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P31006 (KGUA_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:GUK1
Synonyms:GUK
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP.

Catalytic activity

ATP + GMP = ADP + GDP.

Subunit structure

Monomer.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 198197Guanylate kinase
PRO_0000170653

Regions

Domain4 – 186183Guanylate kinase-like
Nucleotide binding11 – 188ATP By similarity

Sites

Active site441 By similarity
Active site1371 By similarity
Active site1481 By similarity
Binding site1711ATP By similarity
Binding site1721ATP; via carbonyl oxygen By similarity

Amino acid modifications

Modified residue21N-acetylglycine Ref.1

Sequences

Sequence LengthMass (Da)Tools
P31006 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 09E9CC7130CCE1A7

FASTA19821,921
        10         20         30         40         50         60 
MGSPRPVVLS GPSGAGKSTL LKKLLQEHSS IFGFSVSHTT RDPRPGEENG KDYYFVTREV 

        70         80         90        100        110        120 
MQRDIAAGDF IEHAEFSGNL YGTSKAAVRA VQAMNRICVL DVDLQGVRNI KKTDLQPIYI 

       130        140        150        160        170        180 
FVQPPSLDVL EQRLRQRNTE TEESLAKRLA AAKADMESSK EPGLFDLIII NDSLDKAYWA 

       190 
LKEALSEEIK KAQATGHS 

« Hide

References

[1]"Purification and sequence determination of guanylate kinase from pig brain."
Zschocke P.D., Schiltz E., Schulz G.E.
Eur. J. Biochem. 213:263-269(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-198.
Tissue: Brain.

Cross-references

Sequence databases

PIRKIPGGU. S23776.

3D structure databases

ProteinModelPortalP31006.
SMRP31006. Positions 5-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000014875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000037640.
HOVERGENHBG003344.

Enzyme and pathway databases

ReactomeREACT_212627. Metabolism.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_PIG
AccessionPrimary (citable) accession number: P31006
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families