRESVE CFYSAQDLLE YGHMLSSTSM VRTPDVESGY FEKSESDASR 190 200 210 220 230 240 DEWEGPSSSS SGAARCRLLS GISGLSVSSS SRHSAEGLRM ELSRFRTMIE TLERESLEKS 250 260 270 280 290 300 QSELQLKAKS KAKPKPKQRS HVQDAAGESG SEQGSERGFW STIFGQAGLA ISQDEEERIA 310 320 330 340 350 360 DIQKAHRALE LLEDYHARLS EPQDRALRIA IERVIRIFKS RLFQALLDIQ EFYELTLLDD 370 380 390 400 410 420 SKSIQQKTAE TLQIATKWEK DGQAVKIADF IKSSNLNRNC AYEFNNDASS NQTNQSALNQ 430 440 450 460 470 480 NPIANNVSAQ AQAEALSRTF KSELEEILNQ RMRIESDTEN AKEPTVEQQQ KQQQAQQRSS 490 500 510 520 530 540 RSPQQQNPQQ QQGSKSRSGS QTVNGDDSWL YEDIQLERGN SGLGFSIAGG TDNPHIGTDT 550 560 570 580 590 600 SIYITKLISG GAAAADGRLS INDIIVSVND VSVVDVPHAS AVDALKKAGN VVKLHVKRKR 610 620 630 640 650 660 GTATTPAAGS AAGDARDSAA SGPKVIEIDL VKGGKGLGFS IAGGIGNQHI PGDNGIYVTK 670 680 690 700 710 720 LMDGGAAQVD GRLSIGDKLI AVRTNGSEKN LENVTHELAV ATLKSITDKV TLIIGKTQHL 730 740 750 760 770 780 TTSASGGGGG GLSSGQQLSQ SQSQLATSQS QSQVHQQQHA TPMVNSQSTA FMLCYTQDDA 790 800 810 NAEGGEIIYR VELPDMEQIT LIYLENNDAD YRKSSI
	Isoform G [UniParc]. Checksum: 15D466336AA4194C	FASTA	975	104,016
	10 20 30 40 50 60 MTTRKKKRDG GGSGGGFIKK VSSLFNLDSV NGDDSWLYED IQLERGNSGL GFSIAGGTDN 70 80 90 100 110 120 PHIGTDTSIY ITKLISGGAA AADGRLSIND IIVSVNDVSV VDVPHASAVD ALKKAGNVVK 130 140 150 160 170 180 LHVKRKRGTA TTPAAGSAAG DARDSAASGP KVIEIDLVKG GKGLGFSIAG GIGNQHIPGD 190 200 210 220 230 240 NGIYVTKLMD GGAAQVDGRL SIGDKLIAVR TNGSEKNLEN VTHELAVATL KSITDKVTLI 250 260 270 280 290 300 IGKTQHLTTS ASGGGGGGLS SGQQLSQSQS QLATSQSQSQ VHQQQHATPM VNSQSTGALN 310 320 330 340 350 360 SMGQTVVDSP SIPQAAAAVA AAANASASAS VIASNNTISN TTVTTVTATA TASNSSSKLP 370 380 390 400 410 420 PSLGANSSIS ISNSNSNSNS NNINNINSIN NNNSSSSSTT ATVAAATPTA ASAAAAAASS 430 440 450 460 470 480 PPANSFYNNA SMPALPVESN QTNNRSQSPQ PRQPGSRYAS TNVLAAVPPG TPRAVSTEDI 490 500 510 520 530 540 TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA DLGSELKRGD QLLSVNNVNL 550 560 570 580 590 600 THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL KQQAALGAGG SGTLLRTTQK 610 620 630 640 650 660 RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD EWWQARRVLG DNEDEQIGIV 670 680 690 700 710 720 PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK NFTFSRKFPF MKSRDEKNED 730 740 750 760 770 780 GSDQEPNGVV SSTSEIDINN VNNNQSNEPQ PFMLCYTQDD ANAEGASEEN VLSYEAVQRL 790 800 810 820 830 840 SINYTRPVII LGPLKDRIND DLISEYPDKF GSCVPHTTRP KREYEVDGRD YHFVSSREQM 850 860 870 880 890 900 ERDIQNHLFI EAGQYNDNLY GTSVASVREV AEKGKHCILD VSGNAIKRLQ VAQLYPVAVF 910 920 930 940 950 960 IKPKSVDSVM EMNRRMTEEQ AKKTYERAIK MEQEFGEYFT GVVQGDTIEE IYSKVKSMIW 970 SQSGPTIWVP SKESL
	Isoform H [UniParc]. Checksum: 47ACCA6E52AD1168	FASTA	911	100,171
	10 20 30 40 50 60 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 70 80 90 100 110 120 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADNQRMRIES DTENAKEPTV EQQQKQQQAQ 130 140 150 160 170 180 QRSSRSPQQQ NPQQQQGSKS RSGSQTVNGD DSWLYEDIQL ERGNSGLGFS IAGGTDNPHI 190 200 210 220 230 240 GTDTSIYITK LISGGAAAAD GRLSINDIIV SVNDVSVVDV PHASAVDALK KAGNVVKLHV 250 260 270 280 290 300 KRKRGTATTP AAGSAAGDAR DSAASGPKVI EIDLVKGGKG LGFSIAGGIG NQHIPGDNGI 310 320 330 340 350 360 YVTKLMDGGA AQVDGRLSIG DKLIAVRTNG SEKNLENVTH ELAVATLKSI TDKVTLIIGK 370 380 390 400 410 420 TQHLTTSASG GGGGGLSSGQ QLSQSQSQLA TSQSQSQVHQ QQHATPMVNS QSTEPGSRYA 430 440 450 460 470 480 STNVLAAVPP GTPRAVSTED ITREPRTITI QKGPQGLGFN IVGGEDGQGI YVSFILAGGP 490 500 510 520 530 540 ADLGSELKRG DQLLSVNNVN LTHATHEEAA QALKTSGGVV TLLAQYRPEE YNRFEARIQE 550 560 570 580 590 600 LKQQAALGAG GSGTLLRTTQ KRSLYVRALF DYDPNRDDGL PSRGLPFKHG DILHVTNASD 610 620 630 640 650 660 DEWWQARRVL GDNEDEQIGI VPSKRRWERK MRARDRSVKF QGHAAANNNL DKQSTLDRKK 670 680 690 700 710 720 KNFTFSRKFP FMKSRDEKNE DGSDQEPFML CYTQDDANAE GASEENVLSY EAVQRLSINY 730 740 750 760 770 780 TRPVIILGPL KDRINDDLIS EYPDKFGSCV PHTTRPKREY EVDGRDYHFV SSREQMERDI 790 800 810 820 830 840 QNHLFIEAGQ YNDNLYGTSV ASVREVAEKG KHCILDVSGN AIKRLQVAQL YPVAVFIKPK 850 860 870 880 890 900 SVDSVMEMNR RMTEEQAKKT YERAIKMEQE FGEYFTGVVQ GDTIEEIYSK VKSMIWSQSG 910 PTIWVPSKES L
	Isoform I (C) (J) [UniParc]. Checksum: BB8F4B44E9DE2562	FASTA	208	24,378
	10 20 30 40 50 60 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 70 80 90 100 110 120 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADNQRMRIES DTENAKEPTV EQQQKQQQAQ 130 140 150 160 170 180 QRSSRSPQQQ NPQQQQGSKS RSGSQTSQIQ IQSLTQTYPN AHQRKRVLVS LHPHQHQHQS 190 200 QIQHQHHYQL RHNNGIQAKM LKRAFEST
	Isoform K [UniParc]. Checksum: 6FE13A27211F2122	FASTA	911	100,458
	10 20 30 40 50 60 MIDWVSIVRH SRRRFSNYVG SRSPVRMRRR RRQLTAPPPQ QQQQQHYHQQ QQQDQHQSRE 70 80 90 100 110 120 RQKKDKEKEK ETEKDNESGG GIGSRYACCC ANNQRMRIES DTENAKEPTV EQQQKQQQAQ 130 140 150 160 170 180 QRSSRSPQQQ NPQQQQGSKS RSGSQTVNGD DSWLYEDIQL ERGNSGLGFS IAGGTDNPHI 190 200 210 220 230 240 GTDTSIYITK LISGGAAAAD GRLSINDIIV SVNDVSVVDV PHASAVDALK KAGNVVKLHV 250 260 270 280 290 300 KRKRGTATTP AAGSAAGDAR DSAASGPKVI EIDLVKGGKG LGFSIAGGIG NQHIPGDNGI 310 320 330 340 350 360 YVTKLMDGGA AQVDGRLSIG DKLIAVRTNG SEKNLENVTH ELAVATLKSI TDKVTLIIGK 370 380 390 400 410 420 TQHLTTSASG GGGGGLSSGQ QLSQSQSQLA TSQSQSQVHQ QQHATPMVNS QSTEPGSRYA 430 440 450 460 470 480 STNVLAAVPP GTPRAVSTED ITREPRTITI QKGPQGLGFN IVGGEDGQGI YVSFILAGGP 490 500 510 520 530 540 ADLGSELKRG DQLLSVNNVN LTHATHEEAA QALKTSGGVV TLLAQYRPEE YNRFEARIQE 550 560 570 580 590 600 LKQQAALGAG GSGTLLRTTQ KRSLYVRALF DYDPNRDDGL PSRGLPFKHG DILHVTNASD 610 620 630 640 650 660 DEWWQARRVL GDNEDEQIGI VPSKRRWERK MRARDRSVKF QGHAAANNNL DKQSTLDRKK 670 680 690 700 710 720 KNFTFSRKFP FMKSRDEKNE DGSDQEPFML CYTQDDANAE GASEENVLSY EAVQRLSINY 730 740 750 760 770 780 TRPVIILGPL KDRINDDLIS EYPDKFGSCV PHTTRPKREY EVDGRDYHFV SSREQMERDI 790 800 810 820 830 840 QNHLFIEAGQ YNDNLYGTSV ASVREVAEKG KHCILDVSGN AIKRLQVAQL YPVAVFIKPK 850 860 870 880 890 900 SVDSVMEMNR RMTEEQAKKT YERAIKMEQE FGEYFTGVVQ GDTIEEIYSK VKSMIWSQSG 910 PTIWVPSKES L
	Isoform L (S97) [UniParc]. Checksum: 6BAFDD6BE66191B7	FASTA	946	104,263
	10 20 30 40 50 60 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL 70 80 90 100 110 120 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADNQRMRIES DTENAKEPTV EQQQKQQQAQ 130 140 150 160 170 180 QRSSRSPQQQ NPQQQQGSKS RSGSQTLHKA SSTKVNGDDS WLYEDIQLER GNSGLGFSIA 190 200 210 220 230 240 GGTDNPHIGT DTSIYITKLI SGGAAAADGR LSINDIIVSV NDVSVVDVPH ASAVDALKKA 250 260 270 280 290 300 GNVVKLHVKR KRGTATTPAA GSAAGDARDS AASGPKVIEI DLVKGGKGLG FSIAGGIGNQ 310 320 330 340 350 360 HIPGDNGIYV TKLMDGGAAQ VDGRLSIGDK LIAVRTNGSE KNLENVTHEL AVATLKSITD 370 380 390 400 410 420 KVTLIIGKTQ HLTTSASGGG GGGLSSGQQL SQSQSQLATS QSQSQVHQQQ HATPMVNSQS 430 440 450 460 470 480 TEPGSRYAST NVLAAVPPGT PRAVSTEDIT REPRTITIQK GPQGLGFNIV GGEDGQGIYV 490 500 510 520 530 540 SFILAGGPAD LGSELKRGDQ LLSVNNVNLT HATHEEAAQA LKTSGGVVTL LAQYRPEEYN 550 560 570 580 590 600 RFEARIQELK QQAALGAGGS GTLLRTTQKR SLYVRALFDY DPNRDDGLPS RGLPFKHGDI 610 620 630 640 650 660 LHVTNASDDE WWQARRVLGD NEDEQIGIVP SKRRWERKMR ARDRSVKFQG HAAANNNLDK 670 680 690 700 710 720 QSTLDRKKKN FTFSRKFPFM KSRDEKNEDG SDQEPFMLCY TQDDANAEGG EIIYRVELPD 730 740 750 760 770 780 MEQITLIYLE NNDADYPSEE NVLSYEAVQR LSINYTRPVI ILGPLKDRIN DDLISEYPDK 790 800 810 820 830 840 FGSCVPHTTR PKREYEVDGR DYHFVSSREQ MERDIQNHLF IEAGQYNDNL YGTSVASVRE 850 860 870 880 890 900 VAEKGKHCIL DVSGNAIKRL QVAQLYPVAV FIKPKSVDSV MEMNRRMTEE QAKKTYERAI 910 920 930 940 KMEQEFGEYF TGVVQGDTIE EIYSKVKSMI WSQSGPTIWV PSKESL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions." Woods D.F., Bryant P.J. Cell 66:451-464(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: Oregon-R. Tissue: Embryo.
[2]	"Novel isoforms of Dlg are fundamental for neuronal development in Drosophila." Mendoza C., Olguin P., Lafferte G., Thomas U., Ebitsch S., Gundelfinger E.D., Kukuljan M., Sierralta J. J. Neurosci. 23:2093-2101(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B; F; H; I AND L), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Embryo.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS F AND I), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 711-970 (ISOFORM G). Strain: Berkeley. Tissue: Embryo and Head.
[6]	Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM G). Strain: Berkeley. Tissue: Embryo.
[7]	"Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors." Bilder D., Li M., Perrimon N. Science 289:113-116(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND THR-714, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M73529 mRNA. Translation: AAA28468.1.
AY332243 mRNA. Translation: AAQ01226.1.
AE014298 Genomic DNA. Translation: AAF48037.2.
AE014298 Genomic DNA. Translation: AAF48038.2.
AE014298 Genomic DNA. Translation: AAF48039.2.
AE014298 Genomic DNA. Translation: AAN09630.1.
AE014298 Genomic DNA. Translation: AAS65308.1.
AE014298 Genomic DNA. Translation: AAS65309.1.
AE014298 Genomic DNA. Translation: AAS65310.1.
AE014298 Genomic DNA. Translation: AAS65311.1.
AE014298 Genomic DNA. Translation: AAS65312.1.
AE014298 Genomic DNA. Translation: AAS65313.1.
AE014298 Genomic DNA. Translation: ABW09394.1.
AE014298 Genomic DNA. Translation: ABW09395.1.
AY059433 mRNA. Translation: AAL13339.1.
AY069408 mRNA. Translation: AAL39553.1. Different initiation.
AY075410 mRNA. Translation: AAL68235.1.
BT099726 mRNA. Translation: ACV53090.1.

PIR

A39651.

RefSeq

NP_001096955.1. NM_001103485.3.
NP_001096956.1. NM_001103486.3.
NP_001162719.1. NM_001169248.2.
NP_001245623.1. NM_001258694.2.
NP_001259447.1. NM_001272518.1.
NP_511120.2. NM_078565.5.
NP_727518.1. NM_167280.2.
NP_727519.1. NM_167281.2.
NP_727520.1. NM_167282.4.
NP_996402.1. NM_206679.2.
NP_996403.1. NM_206680.2.
NP_996404.1. NM_206681.4.
NP_996405.1. NM_206682.4.
NP_996406.1. NM_206683.4.
NP_996407.1. NM_206684.4.

UniGene

Dm.4352.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TVT	X-ray	1.60	A	618-970	[»]

ProteinModelPortal

P31007.

SMR

P31007. Positions 2-65, 214-970.

ModBase

Search...

Protein-protein interaction databases

IntAct

P31007. 16 interactions.

MINT

MINT-287852.

STRING

7227.FBpp0089352.

Proteomic databases

PaxDb

P31007.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0073488; FBpp0089351; FBgn0001624.

GeneID

32083.

KEGG

dme:Dmel_CG1725.

Organism-specific databases

CTD

1739.

FlyBase

FBgn0001624. dlg1.

Phylogenomic databases

eggNOG

COG0194.

GeneTree

ENSGT00560000077048.

InParanoid

P31007.

KO

K12076.

OMA

WNRRITE.

OrthoDB

EOG4X0K7Q.

Gene expression databases

Bgee

P31007.

GermOnline

CG1725. Drosophila melanogaster.

Family and domain databases

InterPro

IPR008144. Guanylate_kin.
IPR008145. Guanylate_kin/L-typ_Ca_channel.
IPR020590. Guanylate_kinase_CS.
IPR004172. L27.
IPR015143. L27_1.
IPR001478. PDZ.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF00625. Guanylate_kin. 1 hit.
PF09058. L27_1. 1 hit.
PF00595. PDZ. 3 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]

SMART

SM00072. GuKc. 1 hit.
SM00569. L27. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 3 hits.
SSF50044. SH3. 1 hit.

PROSITE

PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

dlg1. drosophila.

GenomeRNAi

32083.

NextBio

776723.

Entry information

Entry name

DLG1_DROME

Accession

Primary (citable) accession number: P31007
Secondary accession number(s): A4V4A8 , A4V4B0, A8JUR9, A8JUS0, C7LAH6, Q7KV38, Q7KV39, Q7KV40, Q7YXH8, Q8SY37, Q8T0C6, Q95TF5, Q9VYZ4, Q9VYZ5, Q9VYZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	August 31, 2004
Last modified:	May 1, 2013
This is version 145 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project