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Protein

Guanylate kinase

Gene

GUK1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for recycling GMP and indirectly, cGMP.

Catalytic activityi

ATP + GMP = ADP + GDP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44By similarity1
Active sitei137By similarity1
Active sitei148By similarity1
Binding sitei171ATPBy similarity1
Binding sitei172ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:GUK1
Synonyms:GUK
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001706532 – 198Guanylate kinaseAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP31006.
PeptideAtlasiP31006.
PRIDEiP31006.

PTM databases

iPTMnetiP31006.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014875.

Structurei

3D structure databases

ProteinModelPortaliP31006.
SMRiP31006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 186Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST183

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG0707. Eukaryota.
COG0194. LUCA.
HOGENOMiHOG000037640.
HOVERGENiHBG003344.
InParanoidiP31006.

Family and domain databases

InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPRPVVLS GPSGAGKSTL LKKLLQEHSS IFGFSVSHTT RDPRPGEENG
60 70 80 90 100
KDYYFVTREV MQRDIAAGDF IEHAEFSGNL YGTSKAAVRA VQAMNRICVL
110 120 130 140 150
DVDLQGVRNI KKTDLQPIYI FVQPPSLDVL EQRLRQRNTE TEESLAKRLA
160 170 180 190
AAKADMESSK EPGLFDLIII NDSLDKAYWA LKEALSEEIK KAQATGHS
Length:198
Mass (Da):21,921
Last modified:January 23, 2007 - v2
Checksum:i09E9CC7130CCE1A7
GO

Sequence databases

PIRiS23776. KIPGGU.
UniGeneiSsc.11943.

Similar proteinsi

Entry informationi

Entry nameiKGUA_PIG
AccessioniPrimary (citable) accession number: P31006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families